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Chinese Journal of Polymer Science 2008年第5期26卷 553-559页

作者： Vladimir Zakharov ludmila echevskaya Tatiana Mikenas Mikhail Matsko Andrey Tregubov Marina Vanina Marina Nikolaeva Boreskov Institute of Catalysis Novosibirsk 630090Russia

The effect of chemical composition of highly active supported Ziegler-Natta catalysts with controlled morphology on the MWD of PE has been *** was shown the variation of transition metal compound in the MgCl_2-supported catalyst affect of MWD of PE produced in broad range:Vanadium-magnesium catalyst(VMC)produce PE with broad and bimodal MWD(M_w/M_n=14-21).MWD of PE,produced over titanium-magnesium catalyst(TMC)is narrow or medium depending on Ti content in the catalyst(M_w/M_n=3.1-4.8).The oxidation ...

关键词： Polyethylene(PE) Vanadium magnesium catalyst(VMC) Titanium magnesium catalyst(TMC) Gel permeation chromatography(GPC) Molecular weight distribution(MWD).

HIFs in hypoxic regulation of the extracellular matrix:focus on little-known player HIF-3

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BIOCELL 2024年第5期48卷 677-692页

作者： ALEKSANDRA GORNOSTAEVA ludmila BURAVKOVA MARGARITA LOBANOVA ELENA ANDREEVA Institute of Biomedical Problems of the Russian Academy of Sciences Khoroshevskoye Shosse 76AMoscow123007Russia

The structural and associated molecules of the extracellular matrix(ECM)complex is an important component of the local milieu of cells,both for maintaining their functions and *** is a dynamic structure that is finely tuned to changes in the *** of these factors is hypoxia,which can arise in tissues due to physiological or pathological *** a result of the hypoxic effect,the properties of the ECM are significantly modified,stiffness increases,the balance between degradation and synthesis of structural proteins shifts,and the deposition of biologically active mediators’***-inducible factors(HIFs)contribute significantly to the modification of the properties of the ECM under *** the three HIF isoforms,HIF-1 is the most studied,with numerous identified target genes encoding proteins that participate in all matrisome *** less is known about HIF-2 and *** the context of the effects of hypoxia on the matrisome,HIF-3 isoform is of particular *** the first two isoforms,transiently expressed during the first hours of hypoxia,HIF-3 is activated after around 24 h of exposure to hypoxia and persists for a longer *** addition,its transcription is more pronounced under hypoxia than are HIFs 1 and ***-3,rather than the first two isoforms,is possibly responsible for the changes that occur in matrisome during prolonged hypoxic *** review attempts to summarize the available data on the involvement of HIF-3 in the matrisome modification under hypoxia.

关键词： Hypoxia Hypoxia-inducible factors Matrisome

A rare case of cardiac and ophthalmic manifestations of meningococcal septicemia

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World Journal of Emergency Medicine 2024年第4期15卷 328-330页

作者： Svetlana Rachina Anastasia Shchendrygina Heshan Radeesha de Silva Svetlana Tarasenko Nadezhda Mukhina Irina Komarova ludmila Fedina Elena Burmistrova Elvira Martens Sergey Sidorenko Vladimir Gostev Dmitry Polev Alina Saitova Lyudmila Kraeva Nikita Goncharov Irina Zvetkova Department of Hospital Therapy I M Sechenov First Moscow State Medical UniversityMoscow 119048Russia Outpatient Clinic#64 Moscow 119048Russia Department of Cardiology City Clinical Hospital n.a.S.S.YudinMoscow 119048Russia Department of Medical Microbiology and Molecular Epidemiology Pediatric Research and Clinical Center for InfectiousDiseasesSaint Petersburg 197022Russia Department of Medical Microbiology North-Western State Medical University Named After I.I.MechnikovSaintPetersburg 191015Russia Department of Epidemiology Saint-Petersburg Pasteur InstituteSaint Petersburg 197101Russia

Acute pericarditis is usually a self-limiting disorder that commonly occurs due to viral etiology or unexplained *** pericarditis(MP)is a remarkably uncommon clinical entity that manifests as a complication during the acute or convalescent phase of meningococcal ***,its occurrence within the context of meningococcal septicemia has also been *** report a rare case of a previously healthy male patient who developed both acute pericarditis and uveitis as a presentation of meningococcal septicemia,with no characteristic skin rashes or meningeal signs.

