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MicroRnA-630:A promising avenue for alleviating inflammation in diabetic kidney disease

World Journal of Diabetes 2024年第7期15卷 1398-1403页

作者： Javier donate-Correa Ainhoa González-Luis Jésica Díaz-Vera Juan Ramón Hernandez-Fernaud Research Unit University Hospital Nuestra Señora de Candelaria(UHNSC)Santa Cruz de Tenerife 38010Spain Department of Biochemistry MicrobiologyCell Biology and GeneticsInstituto de Tecnologías BiomédicasUniversidad de La LagunaSanta Cruz de Tenerife 38000Spain

Diabetic kidney disease(DKD)is one of the complications of diabetes,affecting millions of people *** relentless progression of this condition can lead to kidney failure,requiring life-altering interventions such as dialysis or *** evidence suggests that immunologic and inflammatory elements play an important role in initiating and perpetuating the damage inflicted on renal tissues,exacerbating the decline in organ ***-like receptors(TLRs)are a family of receptors that play a role in the activation of the innate immune system by the recognition of pathogen-associated molecular *** data from in vitro and in vivo studies have highlighted the critical role of TLRs,mainly TLR2 and TLR4,in the pathogenesis of *** the diabetic milieu,these TLRs recognize diabetic-associated molecular signals,triggering a proinflammatory cascade that initiates and perpetuates inflammation and fibrogenesis in the diabetic *** non-traditional strategies targeting TLR signaling with potential therapeutic implications in DKD have been *** of these approaches is the use of microRnAs,small non-coding RnAs that can regulate gene *** editorial comments on the results of this approach carried out in a rat model of diabetes by Wu et al,published in this issue of the World Journal of *** results of the experimental study by Wu et al shows that microRnA-630 decreased levels compared to non-diabetic ***,microRnA-630 exerted anti-inflammatory effects in the kidneys of diabetic rats through the modulation of *** findings indicate that the microRnA-630/TLR4 axis might represent a pathological mechanism of DKD and a potential therapeutic target capable of curbing the destructive inflammation characteristic of DKD.

关键词： Diabetes Diabetic kidney disease Inflammation Toll-like receptor 4 microRnA-630

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Influence of the Type of Circulatory/Ventricular Assistance in the Primary Graft Failure and Heart Transplantation Mortality

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World Journal of Cardiovascular Diseases 2019年第8期9卷 545-552页

作者： Raquel López-Vilella Ignacio J.Sánchez-Lázaro María Paz Fuset Cabanes Azucena Pajares Moncho lucía donate bertolín Ricardo Gimeno Costa Ignacio Moreno Puigdollers Luis Martínez Dolz Iratxe Zarragoikoetxea Jauregui Salvador Torregrosa Puerta Luis Almenar Bonet Heart Failure and Transplant Unit Hospital Universitario y Politécnico La FeValenciaSpain Intensive Care Department Hospital Universitario y Politécnico La FeValenciaSpain Anesthesiology Department Hospital Universitario y Politécnico La FeValenciaSpain Cardiovascular Surgery Department Hospital Universitario y Politécnico La FeValenciaSpain

OBJECTIVES: In recent years, the percentage of heart transplantation (HT) with short/medium-term assistance devices has increased. This study aims at analyzing primary graft failure and in-hospital mortality according to the type of care. MATERIAL AnD METHODS: From January 2013 to December?2017 all patients undergoing urgent HT with circulatory/ventricular assistance?were retrospectively and consecutively recruited. Combined transplants, retransplantations and pediatric transplants were excluded. The sample was divided in 10 groups according to the type of shot/medium term assistance devices. RESULTS: A total of 53 patients were recruited, 79% men, average age 49 ± 13 years. 26 patients (51%) had mechanical ventilation at the time of the HT. Primary graft failure occurred in 20 patients (38.5%), whilst it was more frequent in patients assisted with ECMO (8 patients in group 1 (45%) and 7 in group 2 (54%), p 0.5). 14 deaths (27%) were registered, whereas a higher mortality was observed in the group assisted with ECMO (6 patients in group 1 (34%) and 4 in group 2 (31%), p 0.6). Mortality was 17% in the group of non-urgent Levitronix. COnCLUSIOnS: Despite not showing statistical significance due to the low number of patients in some subgroups, hospital?mortality was high in HT patients with circulatory assistance. A trend towards a higher incidence of primary graft failure and mortality in patients assisted with ECMO was observed. The direct implantation of a centrifugal pump as a bridge to urgent transplantation could identify a subgroup with a better prognosis.

