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Effects of the level and source of dietary physically effective fiber on feed intake,nutrient utilization,heat energy,ruminal fermentation,and milk production by Alpine goats

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Animal Nutrition 2024年第2期17卷 312-324页

作者： Raquel V.Lourencon Amlan K.patra luana p.s.ribeiro Ryszard puchala Wei Wang Terry A.Gipson Arthur L.Goetsch American Institute for Goat Research Langston UniversityLangstonOK73050USA

Thirty-two primiparous and 31 multiparous Alpine goats were used to determine influences of diets varying in level and source of forage on performance in early to mid-lactation for 16 *** consisted of 40%,50%,60%,and 70%forage(designated as 40F,50F,60F,and 70F,respectively)with 60F and 70F containing coarsely ground grass hay(primarily orchardgrass)and 40F and 50F containing cottonseed hulls,alfalfa pellets,and coarsely ground wheat *** contained 15.9%to 16.3%crude protein and 37.8%,42.1%,53.5%,and 55.4%neutral detergent fiber(NDF)with 10.0%,15.8%,50.1%,and 55.5%particle retention on a 19-mm sieve,and 26.1%,29.6%,38.3%,and 40.0%physically effective NDF(peNDF)for 40F,50F,60F,and 70F,*** matter intake(2.71,2.75,1.96,and 1.95 kg/d)and milk yield(2.82,2.71,2.23,and 2.10 kg/d for 40F,50F,60F,and 70F,respectively)were lower(ps highest in *** of organic matter was similar among diets(p>0.05),but digestibility of NDF was greater(pspectively).Diet affected(pprotein concentrations(2.62%,2.69%,2.58%,and 2.52%for 40F,50F,60F,and 70F,respectively).Milk energy yield was greater(ps lowest in forage(7.51,7.45,5.68,and 5.34 MJ/d),although yield relative to dry matter intake was not affected(p>0.05)by diet and was lower(pprimiparous ***-arous goats(2.71 and 3.09 MJ/kg).Ruminal pH and acetate proportion were greater for 60F and 70F than for the other diets and the proportion of butyrate was lower for the two diets highest in *** mean lengths of time spent ruminating,eating,standing,and lying were not affected(p>0.05)by diet or parity,but many interactions involving diet,period,hour,and parity were significant(psion,lactational performance of Alpine goats in early to mid-lactation will be constrained with diets high in forage of moderate quality,peN

关键词： physically effective fiber Alpine goat Lactation Ruminal fermentation Feeding behavior

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Effectiveness of sub-acromial injections in rotator cuff injuries:A systematic review and meta-analysis

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World Journal of Orthopedics 2025年第2期16卷 40-54页

作者： luana Tossolini Goulart Fabio Teruo Matsunaga Joao Carlos Belloti Nicola Archetti Netto Thays sellan paim Marcel Jun sugawara Tamaoki Department of Orthopedics and Trauma Federal University of São Paulo-Paulista School of MedicineSão Paulo 04023-062Brazil

BACKGROUND sub-acromial injections are a therapeutic option for rotator cuff injuries;however,evidence regarding the most effective drug in this context is unclear,which needs to be *** To evaluate the effectiveness of various sub-acromial injections for rotator cuff *** We conducted a systematic review and pair-wise and network meta-analyses of randomized clinical trials(RCTs)comparing sub-acromial injections for rotator cuff *** interventions evaluated were hyaluronic acid(HA),platelet-rich plasma(pRp),prolotherapy,and *** outcomes of interest were pain and functional improvement,which were evaluated with standardized *** Risk of Bias 2 tool and the Grading of Recommendations,Assessment,Development and Evaluation methodology were used to assess data *** Twenty RCTs,comprising 1479 participants,were *** the short term,HA achieved the best outcomes[pain mean difference(MD)=-1.48,95%confidence interval(CI)-2.37 to-0.59;function MD=10.18,95%CI:4.96-15.41].In the medium term,HA,pRp,HA+pRp,and corticosteroids were not superior to placebo in improving *** on function,HA+pRp was superior to placebo,corticosteroids,and pRp(MD=26.72;95%CI:8.02-45.41).In the long term,HA,pRp,and corticosteroids were not superior to placebo in reducing ***,based on function,HA+pRp,pRp,and HA were superior to placebo,and HA+pRp had the best result(MD=36.64;95%CI:31.66-33.62).CONCLUsION HA provides satisfactory short-term results,while HA with pRp demonstrates functional improvement in the medium and long ***,no intervention maintained the pain-relief effect on>3-month follow-up.

