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Hereditary Immunity and the Origin of Atherosclerosis

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Open Journal of Immunology 2014年第1期4卷 14-21页

作者： Sergey N. Rumyantsev Vil K. Gerasimov Jergy Grzezczuk Roman A. Aron Nataly F. Avrova Irina V. Belyakova ludmila V. Bobrakova Kirill F. Dubrov ludmila V. Perkus Vladimir F. Pospelov Nina M. Rogacheva Nikolay P. Shabalov Department of Evolutionary Immunology Andent Inc. Jersey City USA

This paper tries to present new confirmation for the opinion about the infectious origin of atherosclerosis from the viewpoint of the current knowledge of hereditary immunity. The performed integrative investigation included the reinterpretation of known clinical and epidemiological observations, supported by immunological, molecular ecological, genetic, and genomic discoveries. The revealed body of firstly achieved information is compatible with the concept that infectious agents contribute the clue step to the development of atherosclerosis over its initial stage performed during the triggering of the arterial endothelial wall by the molecular agent of proposed infectious origin.

关键词： Epidemic Spread Heterozygosity Homozygosity Immune Mosaicism Integrative Approach Plaque Formation

Influence of the Silicon- and Element-Organic Compounds on the Process of Biochemical Oxidation in the Organic Contaminations

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Engineering（科研） 2012年第6期4卷 321-323页

作者： Vilen M. Kantere Tatyana G. Mukhamedzhanova ludmila A. Tchurmasova Olga G. Ryzhova Svetlana V. Zhukova Moscow State University of Food Production Moscow Russia

One of the methods used in practice for the purification of wastewater from vegetable-processing enterprises is biological method of aerobic purification. With the aim to increase air-tank capacity used in traditional systems of biochemical purification of wastewater, different ways effecting to the process of vital activity of microorganisms of active sludge are applied. On the one hand, using the compositions of different salts and complex organic biogenous supplements prevents from the accumulation of some anions in the amounts exceeding the limited concentration, on the other hand- allows different groups of microorganisms to choose biogenous elements, which they assimilate easily and fully. It is known, that compounds of silicon and germanium can cause stimulating effects [1] to the organisms of active sludge. The goal of present studies is the intensification of biological processes of oxidation of organic contamination in wastewater by new bio-degradable chemical compounds or compositions on their basis, and by bio-sorbents.

关键词： Biochemical Oxidation Contamination in Wastewater Biological Method of Aerobic Purification

地震和超声波频率下碳酸盐岩弹性特征的实验室测量

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石油地质科技动态 2009年第4期 12-18页

作者： ludmila Adam Michael Batzle 梁慧（译）白振瑞（校）

饱含流体的岩石可视为粘弹性物质。粘弹性物质的速度和弹性模量随频率的增加而增加。因此，在高频和低频下观测的岩石弹性特征会有所不同。速度和弹性模量的实验室测定通常都是在高于地表地震数据的频率下进行，但是采用应力一应变实验... 详细信息

饱含流体的岩石可视为粘弹性物质。粘弹性物质的速度和弹性模量随频率的增加而增加。因此，在高频和低频下观测的岩石弹性特征会有所不同。速度和弹性模量的实验室测定通常都是在高于地表地震数据的频率下进行，但是采用应力一应变实验方法，在地震频率下也可以在实验室测量岩样的模量和速度。

关键词：超声波频率实验室测量弹性特征地震数据碳酸盐岩弹性模量实验室测定地震频率

Essential Oils from Different Parts of the Sea Buckthorn <i>Hippophae rhamnoides</i>L.

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Advances in Bioscience and Biotechnology 2019年第8期10卷 233-243页

作者： Nikolay M. Slynko Leonid V. Kuibida ludmila E. Tatarova George U. Galitsyn Tatiana N. Goryachkovskaya Sergey E. Peltek The Federal Research Center Institute of Cytology and Genetics SB RAS Novosibirsk Russia Institute of Chemical Kinetics and Combustion SB RAS Novosibirsk Russia

The study investigated essential oils of berries and green biomass of the sea buckthorn at various growth stages. Plant material of H. rhamnoídes ssp. mongolica was collected in the experimental fields of the Institute of Cytology and Genetics SB RAS (Siberia, Russia). Volatile compounds and essential oils were detected. Green spring shoots without leaves, first-year seedlings without leaves and berries were analyzed. In all studied exemplars, 103 volatile compounds were defined among which considerable proportion wasn’t found in a sea-buckthorn earlier. Phenylpropanoids prevailed in essential oils composition from seedlings. Alkanes and phenylpropanoids prevailed in shoots. Berries contained mostly carboxylic acids and their esters. These data can be applied to a fingerprint of various cultivars of a sea-buckthorn with relevance to food science and technology.

