Prenatal programing of motivated behaviors:can innate immunity prime behavior?

作     者：Larisa Montalvo-Martínez Gabriela Cruz-Carrillo Roger Maldonado-Ruiz Luis ATrujillo-Villarreal Eduardo AGarza-Villarreal Alberto Camacho-Morales Larisa Montalvo-Martínez;Gabriela Cruz-Carrillo;Roger Maldonado-Ruiz;Luis A.Trujillo-Villarreal;Eduardo A.Garza-Villarreal;Alberto Camacho-Morales

作者机构：Universidad Autónoma de Nuevo LeónDepartment of BiochemistryCollege of MedicineMonterreyMéxico Universidad Autónoma de Nuevo LeónNeurometabolism UnitCenter for Research and Development in Health SciencesMonterreyMéxico Universidad Nacional Autónoma de MéxicoCampus Juriquilla Instituto de NeurobiologíaQueretaroMéxico 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2023年第18卷第2期

页      面：280-283页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the National Council of Science and Technology in Mexico(CONACYT)708452 CONACYT to LMM 855559 CONACYT to GCC 573686 CONACYT to RMR PAICYT 2021 to ACM。 

主　　题：addiction autism behavior cytokines diet maternal immune activation prenatal programming sociability trained immunity western-diets 

摘      要：Prenatal programming during pregnancy sets physiological outcomes in the offspring by integrating external or internal stimuli.Accordingly,pregnancy is an important stage of physiological adaptations to the environment where the fetus becomes exposed and adapted to the maternal milieu.Maternal exposure to high-energy dense diets can affect motivated behavior in the offs p ring leading to addiction and impaired sociability.A high-energy dense exposure also increases the pro-inflammatory cytokines profile in plasma and brain and favors microglia activation in the offspring.While still under investigation,prenatal exposure to high-energy dense diets promotes structural abnormalities in selective brain regions regulating motivation and social behavior in the offspring.The current review addresses the role of energy-dense foods programming central and peripheral inflammatory profiles during embryonic development and its effect on motivated behavior in the offspring.We provide preclinical and clinical evidence that supports the contribution of prenatal programming in shaping immune profiles that favor structural and brain circuit disruption leading to aberrant motivated behaviors after birth.We hope this minireview encourages future research on novel insights into the mechanisms underlying maternal programming of motivated behavior by central immune networks.