关键词： Rotator cuff injuries Intralesional injection Network meta-analysis systematic review shoulder

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source identification and global implications of black carbon

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Geoscience Frontiers 2022年第1期13卷 404-416页

作者： Erika p.Blanco-Donado Ismael L.schneider paulo Artaxo Jesus Lozano-Osorio luana portz Marcos L.s.Oliveira Department of Civil and Environmental Universidad de la CostaCUCBarranquilla080002Colombia Department of Applied physics Institute of PhysicsUniversity of São PauloSP 05508-220Brazil Universidad de Lima Avenida Javier Prado Este 4600Santiago de Surco 1503Peru

Black carbon(BC)is one of the short-lived air pollutants that contributes significantly to aerosol radiative forcing and global climate *** is emitted by the incomplete combustion of fossil fuels,biofuels,and *** environments are quite complex and thus,the use of mobile jointly with fixed monitoring provides a better understanding of the dynamics of BC distribution in such *** present study addresses the measurement of BC concentration using real-time mobile and ambient monitoring in Barranquilla,an industrialized urban area of the Colombian Caribbean.A microaethalometer(MA200)and an aethalometer(AE33)were used for measuring the BC *** absorption Ångström exponent(AAE)values were determined for the study area,for identifying the BC emission *** results of the ambient sampling show that vehicle traffic emissions prevail;however,the influence of biomass burning was also *** mean ambient BC concentration was found to be 1.04±1.03μg/m^(3) and varied between 0.5 and 4.0μg/m^(3).From the mobile measurements obtained in real traffic conditions on the road,a much higher average value of 16.1±16.5μg/m^(3) was *** parts of the city showed BC concentrations higher than 20μg/m^(3).The spatial distribution of BC concentration shows that vehicle emissions and traffic jams,a consequence of road and transport infrastructure,are the factors that most affect the BC concentration.A comparison of results obtained from two aethalometers indicates that the concentrations measured by MA200 are 9%lower than those measured by *** AAE obtained was found to vary between 1.1 and 1.6,indicating vehicular emissions as the most crucial *** addition,it was observed that the BC concentration on working days was 2.5 times higher than on the weekends in the case of mobile monitoring and 1.5 times higher in the case of ambient monitoring.

关键词： Air pollution Black carbon spatial distribution source apportionment AbsorptionÅngström exponent

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Epigenetic modulators for brain cancer stem cells: Implications for anticancer treatment

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World Journal of stem Cells 2021年第7期13卷 670-684页

作者： luana Abballe Evelina Miele Department of pediatric Hematology/Oncology and Cellular and Gene Therapy Bambino GesùChildren's HospitalIRCCSRome 00165Italy

