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Effect of aging treatment on the microstructures and mechanical properties evolution of 25Cr-20Ni austenitic stainless steel weldments with different Nb contents

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Journal of materials science & Technology 2019年第4期35卷 520-529页

作者： Xu Zhang dianzhong li Yiyi li Shanping Lu Key laboratory of Nuclear materials and Safety Assessment Institute of Metal ResearchChinese Academy of Sciences School of materials science and Engineering University of Science and Technology of China shenyang national laboratory for materials science Institute of Metal ResearchChinese Academy of Sciences

The microstructure evolutions and the mechanical properties of the 25Cr-20Ni austenitic stainless steel weld metals with different Nb contents were investigated during the long term aging treatment at 700~?C.M_(23)C_6,Nb(C,N),α-Cr phase and Nb-nitride phase(Z phase)were observed in the microstructures of the aged weld *** results showed that theα-Cr phase precipitated in the interdendritic regions of the weld metals after being exposed to~ 700?C for 500 h and the element Nb accelerated the precipitation of theα-Cr phase *** density of theα-Cr phase decreased with the increase of the distance away from the primary Nb(C,N).Additionally,theα-Cr phase showed a crystallographic relationship with the austenitic matrix,■.It was observed that the Z phase precipitated in the periphery of the Nb(C,N)and may replace the Nb(C,N)after long term exposure to high *** transformation of the Nb(C,N)into Z phase suggested that the Z phase had a higher stability than the Nb(C,N)par^ticles at 700?C for long term *** tensile strength of the Nb-bearing weld metal showed a continuous decrease at the initial stage of the aging treatment and then went up slightly with the prolonged aging ***,the elongations and the impact energies of the weld metals decreased monotonously with the increase of the aging time.

关键词： 25Cr-20Ni steel Weld metal Nb Aging treatment α-Cr phase Mechanical property

Effect of Structural Parameters of Double Shielded TIG Torch on the Fusion Zone Profile for 0Cr13Ni5Mo Martensitic Stainless Steel

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Journal of materials science & Technology 2014年第9期30卷 922-927页

作者： Dongjie li Shanping Lu dianzhong li Yiyi li shenyang national laboratory for materials science Institute of Metal Research Chinese Academy of Sciences

The effects of double shielded TIG （tungsten inert gas） torch＇s structural parameters, including the flow rate ratio between the inner and outer layers of gas and the extended length of the electrode （abbreviated as ELE in this work）, on the fusion zone profile have been investigated for OCrl3NiSMo martensitic stainless steel. Results show that the double shielded TIG process yields relatively high penetration of the weld pool in a broad range of the structural parameters. ELE over 3 mm is too large and causes adverse reactions on the protection of electrode. The outer gas with relatively high flow rate or the outer layer with high oxygen content is conducive to the oxygen dissolved into the arc, which results in the oxidation of the weld pool surface and the electrode tip. The double shielded TIG welded metal was tested and presented good impact property.

关键词： Structural parameters Flow rate Electrode extended length Impact energy

RNA m^(6)A reader YTHDF2 facilitates precursor miR-126 maturation to promote acute myeloid leukemia progression

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Genes & Diseases 2024年第1期11卷 382-396页

作者： zheng Zhang Keren Zhou li Han Andrew Small Jianhuang Xue Huilin Huang Hengyou Weng Rui Su Brandon Tan Chao Shen Wei li Zhicong Zhao Ying Qing Xi Qin Kitty Wang Keith Leung Mark Boldin Chun-Wei Chen David Ann Zhijian Qian xiaolan Deng Jianjun Chen Zhenhua Chen Department of Systems Biology Beckman Research Institute of City of HopeMonroviaCA 91016USA Irell and Manella Graduate School of Biological sciences Beckman Research Institute of City of HopeDuarteCA 91010USA Gehr Family Center for Leukemia research City of HopeDuarteCA 91010USA Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdong 510060China Guangzhou laboratory GuangzhouGuangdong 510005China Bioland laboratory GuangzhouGuangdong 51005China Department of liver Surgery Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Diabetes Complications and Metabolism Beckman Research Institute of City of HopeDuarteCA 91010USA Department of Biochemistry and Molecular Biology University of FloridaGainesvilleFL 32603USA Tongji Hospital Affiliated to Tongji University Frontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China School of Pharmacy China Medical UniversityShenyangLiaoning 110001China

