检索结果-南通市图书馆

Long non-coding RNAs with essential roles in neurodegenerative disorders

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第6期19卷 1212-1220页

作者： Wandi Xiong Lin lu Jiali Li Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of sciences&Yunnan Province Kunming Institute of Zoologythe Chinese Academy of SciencesKunmingYunnan ProvinceChina Tsinghua-Peking Center for Life sciences BeijingChina National Institute on Drug Dependence Peking UniversityBeijingChina PKU/McGovern Institute for Brain Research Peking UniversityBeijingChina Institute of Mental Health National Clinical Research Center for Mental DisordersKey Laboratory of Mental Health and Peking University Sixth HospitalPeking UniversityBeijingChina

Recently,with the advent of high-resolution and high-throughput sequencing technologies,an increasing number of long non-coding RNAs(lncRNAs)have been found to be involved in the regulation of neuronal function in the central nervous system with specific spatiotemporal patterns,across different neurodegenerative ***,the underlying mechanisms of lncRNAs during neurodegeneration remain poorly *** review provides an overview of the current knowledge of the biology of lncRNAs and focuses on introducing the latest identified roles,regulatory mechanisms,and research status of lncRNAs in Alzheimer's disease,Parkinson's disease,Huntington's disease,and amyotrophic lateral ***,this review discusses the potential valu.s of lncRNAs as diagnostic biomarkers and therapeutic targets for neurodegenerative diseases,hoping to provide broader implications for developing effective treatments.

关键词： Alzheimer's disease amyotrophic lateral sclerosis biomarker Huntington's disease long non-coding RNAs neurodegenerative diseases Parkinson's disease therapy transcriptional regulation translational regulation

Navigating the safe operation of high-voltage cathodes:Challenges and strategies

在线全文

学校读者我要写书评

暂无评论

Nano Research 2024年第10期17卷 8694-8705页

作者： Yue sun Changjian Zuo Yi-Chun lu Electrochemical Energy and Interfaces Laboratory Department of Mechanical and Automation EngineeringThe Chinese University of Hong KongHong Kong 999077China

Lithium-ion batteries play a crucial role in storing energy for renewable sources and electric vehicles,yet face challenges related to insufficient energy *** the working-voltage of cathodes is promising to boost the energy density of batteries by increasing both the output voltage and capacity of cathode,which however could compromise life cycle and *** review provides a comprehensive summary of essential factors governing pathways of cathode-induced thermal runaway,including electrolyte decomposition,phase transitions,and crosstalk-induced *** and electrolyte modifications aimed at mitigating parasitic reactions and preventing crosstalk were also *** review concludes with insights into the future application of these strategies,providing a comprehensive perspective on the realization of high-energy and safe batteries.

关键词： battery safety high-voltage cathode lithium-ion battery thermal runaway

The unique spontaneous polarization property and application of ferroelectric materials in photocatalysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2024年第5期17卷 3571-3585页

作者： Jinghua An Chang Xu lu Li Bo Tang College of Chemistry Chemical Engineering and Materials ScienceKey Laboratory of Molecular and Nano ProbesMinistry of EducationCollaborative Innovation Center of Functionalized Probes for Chemical Imaging in University of ShandongInstitute of Molecular and Nano ScienceShandong Normal UniversityJinan 250014China Laoshan Laboratory 168 Wenhai Middle RdAoshanwei JimoQingdao 266237China

