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Non-alcoholic fatty liver disease:Immunological mechanisms and current treatments

World Journal of Gastroenterology 2023年第32期29卷 4831-4850页

作者： lucy petagine Mohammed Gulrez Zariwala Vinood B Patel Centre for Nutraceuticals School of Life SciencesUniversity of WestminsterLondon W1W6UWUnited Kingdom

Non-alcoholic fatty liver disease(NAFLD)causes significant global disease burden and is a leading cause of *** induces a myriad of aberrant changes in hepatocytes at both the cellular and molecular *** the disease spectrum of NAFLD is widely recognised,the precise triggers for disease progression are still to be fully ***,the propagation to cirrhosis is poorly *** some progress in terms of treatment options have been explored,an incomplete understanding of the hepatic cellular and molecular alterations limits their clinical *** have therefore reviewed some of the key pathways responsible for the pathogenesis of NAFLD such as innate and adaptative immunity,lipotoxicity and fibrogenesis,and highlighted current trials and treatment options for NAFLD patients.

关键词： Liver Fat Inflammation Mitochondria Immune system

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Alcoholic liver disease:Current insights into cellular mechanisms

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World Journal of Biological Chemistry 2021年第5期12卷 87-103页

作者： lucy petagine Mohammed Gulrez Zariwala Vinood B Patel Center for Nutraceuticals School of Life SciencesUniversity of WestminsterLondon W1W 6UWUnited Kingdom

Alcoholic liver disease(ALD)due to chronic alcohol consumption is a significant global disease burden and a leading cause of *** abuse induces a myriad of aberrant changes in hepatocytes at both the cellular and molecular *** the disease spectrum of ALD is widely recognized,the precise triggers for disease progression are still to be fully *** stress,mitochondrial dysfunction,gut dysbiosis and altered immune system response plays an important role in disease pathogenesis,triggering the activation of inflammatory pathways and *** many recent clinical studies treatment options for ALD are limited,especially at the alcoholic hepatitis *** have therefore reviewed some of the key pathways involved in the pathogenesis of ALD and highlighted current trials for treating patients.

关键词： Liver Alcohol Oxidative stress Inflammation Gut microbiome Mitochondria

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