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Agronomic assessment of two populations of intermediate wheatgrass—Kernza^(®)(Thinopyrum intermedium)in temperate South America

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Grassland Research 2022年第4期1卷 262-278页

作者： Andres Locatelli lucia gutierrez Olivier Duchene Pablo R.Speranza Valentin D.Picasso Risso Polo agro-alimentario Centro Universitario Litoral NorteEstacion Experimental Mario Antonio CassinoniUniversidad de la RepúblicaPaysanduUruguay Departamento de Producción Vegetal Facultad de AgronomiaUniversidad de la RepúblicaPaysanduUruguay Departamento de Biometría Estadística y ComputaciónFacultad de AgronomíaUniversidad de la RepúblicaMontevideoUruguay Department of Agronomy University of Wisconsin–MadisonMadisonWisconsinUSA Agroecology and Environment Research Unit ISARALyonFrance Departamento de Biología Vegetal Facultad de AgronomiaUniversidad de la RepúblicaMontevideoUruguay Departamento de Producción Animal y Pasturas Facultad de AgronomiaUniversidad de la RepúblicaMontevideoUruguay

Background Kernza®intermediate wheatgrass is a perennial grain and forage crop that can provide several ecosystem *** research efforts focused on Kernza have taken place in high *** goal of this study was to evaluate,for the first time,the agronomic performance of Kernza in a low-latitude region with mild *** A KS-cycle 4 Kernza population(A)was planted in spring in Wisconsin,USA,and selected in one cycle for lower vernalization requirements,obtaining a new population(B).These two populations,at three nitrogen(N)fertilization rates,were evaluated in a full factorial,completely randomized field experiment in Uruguay over 2 *** The populations were similar in grain yields and flowering time in the 1st year,but population B had 63%lower grain yield in the 2nd year and 20%lower forage yield throughout the *** the N rate to 160 kg ha−1 led to a 63%increase in grain yield and 28%increase in forage yield across *** yields and nutritive values were similar to those reported in the northern ***,grain yields for both the 1st(316 kg ha−1)and 2nd year(41 kg ha−1)were lower due to reduced flowering and weed *** Expansion of Kernza to lower-latitude regions will require further breeding to improve reproductive performance.

关键词： low-latitude regions nitrogen fertilization rates perennial grains Thinopyrum intermedium vernalization requirements

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Multi-omic study to unmask genes involved in prostate cancer development in amulti-case family

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Cancer Communications 2024年第3期44卷 443-447页

作者： lucia Chica-Redecillas Sergio Cuenca-Lopez Eduardo Andres-Leon Laura Carmen Terron-Camero Blanca Cano-gutierrez Jose Manuel Cozar Jose Antonio Lorente Fernando Vazquez-Alonso Luis Javier Martinez-Gonzalez Maria Jesus Alvarez-Cubero GENYO Centre for Genomics and Oncological ResearchPfizerUniversity of GranadaAndalusian Regional GovernmentPTS GranadaGranadaGranadaSpain Department of Biochemistry Molecular Biology III and ImmunologyFaculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Bioinformatics Unit Institute of Parasitology and Biomedicine“López-Neyra”Spanish National Research CouncilGranadaGranadaSpain Nursery Service.University Hospital Clínico San Cecilio GranadaGranadaSpain Urology Department University Hospital Virgen de las NievesGranadaGranadaSpain Legal Medicine and Toxicology Department Faculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Ibs Biosanitary Research InstituteGranadaGranadaSpain

Dear Editor,Hereditary prostate cancer(PC)comprises 5%-10%of all PC *** increased risk of PC in menwith a family his-tory of the disease is well known and is commonly caused by germline mutations,leading to clinical guidelines men-tioning various genes for identifying high-risk ***,the complex inheritance patterns involvingmul-tiple single nucleotide polymorphisms(SNPs)make it a genetically heterogeneous disease,with genetic testing still in its early stages.

关键词： cancer clinical cases

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Reversible acetylation regulates vascular endothelial growth factor receptor-2 activity

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Journal of Molecular Cell Biology 2014年第2期8卷 116-127页

作者： Annalisa Zecchin lucia Pattarini Maria Ines gutierrez Miguel Mano Antonello Mai Sergio Valente Mike P. Myers Sergio Pantano Mauro Giacca Molecular Medicine Laboratory International Centre for Genetic Engineering and Biotechnology (ICGEB) Trieste Italy Istituto Pasteur-Fondazione cenci-Bolognetti Dipartimento di Chimica e Tecnologie del Farmaco Sapienza Universita' di Roma Rome Italy Protein Networks Laboratory International Centre for Genetic Engineering and Biotechno[ogy (ICGEB) Trieste Italy Biomolecular Simulations Group Institut Pasteur de Montevideo' Montevideo Uruguay U932 Immunity and Cancer Integrative Biology of Human Dendritic Cells and T Cells Laboratory Institute Curie Paris France