As the most common internal modification of mRNA,Ne-methyladenosine(m^(6)A)and its regulators modulate gene expression and play critical roles in various biological and patholog-ical processes including *** was reported previously that m^(6)A methyltransferase(writer),methyltransferase-like 3(METTL3)adds m^(6)A in primary microRNAs(pri-miRNAs)and fa-cilitates its processing into precursor miRNAs(pre-miRNAs).However,it is unknown whether m^(6)A modification also plays a role in the maturation process of pre-miRNAs and(if so)whether such a function contributes to ***,we found that YTHDF2 is aberrantly overexpressed in acute myeloid leukemia(AML)patients,especially in relapsed patients,and plays an onco-genic role in ***,YTHDF2 promotes expression of miR-126-3p(also known as miR-126,as it is the main product of precursor miR-126(pre-miR-126)),a miRNA that was reported as an oncomiRNA in AML,through facilitating the processing of pre-miR-126 into mature ***,YTHDF2 recognizes m^(6)A modification in pre-miR-126 and recruits AGO2,a regulator of pre-miRNA processing,to promote the maturation of ***2 posi-tively and negatively correlates with miR-126 and miR-126's downstream target genes,respec-tively,in AML patients,and forced expression of miR-126 could largely rescue YTHDF2/Ythdf2 depletion-mediated suppression on AML cell growth/proliferation and leukemogenesis,indi-cating that miR-126 is a functionally important target of YTHDF2 in ***,our studies not only reveal a previously unappreciated YTHDF2/miR-126 axis in AML and highlight the ther-apeutic potential of targeting this axis for AML treatment,but also suggest that m^(6)A plays a role in pre-miRNA processing that contributes to tumorigenesis.

关键词： AML miR-126 N^(6)-methyladenosine Pre-miRNA maturation YTHDF2

Effects of rare earth on microstructure and impact toughness of low alloy Cr-Mo-V steels for hydrogenation reactor vessels

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Journal of materials science & Technology 2020年第10期42卷 1-14页

作者： Zhonghua Jiang Pei Wang dianzhong li Yiyi li shenyang national laboratory for materials science Institute of Metal ResearchChinese Academy of Sciences72 Wenhua RoadShenyang 110016China School of materials science and Engineering University of Science and Technology of China72 Wenhua Road.Shenyang 110016China

The effects of rare earth(RE) on the microstructure and impact toughness of low alloy Cr-Mo-V bainitic steels have been investigated where the steels have RE content of 0 to 0.048 wt.%. The results indicate that the normalized microstructures of the steels are typical granular bainite(GB) composed primarily of bainitic ferrite and martensite and/or austenite(M-A) constituents. The M-A constituents are transformed into ferrite and carbides and/or agglomerated carbides after tempering at 700℃ for 4 h. The addition of RE decreases the onset temperature of bainitic transformation and results in the formation of finer bainitic ferrite, and reduces the amount of carbon-rich M-A constituents. For the normalized and tempered samples, the ductile-to-brittle transition temperature(DBTT) decreases with increasing RE content to a critical value of 0.012 wt.%. Lower DBTT and higher upper shelf energy are attributed to the decreased effective grain size and lower amount of coarse agglomerated carbides from the decomposition of massive M-A constituents. However, the addition of RE in excess of 0.012 wt.% leads to a substantial increase in the volume fraction of large-sized inclusions, which are extremely detrimental to the impact toughness.

关键词： Low alloy Cr-Mo-V steel Rare earth Microstructure Impact toughness Granular bainite Martensite-austenite constituents

Principles Giving High Penetration under the Double Shielded TIG Process

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Journal of materials science & Technology 2014年第2期30卷 172-178页

作者： Dongjie li Shanping Lu dianzhong li Yiyi li shenyang national laboratory for materials science Institute of Metal ResearchChinese Academy of Sciences

A new welding method named double shielded tungsten inert gas （TIG） has been developed to improve the TIG weld penetration. The main principles to increase the weld depth have been discussed. Results show that the critical oxygen content in the weld pool is around 100 × 10 -6 as the temperature coefficient of surface tension changes from negative to positive. The tracer test using pure silver shows that the direction of Marangoni convection changes as the oxygen content increases in the weld pool. The effect of arc constriction on the weld depth has been evaluated on a water-cooled copper plate, and the result indicates that the torch of double shielded can give a more powerful arc. Heavy oxide on the pool surface has undesirable impacts on the increasing of weld depth as the oxygen excessively accumulates in weld pool. It is possible to form chromium oxide in the weld process, while the iron oxide may form as the weld surface exposes to the air after the shielded gas moving away.

