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stem Cell-Based Hair Cell Regeneration and Therapy in the Inner Ear

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Neuroscience Bulletin 2024年第1期40卷 113-126页

作者： Jieyu Qi Wenjuan Huang Yicheng lu Xuehan Yang Yinyi Zhou Tian Chen Xiaohan Wang Yafeng Yu Jia-Qiang sun Renjie Chai state Key Laboratory of Digital Medical Engineering Department of Otolaryngology Head and Neck SurgeryZhongda HospitalSchool of Life Sciences and TechnologyAdvanced Institute for Life and HealthJiangsu Province High-Tech Key Laboratory for Bio-Medical ResearchSoutheast UniversityNanjing 210096China Hospital of southeast University Nanjing 210096China First Affiliated Hospital of soochow University Suzhou 215006China Department of Otolaryngology-Head and Neck surgery The First Affliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Department of Otolaryngology Head and Neck surgery Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China Co-Innovation Center of Neuroregeneration Nantong UniversityNantong 226001China Institute for stem Cell and Regeneration Chinese Academy of ScienceBeijing 100101China

Hearing loss has become increasingly prevalent and causes considerable disability,thus gravely burdening the global *** loss of hair cells is a main cause of sensorineural hearing loss,and currently,the only relatively effective clinical treatments are limited to digital hearing equipment like cochlear implants and hearing aids,but these are of limited benefit in *** is therefore urgent to understand the mechanisms of damage repair in order to develop new neuroprotective *** present,how to promote the regeneration of functional hair cells is a key scientific question in the field of hearing ***-ple signaling pathways and transcriptional factors trigger the activation of hair cell progenitors and ensure the maturation of newborn hair cells,and in this article,we first review the principal mechanisms underlying hair cell *** then further discuss therapeutic strategies involving the co-regulation of multiple signaling pathways in order to induce effective functional hair cell regeneration after degeneration,and we summarize current achievements in hair cell ***,we discuss potential future approaches,such as small molecule drugs and gene therapy,which might be applied for regenerating functional hair cells in the clinic.

关键词： Hearing loss Cochlea-stem cell Hair cell regeneration

基于元分析的我国上市公司股权激励对企业财务绩效的影响研究

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西北师大学报（社会科学版） 2024年第2期61卷 127-137页

作者：赵雪梅卢洁妤西北师范大学商学院甘肃兰州730070 甘肃省社会科学院甘肃兰州730070

随着股权激励制度的不断发展,关于我国上市公司如何进行股权激励的话题引起学者们的重视,然而用传统的分析方法对中国情境下股权激励与企业财务绩效关系的研究,至今尚未得出一致结论。鉴于此,本研究使用元分析(Meta analysis)方法,对股... 详细信息

随着股权激励制度的不断发展,关于我国上市公司如何进行股权激励的话题引起学者们的重视,然而用传统的分析方法对中国情境下股权激励与企业财务绩效关系的研究,至今尚未得出一致结论。鉴于此,本研究使用元分析(Meta analysis)方法,对股权激励水平与企业财务绩效关系的60篇文献样本,174个效应值,以及股权激励模式与企业财务绩效关系的27篇文献样本,90个效应值进行定量统计分析,以此得出关于股权激励与企业财务绩效关系的阶段性定论。研究结果表明:(1)股权激励水平能够显著提升企业财务绩效;(2)分别实施股票期权与限制性股票的模式均对企业财务绩效有显著的正向影响,且股票期权的激励效果要优于限制性股票;(3)情境调节因素(股权激励的模式、企业上市板块)和方法调节因素(企业财务绩效测量指标、数据类型)能够对股权激励水平与企业财务绩效关系产生显著的调节作用,而企业性质对二者关系不具有调节作用。从更加宏观的视角阐述股权激励与企业财务绩效关系的内在机制,探究可能导致研究结论存在不一致性的潜在调节因素,以期为未来研究提供参考,并为我国上市企业建立更加有效的股权激励制度提供建议。

关键词：股权激励水平股权激励模式企业财务绩效元分析调节效应

Evaluation of Interferon-Gamma Release Assay Testing and Tuberculin skin Test for Early Diagnosis of Tuberculosis in Children and Adolescents

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Open Journal of Pediatrics 2024年第3期14卷 558-567页