关键词： Hippophae rhamnoídes Essential Oils Volatile Compounds Gas Chromatography-Mass Spectrometry (GC-MS) Analysis Chemotaxonomy

Validation of Educational Video to Promote Self-Efficacy in Preventing Childhood Diarrhea

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Health 2015年第2期7卷 192-200页

作者： ludmila Alves do Nascimento Andressa Peripolli Rodrigues Emanuella Silva Joventino Neiva Francenely Cunha Vieira Patrícia Neyva da Costa Pinheiro Lorena Barbosa Ximenes Department of Nursing Federal University of Ceará Fortaleza Brazil

The aim of this study was to evaluate and to validate an educational video to promote maternal self-efficacy in preventing childhood diarrhea with women assisted in a health unit. Validation study, developed with 17 mothers whose children were under five years old, was analyzed on scenes of an educational video according to the validity of appearance (clarity/comprehension) and of content (relevance). The scenes were considered clear and comprehensive with a perceptual above 70% and with an average of 96.9% of agreement. Regarding the relevance, the agreement was maintained between 94% and 100%, however only scenes 03 and 13 presented 76.6% and 70.6% of agreement respectively. Global Content Validation Index of the educational video scenes was 0.97 meaning an excellent level of agreement among mothers. The video showed to be a valid and a trustworthy material to promote maternal self-efficacy in preventing childhood diarrhea. Therefore, it is important that the material is disseminated in other health services so that other mothers may have contact with the same, providing greater reliability of the material.

关键词： Diarrhea Infantile Self Efficacy Educational Technology Health Education Nursing

Colonization of germ-free mice with a mixture of three lactobacillus strains enhances the integrity of gut mucosa and ameliorates allergic sensitization

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Cellular & Molecular Immunology 2016年第2期13卷 251-262页

作者： Hana Kozakova Martin Schwarzer ludmila Tuckova Dagmar Srutkova Elzbieta Czarnowska Ilona Rosiak Tomas Hudcovic Irma Schabussova Petra Hermanova Zuzana Zakostelska Tamara Aleksandrzak-Piekarczyk Anna Koryszewska-Baginska Helena Tlaskalova-Hogenova Bozena Cukrowska Laboratory of Gnotobiology Institute of Microbiology Academy of Sciences of the Czech Republic Novy Hradek Czech Republic Department of Pathology the Children's Memorial Health Institute Warsaw Poland Institute of Specific Prophylaxis and Tropical Medicine Medical University of Vienna Vienna Austria Institute of Biochemistry and Biophysics Polish Academy of Sciences Warsaw Poland

Increasing numbers of clinical trials and animal experiments have shown that probiotic bacteria are promising tools for allergy prevention. Here, we analyzed the immunomodulatory properties of three selected lactobacillus strains and the impact of their mixture on allergic sensitization to Bet v I using a gnotobiotic mouse model. We showed that Lactobacillus （L.） rhamnosus LOCK0900, L. rhamnosus LOCK0908 and L. casei LOCK0919 are recognized via Toll-like receptor 2 （TLR2） and nucleotide-binding oligomerization domain-containing protein 2 （NOD2） receptors and stimulate bone marrow-derived dendritic cells to produce cytokines in species- and strain-dependent manners. Colonization of germ-free （GF） mice with a mixture of all three strains （Lmix） improved the intestinal barrier by strengthening the apical junctional complexes of enterocytes and restoring the structures of microfilaments extending into the terminal web. Mice colonized with Lmix and sensitized to the Bet v I allergen showed significantly lower levels of allergen-specific IgE, IgG 1 and IgG2a and an elevated total IgA level in the sera and intestinal lavages as well as an increased transforming growth factor （TGF）-β level compared with the sensitized GF mice. Splenocytes and mesenteric lymph node cells from the Lmix-colonized mice showed the significant upregulation of TGF-β after in vitro stimulation with Bet v 1. Our results show that Lmix colonization improved the gut epithelial barrier and reduced allergic sensitization to Bet v 1. Furthermore, these findings were accompanied by the increased production of circulating and secretory IgA and the regulatory cytokine TGF-β. Thus, this mixture of three lactobacillus strains shows potential for use in the prevention of increased gut permeability and the onset of allergies in humans,

