TCF7L2 rs7903146 polymorphism is associated with gastric cancer: a case-control study in the Venezuelan population
TCF7L2 rs7903146 polymorphism is associated with gastric cancer: a case-control study in the Venezuelan population作者机构：Laboratorio de Genetica Molecular 'Dr. Jorge Yunis-Turbay' Decanato de Ciencias de la Salud Universidad Centroccidental Lisandro Alvarado Barquisimeto 3001 Venezuela Postgrado en Ciencias Biologicas Departamento de Biologia Celular Universidad Simon Bolivar Caracas 1081-A Venezuela Departamento de Anatomia Patologia Hospital Antonio Maria Pineda-UCLA Barquisimeto 3001 Venezuela Departamento de Patologia Clinica Universidade Estadual de Campinas Campinas 13083 Sao Paulo Brazil
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2016年第22卷第28期
页 面：6520-6526页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Supported by CDCHT-UCLA grant 001-CS-2013
主 题：Gastric cancer Wnt/β -catenin pathway TCF7L2 Single nucleotide polymorphism Genetic susceptibility
摘 要：AIM: To explore the association between TCF7L2 rs12255372 and rs7903146 single nucleotide polymorphisms (SNPs) and gastric cancer risk in Venezuelan ***: We performed a case-control study including 122 paraffin-embedded archived intestinal-type gastric cancer samples and 129 biopsies obtained by superior endoscopy from chronic gastritis patients. Gastric cancer samples were classified according the degree of carcinoma differentiation. Genomic DNA was extracted from tissues, and the two SNPs of TCF7L2 gene (rs12255372 and rs7903146) were genotyped by polymerase chain reaction-restriction fragment length polymorphism reactions. Multiple regression analysis with adjustments for age and gender were performed and best-fitting models of inheritance were determined. Statistic powers were post-hoc ***: After adjusting for age and sex the TCF7L2 rs7903146 TT genotype was associated with gastric cancer risk under the recessive genetic model (OR = 3.11, 95%CI: 1.22-7.92, P = 0.017). We further investigated the distribution of rs12255372 and rs7903146 genotypes according gastric cancer stratified by degree of differentiation, and we observed that carriers of rs7903146 T allele (CT + TT vs CC) had a significantly increased risk of moderate/well differentiated gastric cancer (dominant model, OR = 2.55, 95%CI: 1.35-4.80, P = 0.004), whereas the rs7903146 TT genotype was associated with poorly differentiated gastric cancer in the recessive model (OR = 3.65, 95%CI: 1.25-10.62, P = 0.018). We did not find association between rs12255372 SNP and the susceptibility of developing gastric ***: TCF7L2 rs7903146 polymorphism is associated with gastric cancer risk in the Venezuelan population, and could be related to determine the degree of differentiation of tumor cells.
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