作者： Yelda sorguç Miray Çelebi Yılmaz Yüce Ayhan Yakup Yaman Şener Tulumoğlu Aybüke Akaslan Kara İlker Devrim University of Health sciences Dr. Beh&#231et Uz Child Disease and Pediatric Surgery Training and Research Hospital Medical Microbiology &#304zmir T&#252rkiye Department of Pediatric Infectious Diseases University of Health Sciences Dr. Beh&#231et Uz Child Disease and Pediatric Surgery Training and Research Hospital &#304zmir T&#252rkiye

Background: This study aimed to evaluate the diagnostic value of interferon-γ release assay (IGRA), a sensitive microbiological diagnostic method, in children and adolescents with suspected tuberculosis in a country with a high burden of tuberculosis. Method: This study included 581 children and adolescents aged 4 - 19 years who were suspected of having tuberculosis, were latently infected with Mycobacterium tuberculosis, and had received at least one dose of BCG vaccine between April 17, 2019, and February 24, 2021. The study evaluated the TsT results of 106 patients who had a positive Quantiferon test and were suspected of having tuberculosis. Results: The study included 581 patients aged between 4 and 19 years. Of these, 106 patients tested positive for the Quantiferon test, while 19 were indeterminate and 456 were negative. The Quantiferon test positivity rate was 18.24%. Among the 106 QFT-Plus-positive cases, 23 patients also tested positive for TsT. The difference in distribution was found to be statistically significant. Conclusion: The QFT-Plus test is considered an alternative to TsT and other microbiological diagnostic methods for early tuberculosis diagnosis, particularly in children and adolescents.

关键词： Interferon Gamma Release Assay Children Tuberculin Test Children Latent Tuberculosis

Bioactive compounds of red grapes from Dao region(Portugal):Evaluation of phenolic and organic profile

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Asian Pacific Journal of Tropical Biomedicine 2016年第4期6卷 315-321页

作者： lu.s Rodrigues silva Mafalda Queiroz Health sciences Research Centre Faculty of Health sciences University of Beira Interior Department of Chemical Engineering Faculty of EngineeringUniversity of Porto Polytechnic Institute of Castelo Branco School of Health Dr.Lopes Dias Laboratory of Pharmacognosy Department of ChemistryFaculty of PharmacyUniversity of Porto

Objective:To improve the knowledge on the metabolite profile of five red grapes from D?o region(Portugal),concerning to the phenolic characteristics(coloured and non-coloured phenolics) and organic acid ***:Five red grapes collected from D?o region were *** profiles of phenolic compounds and organic acids were estimated by high-performance liquid chromatography with diode-array detection and high-performance liquid chromatography with UV detector,***:Totally 24 phenolic compounds were identified,and distributed by several classes:8 anthocyanins,1 hydroxybenzoic acid,4 hydroxycinnamic acids,1 stilbene,4flavan-3-ols,6 ***,10 organic acids were detected in all *** contents of each phenolic class and organic acids amounts varied significantly among the different grape cultivars *** principal components analysis differentiates the Touriga Nacional from the other varieties due to their high contents in anthocyanins,non-coloured phenolics and organic *** Nacional is an important red grape cultivar,highly esteemed in D?o region for its ability to produce high quality ***:The results suggest that the red grapes from D?o region present a good composition in bioactive compounds,being important for the production of wines with superior quality.

关键词： Vitis vinifera Grapes Dao region Phenolics Organic acids

Beyond clinical trials:CDK4/6 inhibitor efficacy predictors and nomogram model from real‐world evidence in metastatic breast cancer

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Cancer Innovation 2024年第6期3卷 58-75页

作者： Binliang Liu Zhe‐Yu Hu Ning Xie Liping Liu Jing Li Xiaohong Yang Huawu Xiao Xuran Zhao Can Tian Hui Wu Jun lu Jianxiang Gao Xuming Hu Min Cao Zhengrong shui Yu Tang Quchang Ouyang Department of Breast Cancer Medical Oncology Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangshaHunanChina Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Gastroenterology The Third Xiangya Hospital of Central South UniversityChangshaHunanChina