关键词： Marangoni convection Penetration Tungsten inert gas (TIG) Arc Oxide

Effect of a modified quenching on impact toughness of 52100 bearing steels

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Journal of materials science & Technology 2023年第29期160卷 96-108页

作者： Yonghan li Zhonghua Jiang Pei Wang dianzhong li Yiyi li shenyang national laboratory for materials science Institute of Metal ResearchCASShenyang 110016China School of materials science and Engineering University of Science and Technology of ChinaHefei 230026China

In order to improve the uniformity of microstructures,and thus enhance the mechanical properties,espe-cially the impact toughness,of 52100 bearing steels,modified quenching heat treatments with different austenitizing processes have been *** results show that 740°C is the optimal holding tem-perature(approaching Ac 1=750°C)to improve the impact toughness of the steel by 37%after quench-ing and low-temperature *** observations reveal that 740°C holding shortens the nucleation incubation period of austenitization phase transformation,and inhibits the overfast growth of austenite in some regions,which leads to simultaneous nucleation and growth of austenite during austen-itizing,and homogeneous dissolution of carbides in different austenite *** changes in microstruc-ture evolution improve the microstructure uniformity(carbide and grain size)after *** distributed carbides and grain size effectively reduce stress concentration and retard crack propagation during impact loading,thus resulting in high impact toughness.

关键词： Austenitizing process Carbides distribution Impact toughness 52100 steels

Screening of Proteins Interacting with Nonstructural 1 Protein of H5N1 Avian Influenza Virus from T7-phage Display library

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Chemical research in chinese Universities 2012年第1期28卷 103-107页

作者： ZHU Chun-yu1,2, SUN Ting-ting2, Zhao Jian1,2, WANG Ning1,2, zheng Fang-liang1, AI Hai-xin1, ZHU Jun-feng1,2, WANG xiao-ying3, ZHU Ying4, WU Jian-guo4 and liU Hong-sheng1,2 1. Key laboratory of Animal Resource and Epidemic Disease Prevention of liaoning Province, 2. research Center for Computer Simulating and Information Processing of Bio-macromolecules of liaoning Province, academy of science, liaoning University, shenyang 110036, P. R. china 3. institute of Nutrition and Food Safety, chinese Center for Disease Control and Prevention, Beijing 100050, P. R. china 4. State Key laboratory of Virology, Wuhan University, Wuhan 430072, P. R. china liaoning Univ Acad Sci Key Lab Anim Resource & Epidem Dis Prevent Liaoni Shenyang 110036 Peoples R China liaoning Univ Acad Sci Res Ctr Comp Simulating & Informat Proc Biomacrom Shenyang 110036 Peoples R China chinese Ctr Dis Control & Prevent Inst Nutr & Food Safety Beijing 100050 Peoples R China Wuhan Univ State Key Lab Virol Wuhan 430072 Peoples R China

Avian influenza virus（AIV） nonstructural 1（NS1） gene was amplified by real-time polymerse chain reac tion（RT-PCR） and inserted into pET28a, then transformed into E. coli BL21（DE3） competent cell. With the induction of isopropyl-β-D-thiogalactoside（IPTG） and the purification of Ni-NTA column, we finally obtained purified NS1 protein. T7-phage display system was used to screen the proteins that interacted with NS1 from lung cell cDNA li brary. The selected positive clones were identified by DNA sequencing and analyzed by BLAST program in Gene Bank. Two proteins were obtained as NS1 binding proteins, Homo sapiens nucleolar and coiled-body phosphoprotein 1（NOLC1） and Homo sapiens similar to colon cancer-associated antigen. By co-immunoprecipitation and other me thods, Homo sapiens NOLC1 was found to interact with the NS1 protein, the results would provide the basis for fur ther studying biological function of NS1 protein.

关键词： T7-phage display Nonstructural 1 (NS 1) protein Interacting protein

Effects of Filler metal Composition on Inclusions and Inclusion Defects for ER NiCrFe-7 Weldments

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Journal of materials science & Technology 2013年第5期29卷 458-466页

作者： Wenlin Mo Shanping Lu dianzhong li Yiyi li shenyang national laboratory for materials science Institute of Metal ResearchChinese Academy of Sciences

The effects of filler metal （FM） composition on inclusions and inclusion defects for ER NiCrFe-7 weldments have been investigated and analyzed. Results show that as Al, Ti content in FM increases from 0.14 wt% Al, 0.30 wt% Ti to 0.42 wt% Al, 0.92 wt% Ti, the Al, Ti reduction will increase during welding. Inclusion defects （point-like defects named by welding workers） are prone to form in the high Al, Ti content weldments. Inclusion defects with Mg, Ca, Al, and Ti as major metallic elements have been found on the surface and interior of the weldments, as Al, Ti content in FM is over 0.29 wt% Al, 0.62 wt% Ti. Less -ri content in FM cannot prevent ductility-dip-cracking （DDC） through producing enough intragranular precipitates and lessening intergranular M23C6 precipitates. Nb can be used to replace Ti to reduce the sensitivity of the DDC in the NiCrFe-7 alloy weldments.

