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Global assessment of genetic variation and phenotypic plasticity in the lichen-forming species Tephromela atra

Fungal Diversity 2014年第1期64卷 233-251页

作者： lucia Muggia Sergio Pérez-Ortega Alan Fryday Toby Spribille Martin Grube Institute of Plant Sciences Karl-Franzens-University GrazHolteigasse 68010 GrazAustria Department of Life Science University of TriesteVia Giorgieri 1034127 TriesteItaly Department of Environmental Biology Museo Nacional de Ciencias Naturales(CSIC)C/Serrano 115-dpdoMadridSpain Department of Plant Biology Michigan State UniversityEast LansingMI 48824-1312USA Division of Biological Sciences University of MontanaMissoulaMT 59812USA

Understanding how many species exist and the processes by which they form remains a central topic of ecological and evolutionary biology,but represents a special challenge within microbial *** lichen-forming fungi represent one of the best examples in which species evolution and diversity create patterns of high phenotypic plasticity coupled with wide geographic *** sampled the lichen-forming species Tephromela atra and related species at a world-wide scale to reconstruct a phylogenetic hypothesis using three nuclear *** were also studied for morphological and chemical traits to assess how well the phenotypic relationships with species,previously segregated from ***,agrees with molecular *** used a genealogical concordance approach and identified 15 monophyletic clades,which may represent independent *** combining morphological and chemical characters,ecological preferences and geographic origin we distinguish six different *** subtle phenotypical traits are frequently used for describing previously cryptic species in fungi,the continuum of variability found in morphology and chemical patterns in *** prevents the description of new taxa with characteristic *** observed that phenotypic characters arise in parallel at local or regional scale but are not correlated with genetic ***,they are insufficient for characterizing species with broad geographic ranges within ***.

关键词： Chemistry Ecology Morphology Multigene phylogeny Phylogeography Symbiosis

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How to conjugate the stemness marker ALDH1A1 with tumor angiogenesis,progression,and drug resistance

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Cancer Drug Resistance 2020年第1期3卷 26-37页

作者： Valerio Ciccone lucia Morbidelli Marina Ziche Sandra Donnini Department of Life Sciences University of SienaSiena 53100Italy Department of Medicine Surgery and NeuroscienceUniversity of SienaSiena 53100Italy

Cancer is the second leading cause of death *** survival of cancer patients depends on the efficacy of therapies and the development of *** are many mechanisms involved in the acquisition of drug resistance by cancer cells,including the acquisition of stem-like *** stem cells(CSCs)represent a major source of tumor progression and treatment *** are a subpopulation of cancer cells having the abilities to self-renew and form spheres in *** dehydrogenase 1A1(ALDH1A1)is a cytosolic enzyme involved in the detoxification of cells from toxic aldehydes and belongs to the ALDH *** ALDH1A1 activity is closely related to stemness phenotype of several tumors,possibly contributing to cancer progression and diffusion in the *** have documented the contribution of ALDH1A1 in tumor angiogenesis in breast cancer cells by the activation of hypoxia inducible factor-1αand vascular endothelial growth factor *** review discusses the involvement of ALDH1A1 in the development of different hallmarks of cancer to propose it as a novel putative target for cancer treatment to achieve better ***,we analyze the involvement of ALDH1A1 in the acquisition of stemness phenotype in tumor cells,the regulation of tumor angiogenesis and metastases,and the acquisition of anticancer drug resistance and immune evasion.

关键词： Aldehyde dehydrogenase 1A1 angiogenesis drug resistance immune editing metastases stemness

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Increased circulating zonulin in children with biopsy-proven nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2014年第45期20卷 17107-17114页

作者： lucia Pacifico Enea Bonci Lidia Marandola Sara Romaggioli Stefano Bascetta Claudio Chiesa Department of Pediatrics and Child Neuropsychiatry Sapienza University of Rome Department of Experimental Medicine Sapienza University of Rome Institute of Translational Pharmacology National Research Council

AIM: To investigate the potential association of circulating zonulin with the stage of liver disease in obese children with biopsy-confirmed nonalcoholic fatty liver disease (NAFLD).

