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Hepatitis C virus clearance and less liver damage in patients with high cholesterol, low-density lipoprotein cholesterol and APOE ε4 allele

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World Journal of Gastroenterology 2019年第38期25卷 5826-5837页

作者： Karina Gonzalez-Aldaco Sonia Roman Rafael torres-Valadez Claudia Ojeda-Granados luis a torres-reyes Arturo Panduro Department of Molecular Biology in Medicine Civil Hospital of Guadalajara "Fray Antonio Alcalde" and Health Sciences Center University of Guadalajara

BACKGROUND Cholesterol is related to improvements in the rate of sustained virological response and a robust immune response against the hepatitis C virus(HCV).APOE gene polymorphisms regulate cholesterol levels modifying the course of the HCV *** relationship between cholesterol,APOE alleles,and the outcome of HCV infection has not been evaluated in the admixed population of *** To investigate the role of APOE-ε2,-ε3,and-ε4 alleles and the metabolic profile in the outcome of HCV *** A total of 299 treatment-na?ve HCV patients were included in this retrospective *** were stratified in chronic hepatitis C(CHC)(n=206)and spontaneous clearance(SC)(n=93).A clinical record was *** tests were assessed by dry chemistry *** genotypes were determined using a Real-Time polymerase chain reaction *** Total cholesterol,low-density lipoprotein cholesterol(LDL-c),triglycerides,and hypercholesterolemia were higher in SC than CHC patients as well as the frequency of the APOEε4 allele(12.4%vs 7.3%).SC patients were overweight(54.8%).Theε4 allele was associated with SC(OR=0.55,95%CI:0.31-0.98,P=0.042)and mild fibrosis(F1-F2)in CHC patients(OR 0.091,95%CI 0.01-0.75,P=0.020).LDL-c≥101.5 mg/dL(OR=0.20,95%CI:0.10-0.41,P<0.001)and BMI≥26.6 kg/m2(OR=0.37,95%CI:0.18-0.76,P<0.001)were associated with SC status;while ALT≥50.5 IU/L was negatively associated(OR=5.67,95%CI:2.69-11.97,P<0.001).CONCLUSION In SC patients,the APOEε4 allele and LDL-c conferred a protective effect in the course of the HCV infection in the context of excess body weight.

关键词： Liver damage Body mass index Spontaneous hepatitis C virus clearance Low-density lipoprotein Cholesterol

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Structural performance assessment of GFRP elastic gridshells by machine learning interpretability methods

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Frontiers of Structural and Civil Engineering 2022年第10期16卷 1249-1266页

作者： Soheila KOOKALANI Bin CHENG Jose luis Chavez torres Department of Civil Engineering Shanghai Jiao Tong UniversityShanghai 200240China Department of Civil Engineering Technical University of LojaLoja 110102Ecuador

The prediction of structural performance plays a significant role in damage assessment of glass fiber reinforcement polymer(GFRP)elastic gridshell *** learning(ML)approaches are implemented in this study,to predict maximum stress and displacement of GFRP elastic gridshell *** ML algorithms,including linear regression(LR),ridge regression(RR),support vector regression(SVR),K-nearest neighbors(KNN),decision tree(DT),random forest(RF),adaptive boosting(AdaBoost),extreme gradient boosting(XGBoost),category boosting(CatBoost),and light gradient boosting machine(LightGBM),are implemented in this *** features of structural performance considered in this study are the maximum stress as f1(x)and the maximum displacement to self-weight ratio as f2(x).A comparative study is conducted and the Catboost model presents the highest prediction ***,interpretable ML approaches,including shapely additive explanations(SHAP),partial dependence plot(PDP),and accumulated local effects(ALE),are applied to explain the *** is employed to describe the importance of each variable to structural performance both locally and *** results of sensitivity analysis(SA),feature importance of the CatBoost model and SHAP approach indicate the same parameters as the most significant variables for f1(x)and f2(x).