关键词： allergic sensitization germ-free intestinal barrier Lactobacillus probiotics

In vitro examining the existing prognoses how TBP binds to TATA with SNP associated with human diseases

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Health 2011年第9期3卷 577-583页

作者： Irina A. Drachkova Petr M. Ponomarenko Tatyana V. Arshinova Мikhail P. Ponomarenko Valentin V. Suslov ludmila K. Savinkova Nikolay А. Kolchanov 不详

We in vitro examined the existing prognoses of the dissociation constant, KD, between ТАТА- Binding Protein (TBP) and ТАТА box with single nucleotide polymorphism (SNP) associated with human diseases. Five SNPs of the genes for cytochrome P450 2A6 (associated with lung cancer), β-globin (associated with β-thalassemia), mannose binding lectin (associated with variable immunodeficiency), superoxide dismutase 1 (associated with amyotrophic lateral sclerosis) and triosephosphate isomerase (associated with anemia) fell within the range of –ln(KD;M/KD;WT) between –1.5 and –1 (here KD;WT and KD;M denote the normal ТАТА box and with SNP). The mea-surements using EMSA demonstrated that: 1) all the predictions stating that the affinity between ТВР and ТАТА boxes with SNPs would be reduced were correct;2) the departures of three predictions from the measurements fell within the confidence interval;3) all the predictions consistently underestimated actual mutational damage caused to ТАТА boxes with SNPs (a < 0.05;binomial law) and two of these predictions did so significantly (a < 0.05, Student’s t-test). This consistent underestimation seems to be associated with the damage to the context that modulates ТВP/ТАТА affinity, for example, the contact between the nucleosomal histone H3-Н4 dimer and the core promoter immediately near ТАТА boxes.

关键词： Disease Polymorphism ТАТА Box TATA-Binding Protein Affinity In Vitro In Silico

Quantitative tracking of trans-synaptic nose-to-brain transport of nanoparticles and its modulation by odor,aging,and Parkinson’s disease

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Nano Research 2023年第5期16卷 7119-7133页

作者： Alexander V.Romashchenko Dmitrii V.Petrovskii Sergey Yu.Trotsky Ksenia N.Morozova Nina B.Illarionova Maria V.Zhukova Elena V.Kiseleva Marina B.Sharapova Daniil S.Zuev Konstantin E.Kuper Sergey Yu.Taskaev Anna I.Kasatova Dmitrii A.Kasatov Olga I.Solovieva Ivan A.Razumov ludmila A.Gerlinskaya Mikhail P.Moshkin Yuri M.Moshkin The Federal Research Center Institute of Cytology and Genetics SB RASAcademician Lavrentiev Avenue10Novosibirsk 630090Russia International tomography center Institutskaya st.3ANovosibirsk 630090Russia G.K.Boreskov Institute of Catalysis SB RASAcademician Lavrentiev Avenue5Novosibirsk 630090Russia The Federal Research Center Budker Institute of Nuclear Physics SB RASAcademician Lavrentiev Avenue11Novosibirsk 630090Russia Institute of Computational Technologies Academician M.A.Lavrentiev avenue6Novosibirsk 630090Russia Institute of Gene Biology Russian Academy of SciencesMoscow 117334Russia Institute of Molecular and Cellular Biology SB RASAcad.Lavrentiev Ave8/2Novosibirsk 630090Russia Federal Research Centre of Biological Systems and Agrotechnologies RASst.January 929Orenburg 460000Russia

