检索结果-南通市图书馆

Non-severe burn injury increases cancer incidence in mice and has long-term impacts on the activation and function of T cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Burns & Trauma 2022年第1期10卷 546-557页

作者： lucy w.barrett Vanessa S.Fear Bree Foley Katherine Audsley Samantha Barnes Hannah Newnes Alison McDonnell Fiona M.wood Mark w.Fear Jason waithman Burn Injury Research Unit School of Biomedical SciencesUniversity of Western AustraliaCrawleyWA6009Australia Telethon Kids Institute University of Western AustraliaNorthern EntrancePerth Children’s Hospital15 Hospital AveNedlandsWA6009Australia Fiona wood Foundation Fiona Stanley HospitalMNH(B)Main HospitalCD 15Level Burns Unit 102-118 Murdoch DriveMurdochWA6150Australia and 4Burns Service of Western AustraliaWA Department of HealthNedlandsWA6009Australia

Background:Recent evidence suggests that burn patients are at increased risk of hospital admission for infection,mental health conditions,cardiovascular disease and cancer for many years after discharge for the burn injury *** injury has also been shown to induce sustained immune system *** change to immune function may contribute to the increased risk of chronic disease ***,the mechanisms that disrupt long-term immune function in response to burn trauma,and their link to long-term morbidity,remain *** this study we investigated changes to immune function after burn injury using a murine model of non-severe ***:An established mouse model of non-severe burn injury(full thickness burn equivalent to 8%total body surface area)was used in combination with an orthotopic model of B16 melanoma to investigate the link between burns and *** that CD8^(+)T cells are important drivers of effective tumour suppression in this model,we also investigated potential dysregulation of this immune population using mouse models of burn injury in combination with herpes simplex virus *** cytometry was used to detect and quantify cell populations of interest and changes in immune ***:we demonstrate that 4 weeks after a non-severe burn injury,mice were significantly more susceptible to tumour development than controls using an orthotopic model of B16 *** addition,our results reveal that CD8^(+)T cell expansion,differentiation and memory potential is significantly impaired at 1 month ***:Our data suggests that CD8^(+)T cell-mediated immunity may be dysfunctional for a sustained period after even non-severe burn *** studies in patients to validate these findings may support clinical intervention to restore or protect immunity in patients after burn injury and reduce the increased risk of secondary morbidities observed.

关键词： Immunology Surgery Burn injury T cells Immune dysfunction Cancer

Non-alcoholic fatty liver disease:Immunological mechanisms and current treatments

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

世界胃肠病学杂志:英文版 2023年第32期29卷 4831-4850页

作者： lucy Petagine Mohammed Gulrez Zariwala Vinood B Patel Centre for Nutraceuticals School of Life SciencesUniversity of WestminsterLondon W1W6UWUnited Kingdom

Non-alcoholic fatty liver disease(NAFLD)causes significant global disease burden and is a leading cause of *** induces a myriad of aberrant changes in hepatocytes at both the cellular and molecular *** the disease spectrum of NAFLD is widely recognised,the precise triggers for disease progression are still to be fully ***,the propagation to cirrhosis is poorly *** some progress in terms of treatment options have been explored,an incomplete understanding of the hepatic cellular and molecular alterations limits their clinical *** have therefore reviewed some of the key pathways responsible for the pathogenesis of NAFLD such as innate and adaptative immunity,lipotoxicity and fibrogenesis,and highlighted current trials and treatment options for NAFLD patients.

关键词： Liver Fat Inflammation Mitochondria Immune system

Cytokines from the pig conceptus:roles in conceptus development in pigs

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2015年第2期6卷 130-141页

作者： Rodney D Geisert Matthew C lucy Jeffrey J whyte Jason w Ross Daniel J Mathew Animal Sciences Research Center University of Missouri Department of Animal Science Iowa State University

Establishment of pregnancy in pigs involves maintaining progesterone secretion from the corpora lutea in addition to regulating a sensitive interplay between the maternal immune system and attachment of the rapidly expanding trophoblast for nutrient absorption. The peri-implantation period of rapid trophoblastic elongation followed by attachment to the maternal uterine endometrium is critical for establishing a sufficient placental-uterine interface for subsequent nutrient transport for fetal survival to term, but is also marked by the required conceptus release of factors involved with stimulating uterine secretion of histotroph and modulation of the maternal immune system. Many endometrial genes activated by the conceptus secretory factors stimulate a tightly controlled proinflammatory response within the uterus. A number of the cytokines released by the elongating conceptuses stimulate inducible transcription factors such as nuclear factor kappa B （NFKB） potentially regulating the maternal uterine proinflammatory and immune response. This review will establish the current knowledge for the role of conceptus cytokine production and release in early development and establishment of pregnancy in the pig.