关键词： Urgent Heart Transplantation Short-Medium Term Circulatory/Ventricular Assistance Primary Graft Failure

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In vivo evaluation of additively manufacturedmulti-layered scaffold for the repair of large osteochondral defects

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Bio-Design and Manufacturing 2022年第3期5卷 481-496页

作者： Maryam Tamaddon Gordon Blunn Rongwei Tan Pan Yang Xiaodan Sun Shen-Mao Chen Jiajun Luo Ziyu Liu Ling Wang Dichen Li Ricardo donate Mario Monzón Chaozong Liu Institute of Orthopaedic and Musculoskeletal Science Royal National Orthopaedic HospitalUniversity College LondonStanmore HA74LPUK School of Pharmacy and Biomedical Sciences University of PortsmouthPortsmouth PO12DTUK Guangdong Engineering Research Center of Implantable Medical Polymer Shenzhen Lando Biomaterials Co.Ltd.Shenzhen 518107China School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China State Key Laboratory for Manufacturing System Engineering School of Mechanical EngineeringXi’an Jiaotong UniversityXi’an 710054China Departamento de Ingeniería Mecánica Grupo de Investigación en Fabricación Integrada y AvanzadaUniversidad de Las Palmas de Gran CanariaCampus Universitario de Tafira s/n35017 Las PalmasSpain

The repair of osteochondral defects is one of the major clinical challenges in ***-established osteochondral tissue engineering methods have shown promising results for the early treatment of small ***,less success has been achieved for the regeneration of large defects,which is mainly due to the mechanical environment of the joint and the heterogeneous nature of the *** this study,we developed a multi-layered osteochondral scaffold to match the heterogeneous nature of osteochondral tissue by harnessing additive manufacturing technologies and combining the established art laser sintering and material extrusion *** developed scaffold is based on a titanium and polylactic acid matrix-reinforced collagen“sandwich”composite *** microstructure and mechanical properties of the scaffold were examined,and its safety and efficacy in the repair of large osteochondral defects were tested in an ovine condyle *** 12-week in vivo evaluation period revealed extensive and significantly higher bone in-growth in the multi-layered scaffold compared with the collagen–HAp scaffold,and the achieved stable mechanical fixation provided strong support to the healing of the overlying cartilage,as demonstrated by hyaline-like cartilage *** histological examination showed that the regenerated cartilage in the multi-layer scaffold group was superior to that formed in the control *** genes such as aggrecan and collagen-II were upregulated in the scaffold and were higher than those in the control *** findings showed the safety and efficacy of the cell-free“translation-ready”osteochondral scaffold,which has the potential to be used in a one-step surgical procedure for the treatment of large osteochondral defects.

关键词： Osteochondral scaffold Large animal Additive manufacturing Porous titanium

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Translation through collaboration:practice applied in BAMOS project in in vivo testing of innovative osteochondral scaffolds

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Biomaterials Translational 2022年第2期3卷 102-104页

作者： Ricardo donate Maryam Tamaddon Viviana Ribeiro Mario Monzón J.Miguel Oliveira Chaozong Liu Departamento de Ingeniería Mecánica Grupo de Investigación en Fabricación Integrada y AvanzadaUniversidad de Las Palmas de Gran CanariaLas PalmasSpain Division of Surgery&Interventional Science University College LondonRoyal National Orthopaedic HospitalStanmoreUK B’s Research Group I3B’s-Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoBarcoGuimarãesPortugal ICVS/3B’s-PT Government Associated Laboratory BragaGuimarãesPortugal.

Osteoarthritis is the most common chronic degenerative joint disease,recognized by the World Health Organization as a public health problem that affects millions of people *** project Biomaterials and Additive Manufacturing:Osteochondral Scaffold(BAMOS)innovation applied to osteoarthritis,funded under the frame of the Horizon 2020 Research and Innovation Staff Exchanges(RISE)program,aims to delay or avoid the use of joint replacements by developing novel cost-effective osteochondral scaffold technology for early intervention of *** multidisciplinary consortium of BAMOS,formed by international leading research centres,collaborates through research and innovation staff *** project covers all the stages of the development before the clinical trials:design of scaffolds,biomaterials development,processability under additive manufacturing,in vitro test,and in vivo *** paper reports the translational practice adopted in the project in in vivo assessment of the osteochondral scaffolds developed.

