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Co-nanoencapsulated meloxicam and curcumin improves cognitive impairment induced by amyloid-beta through modulation of cyclooxygenase-2 in mice

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Neural Regeneration Research 2021年第4期16卷 780-786页

作者： Maria Eduarda Ziani Gutierrez Anne Suély Pinto Savall Edina da Luz Abreu Kelly Ayumi Nakama Renata Bem Dos Santos Marina costa Monteiro Guedes Daiana silvaÁvila Cristiane Luchese Sandra Elisa Haas Caroline Brandão Quines Simone Pinton Postgraduation Program in Biochemistry Federal University of Pampa(UNIPAMPA)UruguaianaRSBrazil Postgraduation Program in Pharmaceutical Science Federal University of Pampa(UNIPAMPA)UruguaianaRSBrazil Postgraduation Program in Biochemistry and Bioprospecting Federal University of Pelotas(UFPEL)Capão do LeãoRSBrazil

Alzheimer’s disease is a progressive brain disorder and complex mechanisms are involved in the physiopathology of Alzheimer’s ***,there is data suggesting that inflammation plays a role in its development and ***,some non-steroidal antiinflammatory drugs,such as meloxicam,which act by inhibiting cyclooxygenase-2 have been used as neuroprotective agents in different neurodegenerative disease *** purpose of this study was to investigate the effects of co-nanoencapsulated curcumin and meloxicam in lipid core nanocapsules(LCN)on cognitive impairment induced by amyloid-beta peptide injection in *** were prepared by the nanoprecipitation *** Swiss mice received a single intracerebroventricular injection of amyloid-beta peptide aggregates(fragment 25–35,3 nmol/3μL)or vehicle and were subsequently treated with curcumin-loaded LCN(10 mg/kg)or meloxicam-loaded LCN(5 mg/kg)or meloxicam+curcumin-co-loaded LCN(5 and 10 mg/kg,respectively).Treatments were given on alternate days for 12 days(i.e.,six doses,once every 48 hours,by intragastric gavage).Our data showed that amyloid-beta peptide infusion caused long-term memory deficits in the inhibitory avoidance and object recognition tests in *** the inhibitory avoidance test,both meloxicam and curcumin formulations(oil or co-loaded LCN)improved amyloid-beta-induced memory impairment in ***,only meloxicam and curcumin-co-loaded LCN attenuated non-aversive memory impairment in the object recognition ***,the beneficial effects of meloxicam and curcuminco-loaded LCN could be explained by the anti-inflammatory properties of these drugs through cortical cyclooxygenase-2 *** study suggests that the neuroprotective potential of meloxicam and curcumin co-nanoencapsulation is associated with cortical cyclooxygenase-2 *** study was approved by the Committee on Care and Use of Experimental Animal Resources,the Federal University of Pampa,Brazil(app

关键词： Alzheimer’s disease curcumin cyclooxygenase-2 lipid core nanocapsules meloxicam memory rats inflammation

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FAS-670 Gene Promoter Region Polymorphism in Cervical Intraepithelial Neoplasia Grade 3 (CIN 3) and Invasive Cervical Cancer

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Journal of Cancer Therapy 2015年第5期6卷 434-445页

作者： Edison Fedrizzi Flavio Zucchi Sylvia Brenna Cristina Valletta de Carvalho Fabricio silva Ana Massad costa Ismael Guerreiro da silva Federal University of Santa Catarina Florianópolis Brazil

The human papillomavirus (HPV) is the etiologic agent of genital cancer, but alone it is incapable of inducing oncogenesis. Rather, progression to invasive lesions is associated with host immunity and interference in the process of cellular apoptosis. Among the several genes involved in cell death, theFAS gene appears to be an important factor. The aim of this study was to evaluate whether there is an association between polymorphisms of the FAS-670 gene promoter region and preinvasive and invasive lesions of the cervix. The FAS gene was evaluated for the presence of polymorphisms using polymerase chain reaction and restriction fragment length polymorphism techniques in 225 blood samples for the control group, as well as cervical tissue from patients with cervical intraepithelial neoplasia grade 3 (CIN 3;75 cases) or invasive carcinoma (214 cases). The AG genotype of the FAS-670 gene promoter region was significantly more frequent in women with CIN 3, with an estimated risk of three times (OR = 3.0). No difference, however, was observed in the control group and women with cervical cancer. In women with cancer, the genotypes were similar in the different histological types and degree of tumor differentiation. Assessing allelic distribution (A or G), we observed no difference in frequency of genotypes in studied groups. These data suggest that polymorphism of the promoter region of the FAS-670 gene is associated with increased risk of CIN 3, but not for invasive cancer of the cervix.