Nanoparticles(NPs)can be transported via the nose-to-brain(N_(2)B)***,quantitative data on their spatiotemporal dynamics and regulation of the N_(2)B transport are largely *** surveyed metal oxide/hydroxide NPs as magnetic resonance imaging(MRI)contrasts for quantitative N_(2)B *** containing divalent transition metals were the only ones capable of N_(2)B *** T1-weighted(T1W)MRI,we showed that Mn_(3)O_(4)-NPs were readily engulfed by olfactory receptor neurons(ORNs)without disrupting olfactory sensing,we mapped their N_(2)B *** neurons,the Mn_(3)O_(4)-NPs were localized to the cytosol,mitochondria,vesicles,moved at mixed fast and slow axonal transport velocities intraand extra-vesicularly through *** NPs’axonal transport is dependent on neuronal activity and microtubule *** Mn_(3)O_(4)-NPs were trans-synaptically transmitted through at least four synapses across the olfactory ***-synaptic transmission of the NPs was dependent on N-type Ca^(2+)channels and NMDA receptors but blocked by GABAB receptor activation.A five-parameter Weibull signal increase/decrease model fitted to the T1W MRI data allowed for estimating kinetic parameters of Mn_(3)O_(4)-NP accumulation/*** and relative accumulation rates,but not elimination,correlated negatively with the number of synapses from ORNs,indicating a coupling of the NPs’N_(2)B transport with spontaneous neuronal ***,olfactory stimuli(2,5-dimethylpyrazine and acetophenone)significantly modulated and rerouted the Mn_(3)O_(4)-NP N_(2)B transport odor ***,the NPs’trans-synaptic transmission was impaired by aging and the onset of Parkinson’s *** data suggest new approaches to diagnostics,functional neuroimaging,controlling N_(2)B drug delivery.

关键词： Mn_(3)O_(4)nanoparticles magnetic resonance imaging(MRI) nose-to-brain transport trans-synaptic transmission olfactory stimulation

Contribution at the Study of Neuroprotective Properties of Neuroglobin during Severe Chronic Glaucoma

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World Journal of Neuroscience 2020年第1期10卷 42-67页

作者： Jean Fidèle Nnang Essone Tatiana Harly Mba Aki Angue Mounir Belmalih Rosalie Nkiéma ludmila Betty Eke Ndouo Emmanuel Anyunzoghe Nathan Ekegue Félix Ovono Abessolo Department of Physiology Faculty of Medicine and Health Sciences University of Health Sciences Owendo Libreville Gabon Physiological Functional Exploration and Physical Medicine Services Owendo University Hospital Center Owendo Libreville Gabon Department of Ophthalmology Faculty of Medicine and Health Sciences University of Health Sciences Owendo Libreville Gabon Mother-Child University Hospital Center Libreville Gabon Department of Biochemistry-Chemistry Faculty of Medicine and Health Sciences University of Health Sciences Owendo Libreville Gabon Department of Epidemiology Biostatistics and Medical Informatics Faculty of Medicine and Health Sciences University of Health Sciences Owendo Libreville Gabon Faculty of Pharmacy University of Health Sciences Owendo Libreville Gabon

Introduction: The mechanisms of overexpression of neuroglobin in patients with severe glaucoma (CG+) remain hypothetical. Objective: To study the anti-apoptotic, anti-hypoxic and anti-oxidant properties of neuroglobin in CG+. Population and Methods: The visual field, as well as plasma dosage of neuroglobin (CmNgb, ng/ml), hypoxia inductible factor-1alpha (CmHIF-1α, pg/ml), glutathione peroxidase (CmGpx, pg/ml), and cytochrome C oxidase (CmCyt C, pg/ml) were carried out in 45 CG+ and 45 controls (CG-). The chi-2 test compared the proportions, and Spearman’s test studied the correlations between quantitative variables (p Results: CmNgb was 4.1 in CG+, versus 2.3 in CG- (p = 1.52 × 10-5). CmGpx was 1144.7 in CG+, versus 752.8 in GC- (p = 0.0199). CmHIF-1α was 4.1 in CG+, versus 3.5 in CG- (p = 0.4530). CmCyt C was 2303.26 in CG+, versus 1750.44 in CG- (p = 0.0450). In CG+, there was a correlation between CmNgb and CmGpx (r = 0.417;p = 0.004), CmNgb and CmHIF-1α (r = 0.644;p = 1.8 × 10-6), and between CmHIF-1α and CmGpx (r = 0.447;p = 0.002), CmHIF-1α and CmCyt C (r = 0.371;p = 0.012). None correlation was found between CmNgb and CmCyt C (r = 0.126;p = 0.370), as well as CmGpx and CmCyt C (r = 0.102;p = 0.505). Conclusion: The variations of apoptosis, hypoxic, and oxidative stress biomarkers were found between CG+ and CG-, as well as their correlations, suggesting that neuroglobin overexpression is related to its anti-apoptotic, anti-oxidative, and anti-hypoxic properties.

关键词： Chronic Severe Glaucoma Neuroglobin Neuroprotective-Properties