The unique spontaneous polarization property of ferroelectric material makes it to be a special catalyst in *** spontaneous polarization property can induce the formation of built-in electric field,which can improve the separation of photoelectrons and holes to affect photocatalytic *** internal electric field induced by spontaneous polarization can be influenced by multiple factors such as the morphology,the concentration of defect,the type of doped heteroatoms,as well as the composition of ***,the preparation method,pretreating temperature,the strength of prepolarized external electric field of ferroelectric-based photocatalysts as well as the strength of external mechanical force or external magnetic field in photocatalytic reactions can influence the photocatalytic effectivity via influencing spontaneous polarization-induced internal electric ***,it is urgently to unveil the mystery of structure-activity relationships for ferroelectric materials-based photocatalysts,which is usually *** this in mind,this review was provided for the role of various complex influencing factors on ferroelectric materials-based photocatalysis based on the latest advancement in the fields of new energy development,environmental *** the beginning,the basic structure and properties of ferroelectric material are ***,popular synthesis methods of ferroelectric-based photocatalysts are *** that,two main mechanisms of ferroelectric photocatalysis are *** research progress of ferroelectric photocatalysis is then given emphatically according to the classification of photocatalytic ***,the problems existing nowadays and the challenges facing in the future on the application of ferroelectric materials-based photocatalysts are outlined in the summary and outlook section.

关键词： spontaneous polarization photocatalysis ferroelectric separation of electrons and holes

supramolecular Biomaterials for Cancer Immunotherapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Research 2024年第2期2023卷 491-509页

作者： Huan Liang Qingqing lu Jie Yang Guocan Yu College of science Nanjing Forestry UniversityNanjing 210037P.R.China Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology Department of ChemistryTsinghua UniversityBeijing 100084P.R.China

Cancer immunotherapy has achieved tremendous successful clinical results and obtained historic victories in tumor ***,great limitations associated with feeble immune responses and serious adverse effects still cannot be neglected due to the complicated multifactorial etiology and pathologic microenvironment in *** rapid development of nanomedical science and material science has facilitated the advanced progress of engineering biomaterials to tackle critical *** supramolecular biomaterials with flexible and modular structures have exhibited unparalleled advantages of high cargo-loading efficiency,excellent biocompatibility,and diversiform immunomodulatory activity,thereby providing a powerful weapon for cancer *** past decades,supramolecular biomaterials were extensively explored as versatile delivery platforms for immunotherapeutic agents or designed to interact with the key moleculars in immune system in a precise and controllable *** this review,we focused on the crucial role of supramolecular biomaterials in the modulation of pivotal steps during tumor immunotherapy,including antigen delivery and presentation,T lymphocyte activation,tumor-associated macrophage elimination and repolarization,and myeloid-derived suppressor cell *** on extensive research,we explored the current limitations and development prospects of supramolecular biomaterials in cancer immunotherapy.

关键词： biomaterials limitations thereby

Morphological and sulfur-Isotopic Characteristics of Pyrites in the Deep sediments from Xisha Trough,south China sea

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Ocean University of China 2024年第1期23卷 138-148页

作者： CHANG Jingyi LIU Yujia lu Hailong lu Jing’an sU Xin YE Jianliang XIE Wenwei College of Engineering Peking UniversityBeijing 100871China Beijing International Center for Gas Hydrate School of Earth and Planetary SciencesPeking UniversityBeijing 100871China school of Marine science Nanjing University of Information Science and TechnologyNanjing 210044China MLR Key Laboratory of Marine Mineral Resources Guangzhou Marine Geological SurveyMinistry of Land and ResourcesGuangzhou 510075China school of Ocean sciences China University of GeosciencesBeijing 100083China

Pyrite is one of the common authigenic minerals in marine *** studies have shown that the morphological and isotopic characteristics of pyrite are closely related to the geochemical environment where it is *** better understand the for-mation mechanism of authigenic pyrite,we analyzed the isotopic composition,morphology,and distribution of pyrite in the sediment at 500m below the seafloor from Xisha Trough,south China *** morphologies were observed by scanning electron micros-copy and Raman spectrography.X-Ray computed tomography was applied to measure the particle size of *** size of pyrite crystals in the matrix sediment mainly ranged between 25 and 65µm(***.40µm),although crystals were larger(***.50μm)in the *** pyrites had a fine-grained truncated octahedral shape with occasionally well-developed growth steps,which implies the low growth rate and weak anaerobic oxidation of methane-sulfate reduction when pyrite was ***δ^(34)s valu.s of pyrites ranged from+20.8‰Vienna-defined Canyon Diablo Troilite(V-CDT)to+33.2‰V-CDT and from+44.8‰V-CDT to+48.9‰,which suggest two growth *** the first stage,with the continuous low methane flux,the pyrite possibly formed in an environment with good access to *** the second stage,the pyrites mainly developed in sediment fractures and appeared in veins,probably due to the limited availability of *** less exposure of pyrite to the environment in the second stage was probably caused by sediment accumulation or *** this study,an episodic pyritization process was identified,and the paleoenvironment was reconstructed for the sediment investigated.