The tyrosine kinase receptor vascular endothelial growth factor receptor 2 （VEG FR2） is a key regulator of angiogenesis. Here we show that VEGFR2 is acetylated in endothelial cells both at four lysine residues forming a dense cluster in the kinase insert domain and at a single lysine located in the receptor activation loop. These modifications are under dynamic control of the acetyltransferase p300 and two deacetyiases HDAC5 and HDAC6. We demonstrate that VEGFR2 acetylation essentially regulates receptor phosphorylation. In par- ticular, VEGFR2 acetylation significantly alters the kinetics of receptor phosphorylation after ligand binding, allowing receptor phos- phoryiation and intraceUular signaling upon proLonged stimulation with VEGF. Molecular dynamics simulations indicate that acetylation of the lysine in the activation loop contributes to the transition to an open active state, in which tyrosine phosphorylation is favored by better exposure of the kinase target residues. These findings indicate that post-translational modification by acetyiation is a critical mechanism that directLy affects VEGFR2 function.

关键词： acetylation angiogenesis p300 phosphorylation vascular endothelial growth factor

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Influence of CFH,HTRA1 and ARMS2 polymorphisms in the response to intravitreal ranibizumab treatment for wet age-related macular degeneration in a Spanish population

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International Journal of Ophthalmology(English edition) 2016年第9期9卷 1304-1309页

作者： Fernando Cruz-Gonzalez lucia Cabrillo-Estevez Vanesa Rivero-gutierrez Ana Sanchez-Jara Lourdes De Juan-Marcos Rogelio Gonzalez-Sarmiento Department of Ophthalmology Hospital Universitario Salamanca

AIM：To determine whether gene polymorphisms of the major genetic risk loci for age-related macular degeneration（AMD）：ARMS2（rs10490923）,the complement factor H（CFH）（rs1410996） and HTRA1（rs11200638） influence the response to a treatment regimen with ranibizumab for exudative ***：This study included 100 patients（100 eyes）with exudative *** underwent a treatment with ranibizumab injections monthly during three *** were made when the best corrected visual acuity（BCVA） decrease five letters（ETDRS） or central subfield retinal thickness gained 100 pm in optical coherence tomography ***（rs10490923,rs1410996 and rs11200638） were analyzed using TaqMan probes or polymerase chain reaction-restricted fragment length polymorphisms ***：There were no statistically significant differences in allelic distribution of CFH（rs1410996）,ARMS2（rs10490923） and HTRA1（rs11200638）polymorphisms regarding to response to ranibizumab ***：Ranibizumab treatment response is not related to CFH（rs1410996）,ARMS2（rs10490923） and HTRA1（rs11200638） poymorphisms.

关键词： age-related macular degeneration polymorphisms ARMS2 HTRA1 complement factor H ranibizumab

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Serial Ultrasonographic Measurements to Estimate Age and Viability in <i>Bos indicus</i>Embryos

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Open Journal of Veterinary Medicine 2019年第7期9卷 91-99页

作者： Ana lucia Malvaez Carlos Salvador Galina Ivette gutierrez Manuel Corro Jose Luis Pablos Departamento de Reproducción Facultad de Medicina Veterinaria y Zootecnia Universidad Nacional Autónoma de México Ciudad Universitaria Ciudad de México México Centro de Enseñ anza Investigación y Extensión en Ganadería Tropical Facultad de Medicina Veterinaria y Zootecnia Universidad Nacional Autónoma de México Tlapacoyan Veracruz México Departamento de Genética y Bioestadística Facultad de Medicina Veterinaria y Zootecnia Universidad Nacional Autónoma de México Ciudad Universitaria Ciudad de México México

Early pregnancy diagnosis is a very important routine management to identify non-pregnant cows in order to keep an optimum reproductive efficiency both for dairy and beef cows. Ultrasound equipment allows estimating the viability and size of the embryo during early gestation. With the aim of assessing age and viability of Bos indicus embryos between 24 and 35 days of gestation, 55 cows were divided into 4 clusters. These clusters were conformed according to the first day that an echogenic structure was seen inside the embryonic vesicle (Group 1: day 24, Group 2: day 26, Group 3: day 27 and Group 4: day 28). The age of the embryos was estimated from the date of AI. Three progressive serial measurements of their length were made within 2 to 5 days. With a model GEE (Generalized Estimating Equations), the effect of days was evaluated to compare the second measurement with the first one and the former with the third observation. No differences in the size of the embryos were observed between the first evaluation (24 days) and the second (28 days) (P = 0.387). Also, simple linear regression analysis found a positive linear association between the size of the embryo and gestation days (R2 = 0.593) with an average growth of 0.078 cm per day (P = 0.001). In conclusion, the variation between measurements at a given time does not allow estimating with precision the exact day of gestation. Nonetheless, serial measurements are useful to estimate the healthy growth of the embryo from day 26 of gestation.

关键词： Zebu Cattle Embryo Measurement Reproduction Tropics

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