Background:CDK4/6 inhibitors(CDK4/6i)have shown promising results in the treatment of hormone receptor‐positive(HR+)metastatic breast cancer(MBC)when combined with endocrine therapy(ET).It is crucial to evaluate the actual effectiveness and safety of CDK4/6i in clinical practice,as well as to analyze the factors that can predict their ***:Patients with HR+MBC who received CDK4/6i‐based therapy between May 2016 and May 2023 at Hunan Cancer Hospital were evaluated for progression‐free survival(PFs).Adverse reactions were assessed based on the National Cancer Institute Common Toxicity Criteria(version 5.0).Results:This study included 344 patients,with a median PFs(mPFs)of 12.8 months(range:10.4–15.2 months).After adjustment,Cox multivariate regression analysis revealed that visceral metastasis(specifically liver and brain metastases),Eastern Cooperative Oncology Group Performance status(ECOG Ps)≥1,estrogen receptor≤80%,progesterone receptor≤10%,Ki‐67>30%,and treatment in later stages were significant factors associated with reduced *** on this,we created a prognostic nomogram and validated its performance,obtaining a C‐index of 0.714(95%confidence interval:0.640–0.787)as well as reliable calibration and clinical *** mPFs of CDK4/6i rechallenge was 7.7 months;for patients who initially discontinued CDK4/6i for reasons other than disease progression,CDK4/6i rechallenge still provided a mPFs of 11.4 *** tolerability and safety of combining CDK4/6is with ET were *** events led to treatment discontinuation in 3.8%of ***(29.1%),leukopenia(13.7%),and anemia(4.1%)were the primary grade 3/4 adverse ***:This real‐world study highlights the ample efficacy and reasonable safety of combined CDK4/6i and ET in patients with HR+*** treatment decisions and ongoing safety monitoring are important to optimize the therapeutic benefit of CDK4/6i treatment.

关键词： breast cancer CDK4/6 inhibitor efficacy predictive factors real‐word study

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北极海冰与CP型厄尔尼诺事件的遥相关

海洋与湖沼 2024年第4期55卷 830-839页

作者：郑璐曦刘海龙上海交通大学海洋学院上海200030 中国极地研究中心上海200136 中国极地研究中心、自然资源部极地科学重点实验室上海200136

为了进一步认识高低纬度之间事件的遥相关机制,对北极海冰和中太平洋(central Pacific,CP)型厄尔尼诺现象的相互关系进行了深入研究。首先利用最新的观测和再分析数据,验证了北极冷季海冰损失可以引发次年的类CP型厄尔尼诺增暖现象及相... 详细信息

为了进一步认识高低纬度之间事件的遥相关机制,对北极海冰和中太平洋(central Pacific,CP)型厄尔尼诺现象的相互关系进行了深入研究。首先利用最新的观测和再分析数据,验证了北极冷季海冰损失可以引发次年的类CP型厄尔尼诺增暖现象及相应的副热带北太平洋海气耦合机制,阐明北极海冰异常引起春末夏初的北太平洋气压异常,进而导致热带太平洋海温增加和西风异常,最终在冬季发生类CP型厄尔尼诺现象的变暖。依据前人对CP型厄尔尼诺发展年夏季的研究思路,研究结果显示,在CP型厄尔尼诺发展年冷季,加拿大盆地海冰显著减少导致北极海冰范围总体出现异常低值,但在巴伦支海北部因风场作用海冰异常增加。同时揭示了在CP型厄尔尼诺衰退年,暖季北极海冰显著损失,海表面净热通量显著增加以及海表面风和海冰运动等动力效应有助于拉普捷夫海海冰的损失,北极海冰和CP型厄尔尼诺相互关系的理论得到了一定的完善。

关键词：北极海冰中太平洋型厄尔尼诺海表面净热通量海表面风海冰运动

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女性原发性尿道弥漫大B细胞淋巴瘤1例报告

中华泌尿外科杂志 2024年第9期45卷 714-715页

作者：方杨毅黄志高洪鹏陆敏洪锴卢剑北京大学第三医院泌尿外科北京100191 北京大学第三医院病理科北京100191

原发于泌尿生殖道的恶性淋巴瘤少见,下尿路的原发性恶性淋巴瘤更为罕见,本文报道1例女性原发性尿道弥漫大B细胞淋巴瘤。患者进行性排尿困难,超声提示尿道内口突入膀胱,内见少量血流信号。遂行经尿道膀胱颈部肿物切除术,术后病理确诊弥... 详细信息