关键词： FAS Genetic Polymorphism CIN 3 Uterine Cervical Neoplasms Apoptosis

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Hepatobiliary phases in magnetic resonance imaging using liverspecific contrast for focal lesions in clinical practice

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World Journal of Hepatology 2022年第7期14卷 1459-1469页

作者： Daniel Alvarenga Fernandes Eduardo Andreazza Dal Lago Felipe Aguera Oliver Bruna Melo Coelho Loureiro Daniel Lahan Martins Thiago José Penachim Ricardo Hoelz de Oliveira Barros José de ArimatéiaBatista Araújo Filho Larissa Bastos Eloy da costa Áurea Maria Oliveira da silva Elaine Cristina de Ataíde Ilka de Fátima Santana Ferreira Boin Nelson Marcio Gomes Caserta Department of Radiology School of Medical SciencesUniversity of Campinas-UNICAMPCampinas 13083-888São PauloBrazi Department of Radiology Medical SchoolSão Paulo State University-UNESPBotucatu 18618-970São PauloBrazil Instituto de Radiologia Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo-InRad/HC-FMUSPSão Paulo 05403-010SPBrazil Department of Radiology Sírio-Libanês HospitalSão Paulo 05652-900SPBrazil Department of Pathology School of Medical SciencesUniversity of Campinas-UNICAMPCampinas 13083-888São PauloBrazil Liver Transplant Unit Department of SurgerySchool of Medical SciencesUniversity of Campinas-UNICAMPCampinas 13083-888São PauloBrazil

BACKGROUND Challenging lesions,difficult to diagnose through non-invasive methods,constitute an important emotional burden for each patient regarding a still uncertain diagnosis(malignant x benign).In addition,from a therapeutic and prognostic point of view,delay in a definitive diagnosis can lead to worse *** of the main innovative trends currently is the use of molecular and functional methods to *** liver-specific contrast agents havebeen developed and studied in recent years to improve the performance of liver magnetic resonance imaging(MRI).More recently,one of the contrast agents introduced in clinical practice is gadoxetic acid(gadoxetate disodium).AIM To demonstrate the value of the hepatobiliary phases using gadoxetic acid in MRI for the characterization of focal liver lesions(FLL)in clinical *** Overall,302 Lesions were studied in 136 patients who underwent MRI exams using gadoxetic acid for the assessment of *** radiologists independently reviewed the MRI exams using four stages,and categorized them on a 6-point scale,from 0(lesion not detected)to 5(definitely malignant).The stages were:stage 1-images without contrast,stage 2-addition of dynamic phases after contrast(analogous to usual extracellular contrasts),stage 3-addition of hepatobiliary phase after 10 min(HBP 10’),stage 4-hepatobiliary phase after 20 min(HBP 20’)in addition to stage *** The interobserver agreement was high(weighted Kappa coefficient:0.81-1)at all stages in the characterization of benign and malignant *** diagnostic weighted accuracy(Az)was 0.80 in stage 1 and was increased to 0.90 in stage *** of the hepatobiliary phase increased Az to 0.98 in stage 3,which was also 0.98 in stage *** The hepatobiliary sequences improve diagnostic *** growing potential in the era of precision medicine,the improvement and dissemination of the method among medical specialties can bring benefits in the management of patients w

关键词： Liver Liver neoplasms Liver transplantation Medical oncology Diagnostic imaging Magnetic resonance imaging

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Effects of Cryofrequency in the Different Swine Skin Tissue Layers: In Vitroand in VivoStudy

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Journal of Biosciences and Medicines 2021年第3期9卷 94-104页

作者： Rafaella Rêgo Maia Patrícia Froes Meyer Josebel da costa Emerenciano Joseela Joyce Barbosa da silva Júlio Davi costa e silva Liliane Santos de Vasconcellos Rodrigo Marcel Valentim da silva Tarciso Bruno Montenegro Sampaio Ciro Dantas Soares Federal Universityof Rio Grande do Norte (UFRN) Natal Brazil University Centre of Rio Grande do Norte (UNI-RN) Natal Brazil Potiguar University (UNP) Natal Brazil Maurício de Nassau College Natal Brazil Universityof Campinas (UNICAMP) S&atilde o Paulo Brazil