primary malignant brain tumors are a major cause of morbidity and mortality in both adults and children,with a dismal prognosis despite multimodal therapeutic *** the last years,a specific subpopulation of cells within the tumor bulk,named cancer stem cells(CsCs)or tumor-initiating cells,have been identified in brain tumors as responsible for cancer growth and disease *** features of tumor cells strongly affect treatment response,leading to the escape from conventional therapeutic approaches and subsequently causing tumor *** research efforts have focused at identifying new therapeutic strategies capable of specifically targeting CsCs in cancers by taking into consideration their complex *** epigenetic machinery plays a key role in the genesis and progression of brain tumors as well as inducing CsC reprogramming and preserving CsC ***,reverting the cancer epigenome can be considered a promising therapeutic *** main epigenetic mechanisms have been described:DNA methylation,histone modifications,and non-coding RNA,particularly *** of these mechanisms has been proven to be targetable by chemical compounds,known as epigeneticbased drugs or epidrugs,that specifically target epigenetic *** review here recent advances in the study of epigenetic modulators promoting and sustaining brain tumor stem-like *** focus on their potential role in cancer therapy.

关键词： Cancer stem cells Epigenetics Brain tumors Epigenetic drugs Histone deacetylase inhibitors DNA methyltransferase inhibitors

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Assessing spatial variability and erosion susceptibility of soils in hilly agricultural areas in southern Italy

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International soil and Water Conservation Research 2020年第4期8卷 354-362页

作者： Carmen Maria Rosskopf Erika Di Iorio luana Circelli Claudio Colombo pietro p.C.Aucelli University of Molise Department of Biosciences and Territoryc.da Fonte Lappone86090PescheISItaly University of Molise Department of AgriculturalEnvironmental and Food SciencesVia F.De Sanctis186100CampobassoCBItaly University of Napoli"parthenope" Department of Environmental SciencesCentro Direzionale Isola C/480143NapoliItaly

soil erosion is one of the main environmental problems in the Mediterranean *** problem is becoming even more important especially in Italy,in the Apennines,where severe erosive processes occur due to the action of concentrated running *** erodibility(K-Factor)of a soil,estimated using the Revised Universal soil Loss Equation(RUsLE),is a measure of its susceptibility to erosion and depends on several soil properties such as organic matter,texture and permeability and *** assess the spatial variability of soil properties and soil erodibility in hilly agricultural areas and to investigate the relationships between soil features and landscape morphodynamics,a detailed study in Molise region(southern Italy),in a small drainange basin located along its hilly Adriatic flank,was carried *** this catchment,63 topsoil samples(A horizons)were collected and 10 soil profiles,forming a catena crossing 3 land units,were *** calculated K-Factors ranges between 0.012 and 0.048 t ha h ha-1 MJ-1 mm-1 indicating a complex spatial distribution,due to the several local pedological and geomorphological factors affecting soil *** results give clear evidence about the relationships among soil characteristics,soil erodibility and landscape morpho-dynamics(land units).Comparing the soil loss rates estimated for the study area with those reported in literature,a good correspondence can be observed only for the more stable land unit,not characterized by intense erosive *** proposed methodology is suitable to highlight areas characterized by similar morphodynamics features,and comparable soil erodibility,for a more effective spatialization of K factor.

关键词： Hillslope morphodynamics RUsLE equation K factor Mediterranean region soil catena Land units

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Multi-frame and multi-dimensional historical digital cities: the Como example

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International Journal of Digital Earth 2014年第4期7卷 336-350页

作者： luana Valentini Maria Antonia Brovelli Giorgio Zamboni politecnico di Milano-polo di Como DIIARComoItaly

In this article,we present the realisation of a multi-frame and multi-dimensional WebGIs that allows users to simultaneously analyse a specific portion of the Earth taking into account the historical information,*** graphical panels have been realised:one for the usual 2D view and one for a more realistic 3D *** panels display historical maps of the city,the current orthophoto and the digital topographical *** 3D frame is based on NAsA World Wind,an open source virtual globe from where 3D buildings are shown extruding the 2D shapes using their mean *** to a specifically designed graphical user interface,it is also possible to dynamically thematise the buildings on the globe according to different criteria(*** construction time span)so that only the geometries fulfilling the request are turned *** the proposed application,a synchronisation between the two panels has been implemented,in order to maintain a constant alignment of the two *** application is also open to the time *** fact,assigning to each geometry two dates(e.g.‘year of construction’and‘year of demolition’),it is possible to dynamically view how buildings have changed over time,both in their shape and *** developments of this work will concern the possibility of implementing a city model with a higher level of detail.