关键词： Filler metal composition ER NiCrFe-7 Inclusions Inclusion defects Ductility-dip-cracking

Concurrent chemoradiotherapyof different radiation doses and different irradiation fields for locally advanced thoracic esophageal squamous cell carcinoma:A randomized,multicenter,phase Ⅲ clinical trial

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Cancer Communications 2024年第10期44卷 1173-1188页

作者： Jian Zhang Minghao li Kaixian Zhang Anping zheng Guang li Wei Huang Shaoshui Chen Xiangming Chen xiaomin li Yanxing Sheng Xinchen Sun liping liu xiaowei liu Jie li Jun Wang Hong Ge Shucheng Ye Qingsong Pang Xianwen Zhang Shengbin Dai Richard Yu Wendong Gu Mingming Dai Gaowa Siqin Yunwei Han xiaolin Ge Xin Yuan Yongjing Yang Haiwen Zhu Juan Pu lihua Dong Xiangdong Sun Jundong Zhou Weidong Mao Fei Gao Haiqun lin Heyi Gong Tao Zhou Zhenjiang li Hongsheng li Zhongtang Wang Baosheng li Department of Oncology Central Hospital Affiliated to Shandong First Medical UniversityJinanShandongP.R.China Department of Radiation Oncology Shandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical SciencesJinanShandongP.R.China Department of Oncology Tengzhou Central People’s HospitalTengzhouShandongP.R.China Department of Radiation Oncology Anyang Tumor HospitalAnyangHenanP.R.China Department of Radiation Oncology the First Hospital of China Medical UniversityShenyangLiaoningP.R.China Department of Oncology Binzhou Medical University HospitalBinzhouShandongP.R.China Department of Oncology Taian CentralHospitalTaianShandongP.R.China Department of Radiation Oncology Shanxi Province Cancer HospitalTaiyuanShanxiP.R.China Department of Oncology Liaocheng People’s HospitalLiaochengShandongP.R.China Department of Radiation Oncology the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsuP.R.China Department of Oncology Jining First People′s HospitalJiningShandongP.R.China Department of Oncology the Affiliated Hospital of Jining Medical UniversityJiningShandongP.R.China Department of Radiation Oncology the Fourth Hospital of Hebei Medical UniversityHebei Clinical Research Center for Radiation OncologyShijiazhuangHebeiP.R.China Department of Radiation Oncology the Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhouHenanP.R.China Department of Radiation Oncology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory ofCancer Prevention and TherapyTianjin’s ClinicalResearch Center for CancerTianjinP.R.China Department of Oncology Subei People’s Hospital of Jiangsu ProvinceYangzhouJiangsuP.R.China Department of Oncology Taizhou People’s Hospital of Jiangsu ProvinceTaizhouZhejiangP.R.China Department of Radiation Oncology the Affiliated Hospital of Inner Mongolia Medical UniversityHohhotInner MongoliaP.R.China Department of Radiation O

Background:Concurrent chemoradiotherapy(CCRT)is the standard treatment for locally advanced esophageal squamous cell carcinoma(ESCC).However,the optimal radiotherapy regimen,particularly in terms of total dose and planned range of irradiation field,remains *** phase III clinical trial aimed to compare the survival benefits between different radiation doses and different target ***:This trial compared two aspects of radiation treatment,total dose and field,using a two-by-two factorial *** high-dose(HD)group received 59.4 Gy radiation,and the standard-dose(SD)group received 50.4 *** involved field irradiation(IFI)group and elective nodal irradiation(ENI)group adopted different irradiation *** participants were assigned to one of the four groups(HD+ENI,HD+IFI,SD+ENI and SD+IFI).The primary endpoint was overall survival(OS),and the secondary endpoints included progressionfree survival(PFS).The synergy indexwas used to measure the interaction effect between dose and ***:The interaction analysis did not reveal significant synergistic effects between the dose and irradiation *** comparison to the target field,patients in IFI or ENI showed similar OS(hazard ratio[HR]=0.99,95%CI:0.80-1.23,p=0.930)and PFS(HR=1.02,95%CI:0.82–1.25).TheHDtreatment did not show significantly prolonged OS compared with SD(HR=0.90,95%CI:0.72–1.11,p=0.318),but it suggested improved PFS(25.2 months to 18.0 months).Among the four groups,the HD+IFI group presented the best survival,while the SD+IFI group had the worst *** significant difference in the occurrence of severe adverse events was found in dose or field ***:IFI demonstrated similar treatment efficacy to ENI in CCRT of *** HD demonstrated improved PFS,but did not significantly improve *** dose escalation based on IFI(HD+IFI)showed better therapeutic efficacy than the current recommendation(SD+ENI)and is worth further validation.

关键词： clinical trial concurrent chemoradiotherapy elective nodal radiation esophageal squamous cell carcinoma high dose radiation involved field radiation overall survival standard dose radiation