关键词： Cytokines Embryo development Porcine conceptus Pregnancy Prostaglandins uterus

Cultural knowledge of forests and allied tree system management around Mabira Forest Reserve,Uganda

在线全文

学校读者我要写书评

暂无评论

Journal of Forestry Research 2020年第5期31卷 1787-1802页

作者： lucy w.Mulugo Charles Galabuzi Gorettie N.Nabanoga Nelson Turyahabwe Gerald Eilu Joseph Obua Esezah Kakudidi Nicole Sibelet College of Agricultural and Environmental Sciences Makerere UniversityP.O.Box 7062KampalaUganda National Forestry Resources Research Institute P.O.Box 1752KampalaUganda National Agricultural Research Organization P.O.Box 295EntebbeUganda College of Natural Sciences Makerere UniversityP.O.Box 7062KampalaUganda CIRAD TA 60/15.73Rue J-F Breton34398 Montpellier Cedex 5France CATIE Apartado Postal 7170 TurrialbaTurrialba 30501Costa Rica

The cultural universe is sometimes confusing,surprising and murky,so many cultural maps get drawn,discussed and envisioned.A study was undertaken around Mabira Forest Reserve in central Uganda to identify the trees and shrubs culturally managed on-farm,assess the cultural practices of forest and tree system management and determine the relationship between farmer gender and forest and tree system *** engaged 203 farmers in focus group discussions and semi-structured interviews to collect *** data were jointly evaluated with farmers;quantitative data were analyzed in SPSS *** results showed a high likelihood for involvement of local people in tree or forest management for economic gain,as timber and fast-growing species were highly *** and medicinal species were also regarded as important,suggesting high prospects of integrating them into the local farming system or protecting them in the *** cultural practices(including rituals,trenching,bark slashing,ring barking,spot weeding and use of organic manure and pesticides)of forest and tree system management were ***,their knowledge was mixed and unclear about distinct cultural and supportive arrangements for natural forest and tree *** gender was not a significant cultural attribute for knowledge of the forest and allied tree system management,age substantially affected farmer propensity for various timber *** farmer’s family size influenced the collection of tree wildings and *** encourage considering gender disparities and livelihood needs including income,during selection of cultural practices for forest and tree restoration.

关键词： Traditional Cultural ways Forest management Indigenous knowledge Superstition

Compliance with SEP-1 guidelines is associated with improved outcomes for septic shock but not for severe sepsis

在线全文

学校读者我要写书评

暂无评论

Journal of Intensive Medicine 2022年第3期2卷 167-172页

作者： Shelly NBSloan Nate Rodriguez Thomas Seward lucy Sare Lukas Moore Greg Stahl Kerry Johnson Scott Goade Robert Arnce Department of Primary Care College of MedicineKansas City University2901St.Johns Blvd.JoplinMO 64804USA Department of Quality Improvement Freeman Health SystemJoplinMO 64804USA Department of Mathematics Missouri Southern State UniversityJoplinMO 64801USA Department of Pharmacy Freeman Health SystemJoplinMO 64804USA

