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Current guidelines for the management of non-alcoholic fatty liver disease:A systematic review with comparative analysis

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World Journal of Gastroenterology 2018年第30期24卷 3361-3373页

作者： Simona Leoni Francesco Tovoli Lucia Napoli Ilaria Serio Silvia Ferri luigi bolondi Department of Medical and Surgical Sciences (DIMEC) Division of Internal MedicineUniversity of Bologna

The current epidemic of non-alcoholic fatty liver disease(NAFLD) is reshaping the field of hepatology all around the world.The widespread diffusion of metabolic risk factors such as obesity,type2-diabetes mellitus,and dyslipidemia has led to a worldwide diffusion of NAFLD.In parallel to the increased availability of effective anti-viral agents,NAFLD is rapidly becoming the most common cause of chronic liver disease in Western Countries,and a similar trend is expected in Eastern Countries in the next years.This epidemic and its consequences have prompted experts from all over the word in identifying effective strategies for the diagnosis,management,and treatment of NAFLD.Different scientific societies from Europe,America,and Asia-Pacific regions have proposed guidelines based on the most recent evidence about NAFLD.These guidelines are consistent with the key elements in the management of NAFLD,but still,show significant difference about some critical points.We reviewed the current literature in English language to identify the most recent scientific guidelines about NAFLD with the aim to find and critically analyse the main differences.We distinguished guidelines from 5 different scientific societies whose reputation is worldwide recognised and who are representative of the clinical practice in different geographical regions.Differences were noted in: the definition of NAFLD,the opportunity of NAFLD screening in high-risk patients,the noninvasive test proposed for the diagnosis of NAFLD and the identification of NAFLD patients with advanced fibrosis,in the follow-up protocols and,finally,in the treatment strategy(especially in the proposed pharmacological management).These difference have been discussed in the light of the possible evolution of the scenario ofNAFLD in the next years.

关键词： Non-alcoholic fatty liver disease Metformin Liver steatosis Liver biopsy Non-invasive diagnosis Pioglitazone Clinical guidelines

Clinical and diagnostic aspects of gluten related disorders

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World Journal of Clinical Cases 2015年第3期3卷 275-284页

作者： Francesco Tovoli Chiara Masi Elena Guidetti Giulia Negrini Paola Paterini luigi bolondi Department of Medical and Surgical Sciences University of Bologna

Gluten is one of the most abundant and widely distributed components of food in many areas. It can be included in wheat, barley, rye, and grains such as oats, barley, spelt, kamut, and triticale. Gluten-containinggrains are widely consumed; in particular, wheat is one of the world's primary sources of food, providing up to 50% of the caloric intake in both industrialized and developing countries. Until two decades ago, celiac disease(CD) and other gluten-related disorders were believed to be exceedingly rare outside of Europe and were relatively ignored by health professionals and the global media. In recent years, however, the discovery of important diagnostic and pathogenic milestones led CD from obscurity to global prominence. In addition, interestingly, people feeding themselves with glutenfree products greatly outnumber patients affected by CD, fuelling a global consumption of gluten-free foods with approximately $2.5 billion in United States sales each year. The acknowledgment of other medical conditions related to gluten that has arisen as health problems, providing a wide spectrum of gluten-related disorders. In February 2011, a new nomenclature for gluten-related disorders was created at a consensus conference in London. In this review, we analyse innovations in the field of research that emerged after the creation of the new classification, with particular attention to the new European Society for Paediatric Gastroenterology, Hepatology and Nutrition guidelines for CD and the most recent research about non-celiac gluten sensitivity.