关键词： pyrite sulfur isotope AOM methane flux Xisha Trough south China sea

Lacticaseibacillus rhamnosus Fmb14 ameliorates hyperuricemia-induced hepatocyte pyroptosis via NLRP3 inflammasome cascade inhibition

在线全文

学校读者我要写书评

暂无评论

Food science and Human Wellness 2024年第4期13卷 2174-2186页

作者： Hongyuan Zhao Xiaoyu Chen Li Zhang Fanqiang Meng Libang Zhou Zhaoxin lu Yingjian lu College of Food science&Technology Nanjing Agricultural UniversityNanjing 210095China Institute of Vegetable Gansu Academy of Agricultural SciencesLanzhou 730070China College of Food science&Engineering Nanjing University of Finance and EconomicsNanjing 210023China

Hyperuricemia is a high-risk factor for the development of gout and renal fibrosis,but the adverse effects of hyperuricemia on the liver have been seriously *** research investigated the ameliorating effect of Lacticaseibacillus rhamnosus Fmb14 on hyperuricemia induced liver dysfunction both in vitro and in *** free extracts of high dose *** Fmb14 treatment reduced the death rate of HepG2 cell lines from 24.1%to 14.9%by inhibiting NLRP3 recruitment,which was mainly activated by reactive oxygen species release and mitochondrial membrane potential *** purine dietary induced hyperuricemia(PDIH)mice model,liver oedema and pyroptosis were ameliorated after *** Fmb14 administration through downregulating the expression levels of NLRP3,caspase-1 and gasdermin-D from 1.61 to 0.86,3.15 to 1.01 and 5.63 to 2.02,*** Fmb14 administration restored mitochondrial inner membrane protein(MPV17)and connexin 43 from 2.83 and 0.73 to 0.80 and 0.98 respectively in PDIH mice,indicating that dysbiosis of mitochondrial membrane potential was restored in ***,PDIH pyroptosis stimulates the process of apoptosis,which leads to severe leakage of hepatocytes,and both of pyroptosis and apoptosis were decreased after *** Fmb14 ***,*** Fmb14 is a promising biological resource to maintain homeostasis of the liver in hyperuricemia and the prevention of subsequent complications.

关键词： Lacticaseibacillus rhamnosus Fmb14 Hyperuricemia Pyroptosis NLRP3 pathway

A NONLOCAL KRONECKER-BAsIs-REPREsENTATION METHOD FOR LOW-DOsE CT sINOGRAM RECOVERY

在线全文

学校读者我要写书评

暂无评论

Journal of Computational Mathematics 2024年第4期42卷 1080-1108页

作者： Jian lu Huaxuan Hu Yuru Zou Zhaosong lu Xiaoxia Liu Keke Zu Lin Li shenzhen Key Laboratory of Advanced Machine Learning and Applications College of Mathematics and StatisticsShenzhen UniversityShenzhen 518060China National Center for Applied Mathematics shenzhen(NCAMs) Shenzhen 518055China Department of Industrial and systems Engineering University of Minnesota Twin CitiesMinneapolisMN55455USA Department of Applied Mathematics The Hong Kong Polytechnic UniversityHong Kong SARChina school of Electronic Engineering Xidian UniversityXi'an 710071China