关键词： Zonulin Intestinal permeability Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Children

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T1-weighted dual-echo MRI for fat quantification in pediatric nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2011年第25期17卷 3012-3019页

作者： lucia Pacifico Michele Di Martino Carlo Catalano Valeria Panebianco Mario Bezzi Caterina Anania Claudio Chiesa Department of Pediatrics Sapienza University of Rome Department of Radiological Sciences Sapienza University of Rome Institute of Translational Pharmacology National Research Council

AIM： To determine in obese children with nonalcoholic fatty liver disease （NAFLD） the accuracy of magnetic resonance imaging （MRI） in assessing liver fat concentration. METHODS： A case-control study was performed. Cases were 25 obese children with biopsy-proven NAFLD. Controls were 25 obese children matched for age and gender, without NAFLD at ultrasonography and with normal levels of aminotransferases and insulin. Hepatic fat fraction （HFF） by MRI was obtained using a modification of the Dixon ***： HFF ranged from 2% to 44% [mean, 19.0% （95% CI, 15.1-27.4）] in children with NAFLD, while in the controls this value ranged from 0.08% to 4.69% [2.0% （1.3-2.5）, P 〈 0.0001]. HFF was highly correlated with histological steatosis （r = 0.883, P 〈 0.0001） in the NAFLD children. According to the histological grade of steatosis, the mean HFF was 8.7% （95% CI, 6.0-11.6） for mild, 21.6% （15.3-27.0） for moderate, and 39.7% （34.4-45.0） for severe fatty liver infiltration. With a cutoff of 4.85%, HFF had a sensitivity of 95.8% for the diagnosis of histological steato- sis ≥ 5%. All control children had HFF lower than 4.85%; thus, the specificity was 100%. Alter 12 mo, children with weight loss displayed a significant decrease in HFF. CONCLUSION： MRI is an accurate methodology for liver fat quantification in pediatric NAFLD.

关键词： Nonalcoholic fatty liver disease Children Obesity Fast-magnetic resonance imaging Liver fatquantification

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the 20GD Superfamily： Emerging Functions in Plant Epigenetics and Hormone Metabolism

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Molecular Plant 2018年第10期11卷 1222-1224页

作者： Riad Nadi Eduardo Mateo-Bonmati lucia Juan-Vicente Jose Luis Micol Instituto de Bioingenieria Universidad Miguel Hern&ndez Campus de Elche 03202 Elche Spain

The 2-oxoglutarate and Fe （ll）-dependent dioxygenase （2OGD） superfamily includes oxidative enzymes with an active site con- taining two histidines and （in most cases） one aspartic or glutamic acid residue. This conserved motif is termed the 2-His-1-carboxylate facial triad, chelates iron, and is housed within a double-stranded β-helix fold, also known as the DSBH, jelly-roll, cupin, or Jumonji C fold （Martinez and Hausinger, 2015）. The reactions catalyzed by 2OGDs （also called 2ODDs, 2ODQs, and 2OGXs） include but are not limited to demethylation, demethylenation, hydroxytation, halogenation, desaturation, ring cleavage, ring closure, and epimerization （Farrow and Facchini, 2014）.

关键词： DEMETHYLASE DIVERSITY

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Chronic bacterial prostatitis and irritable bowel syndrome： effectiveness of treatment with rifaximin followed by the probiotic VSL#3

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Asian Journal of Andrology 2014年第5期16卷 735-739,I0009页

作者： Enzo Vicari Sandro La Vignera Roberto Castiglione Rosita A Condorelli lucia O Vicari Aldo E Calogero Section of Endocrinology Andrology and Internal Medicine Department of MedicaJ and Pediatric Sciences Master in Experimental and Clinical Medicine and Cellular Physiopathology University of Catania Catania Italy