关键词： Celiac disease Wheat allergy Gluten sensitivity Non-celiac gluten sensitivity Gluten-free diet Gluten Anti-gliadin antibodies

Long-term durable response to lenalidomide in a patient with hepatic epithelioid hemangioendothelioma

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World Journal of Gastroenterology 2014年第22期20卷 7049-7054页

作者： Maria Caterina Pallotti Margherita Nannini Claudio Agostinelli Simona Leoni Valerio Di Scioscio Anna Mandrioli Cristian Lolli Maristella Saponara Stefano Pileri luigi bolondi Guido Biasco Maria Abbondanza Pantaleo Department of Specialized Experimentaland Diagnostic MedicineS. Orsola-Malpighi HospitalUniversity of Bologna40138 BolognaItaly Hematopathology Section Department of ExperimentalDiagnosticand Specialty MedicineS. Orsola-Malpighi HospitalUniversity of Bologna40138 BolognaItaly Division of Internal Medicine Department of Digestive Disease and Internal MedicineS. Orsola-Malpighi HospitalUniversity of Bologna40138 BolognaItaly Department of Radiology S. Orsola-Malpighi HospitalUniversity of Bologna40138 BolognaItaly InterdepartmentalCentre for Cancer Research "G. Prodi" University of Bologna40138 BolognaItaly

Epithelioid hemangioendothelioma(EH)is a rare tumor arising from the vascular endothelial cells of soft tissue or visceral organs.The most common visceral site is the liver,where it is often involved in a multifocal man-ner known as hepatic EH(HEH).Surgical resection with curative intent represents the gold standard therapy.When surgery is not feasible,or in cases of metastatic disease,no standard medical treatment is currently indicated.In small series,drugs with anti-angiogenic activity(such as bevacizumab,sorafenib,thalidomide,and lenalidomide)have been proposed with promising results.We describe a 73-year-old man with multifocal non-resectable HEH treated with lenalidomide.Disease status was evaluated by abdominal ultrasound and magnetic resonance every four months.The patient was treated for a total of 39 mo with prolonged disease stabilization and,at the time of writing,is still under treatment with a good tolerance profile.During a short period of treatment discontinuation,the disease showed slight progression that immediately resolved after the reintroduction of lenalidomide.Lenalidomide may represent a valid treatment option for HEH due to its anti-angiogenic and antineoplastic activities.This preliminary result merits further study in a large series.

关键词： Hepatic epithelioid hemangioendothelioma Liver Len

Recent advances of versatile reagents as controllable building blocks in organic synthesis

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Chinese Chemical Letters 2024年第2期35卷 24-43页

作者： Shaomin Chen luigi Vaccaro Yanlong Gu Key Laboratory of Material Chemistry for Energy Conversion and Storage Ministry of EducationHubei Key Laboratory of Material Chemistry and Service FailureSchool of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan 430074China Laboratory of Green S.O.C. Dipartimento di ChimicaBiologia e BiotecnologieUniversità degli Studi di PerugiaVia Elce di Sotto 8Perugia 06123Italy School of Chemistry and Chemical Engineering The Key Laboratory for Green Processing of Chemical Engineering of Xinjiang BingtuanShihezi UniversityShihezi 832004China

Diversity-oriented synthesis is a powerful and interesting synthetic tool for the rapid construction of structurally complex and privileged scaffolds from readily accessible starting materials.To date,diversity-oriented synthesis mostly relies on the employment of versatile reagents.Versatile reagents can be regulated as controllable and flexible building blocks for multipurpose utilizations.Over the past decade,a variety of multifunctional reagents have been developed.However,most versatile reagents usually need multi-step synthesis,thus restricting their wide application to a large extent.In terms of the practicalities and universalities,we prefer to pay more attention to the utilization of simple and practical versatile reagents with multiple reactivities,mainly including atropaldehyde acetals,aryl methyl ketones,vinylene carbonate,vinyl azides,aryldiazonium salts,rongalite,halodifluoromethyl compounds.Most importantly,these versatile reagents can also play different roles simultaneously in the same reaction,in which their different reactivities are converged into the final target products.Such strategy can not only offer more possibilities for the synthesis of several active pharmaceutical ingredients,but also minimize the occurrence of some side reactions by lessening the varieties of materials.Also,a perspective is given at the end of this review.