关键词： machine learning gridshell structure regression sensitivity analysis interpretability methods

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Use of two-surfactants mixtures to attain specific HLB values for assisted TPH-diesel biodegradation

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Journal of Environmental Sciences 2004年第6期16卷 950-956页

作者： luis G. torres Neftalí Rojas Rosario Iturbe Instituto de Ingeniería Universidad Nacional Autó noma de México Coordinación de Ingeniería Ambiental Grupo Saneamiento de Suelos y Acuíferos Apartado Postal 70-472 Coyoacán 04510 México D.F. Mexico

In a surfactant assisted biodegradation process, the choice of surfactant(s) is of crucial importance. The question is: does the type of surfactant(i.e. chemical family) affect the biodegradation process at fixed hidrophillic-lypofillic balance(HLB) values? Microcosm assessments were developed using contaminated soil, with around of 5000 mg/kg of hydrocarbons as TPH-diesel. Mixtures of three nonionic surfactants were employed to get a wide range of specific HLB values. Tween20 and Span20 were mixed in the appropriate proportions to get HLB values between 8.6 and 16.7. Tween/Span60 mixtures reached HLB values between 4.7 and 14.9. Finally, Tween/Span80 combinations yielded HLB values between 4.3 and 15. TPH-diesel biodegradation was measured at the beginning, and after 8 weeks, as well as the FCU/gr soil, as a measure of microorganisms′ development during the biodegradation period. A second aim of this work was to assess the use of guar gum as a biodegradation enhancer instead of synthetic products. The conclusions of this work are that surfactant chemical family, and not only the HLB value clearly affects the assisted biodegradation rate. Surfactant's synergism was clearly observed. Regarding the use of guar gum, no biodegradation enhancement was observed for the three assessed concentrations, i.e., 2, 20, and 200 mg/kg, respectively. On the contrary, TPH-diesel removal was lower as the gum concentration increased. It is quite possible that guar gum was used as a microbial substrate.

关键词： aged soils enhanced bioremediation HLB mixtures Tween Span surfactants

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Comparison of biological fitness in crosses between subspecies of Meccus phyllosomus （Hemiptera： Reduviidae： Triatominae） in southern Mexico

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Insect Science 2017年第1期24卷 114-121页

作者： Jose Alejandro Martinez-Ibarra Benjamin Nogueda-torres luis Fernando Salazar-Montano Juan Carlos Garcia-Lino Demver Arroyo-reyes Juan Angel Hernandez-Navarro Area de Entomologia Medica Universidad de Guadalajara Ciudad Guzman Jalisco Mexico Becario de COFAA Escuela Nacional de Ciencias Biologicas Instituto Politecnico Nacional D.F. Mexico Carrera de Medicina Departamento de Salud y Bienestar Centro Universitario del Sur Universidad de Guadalajara Ciudad Guzman Jalisco Mexico

Understanding the biological parameters of some triatomine subspecies of Meccus phyllosomus （Burmeister） is a crucial first step in estimating the epidemiologie importance of this group. Biological parameters related to hatching, lifetime, number of blood meals to molt, percentage of females at the end of the cycle, number of laid eggs, and mortality for each instar of 3 M. phyllosomus subspecies [M. p. mazzottii （Usinger）, M. p. pallidipennis （Stal）, and M. p. phyllosomus] and their laboratory hybrids were evaluated and compared. No significant differences （P 〉 0.05） were found among the experimental hybrids （MaPa, MaPhy, PaPhy） and reciprocal cohorts. In 5 （hatching, number of blood meals to molt, accumulative mortality, percentage of females, and mean number of laid eggs） of the 6 studied parameters （with the exception of development time）, the hybrid cohorts had better fitness results than the parental cohorts involved in each set of crosses. The increase in hybrid fitness found in our study could lead to an increase in the epidemiologic risks caused by transmission of Trypanosoma cruzi to humans.

