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MicroRNA-9 as a paradoxical but critical regulator of cancer metastasis:Implications in personalized medicine

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Genes & Diseases 2021年第6期8卷 759-768页

作者： Yichen Liu Qiong Zhao Tao Xi lufeng zheng Xiaoman Li Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica School of PharmacyNanjing University of Chinese MedicineNanjingJiangsu Province210023PR China School of Life Science and Technology Jiangsu Key Laboratory of Carcinogenesis and InterventionChina Pharmaceutical University639 Longmian RoadNanjingJiangsu Province211198PR China

Metastasis,is a development of secondary tumor growths at a distance from the primary site,and closely related to poor prognosis and ***,there is still no effective treatment for metastatic ***,there is an urgent need to find an effective therapy for cancer *** of evidence indicates that miR-9 can function as a promoter or suppressor in cancer metastasis and coordinate multistep of metastatic *** this review,we summarize the different roles of miR-9 with the corresponding molecular mechanisms in metastasis of twelve common cancers and the multiple mechanisms underlying miR-9-mediated regulation of metastasis,benefiting the further research of miR-9 and metastasis,and hoping to bridge it with clinical applications.

关键词： Cancer Metastasis MiR-9 Oncogene Tumor suppressor

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普济消毒饮古代文献考证与分析

中国中医药图书情报杂志 2024年第1期48卷 16-21页

作者：郑陆峰李鸿涛陈广坤中国中医科学院中医药信息研究所北京100700

搜集有关普济消毒饮的中医古籍文献,采用文献计量学方法对普济消毒饮的历史源流、药物组成、组方原理、剂量炮制、主治病证、用法等进行统计分析。经筛选得到普济消毒饮相关古籍文献235条,涉及中医古籍139部。普济消毒饮源于《东垣试效... 详细信息

搜集有关普济消毒饮的中医古籍文献,采用文献计量学方法对普济消毒饮的历史源流、药物组成、组方原理、剂量炮制、主治病证、用法等进行统计分析。经筛选得到普济消毒饮相关古籍文献235条,涉及中医古籍139部。普济消毒饮源于《东垣试效方》,由黄芩、黄连、人参、陈皮、玄参、甘草、连翘、牛蒡子、板蓝根、马勃、僵蚕、升麻、柴胡、桔梗14味中药组成,主要功效为清热解毒、疏风散邪,主治为上焦热盛所致的大头瘟等疾病。在涉及药味炮制的76条文献中,以甘草最多,多为生(44/45);其次为僵蚕,多为炒(38/44);黄连、黄芩多为酒炒(28/40、24/37);用法上以煮散剂为主,自明末剂型逐渐转变为汤剂。通过数据挖掘整理、系统分析记载普济消毒饮的中医古籍文献,为古代名方的临床应用和现代制剂研发提供参考。

关键词：普济消毒饮东垣试效方中医古籍考证

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《医学辨正》的学术思想及用药规律研究

中国中医基础医学杂志 2024年第7期30卷 1112-1116页

作者：郑陆峰董燕陈广坤李鸿涛中国中医科学院中医药信息研究所北京100700

《医学辨正》是清代医家张学醇编著的中医基础理论类医书,全书分四卷,经考证,现存版本共有4种。书中张学醇的学术思想主要有以下5个方面,即遵从《黄帝内经》,勘误前人;法从阴阳,分寒热证;望闻问切,尤重脉象;拆方用药,剂量平和;用药禁忌... 详细信息

《医学辨正》是清代医家张学醇编著的中医基础理论类医书,全书分四卷,经考证,现存版本共有4种。书中张学醇的学术思想主要有以下5个方面,即遵从《黄帝内经》,勘误前人;法从阴阳,分寒热证;望闻问切,尤重脉象;拆方用药,剂量平和;用药禁忌,须分寒热。此外,基于古今医案云平台对张学醇的用药规律进行综合分析,可以得出以下结论。药味及证型频次分析方面:寒证、热证分型遣方用药相当;药物频次分析方面:与张仲景的《伤寒论》关系密切,涉及寒热、表里、气血、补泻方面的方剂;药物性味频次方面:四气以温、寒性为主,五味以甘、辛、苦味为主,用药性味贴合疾病;聚类分析方面:第1组有甘草、干姜、附子,第2组有当归、麻黄,第3组有石膏、知母,第4组有牡丹皮、黄芩、黄连,前两组药性偏温,用于治疗寒证,后两组药性偏寒,用于治疗热证;关联分析方面:热证多应用甘草、石膏,寒证多应用桂枝、干姜、附子、麻黄、细辛。本研究着重讨论《医学辨正》的基本情况、张学醇的学术思想和用药规律,为今后继续研究张学醇及其学术思想和用药规律提供科学依据。