关键词： web application multi-frame multi-dimensional time historical maps 3D

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In This Issue

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General psychiatry 2019年第6期32卷 293-294页

作者： Nicole J LeBlanc luana Marques Department of psychiatry Massachusetts General Hospital Boston Massachusetts USA Department of psychiatry Massachusetts General Hospital Boston Massachusetts USA Harvard Medical school Boston Massachusetts USA

Despite ongoing research on the aetiology,phenomenology and treatment of anxiety disorders,these conditions continue to afflict myriads of individuals *** estimated 11.6%of the global population meets criteria for an anxiety disorder each year,1 and individuals with anxiety disorders experience both functional impairment2 and increased risk for physical health problems.3 In addition to the personal suffering associated with anxiety disorders,these conditions lead to considerable costs for society,including medical expenditures and lost work productivity.4 Moreover,although efficacious interventions for anxiety disorders are available,many individuals do not respond to these treatments5 or struggle to access evidence-based care.6 Thus,much work remains to be done to reduce the global burden of anxiety disorders.

关键词： impairment treatment etiology

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In vitro differentiation capacity of human breastmilk stem cells:A systematic review

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World Journal of stem Cells 2019年第11期11卷 1005-1019页

作者： Camila Maria ribeiro pacheco priscila Elias Ferreira Claudia sayuri sacaki luana Alves Tannous Idiberto Jose Zotarelli-Filho Luiz Cesar Guarita-souza Katherine Athayde Teixeira de Carvalho Cell Therapy and Biotechnology in Regenerative Medicine Department Pele Pequeno Príncipe InstituteChild and Adolescent Health Research and Pequeno Príncipe FacultyCuritiba 80.240-020ParanáBrazil pUCpR-Institute of Biological and Health sciences CCBSCuritiba 80.215-901ParanáBrazil post Graduate and Continuing Education(Unipos) Department of Scientific ProductionSao Jose do Rio Preto 15.020-040Sao PauloBrazil

BACKGROUND Mesenchymal stem cells are pluripotent cells that have the ability to generate cells from a cell line or in other cell types from different tissues but from the same *** those cells have more limited differentiation capacity than embryonic stem cells,they are easily obtained from somatic tissue and can be grown in large *** characteristic of undifferentiated stem cells differentiating into different cell lines arouses strategies in regenerative medicine for the treatment of different diseases such as neurodegenerative *** To evaluate the cell differentiation capacity of human breastmilk stem cells for the three germ layers by a systematic *** The searched databases were pubMed,EMBAsE,OVID,and COCHRANE LIBRARY,published between 2007 and 2018 in the English *** were in vitro studies for analysis of the"cell differentiation potential"in the literature using the keywords“human breastmilk,”“stem cells,”and keywords combined with the Boolean operator“NOT”were used to exclude those articles that had the word“CANCER”and their respective synonyms,which were previously consulted according to medical subject heading *** 2009 guidelines were followed in this *** A total of 315 titles and abstracts of articles were *** these,21 were in common with more than one database,leaving 294 articles for *** that total,five publications met the inclusion *** analyzing the publications,it was demonstrated that human breastmilk stem cells have a high cellular plasticity,exhibiting the ability to generate cells of all three germ layers,endoderm,mesoderm,and ectoderm,demonstrating their *** cells expressed the genes,TRA-1-60/81,octamer-binding transcription factor 4,and NANOG,of which NANOG,a critical regulator for self-renewal and maintenance,was the most highly *** cells have the ability to differentiate in vitro into adipocytes,chondrocytes,osteocytes,oligod

关键词： Human breastmilk stem cells Cell differentiation pluripotency stemness

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parallel evolution of fish bi-modal breathing and expansion of olfactory receptor(OR)genes:toward a universal ORs nomenclature