关键词： biological parameters Chagas disease Meccus subspecies Mexico tri- atomines Trypanosoma cruzi transmission

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Segment Anything for Comprehensive Analysis of Grapevine Cluster Architecture and Berry Properties

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Plant Phenomics 2024年第3期6卷 696-707页

作者： Efrain torres-Lomas Jimena Lado-Bega Guillermo Garcia-Zamora luis Diaz-Garcia Department of Viticulture and Enology University of California DavisDavisCA 95616USA Soil and Water Department Universidad de la RepublicaMontevideo 11400Uruguay

Grape cluster architecture and compactness are complex traits influencing disease susceptibility,fruit quality,and *** methods for these traits include visual scoring,manual methodologies,and computer vision,with the latter being the most scalable *** of the existing computer vision approaches for processing cluster images often rely on conventional segmentation or machine learning with extensive training and limited *** Segment Anything Model(SAM),a novel foundation model trained on a massive image dataset,enables automated object segmentation without additional *** study demonstrates out-of-the-box SAM's high accuracy in identifying individual berries in 2-dimensional(2D)cluster *** this model,we managed to segment approximately 3,500 cluster images,generating over 150,000 berry masks,each linked with spatial coordinates within their *** correlation between human-identified berries and SAM predictions was very strong(Pearson's r^(2)=0.96).Although the visible berry count in images typically underestimates the actual cluster berry count due to visibility issues,we demonstrated that this discrepancy could be adjusted using a linear regression model(adjusted R^(2)=0.87).We emphasized the critical importance of the angle at which the cluster is imaged,noting its substantial effect on berry counts and *** proposed different approaches in which berry location information facilitated the calculation of complex features related to cluster architecture and ***,we discussed SAM's potential integration into currently available pipelines for image generation and processing in vineyard conditions.

关键词： architecture analysis cluster anything berry comprehensive grapevine properties segment

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Context-dependent insect predation pressure on an avian ectoparasite

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Insect Science 2023年第6期30卷 1784-1797页

作者： Angela Salido Jesús Veiga Joaquín luis reyes-López Francisco Valera Department of Botany Ecology and Plant PhysiologyUniversity of CórdobaCórdobaSpain Departamento de Ecología Funcional y Evolutiva Estación Experimental de ZonasÁridas(EEZA-CSIC)AlmeríaSpain Department of Parasitology University of GranadaGranadaSpain MEMEG Department of BiologyLund UniversityLundSweden

Context dependence arises when ecological relationships vary with the conditions under which they are observed. Context dependence of interactions involving parasites is poorly known, even if it is key to understanding host–parasite relationships and food web dynamics. This paper investigates to which extent predation pressure on an avian ectoparasite (Carnus hemapterus) is context-dependent. Based on a predator-exclusion experiment, predation pressure on C. hemapterus pupae in the host's nest for 3 years, and its variation between habitat types are quantified. Variation in precipitation and normalized difference vegetation index (NDVI) is also explored as a likely cause of context dependency. We hypothesize that predation pressure should fluctuate with such surrogates of food availability, so that inter-annual and intra-annual differences may emerge. The number of nests with significant reduction of pupae varied widely among years ranging from 24% to 75%. However, average pupae reduction in nests where a significant reduction occurred did not vary between years. No differences in predation rates between habitat types were detected. Precipitation and NDVI varied widely between years and NDVI was consistently lower around nests on cliffs than around nests on trees and farmhouses. Parallels were found between variation in predation pressure and precipitation/NDVI at a wide scale (highest predation the driest year, and much lower the 2 rainier ones), but not at the nest scale. This paper shows clear context-dependent insect predation pressure on an ectoparasite under natural conditions, and that such interaction changes in signs rather than magnitude between years. The causes for these variations require longer-term studies and/or well-designed, large-scale experiments.

关键词： ants arid areas Carnus hemapterus consumer-resource interaction ecosys-tem productivity predator-parasite rainfall

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TCF7L2 rs7903146 polymorphism is associated with gastric cancer: a case-control study in the Venezuelan population

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World Journal of Gastroenterology 2016年第28期22卷 6520-6526页

作者： Keila torres luis Labrador Elvis Valderrama Miguel Angel Chiurillo Laboratorio de Genetica Molecular 'Dr. Jorge Yunis-Turbay' Decanato de Ciencias de la Salud Universidad Centroccidental Lisandro Alvarado Barquisimeto 3001 Venezuela Postgrado en Ciencias Biologicas Departamento de Biologia Celular Universidad Simon Bolivar Caracas 1081-A Venezuela Departamento de Anatomia Patologia Hospital Antonio Maria Pineda-UCLA Barquisimeto 3001 Venezuela Departamento de Patologia Clinica Universidade Estadual de Campinas Campinas 13083 Sao Paulo Brazil