This study was undertaken to evaluate the influence of treatment with rifaximin followed by the probiotic VSL#3 versus no treatment on the progression of chronic prostatitis toward chronic microbial prostate-vesiculitis （PV） or prostate-vesiculo-epididymitis （PVE）. A total of 106 selected infertile male patients with bacteriologically cured chronic bacterial prostatitis （CBP） and irritable bowel syndrome （IBS） were randomly prescribed rifaximin （200 mg, 2 tablets bid, for 7 days monthly for 12 months） and probiotic containing multiple strains VSL#3 （450 × 10^9 CFU per day） or no treatment. Ninety-five of them （89.6%） complied with the therapeutic plan and were included in this study. Group A = ＂6Tx/6-＂： treatment for the initial 6 and no treatment for the following 6 months （n = 26）; Group B = ＂12Tx＂： 12 months of treatment （n = 22）; Group C = ＂6-/6Tx＂： no treatment for the initial 6 months and treatment in the last 6 months （n = 23）; Group D = ＂12-＂： no treatment （n = 24）. The patients of Groups A = ＂6Tx/6-＂ and B = ＂12Tx＂ had the highest frequency of chronic prostatitis （88.5% and 86.4%, respectively）. In contrast, group ＂12-＂： patients had the lowest frequency of prostatitis （33.4%）. The progression of prostatitis into PV in groups ＂6Tx/6-＂（15.5%） and ＂6-/6Tx＂（13.6%） was lower than that found in the patients of group ＂12-＂（45.8%）. Finally, no patient of groups ＂6Tx/6-＂ and ＂6-/6Tx＂ had PVE, whereas it was diagnosed in 20.8% of group ＂12-＂ patients. Long-term treatment with rifaximin and the probiotic VSL#3 is effective in lowering the progression of prostatitis into more complicated forms of male accessory gland infections in infertile patients with bacteriologically cured CBP plus IBS.

关键词： chronic bacterial prostatitis irritable bowel syndrome probiotic VSL#3 prostate-vesiculitis prostate-vesiculo-epididymitis rifaximin

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Methionine adenosyltransferases in liver cancer

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World Journal of Gastroenterology 2019年第31期25卷 4300-4319页

作者： Ben Murray lucia Barbier-Torres Wei Fan JoséM Mato Shelly C Lu Division of Digestive and Liver diseases Department of MedicineCedars-Sinai Medical CenterLos AngelesCA 90048United States CIC bioGUNE Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas(Ciberehd)TechnologyPark of BizkaiaDerio 48160BizkaiaSpain

Methionine adenosyltransferases(MATs)are essential enzymes for life as they produce S-adenosylmethionine(SAMe),the biological methyl donor required for a plethora of reactions within the *** systems express two genes,MAT1A and MAT2A,which encode for MATα1 and MATα2,the catalytic subunits of the MAT isoenzymes,respectively.A third gene MAT2B,encodes a regulatory subunit known as MATβwhich controls the activity of MATα***1A,which is mainly expressed in hepatocytes,maintains the differentiated state of these cells,whilst MAT2A and MAT2B are expressed in extrahepatic tissues as well as non-parenchymal cells of the liver(e.g.,hepatic stellate and Kupffer cells).The biosynthesis of SAMe is impaired in patients with chronic liver disease and liver cancer due to decreased expression and inactivation of MATα1.A switch from MAT1A to MAT2A/MAT2B occurs in multiple liver diseases and during liver growth and dedifferentiation,but this change in the expression pattern of MATs results in reduced hepatic SAMe *** of study have utilized the Mat1a-knockout(KO)mouse that spontaneously develops non-alcoholic steatohepatitis(NASH)and hepatocellular carcinoma(HCC)to elucidate a variety of mechanisms by which MAT proteins dysregulation contributes to liver *** increasing volume of work indicates that MATs have SAMe-independent functions,distinct interactomes and multiple subcellular *** we aim to provide an overview of MAT biology including genes,isoenzymes and their regulation to provide the context for understanding consequences of their *** will highlight recent breakthroughs in the field and underscore the importance of MAT’s in liver tumorigenesis as well as their potential as targets for cancer therapy.

关键词： Methionine adenosyltransferases S-adenosylmethionine Liver cancer Hepatocellular carcinoma Cholangiocarcinoma Biomarkers Therapeutic targets

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Probiotics for the treatment of Helicobacter pylori infection in children

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World Journal of Gastroenterology 2014年第3期20卷 673-683页

作者： lucia Pacifico John Frederick Osborn Enea Bonci Sara Romaggioli Rossella Baldini Claudio Chiesa Department of Pediatrics and Child Neuropsychiatry Sapienza University of Rome Department of Health Sciences and Infectious Diseases Sapienza University of Rome Department of Experimental Medicine Sapienza University of Rome Department of Human Anatomy Sapienza University of Rome Institute of Translational Pharmacology National Research Council

The combination of a proton pump inhibitor and two antibiotics(clarithromycin plus amoxicillin or metronidazole)has been the recommended first-line therapy since the first guidelines for Helicobacter pylori(***)infection in children were *** recent years,the success of eradication therapies has declined,in part due to the development of *** resistant *** *** treatments are currently becoming more popular than the traditional eradication *** that may be used either as a monotherapy or,in combination with antimicrobials,resulting in a more effective *** therapy have been investigated in depth by several *** of the potential therapies is probiotic cultures;promising results have been observed in initial studies with numerous probiotic ***,many questions remain *** this article,we comprehensively review the possible mechanisms of action of probiotics on *** infection,and present the results of published studies using probiotics as possible agents to control *** infection in *** effect of the addition of probiotics to the standard *** eradication therapy for the prevention of antibiotic associated side-effects is also discussed.

