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Prime time for base editing in the mitochondria

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Signal Transduction and Targeted Therapy 2022年第8期7卷 2630-2631页

作者： Michael A.Morgan lucas lange Axel Schambach Institute of Experimental Hematology Hannover Medical SchoolHannover 30625Germany REBIRTH Research Center for Translational Regenerative Medicine Hannover Medical SchoolHannover 30625Germany Division of Hematology/Oncology Boston Children’s HospitalHarvard Medical SchoolBostonMA 02115USA

A recent study published in Cell by the Kim lab represents a great advance towards expanding DNA editing possibilities to mitochondrial DNA(mtDNA)as they show reasonable targeted A-to-G conversions in human mtDNA using base editors to broaden the arsenal of available tools.1 Mutations in mitochondrial DNA(mtDNA)are linked to several diseases(Fig.1),thus,development of gene therapy and editing approaches could lead to curative options for patients suffering from these *** this direction,gene editing tools such as zinc-finger nucleases(mitoZFN),transcription activator-like effector nucleases(mitoTALENs)and meganucleases(mitoARCUS)were shown to eliminate mutant mtDNA and shift heteroplasmy.

关键词： diseases base curative

Back to pluripotency:fully chemically induced reboot of human somatic cells

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Signal Transduction and Targeted Therapy 2022年第8期7卷 2658-2659页

作者： lucas lange Miguel A.Esteban Axel Schambach Institute of Experimental Hematology Hannover Medical SchoolHannover 30625Germany REBIRTH Research Center for Translational Regenerative Medicine Hannover Medical SchoolHannover 30625Germany Laboratory of Integrative Biology Guangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou 510530China Division of Hematology/Oncology Boston Children’s HospitalHarvard Medical SchoolBostonMA 02115USA

In a recent study published in Nature,Guan et al.1 showed an exciting strategy to reprogram human somatic cells into human chemically induced pluripotent stem cells(hCiPSCs).Thereby,they identified crucial steps and p... 详细信息

关键词： al. chemically steps

Peptidylarginine deiminases and extracellular vesicles: prospective drug targets and biomarkers in central nervous system diseases and repair

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Neural Regeneration Research 2021年第5期16卷 934-938页

作者： Sigrun lange Tissue Architecture and Regeneration Research Group School of Life SciencesUniversity of WestminsterLondonUK

Peptidylarginine deiminases are a family of calcium-activated enzymes with multifaceted roles in physiological and pathological processes,including in the central nervous *** deiminases cause post-translational deimination/citrullination,leading to changes in structure and function of a wide range of target *** can facilitate protein moonlighting,modify protein-protein interaction,cause protein dysfunction and induce inflammatory *** deiminases also regulate the biogenesis of extracellular vesicles,which play important roles in cellular communication through transfer of extracellular vesicle-cargo,e.g.,proteins and genetic *** peptidylarginine deiminases and extracellular vesicles are linked to a number of pathologies,including in the central nervous system,and their modulation with pharmacological peptidylarginine deiminase inhibitors have shown great promise in several in vitro and in vivo central nervous system disease ***,extracellular vesicles derived from mesenchymal stem cells have been assessed for their therapeutic application in central nervous system *** circulating extracellular vesicles can be used as non-invasive liquid biopsies,their specific cargo-signatures(including deiminated proteins and microRNAs)may allow for disease“fingerprinting”and aid early central nervous system disease diagnosis,inform disease progression and response to *** mini-review discusses recent advances in the field of peptidylarginine deiminase and extracellular vesicle research in the central nervous system,focusing on several central nervous system acute injury,degeneration and cancer models.