Background: In 2018, the Centers for Medicaid and Medicare Services (CMS) issued a protocol for the treatment of sepsis. This bundle protocol, titled SEP-1 is a multicomponent 3 h and 6 h resuscitation treatment for patients with the diagnosis of either severe sepsis or septic shock. The SEP-1 bundle includes antibiotic administration, fluid bolus, blood cultures, lactate measurement, vasopressors for fluid-refractory hypotension, and a reevaluation of volume status. we performed a retrospective analysis of patients diagnosed with either severe sepsis or septic shock comparing mortality outcomes based on compliance with the updated SEP-1 bundle at a rural community hospital. Methods: Mortality outcome and readmission data were extracted from an electronic medical records database from January 1, 2019, to June 30, 2020. International Classification of Diseases (ICD)-10 codes were used to identify patients with either severe sepsis or septic shock. Once identified, patients were separated into four populations: patients with severe sepsis who met SEP-1, patients with severe sepsis who failed SEP-1, patients with septic shock who met SEP-1, and patients with septic shock who failed SEP-1. A patient who met bundle criteria (SEP-1 criteria) received each component of the bundle in the time allotted. Using chi-squared test of homogeneity, mortality outcomes for population proportions were investigated. Two sample proportion summary hypothesis test and 95% confidence intervals (CI) determined significance in mortality outcomes. Results: Out of our 1122 patient population, 437 patients qualified to be measured by CMS criteria. Of the 437 patients, 195 met the treatment bundle and 242 failed the treatment bundle. Upon comparing the two groups, we found the probable difference in mortality rate between the met(14.87%) and failed bundle(27.69%) groups to be significant(95% CI: 5.28-20.34, P = 0.0013). However, the driving force of this result lies in the subgroup of patients w

关键词： SEP-1 Sepsis Early goal-directed therapy Centers for Medicaid and Medicare Services Quality improvement Reimbursement

SLC11A1 polymorphisms in inflammatory bowel disease and Mycobacterium avium subspecies paratuberculosis status

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

world Journal of Gastroenterology 2010年第45期16卷 5727-5731页

作者： lucy C Stewart Andrew S Day John Pearson Murray L Barclay Richard B Gearry Rebecca L Roberts Robert w Bentley Department of Paediatrics University of OtagoChristchurch 8140New Zealand Department of Paediatrics Christchurch HospitalChristchurch 8140New Zealand Department of Pathology University of OtagoChristchurch 8140New Zealand Department of Medicine University of OtagoChristchurch 8140New Zealand Department of Gastroenterology Christchurch HospitalChristchurch 8140New Zealand Department of Biochemistry University of OtagoDunedin 9054New Zealand

AIM: To test for association of SLC11A1 with inflammatory bowel disease (IBD) and Mycobacterium avium subspecies paratuberculosis (MAP) status in a Caucasian cohort. METHODS: Five hundred and seven Crohn's disease (CD) patients, 474 ulcerative colitis (UC) patients, and 569 healthy controls were genotyped for SLC11A1 1730G>A and SLC11A1 469+14G>C using pre-designed TaqMan  SNP assays. χ 2 tests were applied to test for association of single nucleotide polymorphisms (SNPs) with disease, and the presence of MAP ***:SLC11A1 1730G>A and SLC11A 1469+14G>C were not associated with CD, UC, or IBD. The SLC11A1 1730A minor allele was over-represented in patients who did not require immunomodulator therapy (P = 0.002, OR: 0.29, 95% CI: 0.13-0.66). The frequency of the SLC11A1 469+14C allele was higher in the subset of study participants who tested positive for MAP DNA (P = 0.02, OR: 1.56, 95% CI: 1.06-2.29). No association of SLC11A1 1730G>A with MAP was ***: Although SLC11A1 was not associated with IBD, association with MAP suggests that SLC11A1 is important in determining susceptibility to bacteria implicated in the etiology of CD.

关键词： NRAMP1 Crohn’s disease Ulcerative colitis IS900 polymerase chain reaction

Impact of Secondary Conditions on Rehabilitation and Quality of Life

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国康复理论与实践 2006年第9期12卷 749-752页

作者： lucy wong Hernandez Daniel w. wong Department of Rehabilitation Studies School of Allied Health Sciences East Carolina University Greenville North Carolina27858-4353USA.

In this paper, we will discuss the consequences of secondary conditions and their impact on rehabilitation outcomes and quality of life for persons with disabilities. Health promotion as a preventive method for secondary conditions for persons with disabilities has not been a significant area of interest on the part of the general health care and rehabilitation services community in western societies. In the U.S., after years of careful evaluation a shift in scientific and advocacy thinking has encouraged researchers, funding agencies, health care providers, rehabilitation professionals and persons with disabilities, as well as the consumers of health care services to prioritize future studies in this specific area and establishing quality health care and the best possible rehabilitation outcomes for millions of individuals with disabilities.