关键词： acute Acute rare

Systematic Analysis of Factors Associated with Late Breast Cancer Screening in Women in Sub-Saharan Africa from 2014 to 2020

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Open Journal of Epidemiology 2024年第3期14卷 480-492页

作者： Akossito Hermine Tognon Ahmed Kabore Nayi Zongo Nestor Bationo Francis Tognon Tchegnonsi ludmila Akoyi Abdoul Halim Bague Maxime Koine Drabo Department of Public Health University Joseph KI-ZERBO Ouagadougou Burkina Faso Yalgado Ouédraogo University Hospital Center Ouagadougou Burkina Faso Institute of Training in Nursing and Obstetrics Parakou Benin National Center for Scientific and Technological Research (CNRT) Ouagadougou Burkina Faso

Research background: Breast cancer remains a major public health problem, with a high number of new cases and deaths each year. However, despite advances in research to improve this disease, there is a high rate of late detection, leading to diagnosis at an advanced stage and a reduced chance of survival. Objective: The aim of this study is to identify the factors associated with late detection of breast cancer in women in Sub-Saharan Africa from 2014 to ***: This systematic review focuses on sub-Saharan Africa. Methods: We searched for articles in four databases (PubMed, Embase, Global-Health and CINAHL) between 2014 and 2020 and performed a narrative synthesis to organize and group the different factors associated with late breast cancer detection. Result: After reviewing 583 publications, 6 studies were selected, highlighting factors such as lack of awareness, knowledge gaps, difficulties in accessing health services and financial constraints associated with late breast cancer screening. The participants, who ranged in number from 20 to 1776, were mainly aged between 18 and 25, with a mean age of 25 years and 6 months. Conclusion: The analysis enabled us to identify various factors associated with late breast cancer screening. Collaboration between health professionals, community organizations and policy-makers is essential to foster an environment conducive to the prevention and early detection of breast cancer.

关键词： Associated Factors Late Screening Breast Cancer Women Sub-Saharan Africa

Application of comprehensive two-dimensional gas chromatography with masss pectrometric detection for the analysis of selected drug residues in wastewater and surface water

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Journal of Environmental Sciences 2013年第1期25卷 204-212页

作者： Petr Lacina ludmila Mravcov Milada Vvrov Institute of Chemistry and Technology of Environmental Protection Faculty of ChemistryBrno University of Technology Geotest a.s.Smahova 1244/112Brno 62700Czech Republic

Pharmaceutical residues have become tightly controlled environmental contaminants in recent years, due to their increasing concentration in environmental components. This is mainly caused by their high level of production and everyday consumption. Therefore there is a need to apply new and sufficiently sensitive analytical methods, which can detect the presence of these contaminants even in very low concentrations. This study is focused on the application of a reliable analytical method for the analysis of 10 selected drug residues, mainly from the group of non-steroidal anti-inflammatory drugs （salicylic acid, acetylsalicylic acid, ctofibric acid, ibuprofen, acetaminophen, caffeine, naproxen, mefenamic acid, ketoprofen, and dicofenac）, in wastewaters and surface waters. This analytical method is based on solid phase extraction, derivatization by N-methyl-N-（trimethylsilyl）trifluoroacetamide （MSTFA） and finally analysis by comprehensive two-dimensional gas chromatography with Time-of-Flight mass spectrometric detection （GC×GC- TOF MS）. Detection limits ranged from 0.18 to 5 ng/L depending on the compound and selected matrix. The method was successfully applied for detection of the presence of selected pharmaceuticals in the Svratka River and in wastewater from the wastewater treatment plant in Brno-Modrice, Czech Republic. The concentration of pharmaceuticals varied from one to several hundreds of ng/L in surface water and from one to several tens of μg/L in wastewater.