关键词：《医学辨正》张学醇学术思想用药规律

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《温热经纬》辨治疫病学术思想研究

中国中医药图书情报杂志 2024年第2期48卷 166-169页

作者：郑陆峰陈广坤何畅李鸿涛中国中医科学院中医药信息研究所北京100700

本文系统梳理现代学者关于《温热经纬》的研究概况,分析王士雄研究疫病的历史背景和引证诸多医家的评注,总结王士雄辨治疫病的学术思想。王士雄在大框架下遵从张仲景对于疫病的认识,同时补充陈坤、余师愚等多位医家的观点。本文从其补... 详细信息

本文系统梳理现代学者关于《温热经纬》的研究概况,分析王士雄研究疫病的历史背景和引证诸多医家的评注,总结王士雄辨治疫病的学术思想。王士雄在大框架下遵从张仲景对于疫病的认识,同时补充陈坤、余师愚等多位医家的观点。本文从其补充张仲景疫病辨证理论体系、创新认识、病因病机、治则治法、预后防变五方面进行论述,以期为现代疫病理论体系的研究提供参考。

关键词：温热经纬疫病学术思想王士雄

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无需预先测速的靶场弹丸落点定位算法实现

电子与信息学报 2017年第2期39卷 322-327页

作者：李鹏宇车录锋郑春雷中国科学院上海微系统与信息技术研究所微系统技术国家级重点实验室上海200050 中国科学院大学北京100049 中国科学院上海微系统与信息技术研究所上海200050

该文针对现有靶场弹丸落点定位系统需要提前测量波速,实际应用复杂,定位误差大等问题,提出一种无需预先测速的弹丸落点定位算法,此算法采用米字型传感器阵列,米字型阵列又可以分解成2组五元十字阵,通过来波方向(DOA)算法预先估计波速,... 详细信息

该文针对现有靶场弹丸落点定位系统需要提前测量波速,实际应用复杂,定位误差大等问题,提出一种无需预先测速的弹丸落点定位算法,此算法采用米字型传感器阵列,米字型阵列又可以分解成2组五元十字阵,通过来波方向(DOA)算法预先估计波速,然后把波束估计值代入到达时间差算法(TDOA)方程中计算初始位置,再把初始位置和估计波速作为参数代入到泰勒级数展开算法中,收敛定位。由于不需要预先人工测量波速,减少了波速测量误差,波速和定位位置都是在迭代算法中逐步收敛求精的,所以该算法提高了弹丸落点定位精度,减少了实际应用的复杂性。仿真算法也验证了此方法的可行性,在距离定位阵列1000 m范围内迭代算法都是收敛的。

关键词：弹丸落点定位到达时间差算法泰勒级数

MicroRNA-10b调控乳腺癌细胞生长增殖与凋亡的研究

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中国药科大学学报 2015年第2期46卷 242-249页

作者：顾忆李小曼郑禄枫杨珏奚涛中国药科大学生命科学与技术学院南京210009

研究MicroRNA-10b(miR-10b)对乳腺癌细胞MCF-7、MDA-MB-231的生长增殖和凋亡的调控作用。采用能模拟内源miR-10b的miR-10b模拟物以及能特异靶向敲除内源miR-10b的miR-10b抑制剂分别转染乳腺癌细胞MCF-7和MDA-MB-231。RT-PCR测定转染后细胞中miR-10b的表达水平,MTT检测miR-10b对细胞增殖活力的影响,流式细胞仪检测miR-10b对细胞周期和凋亡的影响。生物信息学软件预测miR-10b潜在的靶基因,3'UTR荧光素酶报告法验证其靶向性,Western blot检测caspase-3、P21的蛋白表达水平。研究证实,miR-10b模拟物上调乳腺癌中miR-10b的表达水平,与对照组相比,细胞增殖能力提高,细胞周期加速,细胞凋亡率降低;反之miR-10b抑制剂能显著下调miR-10b的表达,与对照组相比,细胞增殖能力降低,细胞周期阻滞,细胞凋亡率上调。初步探讨miR-10b的作用机制可能是通过靶向作用于TP53INP1,抑制细胞周期与凋亡关键蛋白caspase-3、P21的表达水平,从而促进乳腺癌的发生发展。

关键词： MicroRNA miR-10b 乳腺癌增殖细胞周期凋亡 TP53INP1

Plate tectonics in the Archean:Observations versus interpretations

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Science China Earth Sciences 2024年第1期67卷 1-30页

作者： YongFei zheng School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China Key Laboratory of Crust-Mantle Materials and Environment Chinese Academy of SciencesHefei 230026China Center of Excellence for Comparative Planetology Chinese Academy of SciencesHefei 230026China