Introduction: Cryofrequency is a novel therapy which was developed with the combination of cold (cryotherapy) and heat (radiofrequency) application, causing a thermal shock effect on skin tissue. The thermal shock is believed to alter local metabolism. Objective: To investigate the effect of cryofrequency on the skin tissue of a mini pig in an in vitro and in vivo experimental model. Methodology: A small swine of the S. domesticus species, a male mini-pig (30 kg weight) was elected for the in vivo procedure subject. The in vitro step was performed on the extracted abdominal part of another subject of the same species and breed. Then, after the application of cryofrequency in the monopolar and bipolar form in vivo, a histological analysis was performed. Results: A higher temperature variation was observed comparing the pilot study in vitro with respect to the experimental one in vivo. Microscopically, an increase of collagen fibers and blood supply and decreased adipose tissue was observed after cryofrequency application. Conclusion: With the bipolar cryofrequency, no reduction of adipose tissue was observed, but regarding the connective tissue, extensive areas of collagen deposition were observed, as well as a great amount of new-formed collagen fibers.

关键词： Cryotherapy Radio Frequency Adiposity Collagen Temperature

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Maternal low protein diet induces persistent expression changes in metabolic genes in male rats

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World Journal of Diabetes 2020年第5期11卷 182-192页

作者： Allan de Oliveira Lira JoséLuiz de Brito Alves Mariana Pinheiro Fernandes Diogo Vasconcelos David Filipe Santana João Henrique da costa-silva Béatrice Morio Carol Góis Leandro Luciano Pirola Department of Nutrition Federal University of PernambucoVitoria de Santo AntãoPernambuco 55608680Brazil Department of Nutrition Federal University of ParaíbaJoao Pessoa 74556060Brazil Henrique da costa-silva Luciano PirolaDepartment of Physical Education and Sport SciencesFederal University of PernambucoVitoria de Santo AntãoPernambuco 55608680Brazil Carmen(Cardiology Metabolism and Nutrition)LaboratoryINSERM U1060Lyon-1 UniversitySouth Lyon Medical FacultyPierre Benite 69310France

BACKGROUND Perinatal exposure to a poor nutritional environment predisposes the progeny to the development of metabolic disease at the adult age,both in experimental models and *** adaptive responses to maternal protein restriction have been reported in metabolic ***,the expression of glucose/fatty acid metabolism-related genes in adipose tissue and liver needs to be *** To evaluate the metabolic impact of perinatal malnutrition,we determined malnutrition-associated gene expression alterations in liver and adipose *** In the present study,we evaluated the alterations in gene expression of glycolytic/Krebs cycle genes(Pyruvate dehydrogenase kinase 4 and citrate synthase),adipogenic and lipolytic genes and leptin in the adipose tissue of offspring rats at 30 d and 90 d of age exposed to maternal isocaloric low protein(LP)diet throughout gestation and *** also evaluated,in the livers of the same animals,the same set of genes as well as the gene expression of the transcription factors peroxisome proliferator-activated receptor gamma coactivator 1,forkhead box protein O1 and hepatocyte nuclear factor 4 and of gluconeogenic *** In the adipose tissue,we observed a transitory(i.e.,at 30 d)downregulation of pyruvate dehydrogenase kinase 4,citrate synthase and carnitine palmitoyl transferase 1b gene *** transcriptional changes did not persist in adult LP rats(90 d),but we observed a tendency towards a decreased gene expression of leptin(P=0.052).The liver featured some gene expression alterations comparable to the adipose tissue,such as pyruvate dehydrogenase kinase 4 downregulation at 30 d and displayed other tissue-specific changes,including citrate synthase and fatty acid synthase upregulation,but pyruvate kinase downregulation at 30 d in the LP group and carnitine palmitoyl transferase 1b downregulation at 90 *** gene alterations,together with previously described changes in gene expression in

关键词： Metabolic adaptation Phenotype plasticity Liver Adipose tissue Metabolism Maternal protein undernutrition Rats

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Fungal rhinosinusitis with atypical presentation-a report of two cases

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Journal of Coastal Life Medicine 2015年第5期 418-420页

作者： Rafael da costa Monsanto Rodrigo silva Orem Fernanda Resende e silva Fabio Hiroshi Okuyama Fabio Tadeu Moura Lorenzetti Department of Otolaryngology Banco de Olhos de Sorocaba HospitalBrazil Faculdade de Medicina da Pontifícia Universidade Católica de São Paulo Brazil

Rhinosinusitis affects approximately 20%of the population,and the chronic rhinosinusitis represents over 90%of all cases of *** correct diagnosis is important for proper treatment and to predict its *** study presents two cases of atypical frontal sinus disease,which the follow-up revealed a diagnosis of fungal *** present study aims to describe the cases of two patients with atypical lesions on the left frontal sinus;the treatment options,surgical approach,results,diagnosis and follow-up are further discussed.A significant increase in the reported cases of fungal rhinosinusitis has been seen in the last two decades,justified by the use of broad-spectrum antibiotics and steroids,as well as the increased number of immunocompromised *** study reports the cases of two patients with a type of fungal rhinosinusitis named"fungal ball",characterized by a tangle of hyphae in the sinuses without tissue *** treatment included surgical removal of the fungal infectious process with aeration of the affected sinus,and the procedure was successfully performed in our patients.