关键词： bone cartilage in vivo evaluation regenerative medicine tissue engineering

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Comparison of ultrashort pulse ablation of gold in air and water by time-resolved experiments

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Light(Science & Applications) 2022年第4期11卷 615-627页

作者： Maximilian Spellauge Carlos donate-Buendia Stephan Barcikowski Bilal Gokce Heinz P.Huber Department of Applied Sciences and Mechatronics Munich University of Applied SciencesLothstraBe 3480335 MunichGermany Technical Chemistry I and Center for nanointegration Duisburg-Essen(CEnIDE) University of Duisburg-Essen45141 EssenGermany Materials Science and Additive Manufacturing School of Mechanical Engineering and Safety EngineeringUniversity of Wuppertal42119 WuppertalGermany

Laser ablation in liquids is a highly interdisciplinary method at the intersection of physics and chemistry that offers the unique opportunity to generate surfaaant-free and stable nanoparticles from virtually any *** the last decades,numerous experimental and computational studies aimed to reveal the transient processes governing laser ablation in *** experimental studies investigated the involved processes on timescales ranging from nanoseconds to ***,the ablation dynamics occurring on a sub-nanosecond timescale are of fundamental importance,as the conditions under which nanoparticles are generated are established within this ***,experimental investigations of the early timescales are required to test computational *** visualize the complete spatiotemporal picosecond laser-induced ablation dynamics of gold immersed in air and water using ultrafast pump-probe *** reflectivity measurements reveal that the water confinement layer significantly influences the ablation dynamics on the entire investigated timescale from picoseconds to *** influence of the water confinement layer includes the electron injection and subsequent formation of a dense plasma on a picosecond timescale,the confinement of ablation products within hundreds of picoseconds,and the generation of a cavitation bubble on a nanosecond ***,we are able to locate the temporal appearance of secondary nanoparticles at about 600 ps after pulse *** results support computational predictions and provide valuable insight into the early-stage ablation dynamics governing laser ablation in liquids.

关键词： pulse ultrashort pump

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Characterizing bubble interaction effects in synchronous-double-pulse laser ablation for enhanced nanoparticle synthesis

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Photonics Research 2023年第12期11卷 2054-2071页

作者： FARBOD RIAHI ALEXAnDER BUßMAnn CARLOS donate-BUEnDIA STEFAn ADAMI nICOLAUS AADAMS STEPHAn BARCIKOWSKI BILAL GOKCE Chair of Materials Science and Additive Manufacturing School of Mechanical Engineering and Safety EngineeringUniversity of Wuppertal42119 WuppertalGermany Chair of Aerodynamics and Fluid Mechanics School of Engineering and DesignTechnical University of Munich85748 Garching bei MünchenGermany Munich Institute of Integrated Materials Energyand Process Engineering(MEP)Technical University of Munich85748 Garching bei MünchenGermany Technical Chemistry I and Center for nanointegration Duisburg-Essen(CEnIDE) University of Duisburg-Essen45141 EssenGermany

To further advance nanomaterial applications and reduce waste production during synthesis,greener and sustainable production methods are *** laser ablation in liquid(PLAL)is a green technique that enables the synthesis of *** study uses synchronous-double-pulse PLAL to understand bubble interaction effects on the nanoparticle *** adjusting the lateral separation of the pulses relative to the maximum bubble size,an inter-pulse separation is identified where the nanoparticle size is *** cavitation bubble pair interaction is recorded using a unique coaxial diffuse shadowgraphy *** system allows us to record the bubble pair interaction from the top and side,enabling the identification of the bubble’s morphology,lifetime,volumetric,and displacement *** is found that the collision and collapse of the bubbles generated at a certain inter-pulse separation results in a larger nanoparticle *** results mark a significant advancement by controlling the abundance of larger nanoparticles in PLAL,where previous efforts were primarily focused on reducing the average nanoparticle *** experimentally observed trends are confirmed by numerical simulations with high spatial and temporal *** study serves as a starting point to bridge the gap between upscaled multi-bubble practices and fundamental knowledge concerning the determinants that define the final nanoparticle size.

关键词： interaction synthesis bubble

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Functionally graded additive manufacturing to achieve functionality specifications of osteochondral scaffolds

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Bio-Design and Manufacturing 2018年第1期1卷 69-75页

作者： Mario Monzon Chaozong Liu Sara Ajami Miguel Oliveira Ricardo donate Viviana Ribeiro Rui L. Reis Departamento de Ingenieria Mecanica Universidad de Las Palmas de Gran Canaria Edificio de fabricacion integrada 35017 Las Palmas de GC Spain Division of Surgery and Interventional Science University College London Stanmore London HA7 4LP UK 3Bs Biomaterials Biodegradables and Biomimetics Universidade Do Minho Parque de Ciencia e Tecnologia Zona Industrial da Gandra 4805-17 Barco GMR Portugal Integrated and Advanced Manufacturing Processes Research Group Universidad de Las PaJmas de Gran Canaria Edificio de fabricacion integrada 35017 Las Palmas de GC Spain

IntroductionOsteoarthritis (OA) is a degenerative joint disease,characterized by cartilage loss and changes in bone at the interface of a joint resulting in pain,stiffness and reduced *** is one of the most prevalent chronic conditions as identified in Bone and Joint *** to the World Health Organization,40％ of people over the age of 70 have *** joint disease affects around 0.4 billion people with patients in Europe accounting for up to 30％.The figure is set to increase with the ageing problem.