关键词： central nervous system citrullination/deimination COVID-19 ectracellular trap formation extracellular vesicles glioblastoma neurodegeneration peptidylarginine deiminases regeneration

Food intolerance and the few-foods(or oligoantigenic)diet in children with attention-deficit hyperactivity disorder

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Food Science and Human Wellness 2024年第4期13卷 1729-1738页

作者： Klaus W.lange Andreas Reissmann Yukiko Nakamura Katharina M.lange Faculty of Human Sciences University of RegensburgRegensburg 93040Germany Department of Psychology University of BathBath BA27AYUnited Kingdom

The hypothesis that some children with attention-deficit hyperactivity disorder(ADHD)may show sensitivity or allergic reactions to various food items has led to the development of the the few-foods(or oligoantigenic)*** rationale of the diet is to eliminate certain foods from the diet in order to exclude potential allergens contained either naturally in food or in artificial ingredients with allergenic *** oligoantigenic diet attempts to identify individual foods to which a person might be ***,ADHD symptoms are monitored while multiple foods are excluded from the ***,if symptoms remit,foods are re-introduced,while observing the individual for the return of *** advantage of the oligoantigenic diet is that it can be tailored to the individual.A growing body of evidence suggests that behavioral symptoms of subgroups of children with ADHD may benefit from the elimination of certain *** effect sizes of an oligoantigenic diet regarding improvement of ADHD symptoms have been found to be medium to *** evidence suggests that the investigation of the role of food hypersensitivities in ADHD is a promising avenue worthy of further *** large-scale,randomized controlled studies including assessment of long-term outcome are therefore warranted.

关键词： Attention-deficit hyperactivity disorder Food intolerance Few-foods diet Etiology Treatment

Green tea, epigallocatechin gallate and the prevention of Alzheimer’s disease: clinical evidence

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Food Science and Human Wellness 2022年第4期11卷 765-770页

作者： Klaus W.lange Katharina M.lange Yukiko Nakamura Department of Experimental Psychology University of RegensburgRegensburg 93040Germany

Given its increasing global prevalence,Alzheimer’s disease(AD)has become a major public health challenge *** symptomatic treatments available for AD have shown no significant efficacy,and no disease-modifying interventions are capable of slowing the progression of the *** potential of lifestyle-related factors,including diet,is increasingly recognized as an important consideration in the primary prevention of *** mechanisms potentially underlying neuroprotective effects of bioactive components contained in tea,such as(-)-epigallocatechin-3-gallate,as well as their preventive efficacy against AD,have been elucidated in preclinical ***,in contrast to the abundance of mechanistic findings in animals,clinical results demonstrating efficacy in humans are *** epidemiological studies have provided some evidence indicating that green tea consumption is associated with a reduced risk of age-related cognitive decline and AD,a causal relationship cannot be established on the basis of these *** clinical evidence regarding preventive or therapeutic effects of green tea and its bioactive components is unsatisfactory.A role of green tea in the prevention of AD cannot be recommended until well-designed,randomized,placebo-controlled clinical trials using standardized formulations confirm the purported beneficial effects of green tea.

关键词： Green tea Epigallocatechin gallate Alzheimer’s disease Neurodegeneration Prevention

Tea in cardiovascular health and disease:a critical appraisal of the evidence

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Food Science and Human Wellness 2022年第3期11卷 445-454页

作者： Klaus W.lange Department of Experimental Psychology University of RegensburgRegensburg 93040Germany

The findings of various epidemiological studies,interventions using randomized controlled trials and mechanistic experiments have suggested a protective role of tea and its bioactive components in cardiovascular *** potential of tea in the prevention of cardiovascular diseases(CVDs)has therefore attracted increasing research ***,in particular flavonoids,found in both green and black tea,have been suggested to play a primary role in the reduction of CVD *** promising results regarding the effects of tea on blood pressure and other CVD-related biomarkers have been found in preclinical experiments,the effects demonstrated in human studies are modest and less *** discrepancy may be explained,at least in part,by different research strategies used in human and animal ***,since tea is globally one of the most commonly consumed beverages,even small beneficial effects in humans may shift the population distribution of CVD risk,with major implications for public ***,research conducted to date does not yield sufficiently robust evidence to allow a recommendation as to an optimal level of tea consumption as an element of health policies seeking to prevent hypertension and improve cardiovascular health.