关键词： Frontal sinusitis Fungus Treatment Surgery

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Evaluation of physicochemical properties as supporting information on quality control of raw materials and veterinary pharmaceutical formulations

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Journal of Pharmaceutical Analysis 2018年第3期8卷 168-175页

作者： Sara da silva Anacleto Marcella Matos Cordeiro Borges Hanna Leijoto de Oliveira Andressa Reis Vicente Eduardo costa de Figueiredo Marcone Augusto Leal de Oliveira Barbara Juliana Pinheiro Borges Marcelo Antonio de Oliveira Warley de Souza Borges Keyller Bastos Borges Departamento de Ciencias Naturals Universidade Federal de Sao Joao del-Rei Campus Dom Bosco Praca Dora Helvecio 74 Fabricas 36301-160 Sao Joao del-Rei Minas Gerais Brazil Departamento de Quimica Universidade Federal do Espirito Santo Avenida Fernando Ferrari 514 Goiabeiras 29075-910 Vitdria Espirito Santo Brazil Laboratorio de Analise de Toxicantes e Farmacos Faculdade de Ciencias Farmaceuticas Universidade Federal de Alfenas Rua Gabriel Monteiro da Silva 700 Centro 37130-000 Alfenas Minas Gerais Brazil Departamento de Quimica Universidade Federal de Juiz de Fora Rua Jose Lourenco Kelmer s/n 36036-330 Juiz de Fora Minas Gerais Brazil Centro de Ciencias da Saude Universidade Federal do Espirito Santo Avenida Marechal Campos 1468 Maruipe 29.043-900 Vitori Espirito Santo Brazil Centro Universitario Norte do Espirito Santo Universidade Federal do Espirito Santo Br 101 Norte Km 67 Sao Mateus Espirito Santo Brazil

This study aimed to show that the physicochemical proprieties obtained by Fourier transform infrared spectroscopy （FTIR）, thermogravimetry （TG）, and scanning electronic microscopy （SEM） can be useful tools for evaluating the quality of active pharmaceutical ingredients （APIs） and pharmaceutical products. In addition, a simple, sensitive, and efficient method employing HPLC-DAD was developed for simulta- neous determination of lidocaine （LID）, ciprofloxacin （CFX） and enrofloxacin （EFX） in raw materials and in veterinary pharmaceutical formulations. Compounds were separated using a Gemini Cm （250 mm×4.6 mm, 5μm） Phenomenex column, at a temperature of 25℃, with a mobile phase containing 10 mM of phosphoric acid （pH 3.29）： acetonitrile （85.7：14.3, v/v） and a flow rate of 1.5 mL/min. Physicochemical characterization by TG, FTIR, and SEM of raw materials of LID, CFX, and EFX provided information useful for the evaluation, differentiation, and qualification of raw materials. Finally, the HPLC method was proved to be useful for evaluation of raw material and finished products, besides satisfying the need for an analytical method that allows simultaneous determination of EFX, CFX, and LID, which can also be extended to other matrices and applications.

关键词： HPLC Physicochemical characterization Quality control Veterinary pharmaceutical formulation Raw material

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Correction of Acidity of a Brazilian Cerrado Oxisol with Limestone and Wood Ash on the Initial Growth of Cowpea

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Agricultural Sciences 2019年第7期10卷 841-851页

作者： Edna Maria Bonfim-silva Alisson silva costa Jefferson Vieira José André Pereira Freire Ferraz Ana Paula Alves Barreto Damasceno Tonny José Araújo da silva Department of Agricultural and Environmental Engineering Institute of Agricultural Sciences and Technology Federal University of Mato Grosso Rondonópolis Brazil

Among Brazilian soils orders, there are some of it classified as acid soils, which need correction to guarantee crop productivity. Currently, limestone is the most used soil corrective and wood ash has been a sustainable alternative to this process. Thus, the objective was to evaluate the effect of two correctives of soil acidity on an Oxisol collected in the Brazilian Cerrado area using limestone and wood ash and the effect of soil correction on initial growth of cowpea. Two greenhouse experiments were carried out: 1) with limestone, using base saturation levels (V%) of 0, 20, 40, 60 and 80;and 2) wood ash, with doses of 0, 8, 16, 24 and 32 g⋅dm−3, both in five randomized blocks. At 40 days after sowing, it was verified that pH values were within the range considered ideal for soil (pH of 5 to 7), according to the increase of base saturation levels and wood ash doses, but limestone provided faster results. Initial growth of cowpea was positively influenced by soil correction with use of both correctives. Wood ash and limestone increased soil pH to adequate values and resulted in better initial crop development.