关键词： non-steroidal anti-inflammatory drugs solid phase extraction derivatization comprehensive two-dimensional gaschromatography surface water wastewater

Breeding versus survival:proximate causes of abrupt population decline under environmental change in a desert rodent,the midday gerbil(Meriones meridianus)

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Integrative Zoology 2019年第4期14卷 366-375页

作者： Andrey TCHABOVSKY ludmila SAVINETSKAYA Elena SURKOVA Laboratory for Population Ecology A.N.Severtsov Institute of Ecology and EvolutionRussian Academy of SciencesMoscowRussia

Studying abrupt ecological shifts under gradual environmental change caused,in particular,by human activity is important for understanding the fundamental aspects and underlying mechanisms of ecological *** of the rare well-documented examples of an abrupt ecological shift is the delayed step transition of the population of a desert rodent,the midday gerbil(Meriones meridianus),from high-abundance(1994-2002)to low-abundance(2003-2017)*** was in response to landscape transformation from desert to steppe caused by the drastic reduction of livestock in the rangelands of southern Russia after the collapse of the USSR in the early *** this study,we tested whether demographic parameters were correlated with the observed abrupt downward population *** found that reproductive activity(the percentage of breeding females,the number of litters,fecundity and the number of young recruited per female)showed no trend over time and did not differ between periods of high and low *** contrast,the adult sex ratio(SR=males:females)decreased significantly with time and was as much as twice more female-biased for the low-abundance population ***,SR was not related to any reproductive parameter,including the percentage of breeding fe*** conclude that proximate reasons for an abrupt population decline in *** are not associated with the changes in breeding patterns or mate limitation caused by the Allee effect but relate to the increased mortality as a result of the desert landscape being fragmented by *** mortality is expected to be higher for males as the mobile and dispersing sex.

关键词： demography landscape change rangelands reproduction threshold population dynamics

Role of Osteoprotegerin and Receptor Activator of Nuclear Factor-kB Ligand in Bone Loss Related to Advanced Chronic Obstructive Pulmonary Disease

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Chinese Medical Journal 2016年第14期129卷 1696-1703页

作者： ludmila Ugay Evgenia Kochetkova Vera Nevzorova Yuliya Maistrovskaia Departement of Pulmonology Central Scientific Research Laboratory Pacific State Medical University Vladivostok 690950 Russian Federation

Background： Osteoporosis is a common complication of chronic obstructive pulmonary disease （COPD）. Recent clinical and biological researches have increasingly delineated the biomolecular pathways of bone metabolism regulation in COPD. We extended this work by examining the specific association and potential contribution of the osteoprotegerin （OPG）/receptor activator of nuclear factor-riB ligand （RANKL） axis to the pathogenesis of osteoporosis in advanced COPD. The aim of this study was to assess the relationships of serum OPG, RANKL, and tumor necrosis factor-alpha （TNF-a） with bone turnover in men with very severe COPD. Methods： Pulmonary function, T-score at the lumbar spine （LS） and femoral neck （FN）, serum OPG, RANKL, soluble receptor of tumor necrosis factor-alpha-1 and 11 （sTNFR-I, sTNFR-II）, osteocalcin （OC）, and β-CrossLaps （βCL） levels were measured in 45 men with very severe stage COPD and 36 male non-COPD volunteers. COPD patients and healthy controls were compared using all independent t-test and Mann-Whitney U-test. The Pearson coefficient was used to assess the relationships between variables. Results： OPG and OC were lower in male COPD patients than in control subjects whereas RANKL, serum ~CL, TN F-o~, and its receptors were higher. OPG directly correlated with forced expiratory volume in I s （FEVI） % predicted （r = 0.46, P 〈 0.005）, OC （r= 0.34, P 〈 0.05）, LS （I.= 0.56, P 〈 0.001 ）, and FN T-score （r= 0.47, P 〈 0.01 ）. In contrast, serum RANKL inversely associated with LS and FN T-score （r = -0.62, P 〈 0.001 and r = -0.48, P 〈 0.001 ） but directly correlated with [3CL （r = 0.48, P 〈 0.001 ）. In addition, OPG was inversely correlated with RANKL （r = -0.39, P 〈 0.01 ）, TNF-a （r = -0.56, P 〈 0.001 ）, and sTNFR-I （r = -0.40, P 〈 0.01 ）. Conelusion： Our results suggest that serum OPG and RANKL levels are inversely associated with bone loss in men with advanced stage COPD.

