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Changes in higher order aberrations after central corneal regularization-a comparative two-year analysis of a semiautomated topography-guided photorefractive keratectomy combined with corneal cross-linking

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Eye and Vision 2020年第1期7卷 99-108页

作者： Katja C.Iselin Philipp B.Baenninger lucas m.bachmann Frank Bochmann michael A.Thiel Claude Kaufmann Department of Ophthalmology Lucerne Cantonal HospitalLucerneSwitzerland medignition Healthcare Innovations ZurichSwitzerland

Background:The optical quality in progressive keratoconus deteriorates due to ectasia and distortion of the corneal shape and *** corneal cross-linking(CXL)aims at stopping disease progression,“CXL-Plus”combines CXL with excimer laser ablation to improve visual *** Corneal Regularization(CCR)represents a therapeutic excimer laser modality specifically designed to smoothen the ectatic corneal shape and to reduce higher order aberrations(HOA).We set out to compare CXL-Plus,consisting of CXL combined with CCR,with CXL by itself for patients with progressive ***:Retrospective 2-year matched group analysis of patients who either underwent CXL-Plus(n=28)or CXL as a sole procedure(n=28)for progressive *** outcome parameters were HOA,visual function and tomographic results 12 and 24 months ***:After 12 months,the total HOA root mean square wavefront error was reduced from 0.79±0.30 to 0.40±0.19μm(CXL-Plus;pm 0.71±0.28 to 0.73±0.36μm(CXL;p=0.814).Uncorrected distance visual acuity improved from 0.70±0.35 to 0.36±0.29 logmAR(CXL-Plus;p=0.0002)and from 0.65±0.39 to 0.46±0.37 logmAR(CXL;p=0.067),translating to gains of three or more lines in 50%(CXL-Plus)and 36%(CXL)of *** steepest keratometry value(Kmax)regressed by 5.84 D(CXL-Plus;pmeters a statistically significant change could be shown between 12 and 24 ***:CXL-Plus in the form of a CCR reduces HOA and Kmax more effectively than CXL as a sole procedure.

关键词： Keratoconus Corneal cross-linking CXL-plus Photorefractive keratectomy Central corneal regularization Higher order aberrations Coma-like aberrations

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Bird species present in urban parks are more colorful than urban avoiders:A test in the Argentinian Pampas

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Avian Research 2024年第1期15卷 22-26页

作者： lucas m.Leveau Departamento de Ecología Genetica y EvolucionFacultad de Ciencias Exactas y NaturalesUniversidad de Buenos Aires-IEGEBA(CONICET-UBA)Intendente Güiraldes 2160Ciudad UniversitariaC1428EGABuenos AiresArgentina

Bird plumage color has been assessed as a possible trait driving the presence of bird species in urban *** some species can see the ultraviolet(UV) spectrum,the mentioned studies did not take into account UV reflectance when characterizing bird *** study aimed to use a recent database of the colorfulness in passerines that incorporated the UV spectrum to compare bird colorfulness and other traits between urban parks and rural areas in Central-East *** in urban parks were surveyed in 51 parks in 6 cities during breeding and non-breeding seasons.A list of Passeriformes species from parks was created,and a list of urban avoider species was created from the *** traits were body mass,clutch size,migratory status,nesting site,diet and habitat breadth,and plumage colorfulness.A total of 85 species were detected in the regional pool,of which 30 species were detected in urban *** species present in urban parks were more colorful than bird species only present in rural *** addition,bird presence in urban parks was positively related to their regional frequency and diet ***,urban presence was related to nesting on trees and buildings,whereas species not present in urban parks nested on the *** results obtained showed that bird color is significantly associated with presence of bird species in urban parks.

