Non-alcoholic fatty liver disease:Immunological mechanisms and current treatments
作者机构：Centre for NutraceuticalsSchool of Life SciencesUniversity of WestminsterLondon W1W6UWUnited Kingdom
出 版 物：《世界胃肠病学杂志:英文版》 (World Journal of Gastroenterology)
年 卷 期：2023年第29卷第32期
页 面：4831-4850页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Liver Fat Inflammation Mitochondria Immune system
摘 要：Non-alcoholic fatty liver disease(NAFLD)causes significant global disease burden and is a leading cause of *** induces a myriad of aberrant changes in hepatocytes at both the cellular and molecular *** the disease spectrum of NAFLD is widely recognised,the precise triggers for disease progression are still to be fully ***,the propagation to cirrhosis is poorly *** some progress in terms of treatment options have been explored,an incomplete understanding of the hepatic cellular and molecular alterations limits their clinical *** have therefore reviewed some of the key pathways responsible for the pathogenesis of NAFLD such as innate and adaptative immunity,lipotoxicity and fibrogenesis,and highlighted current trials and treatment options for NAFLD patients.
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