AIM: To explore the association between TCF7L2 rs12255372 and rs7903146 single nucleotide polymorphisms (SNPs) and gastric cancer risk in Venezuelan ***: We performed a case-control study including 122 paraffin-embedded archived intestinal-type gastric cancer samples and 129 biopsies obtained by superior endoscopy from chronic gastritis patients. Gastric cancer samples were classified according the degree of carcinoma differentiation. Genomic DNA was extracted from tissues, and the two SNPs of TCF7L2 gene (rs12255372 and rs7903146) were genotyped by polymerase chain reaction-restriction fragment length polymorphism reactions. Multiple regression analysis with adjustments for age and gender were performed and best-fitting models of inheritance were determined. Statistic powers were post-hoc ***: After adjusting for age and sex the TCF7L2 rs7903146 TT genotype was associated with gastric cancer risk under the recessive genetic model (OR = 3.11, 95%CI: 1.22-7.92, P = 0.017). We further investigated the distribution of rs12255372 and rs7903146 genotypes according gastric cancer stratified by degree of differentiation, and we observed that carriers of rs7903146 T allele (CT + TT vs CC) had a significantly increased risk of moderate/well differentiated gastric cancer (dominant model, OR = 2.55, 95%CI: 1.35-4.80, P = 0.004), whereas the rs7903146 TT genotype was associated with poorly differentiated gastric cancer in the recessive model (OR = 3.65, 95%CI: 1.25-10.62, P = 0.018). We did not find association between rs12255372 SNP and the susceptibility of developing gastric ***: TCF7L2 rs7903146 polymorphism is associated with gastric cancer risk in the Venezuelan population, and could be related to determine the degree of differentiation of tumor cells.

关键词： Gastric cancer Wnt/β -catenin pathway TCF7L2 Single nucleotide polymorphism Genetic susceptibility

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Optimal Design of Hybrid Microgrid in Isolated Communities of Ecuador

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 488-499页

作者： luis A.Pesantes Ruben Hidalgo-León Johnny Rengifo Miguel torres Jorge Aragundi JoséCordova-Garcia luis F.Ugarte Facultad de Ingeniería en Electricidad y Computación of Escuela Superior Politécnica del Litoral(ESPOL)University GuayaquilEcuador Department of Electrical Engineering at Universidad Técnica Federico Santa María SantiagoChile IEEE

In rural territories, the communities use energy sources based on fossil fuels to supply themselves with electricity, which may address two main problems: greenhouse gas emissions and high fuel prices. Hence, there is an opportunity to include renewable resources in the energy mix. This paper develops an optimization model to determine the optimal sizing, the total annual investment cost in renewable generation, and other operating costs of the components of a hybrid microgrid. By running a k-means clustering algorithm on a meteorological dataset of the community under study, the hourly representative values become input parameters in the proposed optimization model. The method for the optimal design of hybrid microgrid is analyzed in six operating scenarios considering:(1) 24-hour continuous power supply;(2) load shedding percentage;(3) diesel power generator(genset) curtailment;(4) the worst meteorological conditions;(5) the use of renewable energy sources including battery energy storage systems(BESSs);and(6) the use of genset. A mathematical programming language(AMPL) tool is used to find solutions of the proposed optimization model. Results show that the total costs of microgrid in the scenarios that cover 100% of the load demand(without considering the scenario with 100% renewables) increase by over 16% compared with the scenario with genset operation limitation. For the designs with power supply restrictions, the total cost of microgrid in the scenario with load shedding is reduced by over 27% compared with that without load shedding.