关键词： secondary conditions quality of life rehabilitation

why is malaria associated with poverty? Findings from a cohort study in rural Uganda

在线全文

学校读者我要写书评

暂无评论

Infectious Diseases of Poverty 2016年第1期5卷 715-725页

作者： lucy S.Tusting John Rek Emmanuel Arinaitwe Sarah G.Staedke Moses R.Kamya Jorge Cano Christian Bottomley Deborah Johnston Grant Dorsey Steve w.Lindsay Jo Lines Department of Disease Control London School of Hygiene&Tropical MedicineLondonUK Big Data Institute Nuffield Department of MedicineUniversity of OxfordOxfordUK Infectious Diseases Research Collaboration KampalaUganda Department of Clinical Research London School of Hygiene and Tropical MedicineLondonUK School of Medicine Makerere University College of Health SciencesKampalaUganda MRC Tropical Epidemiology Group London School of Hygiene and Tropical MedicineLondonUK Department of Economics SOASUniversity of LondonLondonUK Department of Medicine University of CaliforniaSan FranciscoUSA School of Biological and Biomedical Sciences Durham UniversityDurhamUK

Background:Malaria control and sustainable development are linked,but implementation of‘multisectoral’intervention is restricted by a limited understanding of the causal pathways between poverty and *** investigated the relationships between socioeconomic position(SEP),potential determinants of SEP,and malaria in Nagongera,rural ***:Socioeconomic information was collected for 318 children aged six months to 10 years living in 100 households,who were followed for up to 36 *** density was recorded using monthly light trap *** prevalence was measured routinely every three months and malaria incidence determined by passive case ***,we evaluated the association between success in smallholder agriculture(the primary livelihood source)and ***,we explored socioeconomic risk factors for human biting rate(HBR),parasite prevalence and incidence of clinical malaria,and spatial clustering of socioeconomic ***,we investigated the role of selected factors in mediating the association between SEP and ***:Relative agricultural success was associated with higher *** turn,high SEP was associated with lower HBR(highest versus lowest wealth index tertile:Incidence Rate Ratio 0.71,95%confidence intervals(CI)0.54–0.93,P=0.01)and lower odds of malaria infection in children(highest versus lowest wealth index tertile:adjusted Odds Ratio 0.52,95%CI 0.35–0.78,P=0.001),but SEP was not associated with clinical malaria *** analysis suggested that part of the total effect of SEP on malaria infection risk was explained by house type(24.9%,95%CI 15.8–58.6%)and food security(18.6%,95%CI 11.6–48.3%);however,the assumptions of the mediation analysis may not have been fully ***:Housing improvements and agricultural development interventions to reduce poverty merit further investigation as multisectoral interventions against *** interdisplinary research is needed to understa

关键词： Malaria Socioeconomic Poverty Development Housing wealth index Uganda

The Diseases of Coffee under the Changing Climate： The Established Situation in Kenya

在线全文

学校读者我要写书评

暂无评论

Journal of Agricultural Science and Technology(A) 2012年第2期2卷 265-272页

作者： Harrison M. Mugo lucy w. Irungu Paul N. Ndegwa Coffee Research Foundation Ruiru Kenya University of Nairobi School of Biological Sciences Nairobi Kenya

The distribution of key diseases of coffee particularly the Coffee berry disease (CBD) and Coffee leaf rust (CLR) in Kenya depended on coffee growing agro-ecological zones, which have varied climatic conditions. Under the changing climate, there has been an observed shift in their altitudinal distribution. To ascertain whether these diseases have shifted in their distribution, an extensive field survey covering 120 coffee farmers/households in all the coffee growing agro ecological zones was conducted. The survey established four coffee diseases; viz. Coffee berry disease, Coffee leaf rust, Fusarium root disease (FRD) and Bacterial blight of coffee (BBC) as of economic importance to the farming community. The CBD, CLR and FRD were widely distributed in all coffee growing agro ecological zones. Of the four diseases, the CBD (65%) and CLR (63.3%) were most common as reported by the farmers, however these diseases dominated in their respective agro ecological zones; CBD (72.2%) in Upper Midland 1 (UM1) and CLR (75.0%) in Upper Midland 2 (UM2). Both diseases equally infected coffee farms (69.2%) in main coffee zone (UM2). According to the survey said diseases have increased their altitudinal range, a trend that will increase diseases pressure in coffee growing areas.

关键词：气候变化肯尼亚咖啡疾病生物多样性公约农业生态区 CLR 种植区