Low-dose computed tomography(LDCT)contains the mixed noise of Poisson and Gaus-sian,which makes the image reconstruction a challenging *** order to describe the statistical characteristics of the mixed noise,we adopt the sinogram preprocessing as a stan-dard maximum a posteriori(MAP).Based on the fact that the sinogram of LDCT has non-local self-similarity property,it exhibits low-rank *** conventional way of solving the low-rank problem is implemented in matrix forms,and ignores the correlations among similar patch *** avoid this issue,we make use of a nonlocal Kronecker-Basis-Representation(KBR)method to depict the low-rank problem.A new denoising model,which consists of the sinogram preprocessing for data fidelity and the nonlocal KBR term,is developed in this *** proposed denoising model can better illustrate the generative mechanism of the mixed noise and the prior knowledge of the ***-merical results show that the proposed denoising model outperforms the state-of-the-art algorithms in terms of peak-signal-to-noise ratio(PsNR),feature similarity(FsIM),and normalized mean square error(NMsE).

关键词： Low-dose computed tomography Kronecker-basis-representation Low-rank imation.Noise-generating-mechanism

Different topological phase transitions in the su–schrieffer–Heeger model under different disorder structures

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics B 2024年第9期33卷 217-221页

作者： Yan Gu Zhanpeng lu shanxi Vocational University of Engineering science and Technology Jinzhong 030619China Institute of Theoretical Physics and state Key Laboratory of Quantum Optics and Quantum Optics Devices Shanxi UniversityTaiyuan 030006China

We investigate the topological phase transition in the su–schrieffer–Heeger model with the long-range hopping and quasi-periodic *** numerically calculating the real-space winding number,we obtain topological phase diagrams for different disordered *** diagrams suggest that topological phase transitions are different by selecting the specific disordered *** quasi-periodic modulation is applied to intracell hopping,the resulting disorder induces topological Anderson insulator(TAI)phase with high winding number(W=2),but the topological states are destroyed as the disorder ***,when intercell hoppings are modulated quasi-periodically,both TAI phase and the process of destruction and restoration of topological zero modes can be induced by *** topological states remain robust even under strong disorder *** work demonstrates that disorder effects do not always disrupt topological states;rather,with a judicious selection of disordered structures,topological properties can be preserved.

关键词： topological insulator quasi-periodic modulation

Analysis of thermal management and anti-mechanical abuse of multi-functional battery modules based on magneto-sensitive shear thickening fluid

在线全文

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Edition) 2024年第3期45卷 529-542页

作者： Yang XIONG Bo lu Yicheng sONG Junqian ZHANG shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai Frontier Science Center of MechanoinformaticsShanghai Institute of Applied Mathematics and MechanicsSchool of Mechanics and Engineering ScienceShanghai UniversityShanghai 200444China Zhejiang Laboratory Hangzhou 311100China

Electric vehicles(EVs)have garnered significant attention as a vital driver of economic growth and environmental ***,ensuring the safety of high-energy batteries is now a top priority that cannot be overlooked during large-scale *** paper proposes an innovative active protection and cooling integrated battery module using smart materials,magneto-sensitive shear thickening fluid(MsTF),which is specifically designed to address safety threats posed by lithium-ion batteries(LIBs)exposed to harsh mechanical and environmental *** theoretical framework introduces a novel approach for harnessing the smoothed-particle hydrodynamics(sPH)methodology that incorporates the intricate interplay of non-Newtonian fluid behavior,capturing the fluid-structure coupling inherent to the *** approach is further advanced by adopting an enhanced Herschel-Bulkley(H-B)model to encapsulate the intricate rheology of the MsTF under the influence of the magnetorheological effect(MRE)and shear thickening(sT)*** simulation results show that in the case of cooling,the MsTF is an effective cooling medium for rapidly reducing the *** terms of mechanical abuse,the MsTF solidifies through actively applying the magnetic field during mechanical compression and impact within the battery module,resulting in 66%and 61.7%reductions in the maximum stress within the battery jellyroll,and 31.1%and 23%reductions in the reaction force,*** mechanism effectively lowers the risk of short-circuit *** groundbreaking concepts unveiled in this paper for active protection battery modules are anticipated to be a valuable technological breakthrough in the areas of EV safety and lightweight/integrated design.

关键词： magneto-sensitive shear thickening fluid(MsTF) battery module impact protection temperature control integrated design