关键词： Avian Filter Phenotype Selection Ultraviolet

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Convective drying of wood chips:Accelerating coupled DEm-CFD simulations with parametrized reduced single particle models

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Particuology 2024年第1期84卷 158-167页

作者： lucas Reineking Jonas Fischer Ali mjalled Enric Illana Siegmar Wirtz Viktor Scherer martin monnigmann Automatic Control and System Theory Ruhr-Universität-BochumUniversitätstraße 150Bochum44801Germany Energy Plant Technology Ruhr-Universität-BochumUniversitätstraße 150Bochum44801Germany

The simulation of industry-scale reactive bulks is challenging due to the complex interaction between fluid and *** particles in the bulk and their interaction with the fluid flow can be described by combined Discrete Element method-Computational Fluid Dynamics(DEm-CFD)***,the computational cost of the Finite Volume(FV)methods deployed in these models can become prohibi-tively expensive,especially for high inner-particle *** particle Reduced models(Rms)can be used to achieve both fast and accurate descriptions of the processes in each *** an example of bulk systems comprising heat and mass transfer,we compared FV and Rm simulations for the drying of wood chips in a bulk reactor.A manifold-based nonlinear interpolation was applied to resolve changing boundary conditions for the *** simulations showed that Rms provide accurate values for the thermodynamic state variables of the ***,the time required for the bulk simulation was reduced by 67%with the *** is evident that simulations with high inner-particle resolution can be accelerated by Rms if manifold-based nonlinear interpolation is used to address changing boundary conditions.

关键词： Reduced model Reactive bulk Discrete element method manifold-based interpolation Drying of porous mediaDEm-CFD

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NeuroPNm:model reduction of pore network models using neural networks

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Particuology 2024年第3期86卷 239-251页

作者： Robert Jendersie Ali mjalled Xiang Lu lucas Reineking Abdolreza Kharaghani martin monnigmann Christian Lessig Otto-von-Guericke-Universitat magdeburg Universitatsplatz 2Magdeburg39106Germany Ruhr-Universitat-Bochum Universitatstraβe 150Bochum44801Germany

Reacting particle systems play an important role in many industrial applications,for example biomass drying or the manufacturing of *** numerical modeling and simulation of such systems is therefore of great importance for an efficient,reliable,and environmentally sustainable operation of the *** complex thermodynamical,chemical,and flow processes that take place in the particles are a particular challenge in a ***,typically a large number of particles is involved,rendering an explicit treatment of individual ones impossible in a reactor-level *** approach for overcoming this challenge is to compute effective,physical parameters from single-particle,high-resolution *** can be combined with model reduction methods if the dynamical behaviour of particles must be *** network models with their unrivaled resolution have thereby been used successfully as high-resolution models,for instance to obtain the macroscopic diffusion coeffcient of *** parameter identification and model reduction have recently gained new impetus by the dramatic progress made in machine learning in the last *** report results on the use of neural networks for parameter identification and model reduction based on three-dimensional pore network models(PNm).We believe that our results provide a powerful complement to existing methodologies for reactor-level simulations with many thermally-thick particles.

关键词： Porenetwork models Neural networks Parameter estimation Reduced order model

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Association between lifestyle factors and thyroid function in young euthyroid adults

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Food Science and Human Wellness 2024年第1期13卷 265-275页

作者： Elisa merchan-Ramirez Guillermo Sanchez-Delgado lucas Jurado-Fasoli Francisco m Acosta manuel munoz-Torres Jose m.Llamas-Elvira Jonatan R Ruiz Sport and Health University Research Institute(imUDS) Faculty of Sports ScienceUniversity of GranadaGranada 18016Spain Pennington Biomedical Research Center Baton Rouge 70808USA Faculty of medicine University of GranadaGranada 18071Spain Turku PET Centre University of TurkuTurku 20500Finland Turku PET Centre Turku University HospitalTurku 20520Finland Biosanitary Research Institute of Granada(Ibs.Granada) Granada 18012Spain CIBERFES Instituto de Salud CarlosⅢMadrid 28029Spain Endocrinology and Nutrition Service University Hospital San CecilioGranada 18016Spain Nuclear medicine Service "Virgen de las Nieves"University HospitalGranada 18014Spain