关键词： Chronic Obstructive Puhnonary Disease Osteoporosis Osteoprotegerin Receptor Activator of Nuclear Factor-KBLigand Tumor Necrosis Factor Receptors: Tumor Necrosis Factor-alpha

β-Carotene-properties and production methods

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Food Quality and Safety 2018年第2期2卷 69-74页

作者： ludmila Bogacz-Radomska Joanna Harasym Department of Biotechnology and Food Analysis Faculty of Engineering and EconomicsWroclaw University of EconomicsWroclawPoland epartment of Agriculture and Forestry Engineering College of Agricultural and Forestry EngineeringUniversity of ValladolidValladolidSpain

β-Carotene belongs to a group of more than 600 compounds,jointly called as *** has numerous biological functions in the human body and because human is not able to synthesize any of them,it is necessary to supply these valuable compounds with food or ***,therefore,market demand stimulates the development of its diverse production ***β-carotene was recovered from plants by physicochemical extraction and mainly from ***β-carotene is mainly produced through chemical *** quite recently biotechnology makes a great approach towardβ-carotene production as bioactive compounds of natural origin reveal higher bioaccessibility and higher consumer trust on market.

关键词： β-carotene properties production methods

Analysis of EX5del4232ins268 and EX5del955 PAH gene mutations in Ukrainian patients with phenylketonuria

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Genes & Diseases 2017年第2期4卷 108-110页

作者： Volodymyr Pampukha Maryna Nechyporenko ludmila Livshyts Institute of Molecular Biology and Genetics of the National Academy of Sciences of Ukraine Department of Human Genomics150Zabolotnogo str.03680 KyivUkraine

Phenylketonuria(PKU)is an autosomal recessive metabolic disorder caused by deficiency of phenylalanine hydroxylase(PAH).The major molecular defects causing PKU are missense mutations of PAH *** deletions of exon 5(EX5del955 and EX5del4232ins)were first reported by the Czech study and were later found also in the Polish,Slovak,Slovenian and Italian *** observations demonstrate the existence of a common subset of this mutation predominantly among Central European populations of Slavic *** is why we suggest that EX5del1955 and EX5del4232ins268 mutations might be frequent causes of PKU in Ukrainian ***5del955 and EX5del4232ins268 mutations were analyzed in 106 unrelated PKU patients negative for PAH gene mutations on one or both alleles from our previous *** simultaneous detection of EX5del4232ins268 and EX5del955 mutations was performed by PCR amplification of mutant ***5del955 mutation was not detected in the Ukrainian *** relative alleles frequency of EX5del4232ins268 mutation in the Ukrainian PKU population was determined as 1,66%.Our findings can be the one more evidence of Central European Slavic origin of EX5del4232ins268 mutation,suggested *** finding is important for the improvement of DNA diagnosis necessary for the management of PKU patients from Ukraine.

关键词： Large deletions Mutation analysis Phenylalanine hydroxylase Phenylketonuria

Inflammatory priming of mesenchymal stem cells:Focus on growth factors enhancement

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BIOCELL 2022年第9期46卷 2049-2052页

作者： ALEKSANDRA GORNOSTAEVA ELENA ANDREEVA ludmila BURAVKOVA Cell Physiology Laboratory Institute of Biomedical Problems of Russian Academy of SciencesMoscow123007Russia

Multipotent mesenchymal stromal cells(MSCs)are actively involved in reparation and inflammation processes,providing damaged tissue reparation and suppressing immune cell responses in *** effects are mostly due to the production of a wide range of paracrine factors,including growth factors and immunomodulatory *** induce immunosuppressive activity,MSCs are primed by inflammatory cytokines,which results in an increased production of immunomodulatory ***,stimulation of reparative properties is also *** viewpoint manuscript highlights the possibilities of inflammatory priming to increase the production of growth factors by MSCs.

关键词： Multipotent mesenchymal stromal cells Priming Growth factors