关键词： Tea Cardiovascular diseases Health Prevention Treatment

Food science and COVID-19

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Food Science and Human Wellness 2021年第1期10卷 1-5页

作者： Klaus W.lange Department of Experimental Psychology University of RegensburgRegensburgGermany

Theories proposing a role of specific dietary components or food supplements in the prevention or treatment of COVID-19 have received extensive social media coverage.A multitude of scientific publications have also pointed to the importance of food and nutrition in combating the COVID-19 *** present perspective critically addresses the question of what food science can actually contribute in this *** studies suggest that micronutrients,food bioactives or functional foods may carry the potential to augment viral ***,the specific roles of food components in viral infectious diseases in humans remain *** research assessing the efficacy of food compounds in counteracting infections would require long-term randomized controlled trials in large *** no foods,single nutrients or dietary supplements are capable of preventing infection with COVID-19,a balanced diet containing sufficient amounts of macronutrients and diverse micronutrients is a prerequisite of an optimally functioning immune ***-energy diets and obesity are major risk factors for a more severe course of ***,population-wide body weight control and weight reduction in overweight people are important preventive *** may play a beneficial role in maintaining a healthy body weight and preventing non-communicable conditions.

关键词： COVID-19 Food science Micronutrients Functional foods Obesity

Rainwater harvesting to alleviate water scarcity in dry conditions:A case study in Faria Catchment,Palestine

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Water Science and Engineering 2010年第2期3卷 132-143页

作者： Sameer SHADEED Jens lange Department of Civil Engineering College of EngineeringAn-Najah National University Institute of Hydrology University of Freiburg

In arid and semi-arid regions, the availability of adequate water of appropriate quality has become a limiting factor for development. This paper aims to evaluate the potential for rainwater harvesting in the arid to semi-arid Faria Catchment, in the West Bank, Palestine. Under current conditions, the supply-demand gap is increasing due to the increasing water demands of a growing population with hydrologically limited and uncertain supplies. By 2015, the gap is estimated to reach 4.5 x 106 m3. This study used the process-oriented and physically-based TRAIN-ZIN model to evaluate two different rainwater harvesting techniques during two rainfall events. The analysis shows that there is a theoretical potential for harvesting an additional 4 x 106 m3 of surface water over the entire catchment. Thus, it is essential to manage the potential available surface water supplies in the catchment to save water for dry periods when the supply-demand gap is comparatively high. Then a valuable contribution to bridging the supply-demand gap can be made.

关键词： rainwater harvesting surface water management options water resources Faria Catchment arid and semi-arid catchments TRAIN-ZIN model

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Tea and depression

Food Science and Human Wellness 2022年第3期11卷 476-482页

作者： Klaus W.lange Yukiko Nakamura Katharina M.lange Hui Zhao Department of Experimental Psychology University of RegensburgRegensburg 93040Germany Tianjin Key Laboratory of Food and Biotechnology University of CommerceTianjin 300134China

The available evidence,which derives from studies investigating mechanistic effects of tea,research on animal models as well as epidemiological studies and intervention trials in humans,suggests that compounds contained in tea may have the potential to aid in the prevention of depression or in its treatment as an addition to established therapies.A wide range of potentially antidepressive biological activities of tea components have been ***,the mechanisms of tea phytochemicals possibly capable of decreasing the risk of depressive symptoms are complex,multifaceted and not well *** pharmacological effects on circumscribed neurobiological systems may be produced not by individual tea components but rather by the synergistic action of various compounds on multiple pathophysiological mechanisms involved in *** epidemiological studies have generally demonstrated beneficial effects of tea consumption on mood and depressive symptoms,cross-sectional studies are unable to prove a cause-effect *** positive effects on mood could be firmly established,tea drinking could support mental ***,the moderate antidepressive effects observed in healthy people are not necessarily indicative of possible clinical effects in major depressive *** controlled intervention studies are needed to establish a causal relationship between bioactive compounds in tea and depression.

关键词： Depression Tea L-theanine Prevention Treatment