Purpose:The present work examines the associations of dietary habits,sedentarism,physical activity(PA)levels and sleep habits,with thyroid function in young euthyroid ***:A total of 105 young euthyroid adults participated in this cross-sectional *** function was determined in fasting conditions(>6 h).Dietary habits were measured by a food frequency questionnaire and three non-consecutive 24 h recalls,and different dietary intake and patterns were then *** time spent in sedentary,PA levels and sleep habits were objectively measured using a wrist-worn ***:Energy and carbohydrate intake were positively associated with thyroid stimulating hormone(TSH)(β=0.222;R^(2)=0.102;P=0.022 andβ=0.425;R^(2)=0.129;P=0.007,respectively)whereas fat intake was negatively associated with TSH(β=-0.428;R^(2)=0.137;P=0.004).Energy intake was also positively associated with free triiodothyronine(β=0.277;R^(2)=0.137;P=0.004).Further,adherence to the mediterranean diet was negatively related to TSH and free thyroxine(FT4)(β=-0.221;R^(2)=0.113;P=0.020 andβ=-0.268;R^(2)=0.071;P=0.007,respectively).Vigorous-intensity and overall PA were negatively associated with FT4(β=-0.227;R^(2)=0.052;P=0.022 andβ=-0.204;R^(2)=0.042;P=0.041,respectively).In contrast,no associations were found between sleep parameters and thyroid ***:Lifestyle factors such as dietary intake and PA levels seems to be related to thyroid function even in young euthyroid adults.

关键词： Thyroid hormones Dietary intake Sleep Physical activity Euthyroid

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Praseodymium metal nanorods as a 5-fluorouracil carrier

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Journal of Rare Earths 2024年第7期42卷 1328-1336,I0005页

作者： Varnitha manikantan Govindaraj Sri Varalakshmi Ujma Ashapak Tamboli Archana Sumohan Pillai Aleyamma Alexander Anushka lucas Bose Allben Akash Israel V.m.V.Enoch Centre for Nanoscience and Genomics Karunya Institute of Technology and Sciences(Deemed University)Coimbatore641114Tamil NaduIndia Department of Applied Chemistry Karunya Institute of Technology and Sciences(Deemed University)Coimbatore641114Tamil NaduIndia

Interest in metal nanoparticles as nanoscale drug-carrying vehicles has been *** such an aspect,lanthanide metal nanoparticles are particularly ***,we report praseodymium nanoparticles as a novel anticancer therapeutic transporting *** material was made as a composite with the supramolecular host polymer,poly-β-*** praseodymium nanorods were characterized using standard analytical techniques,including X-ray diffraction(XRD),X-ray photoelectron spectroscopy(XPS),and thermogravimetric analysis(TGA).In addition,they were imaged using transmission electron *** nanostructures are a long rod-shaped material with 2.0±0.1μm in length and 230±10 nm in *** material shows a saturation magnetization value above 30 emu/g with a coercivity value of 130 *** nanocarrier is freighted with the drug 5-fluorouracil,and the encapsulation efficiency is 76.09%.The drug release is continuous from the nanocarrier(polymer-containing praseodymium nanoparticles)and proceeds for above 250 *** in vitro cytotoxicities of the blank nanocarrier and the 5-fluorouracil-loaded one are deduced by testing them on mCF-7 and Vero(non-cancerous)cell *** cytotoxicity on the cancerous cell lines is observed,whereas the non-cancerous cells are *** IC_(50)values on the cell lines are reported.