关键词： Versatile reagents Divergent synthesis Dual synthons Bond cleavage Tandem reactions

Edge-Enabled Metaverse:The Convergence of Metaverseand Mobile Edge Computing

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Tsinghua Science and Technology 2024年第3期29卷 795-805页

作者： Nyothiri Aung Sahraoui Dhelim Liming Chen Huansheng Ning luigi Atzori Tahar Kechadi Information Engineering College Xinjiang Institute of EngineeringUrumqi 830023Chinaand also with School of Computer ScienceUniversity College DublinDublinD04 V1W8Ireland School of Computing Ulster UniversityBelfastBT151EDUK School of Computer and Communication Engineering University of Science and Technology BeijingBeijing 100083China Department of Electrical and Electronic Engineering University of CagliariSardinia 09124Italy School of Computer Science University College DublinDublinD04 V1W8Ireland

Metaverse is a virtual environment where users are represented by their avatars to navigate a virtual world having strong links with its physical counterpart.The state-of-the-art Metaverse architectures rely on a cloud-based approach for avatar physics emulation and graphics rendering computation.The current centralized architecture of such systems is unfavorable as it suffers from several drawbacks caused by the long latency of cloud access,such as low-quality visualization.To this end,we propose a Fog-Edge hybrid computing architecture for Metaverse applications that leverage an edge-enabled distributed computing paradigm.Metaverse applications leverage edge devices’computing power to perform the required computations for heavy tasks,such as collision detection in the virtual universe and high-computational 3D physics in virtual simulations.The computational costs of a Metaverse entity,such as collision detection or physics emulation,are performed at the device of the associated physical entity.To validate the effectiveness of the proposed architecture,we simulate a distributed social Metaverse application.The simulation results show that the proposed architecture can reduce the latency by 50%when compared with cloud-based Metaverse applications.

关键词： industrial Metaverse edge computing Blockchain virtual environment task offloading fog computing

Autonomous Vehicle Platoons In Urban Road Networks:A Joint Distributed Reinforcement Learning and Model Predictive Control Approach

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IEEE/CAA Journal of Automatica Sinica 2024年第1期11卷 141-156页

作者： luigi D’Alfonso Francesco Giannini Giuseppe Franzè Giuseppe Fedele Francesco Pupo Giancarlo Fortino IEEE the Department of Computer Engineering ModelingElectronics and SystemsUniversitàdella CalabriaVia Pietro BucciCubo 42-CRende(CS)87036Italy the Department of Mechanical Engineering Energy Engineering and ManagementUniversitàdella CalabriaVia Pietro BucciCubo 42-CRende(CS)87036Italy

In this paper, platoons of autonomous vehicles operating in urban road networks are considered. From a methodological point of view, the problem of interest consists of formally characterizing vehicle state trajectory tubes by means of routing decisions complying with traffic congestion criteria. To this end, a novel distributed control architecture is conceived by taking advantage of two methodologies: deep reinforcement learning and model predictive control. On one hand, the routing decisions are obtained by using a distributed reinforcement learning algorithm that exploits available traffic data at each road junction. On the other hand, a bank of model predictive controllers is in charge of computing the more adequate control action for each involved vehicle. Such tasks are here combined into a single framework:the deep reinforcement learning output(action) is translated into a set-point to be tracked by the model predictive controller;conversely, the current vehicle position, resulting from the application of the control move, is exploited by the deep reinforcement learning unit for improving its reliability. The main novelty of the proposed solution lies in its hybrid nature: on one hand it fully exploits deep reinforcement learning capabilities for decisionmaking purposes;on the other hand, time-varying hard constraints are always satisfied during the dynamical platoon evolution imposed by the computed routing decisions. To efficiently evaluate the performance of the proposed control architecture, a co-design procedure, involving the SUMO and MATLAB platforms, is implemented so that complex operating environments can be used, and the information coming from road maps(links,junctions, obstacles, semaphores, etc.) and vehicle state trajectories can be shared and exchanged. Finally by considering as operating scenario a real entire city block and a platoon of eleven vehicles described by double-integrator models, several simulations have been performed with the aim to put in light the main f eatures of the pro

关键词： Distributed model predictive control distributed reinforcement learning routing decisions urban road networks

A giant scrotal pendulous fibroma mimicking a supernumerary testis

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Asian Journal of Andrology 2024年第2期26卷 227-228页

作者： luigi Quaresima Rocco Francesco Delle Fave Giordano Polisini Daniela Fasanella Willy Giannubilo Urology Division Civitanova Marche HospitalCivitanova Marche 62012Italy Department of Clinical and Specialist Sciences Division of UrologyPolytechnic University of the Marche Region Medical SchoolAncona 60126Italy Department of Life Health and Environmental SciencesUniversity of L'AquilaL'Aquila 67100Italy