原发于泌尿生殖道的恶性淋巴瘤少见,下尿路的原发性恶性淋巴瘤更为罕见,本文报道1例女性原发性尿道弥漫大B细胞淋巴瘤。患者进行性排尿困难,超声提示尿道内口突入膀胱,内见少量血流信号。遂行经尿道膀胱颈部肿物切除术,术后病理确诊弥漫性大B细胞淋巴瘤,非特指型。术后接受4个疗程R-CHOP方案化疗。术后随访6个月,患者排尿症状缓解,未见复发和转移。

关键词：尿道肿瘤淋巴瘤,非霍奇金弥漫大B细胞淋巴瘤原发

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公共空间公共性的理论研究与分析框架构建

国际城市规划 2024年第3期39卷 82-90页

作者：蒋敏中岛直人卢峰重庆大学建筑城规学院东京大学工学部都市工学系

当前公共空间建设、管理和运营过程中日益多样的参与主体和灵活的合作模式拓展了公共空间的内涵与边界,这种转变带来一种区别于公私二元对立的新视角。在这样的背景下,将公共性视为一种价值和愿景而非“私”的对立面,从更本质的角度理... 详细信息

当前公共空间建设、管理和运营过程中日益多样的参与主体和灵活的合作模式拓展了公共空间的内涵与边界,这种转变带来一种区别于公私二元对立的新视角。在这样的背景下,将公共性视为一种价值和愿景而非“私”的对立面,从更本质的角度理解公共性的内涵有助于为复杂的利益博弈和权利平衡提供一种价值参照。本文通过研究西方代表性文献,分析了公私二元对立关系的瓦解过程,将公共性的核心价值总结为公开性、异质性和共同性,进而分析了公共空间公共性的价值。在此基础上,受现象学和新行为主义心理学的启发,本文提出将公共空间公共性视为一种主观感知的研究思路,继而融合公共空间的客观特征和使用人群的主观感知构建了一种新的公共空间公共性分析框架,规避了公私的二元对立,实现了评价主体的转变,且有助于反映文脉特征和地域差异,为公共空间公共性的定量研究和机制探索提供新的思路。

关键词：公共空间公共性理论研究公共性感知分析框架

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基于质谱技术的单细胞蛋白质组学

生物化学与生物物理进展 2024年第10期51卷 2705-2716页

作者：谢井盛叶子璐中国医学科学院系统医学研究院/苏州系统医学研究所重大疾病共性机制研究全国重点实验室苏州215123 苏州大学附属第二医院妇产科苏州215004

近年来,单细胞测序技术的发展极大地推动了单细胞基因组和转录组的研究。然而,直接关联单细胞生命过程的蛋白质组学研究则因技术进展缓慢而受限。随着样品前处理技术、色谱分离技术和质谱检测技术的进步,单细胞蛋白质组学(single-cell p... 详细信息

近年来,单细胞测序技术的发展极大地推动了单细胞基因组和转录组的研究。然而,直接关联单细胞生命过程的蛋白质组学研究则因技术进展缓慢而受限。随着样品前处理技术、色谱分离技术和质谱检测技术的进步,单细胞蛋白质组学(single-cell proteomics,sCP)的分析灵敏度显著提升。本综述深入回顾了sCP的发展历程及其在生命科学研究中的应用。在样品前处理方面,针对不同细胞的存在形式,研究者开发了基于声波激发、微流控芯片和激光切割等单细胞分选方法,并逐步从多步法前处理流程统一到一步法,降低了样品处理过程中的损失。在质谱技术方面,无标记定量(label-free quantification,LFQ)与基于同位素和同质素标记的方法都得到了充分的探索,各具技术优势与不足。在应用层面,sCP已在胚胎细胞早期发育、干细胞分化、肝脏组织空间异质性等方面揭示了新的生物学发现。最后,总结了当前sCP技术面临的挑战,包括检测通量、成本和数据分析的复杂性,并展望了其未来的发展方向,强调了sCP在基础研究和临床应用中的广阔前景。

关键词：单细胞蛋白质组学液相色谱质谱