关键词： metal nanoparticles Praseodymium Poly-cyclodextrin Drug delivery Anticancer activity Rare earths

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Enabling low-cost decentralized power reserves adopting carbon dioxide for green methane exchange in stabilized clathrate adsorbent

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Journal of Energy Chemistry 2024年第10期97卷 438-443页

作者： lucas Hanssens maarten Houlleberghs C.Vinod Chandran Geert Watson Sambhu Radhakrishnan Pascal Van Der Voort Joeri F.m.Denayer Christine E.A.Kirschhock Johan A.martens Eric Breynaert Centre for Surface Chemistry and Catalysis-Characterization and Application Team (COK-KAT) NmR/X-Ray Platform for Convergence Research (NmRCoRe) Centre for Ordered materials Organometallics and Catalysis (COMOC) Department of Chemistry Ghent University Department of Chemical Engineering Vrije Universiteit Brussel

*** circular methane energy systems In recent decades,methane-based energy systems have rapidly gained traction across the globe because of the increasing availability of low-cost methane production ***,fossil methane... 详细信息

关键词： Long duration energy storage Green methane Carbon neutrality Confined clathrate hydrates CH4 /CO2 exchange Direct gas exchange ENERGY-STORAGE CONFINED NANOSPACE TO-mETHANE GAS mECHANISmS ADSORPTION HYDROGEN

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Different no-till grain production systems with Urochloa *** soil microbial community structure,biomass and activity in a tropical Ultisol

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Soil Ecology Letters 2024年第1期6卷 119-129页

作者： matheus Emannuel Oliveira Vieira lucas Dantas Lopes France mario Costa Viviane Talamini Edson Patto Pacheco marcelo Ferreira Fernandes PPGAGRI Universidade Federal de SergipeAv.Marechal Rondons/n-49100-000-Sao CristovaoSEBrazil Embrapa Coastal Tablelands Av Govemador Paulo Barreto de Menezesn°3250-49025-040-AracajuSEBrazil

Integrated grain cropping systems promote soil health(SH)and *** biomass and activity(mBA)and community structure(mCS)are key to *** of maize with Urochloa pastures strongly impacts mBA and *** is more sensitive than mCS to shifts in grain cropping *** under continuous Urochloa increased microbial activity and AmF *** soils are prone to *** of conservation agricultural practices is essential to improve soil health,which is influenced by soil *** this study we analyzed shifts in microbial biomass and activity(mBA)and microbial community structure(mCS)based on fatty acid methyl esthers(FAmEs)between five no-till agricultural practices:maize monoculture(mm);maize annualy intercropped with Urochloa decumbens(m/Ud);m/Ud with soybean rotation every other year(m/Ud-S);m/Ud keeping the pasture for the next two years(m/Ud-Ud-Ud);and maize intercropped with *** keeping the pasture for the next two years(m/Ur-Ur-Ur).Results indicated that mBA was affected by the inclusion of Urochloa intercropping and by rotation with *** under a longer residence time with Urochloa in the field had higherβ-glucosidase activity and soil basal respiration,indicating a greater microbial *** was less affected than mBA by the investigated cropping *** changed only in the continuous pasture systems,which were enriched in arbuscular mycorrhyzal fungi(AmF).Additionally,the continuous pasture systems had lower microbial stress ratios than the other agricultural *** sum,our study showed that utilization of Urochloa *** longer periods in no-till agricultural practices contributes to increase microbial activity,AmF abundance and decrease microbial stress *** changes are primarily beneficial for soil health.

关键词： crop-pasture integration crop rotation no-tillage soil health microbial ecology

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Dysregulated microRNAs in type 2 diabetes and breast cancer:Potential associated molecular mechanisms

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World Journal of Diabetes 2024年第6期15卷 1187-1198页

作者： Alex Cleber Improta-Caria Filipe Ferrari João lucas Penteado Gomes Paloma Brasilio Villalta Úrsula Paula RenóSoci Ricardo Stein Edilamar m Oliveira Laboratory of Biochemistry and molecular Biology of the Exercise Physical Education and Sport SchoolUniversity of São PauloSão Paulo 05508-030Brazil Graduate Program in Cardiology and Cardiovascular Sciences Federal University of Rio Grande do SulHospital de Clínicas de Porto AlegrePorto Alegre 90035003Brazil Laboratory of metabolic Disorders(Labdime) School of Applied SciencesUniversity of Campinas-UNICAMPCampinas 13484-350Brazil Departments of Internal medicine Molecular Pharmacology and PhysiologyCenter for Regenerative MedicineUSF Health Heart InstituteMorsani College of MedicineUniversity of South FloridaTampaFL 33602United States