关键词： Vigna unguiculata Solid Waste Disposal Alternative Soil Corrective Soil pH

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Natural Regeneration in Tropical Secondary Forest in Southern Amazonia, Brazil

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Open Journal of Forestry 2014年第2期4卷 151-160页

作者： Alexandre Ebert Leandro Ribeiro Teixeira Adriana Zanirato Contini da silva Reginaldo Brito da costa Faculty of Forestry Engineering Federal University of Mato Grosso Cuiabá Brazil

The study aimed to establish floral composition, diversity levels, category size, phytosociological structure, commercial use and ecological group of species present in the regeneration of open ombrophile forest in southern Amazon, Brazil. Data were collected at S?o Nicolau farm, in the municipality of Cotrigua?u, northwest of Mato Grosso state, coordinates 51°9'19.5"S and 58°14'53"W. One hundred plots of 10 × 10 m were allocated. All individuals between 29.9 and 59.9 cm had circumference at breast height (CAP) measure, with sub-plots of 5 × 5 m which were measured in all subjects between 1:50 m in height 29.9 cm CAP and sub-plots of 2 × 2 m for individuals between 0.30 to 1.5 m tall. The information obtained in the field were processed in excel spreadsheet. The results showed the occurrence of 610 individuals belonging to 82 species, 34 plant families, with a diversity index of Shannon & Weaver’s 2.77. The index of value of importance showed species Protium robustum, Maquira calophilla and Inga fagifolium with greater ecological importance in fitocenose. The higher values for Natural Regeneration were the species Protium robustum, Maquira calophilla and Inga fagifolium with 16.42, 8.03 and 7.76 respectively.

关键词： Vertical Structure Ecological Analysis Forest Management

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Association between Infrared Thermography, Blood Count and Creatine Kinase in the Evaluation of the Welfare of Vaquejada Horses

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Open Journal of Veterinary Medicine 2023年第6期13卷 53-67页

作者： Carolina Jones Ferreira Lima da silva Keity Laiane Gomes Trindade Raissa Karolliny Salgueiro Cruz César Fabiano Vilela Clarisse Simões Coelho José Dantas Ribeiro Filho Helena Emília Cavalcanti da costa Cordeiro Manso Hélio Cordeiro Manso Filho Núcleo de Pesquisa Equina Universidade Federal Rural de Pernambuco Recife Brazil Faculdade de Medicina Veterinária Centro Universitário Cesmac Maceió Brazil Médico Veterinário Privado Americana Brazil Faculdade de Medicina Veterinária Universidade Lusófona de Humanidades e Tecnologias Lisboa Portugal Departamento de Medicina Veterinária Universidade Federal de Vi&#231osa Vi&#231osa Brazil

The Quarter-Horses regularly participate in non-traditional sports that simulate activities on cattle ranches. In the vaquejada races, the horses run at about 30 km/h, reaching maximum heart rates of around 200 bpm, indicating the great physical effort during competitions and with that could impact welfare. To test the hypothesis that vaquejada horses can be evaluated for the quality of welfare through a combination of non-invasive and invasive methods, an experiment was developed that aimed to assess the quality of welfare through thermography and blood biomarkers before and after vaquejada races. Ten vaquejada horses, which were in regular competition, were submitted to the vaquejadas racing test were used. Thermography was performed in 14 regions of interest (head, neck and thorax) in the following phases: pre-race and +1, +4 and +24 hours of the races. Blood samples were collected in pre-race, immediately after and +1, +4 and +24 hours of the races. Results were submitted to ANOVA and Tukey’s test, with p set at 5%. Thermography showed that local temperatures before the race and +24 hours after the races were similar (p > 0.05), as well as between +1 and +4 hours after the races (p > 0.05), which showed higher surface temperatures than the first group (pre-race and +24 hours) (p 0.05) after the exercises. In conclusion, the vaquejada horses evaluated by infrared thermography and blood analyses maintained the quality of well-being, with the physiological elevation of several parameters after the races and recovery in less than 24 hours after the races. Thermographic images were also able to help in the analysis of the regions of interest that have contact with harnesses, demonstrating that the use of adequate and correct equipment does not compromise animal welfare.

关键词： Exercise Equine CK Hematology Equestrian Sports Well-Being

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