关键词： Battery energy storage system(BESS) isolated community microgrid renewable energy optimization

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Novel strategies to tailor the photocatalytic activity of metal–organic frameworks for hydrogen generation: a mini-review

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Frontiers in Energy 2022年第5期16卷 734-746页

作者： luis A.ALFONSO-HERRERA Leticia M.torres-MARTINEZ J.Manuel MORA-HERNANDEZ Universidad Autónoma de Nuevo León UANLFacultad de Ingeniería CivilDepartamento de Ecomateriales y EnergíaAv.Universidad S/N Ciudad UniversitariaSan Nicolás de los GarzaNuevo León 66455México Centro de Investigación en Materiales Avanzados S.C.(CIMAV)Miguel de Cervantes No.120.Complejo Ind.ChihuahuaChihuahuaChih 31136México CONACYT-Universidad Autónoma de Nuevo León UANLFacultad de Ingeniería CivilDepartamento de Ecomateriales y EnergíaAv.Universidad S/N Ciudad UniversitariaSan Nicolás de los GarzaNuevo León 66455México

This review provides a recompilation of the most important and recent strategies employed to increase the efficiency of metal-organic framework(MOF)-based systems toward the photocatalytic hydrogen evolution(PHE)reaction through specific strategies:tailoring the photocatalytic activity of bare MOFs and guest@MOF composites,formation of heterojunctions based on MOFs and various photocatalysts,and inorganic photocatalysts derived from *** to the data reported in this mini-review,the most effective strategy to improve the PHE of MOFs relies on modifying the linkers with new secondary building units(SBUs).Although several reviews have investigated the photocatalytic activity of MOFs from a general point of view,many of these studies relate this activity to the physicochemical and catalytic properties of ***,they did not consider the interactions between the components of the photocatalytic *** study highlights the effects of strength of the supramolecular interactions on the photocatalytic performance of bare and MOF-based materials during PHE.A thorough review and comparison of the results established that metal-nanoparticle@MOF composites have weak van der Waals forces between components,whereas heterostructures only interact with MOFs at the surface of bare *** material derivatives from MOFs,we found that pyrolysis destroyed some beneficial properties of MOFs for ***,we conclude that adding SBUs to organic linkers is the most efficient strategy to perform the PHE because the SBUs added to the MOFs promote synergy between the two materials through strong coordination bonds.

关键词： metal-organic frameworks(MOFs) photocatalytic hydrogen evolution MOF heterojunctions materials derived from MOFs bandgap recombination

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Sorption and desorption behavior of residual antidepressants and caffeine in freshwater sediment and sewage sludge

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International Journal of Sediment Research 2022年第3期37卷 346-354页

作者： Ismael Laurindo Costa Junior Christiane Schinneider Machado Adelmo Lowe Pletsch Yohandra reyes torres Department of Chemistry Federal University of Technology-Paraná (UTFPR) Department of Chemistry State University of Midwest (UNICENTRO)

The use of antidepressants is widespread in modern times. Thus, they present a potential risk for ecosystems due to occurrence in domestic sewage containing unaltered metabolites and structures, even after the treatment plants have processed the sewage. The current research investigated the sorption and desorption of antidepressants(citalopram, venlafaxine, fluoxetine, sertraline, and amitriptyline) and caffeine from freshwater sediment and sewage sludge. The samples of freshwater sediment were collected in a river spring in an area with few anthropogenic sources of pollution and samples of sewage sludge were taken from stabilization ponds of a sewage treatment. The matrices were mainly composed of organic fractions, sediment of humic nature, and aliphatic biomolecules in sludges. The presence of silt and clay in the sediment proved to be important for the sorption process when compared to the flocs and colloidal structure of the sludge. The kinetic study indicated pseudo-first order behavior. The Freundlich isotherm was satisfactorily used in the interpretation of sorption and desorption for all analytes and matrices. The high percentages obtained for desorption suggest analyte mobility, which is more intense in the sludge than in the sediment since each matrix has a different composition. It can be considered that the information obtained here reinforces the ecotoxicological concern with respect to pharmacological residues in the environment, as processes of retention by sorption in the sludge and the sediment have been confirmed, as well as the preferential partition of some analytes by the aqueous phase.

关键词： Emerging pollutants Drugs Persistence Partition Mobility Sorption

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