Type 2 diabetes(T2D)is a multifaceted and heterogeneous syndrome associated with complications such as hypertension,coronary artery disease,and notably,breast cancer(BC).The connection between T2D and BC is established through processes that involve insulin resistance,inflammation and other *** this comprehension the specific cellular and molecular mechanisms linking T2D to BC,especially through microRNAs(miRNAs),remain *** are regulators of gene expression at the post-transcriptional level and have the function of regulating target genes by modulating various signaling pathways and biological ***,the signaling pathways and biological processes regulated by miRNAs that are associated with T2D and BC have not yet been *** review aims to identify dysregulated miRNAs in both T2D and BC,exploring potential signaling pathways and biological processes that collectively contribute to the development of BC.

关键词： Type 2 diabetes Breast cancer microRNAs molecular mechanisms

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Satellite-enabled enviromics to enhance crop improvement

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molecular Plant 2024年第6期17卷 848-866页

作者： Rafael T.Resende Lee Hickey Cibele H.Amaral lucas L.Peixoto Gustavo E.marcatti Yunbi Xu Universidade Federal de Goia´s(UFG) Agronomy DepartmentPlant Breeding SectorGoiania(GO)74690-900Brazil TheCROP a Precision-Breeding Startup:EnviromicsPhenomicsand GenomicsNo Zip-codeOperating VirtuallyGoiania(GO)and Sete Lagoas(MG)Brazil Queensland Alliance for Agriculture and Food Innovation The University of QueenslandBrisbaneQLDAustralia Earth Lab Cooperative Institute for Research in Environmental SciencesUniversity of Colorado BoulderBoulderCO 80303USA Environmental Data Science Innovation&Inclusion Lab Cooperative Institute for Research in Environmental SciencesUniversity of Colorado BoulderBoulderCO 80303USA Universidade Federal de Sa˜o Joa˜o del-Rei Forest Engineering DepartmentCampus Sete LagoasSete Lagoas(MG)35701-970Brazil Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China Peking University Institute of Advanced Agricultural Sciences WeifangShandong 261325China BGI Bioverse Shenzhen 518083China

Enviromics refers to the characterization of micro-and macroenvironments based on large-scale environmental *** providing genotypic recommendations with predictive extrapolation at a site-specific level,enviromics could inform plant breeding decisions across varying conditions and anticipate productivity in a changing ***-based integration of statistics,envirotyping(i.e.,determining environmental factors),and remote sensing could help unravel the complex interplay of genetics,environment,and *** support this goal,exhaustive envirotyping to generate precise environmental profiles would significantly improve predictions of genotype performance and genetic gain in ***,informatics management platforms aggregate diverse environmental datasets obtained using optical,thermal,radar,and light detection and ranging(LiDAR)sensors that capture detailed information about vegetation,surface structure,and *** wealth of information,coupled with freely available climate data,fuels innovative enviromics *** enviromics holds immense potential for breeding,a few obstacles remain,such as the need for(1)integrative methodologies to systematically collect field data to scale and expand observations across the landscape with satellite data;(2)state-of-the-art AI models for data integration,simulation,and prediction;(3)cyberinfrastructure for processing big data across scales and providing seamless interfaces to deliver forecasts to stakeholders;and(4)collaboration and data sharing among farmers,breeders,physiologists,geoinformatics experts,and programmers across research *** these challenges is essential for leveraging the full potential of big data captured by satellites to transform 21st century agriculture and crop improvement through enviromics.

关键词： envirotyping precision breeding genotype-environment interactions remote sensing predictive models enviromic information

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