关键词：骨性关节炎疾病治疗方法生物技术

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Implications of Klotho in vascular health and disease

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World Journal of Cardiology 2014年第12期6卷 1262-1269页

作者： Ernesto Martín-núez Javier donate-Correa Mercedes Muros-de-Fuentes Carmen Mora-Fernández Juan F navarro-González Research Unit University Hospital Nuestra Se?ora de Candelaria 38010 Santa Cruz de Tenerife Spain Clinical Analysis Service and Research Unit University Hospital Nuestra Se ora de Candelaria 38010 Santa Cruz de Tenerife Spain nephrology Service and Research Unit University Hospital Nuestra Se ora de Candelaria 38010 Santa Cruz de Tenerife Spain

Cardiovascular disease(CVD) is a prevalent condition in general population and the first cause of death overall. Klotho, a pleiotropic protein related to longevity that acts as a co-receptor of the fibroblast growth factor 23, has been proposed as a key regulator of the development of CVD. In the few clinical studies made, it has been observed a relationship between low levels of soluble Klotho and the occurrence and severity of CVD, as well as a reduction of cardiovascular risk when they are high. Also, different polymorphisms of human Klotho gene have been related to the incidence of cardiovascular events. Moreover, several experimental studies indicate that this protein acts in the maintenance of vascular homeostasis. Klotho improves endothelial dysfunction through promotion of nO production and mediates antiinflammatory and anti-aging effects such as suppression of adhesion molecules expression, attenuation of nuclear factor-kappa B or inhibition of Wnt signaling. Furthermore,this protein is related to the attenuation of vascular calcification as well as prevention of cardiac hypertrophy. The expression of this protein in the vascular wall implies a new scenario for the treatment of vascular disorders. The purpose of this review is to provide an overview of the relationship between the Klotho protein and CVD, in addition to its role in the maintenance of functional vascular integrity.

关键词： maintenance cardiovascular hypertrophy homeostasis suppression severity prevalent overview attenuation scenario

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Molecular Microbial Diagnostic in Lung Transplant Recipients

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Journal of Cancer Therapy 2012年第5期3卷 511-520页

作者： Sebastián Méndez-álvarez Gerardo Pulido-Reyes Javier donate-Correa Arturo Soriano Benítez de Lugo General Surgery Service Hospital Universitario Ntra. Sra. de Candelaria Santa Cruz de Tenerife Spain. Research Unit Hospital Universitario Ntra. Sra. de Candelaria Santa Cruz de Tenerife Spain

The appearing of microbial lineages carrying multiple dangerous loci are results from the extensive use of antibiotics and has brought a huge increase in the infections-derived morbidity and mortality, which is critical in the hospital setting. Etiologic agents of these non easily tractable infections include bacteria, such as the genus Staphylococcus, but also fungi and virus. Alterations in the immune system allow these organisms to invade and affect the functionality of any tissue, organ or system of the human being. Pulmonary infection occurs as result of deficient lung systemic defence mechanisms which could be altered by medical treatments or by environmental factors. The infective agents commonly gain access to the lung by air, but also by blood or lymphatic system. Staphylococcus aureus strains that share antibiotic resistance and virulence factors represent the aetiological agent responsible of many cases of bacterial pneumonia, thoracic surgery postoperative infections, and diverse tissue infections, resulting in significant disease and morbidity in recipient patients after lung transplantation. The control and treatment of Staphylococcus infections, especially methicillin resistant strains, need for developing reliable and rapid methods of detection and characterization of these microorganisms. nowadays, new insights into the diagnostic and epidemiology of MRSA and other pathogenic staphylococci have been developed employing molecular methods. This has meant an important advance in the diagnostic and treatment plans of such infective bacteria.

关键词： Molecular Microbial Diagnostic Lung Transplant Recipients

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高山上的小邮局

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2018年

作者： (西)安赫莱斯·多尼亚特(Angeles donate)

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