DearEditor,Pendulous fibroma,also called acrochordon,is a benign skin neoplasm,originating from the dermis.Usually,small in size,it can arise from any point of the dermis(frequently from the axillary area,inguinal region,eyelid,or neck),and in some cases,it can be unesthetic.Pendulous fibromas are more frequent in obese subjects,and most of the time,they are sporadic,although sometimes,they can be observed in Birt-Hogg-Dube syndrome.In some rare cases,they can reach considerable dimensions.Occasionally,they are associated with diabetes mellitus,obesity,and intestinal polyps.Often,the pedicle undergoes torsion,causing pain and ischemic necrosis of the fibroma,which requires rapid removal of the tumor.We present a case of giant pendulous fibroma of the scrotum.The patient has given his consent to the publication of his clinical information and photographic images in an anonymous form.

关键词： frequent obesity clinical

Unlocking the versatile potential:Adipose-derived mesenchymal stem cells in ocular surface reconstruction and oculoplastics

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World Journal of Stem Cells 2024年第2期16卷 89-101页

作者： Pier luigi Surico Anna Scarabosio Giovanni Miotti Martina Grando Carlo Salati Pier Camillo Parodi Leopoldo Spadea Marco Zeppieri Schepens Eye Research Institute of Mass Eye and Ear Harvard Medical SchoolBostonMA 02114United States Department of Ophthalmology Campus Bio-Medico UniversityRome 00128Italy Department of Plastic Surgery University Hospital of UdineUdine 33100Italy Department of Internal Medicine Azienda Sanitaria Friuli OccidentaleSan Vito al Tagliamento 33078Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy Eye Clinic Policlinico Umberto I“Sapienza”University of RomeRome 00142Italy

This review comprehensively explores the versatile potential of mesenchymal stem cells(MSCs)with a specific focus on adipose-derived MSCs.Ophthalmic and oculoplastic surgery,encompassing diverse procedures for ocular and periocular enhancement,demands advanced solutions for tissue restoration,functional and aesthetic refinement,and aging.Investigating immunomodulatory,regenerative,and healing capacities of MSCs,this review underscores the potential use of adipose-derived MSCs as a cost-effective alternative from bench to bedside,addressing common unmet needs in the field of reconstructive and regenerative surgery.

关键词： Stem cells Adipose stem cell Ocular therapy Oculoplastics Regenerative

Experimental and Finite Element Analysis of Corroded High-Pressure Pipeline Repaired by Laminated Composite

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1783-1806页

作者： Seyed Mohammad Reza Abtahi Saeid Ansari Sadrabadi Gholam Hosein Rahimi Gaurav Singh Hamid Abyar Daniele Amato luigi Federico Faculty of Mechanical Engineering Tarbiat Modares UniversityTehran***Iran A.Leon Linton Department of Mechanical Robotics and Industrial EngineeringLawrence Technological UniversitySouthfieldMI48075USA Department of Mechanical Engineering Faculty of EngineeringMeybod UniversityYazd***Iran Department of Industrial Engineering University of SalernoVia Giovanni PaoloⅡFiscianoItaly Italian Aerospace Research Center(C.I.R.A.) Via MaioriseCapuaCE81043Italy

Repairs of corroded high-pressure pipelines are essential for fluids transportation under high pressure.One of the methods used in their repairs is the use of layered composites.The composite used must have the necessary strength.Therefore,the experiments and analytical solutions presented in this paper are performed according to the relevant standards and codes,including ASME PCC-2,ASME B31.8S,ASME B31.4,ISO 24817 and ASME B31.G.In addition,the experimental tests are replicated numerically using the finite element method.Setting the strain gauges at different distances from the defect location,can reduce the nonlinear effects,deformation,and fluctuations due to the high pressure.The direct relationship between the depth of an axial defect and the stress concentration is observed at the inner side edges of the defect.Composite reparation reduces the non-linearities related to the sharp variation of the geometry and a more reliable numerical simulation could be performed.

关键词： High-pressure pipeline composite repair ASME PCC-2 ISO 24817