Plate tectonics theory,established in the 1960s,has been successful in explaining many geological phenomena,processes and events that occurred in the ***,the theory has often struggled to provide a coherent framework in interpreting geological records in continental interior and Precambrian *** dealing with the relationship between plate tectonics and continental geology,continental interior tectonics was often separated from continental margin tectonics in the inheritance and development of their structure and *** separation led to the illusion that the plate tectonics theory is not applicable to Precambrian geology,particularly in explaining the fundamental geological characteristics of Archean *** this illusion does not mean that the Archean continental crust did not originate from a regime of plate tectonics,it led to the development of alternative tectonic models,often involving vertical movements under a regime of stagnant lid tectonics,including not only endogenous processes such as gravitational sagduction,mantle plumes and heat pipes but also exogenous processes such as bolide *** vertical processes were not unique to the Archean but persisted into the *** result from mantle poloidal convection at different depths,not specific to any particular *** the plate tectonics theory from the traditional kinematic model in the 20th century to a holistic kinematic-dynamic model in the 21st century and systematically examining the vertical transport of matter and energy at plate margins,it is evident that plate tectonics can explain the common geological characteristics of Archean cratons,such as lithological associations,structural patterns and metamorphic *** deciphering the structure and composition of convergent plate margins as well as their dynamics,the formation and evolution of continental crust since the Archean can be divided into ancient plate tectonics in the Preca

关键词： Plate tectonics Archean geology Continental origin Crustal reworking Plate interior Plate margin

Safe Motion Planning and Control Framework for Automated Vehicles with Zonotopic TRMPC

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Engineering 2024年第2期33卷 146-159页

作者： Hao zheng Yinong Li Ling zheng Ehsan Hashemi State Key Laboratory of Mechanical Transmissions College of Mechanical and Vehicle EngineeringChongqing UniversityChongqing 400044China Department of Mechanical Engineering University of AlbertaEdmontonAB T6G 2H5Canada

Model mismatches can cause multi-dimensional uncertainties for the receding horizon control strategies of automated vehicles(AVs).The uncertainties may lead to potentially hazardous behaviors when the AV tracks ideal trajectories that are individually optimized by the AV's planning *** address this issue,this study proposes a safe motion planning and control(SMPAC)framework for *** the control layer,a dynamic model including multi-dimensional uncertainties is established.A zonotopic tube-based robust model predictive control scheme is proposed to constrain the uncertain system in a bounded minimum robust positive invariant set.A flexible tube with varying cross-sections is constructed to reduce the controller *** the planning layer,a concept of safety sets,representing the geometric boundaries of the ego vehicle and obstacles under uncertainties,is *** safety sets provide the basis for the subsequent evaluation and ranking of the generated *** efficient collision avoidance algorithm decides the desired trajectory through the intersection detection of the safety sets between the ego vehicle and obstacles.A numerical simulation and hardware-in-the-loop experiment validate the effectiveness and real-time performance of the *** result of two driving scenarios indicates that the SMPAC can guarantee the safety of automated driving under multi-dimensional uncertainties.

关键词： Automated vehicles Automated driving Motion planning Motion control Tube MPC Zonotope

Discovery of the Significant Impacts of Swell Propagation on Global Wave Climate Change

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Journal of Ocean University of China 2024年第3期23卷 594-604页

作者： zheng Chongwei Dalian Naval Academy Dalian 116018China Marine Resources and Environment Research Group on the Maritime Silk Road Dalian 116018China

This study compared the differences in the wave climate in the South China Sea and North Indian Ocean under these two datasets:ERA-40 wave reanalysis and Mei’s hindcast wave *** the numerical calculation of regional ocean waves,the wave climate characteristics exhibited significant bias if the influence of external swells(swells from afar)was not fully considered,which may provide an incorrect basis for global climate change analysis.1)The trends of the significant wave height(SWH)obtained from the two datasets showed significant differences,such as those of the Bay of Bengal and the Java Sea in *** the past 45 years,SWH from ERA-40(SWH-ERA)exhibited a significant annual increase in low-latitude waters of the North Indian Ocean(0.2-0.6 cm yr^(-1))and South China Sea(0.2-0.8 cm yr^(-1)).2)In the Bay of Bengal,the SWH-ERA in each month was generally 0.5 m higher than the SWH from Mei’s hindcast wave data(SWH-Mei)and can reach 1.0 m higher in some months.3)In the Bay of Bengal,SWH-ERA and SWH-Mei increased significantly at annual rates of 0.13 and 0.27 cm yr^(-1),*** increasing trend was mainly reflected after ***-ERA showed a trough in 1975(1.33 m)and a crest in 1992(1.83 m),which were not reflected in SWH-Mei.

关键词： wave climate climatic trend monthly variation annual variation external swell