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Journal of Genetics and Genomics 2023年第8期50卷 600-610页

作者： Liliana silva Tito Mendes luana Ramos Guojie Zhang Agostinho Antunes CIIMAR/CIMAR Interdisciplinary Centre of Marine and Environmental ResearchUniversity of PortoTerminal de Cruzeiros do Porto de LeixõesAv.General Norton de Matoss/n4450-208PortoPortugal Department of Biology Faculty of SciencesUniversity of PortoRua do Campo Alegre4169-007PortoPortugal Villum Centre for Biodiversity Genomics Section for Ecology and EvolutionDepartment of BiologyUniversity of CopenhagenDK-2100 CopenhagenDenmark BGI-shenzhen Beishan Industrial ZoneShenzhenGuangdong 518083China state Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China

Olfactory receptors(ORs)play a key role in the prime sensorial perception,being highly relevant for intra/interspecific *** are a subgroup of G-protein coupled receptors that exhibit highly complex subgenomes in ***,OR repertoires remain poorly studied in fish lineages,precluding finely retracing their origin,evolution,and diversification,especially in the most basal ***,we conduct an exhaustive gene screening upon 43 high-quality fish genomes exhibiting varied gene repertoires(2e583 genes).While the early vertebrates performed gas exchange through gills,we hypothesize that the emergence of new breathing structures(swim bladder and paired lungs)in early osteichthyans may be associated with expansions in the ORs gene families sensitive to airborne ***,we verify that the OR repertoire of moderns actinopterygians has not increased as expected following a whole genome duplication,likely due to regulatory mechanisms compensating the gene load ***,we identify 25 distinct OR families,allowing us to propose an updated universal nomenclature for the fish ORs.

关键词： Fish OR repertoires Updated ORs nomenclature ORs expansion Bi-modal breathing WGD and ORs diversification

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Evaluation of the WRF Weather Forecasts over the southern Region of Brazil

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American Journal of Climate Change 2016年第1期5卷 103-115页

作者： luana ribeiro Macedo João Luiz Martins Basso Yoshihiro Yamasaki Atmospheric sciences Geophysics and Astronomy Institute University of S&#227 o paulo S&#227 o paulo Brazil Faculty of Meteorology Federal University of Pelotas Rio Grande do Sul Brazil

The data assimilation technique, known as 3DVAR, of the WRF mesoscale modeling system has been used in order to perform the impact analysis of meteorological data assimilation in the weather forecasts over the Rio Grande do sul state in Brazil. The consistency of the data assimilation has been analyzed by investigating and evaluating the model forecast results processed with and without data assimilations. Two different procedures of data assimilation have been conducted to perform the study. The forecasts of the accumulated rainfall model variable, spatially plotted over the model integration domains, have been compared and validated against the Tropical Rain Measuring Mission (TRMM) satellite based data, as well as with the Canguçu city meteorological radar reflectivity data. The comparison has been made considering the total amount of the accumulated rainfall predicted by the model against the automatic weather station data and most of the conducted processing presented compatible results. It has also been observed that, the inclusion of assimilated data enabled an improvement in the intensity as well as in the location of the main convective cell. The radar reflectivity field showed a significant performance in all processed experiments with data assimilation. However, for some regions, more significant obtained results have been shown to be the case in which the spectral radiances were assimilated, as compared with the case in which the spectral radiances were not included. The evaluation of the vertical atmospheric profiles of temperature and dew point temperature showed only a small impact of data assimilation. However, both simulations coherently presented the two vertical profiles, when compared with the observed profiles. In short, the study shows that, although the forecasts presented some inconsistencies in the evaluated results, the 3DVAR assimilation improves significantly the forecasting of the Weather WRF model.

关键词： Data Assimilation 3DVAR Tropical Rainfall Measuring Mission WRF Radiances

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