关键词： Helicobacter pylori Children Probiotics Eradication treatment Prevention

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Induction of apoptosis on human hepatocarcinoma cell lines by an alkyl resorcinol isolated from Lithraea molleoides

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World Journal of Gastroenterology 2006年第37期12卷 5959-5963页

作者： luciana Barbini Paula Lopez Julieta Ruffa Virginia Martino Graciela Ferraro Rodolfo Campos lucia Cavallaro Catedra de Virologia Facultad de Farmacia y Bioquimica Universidad de Buenos Aires. Junin 956 (1113) Buenos Aires Argentina Catedra de Farmacognosia Facultad de Farmacia y Bioquimica Universidad de Buenos Aires. Junin 956 (1113) Buenos Aires Argentina

AIM: To study the mechanism of cytotoxicity of a new active 5-alkyl resorcinol [1, 3-dihydroxy-5- (tridec-4’, 7’ -dienyl) benzene] isolated from Lithraea molleoides leaves on liver tumor cells. METHODS: Human hepatocarcinoma cell lines (HepG2 and Hep3B) in culture were treated with inhibitory concentrations, 50% of the compound, for 24 h. The induction of apoptosis was detected in treated cells by analysis of DNA fragmentation, DNA content, and acridine orange and propidium iodide staining. RESULTS: After 24 h of 5-alkyl resorcinol treatment, both cell lines showed: (1) the typical morphological alterations of apoptosis; (2) DNA fragmentation, detected by laddering and appearance of a subG0 population by flow cytometry; and (3) condensed and fragmented nuclei by acridine orange-propidium iodide staining. CONCLUSION: Based on the results, this compound exerts its cytotoxic effect in both hepatocellular cell lines through apoptotic cell death. For Hep3B, cells with mutated p53 and Fas, apoptosis would proceed by p53- or Fas-independent pathways.

关键词： Lithraea molleoides Cytotoxic activity Alkyl resorcinol Apoptosis Hepatoma

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Role of osteoprotegerin/receptor activator of nuclear factor kappa B/receptor activator of nuclear factor kappa B ligand axis in nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2018年第19期24卷 2073-2082页

作者： lucia Pacifico Gian Marco Andreoli Miriam D'Avanzo Delia De Mitri Pasquale Pierimarchi Policlinico Umberto I Hospital Sapienza University of Rome Institute of Translational Pharmacology National Research Council

Concomitantly with the increase in the prevalences of overweight/obesity, nonalcoholic fatty liver disease(NAFLD) has worldwide become the main cause of chronic liver disease in both adults and children. Patients with fatty liver display features of metabolic syndrome(Met S), like insulin resistance(IR), glucose intolerance, hypertension and dyslipidemia. Recently, epidemiological studies have linked obesity, Met S, and NAFLD to decreased bone mineral density and osteoporosis, highlighting an intricate interplay among bone, adipose tissue, and liver. Osteoprotegerin(OPG), an important symbol of the receptor activator of nuclear factor-B ligand/receptor activator of nuclear factor kappa B/OPG system activation, typically considered for its role in bone metabolism, may also play critical roles in the initiation and perpetuation of obesityrelated comorbidities. Clinical data have indicated that OPG concentrations are associated with hypertension, left ventricular hypertrophy, vascular calcification, endothelial dysfunction, and severity of liver damage in chronic hepatitis C. Nonetheless, the relationship between circulating OPG and IR as a key feature of Met S as well as between OPG and NAFLD remains uncertain. Thus, the aims of the present review are to provide the existent knowledge on these associations and to discuss briefly the underlying mechanisms linking OPG and NAFLD.

关键词： Nonalcoholic fatty liver disease Insulin resistance Metabolic syndrome Osteoprotegerin Receptor activator of nuclear factor kappa B Receptor activator of nuclear factor kappa B ligand

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