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Identification and characterization of camptothecin tailoring enzymes in Nothapodytes tomentosa

Journal of Integrative Plant Biology 2024年第6期66卷 1158-1169页

作者： Yin Chen Jian-Ping huang Yong-Jiang Wang Meng-Ling Tu Junheng Li Bingyan Xu Guoqing Peng Jing Yang sheng-Xiong huang State Key Laboratory of Phytochemistry and Plant Resources in West China and Yunnan Key Laboratory of Natural Medicinal Chemistry Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory for Economic Plants and Biotechnology Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China

Camptothecin is a complex monoterpenoid indole alkaloid with remarkable antitumor *** that two C-10 modified camptothecin derivatives,topotecan and irinotecan,have been approved as potent anticancer agents,there is a critical need for methods to access other aromatic ringfunctionalized congeners(e.g.,C-9,C-10,etc.).However,contemporary methods for chemical oxidation are generally harsh and low-yielding when applied to the camptothecin scaffold,thereby limiting the development of modified *** herein,we have identified four tailoring enzymes responsible for C-9 modifications of camptothecin from Nothapodytes tomentosa,via metabolomic and transcriptomic *** consist of a cytochrome P450(Nt CPT9H)which catalyzes the regioselective oxidation of camptothecin to 9-hydroxycamptothecin,as well as two methyltransferases(Nt OMT1/2,converting 9-hydroxycamptothecin to 9-methoxycamptothecin),and a uridine diphosphate-glycosyltransferase(Nt UGT5,decorating 9-hydroxycamptothecin to9-β-D-glucosyloxycamptothecin).Importantly,the critical residues that contribute to the specific catalytic activity of Nt CPT9H have been elucidated through molecular docking and mutagenesis *** work provides a genetic basis for producing camptothecin derivatives through metabolic *** will hasten the discovery of novel C-9 modified camptothecin derivatives,with profound implications for pharmaceutical manufacture.

关键词： camptothecin biosynthesis enzymatic assay Nothapodytes tomentosa tailoring enzyme transcriptomic analysis

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Review on piezoelectric actuators:materials,classifications,applications,and recent trends

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Frontiers of Mechanical Engineering 2024年第1期19卷 5-33页

作者： Xuyang ZHOU Shuang WU Xiaoxu WANG Zhenshan WANG Qixuan ZHU Jinshuai SUN Panfeng huang Xuewen WANG Wei huang Qianbo lu Institute of Flexible Electronics(IFE) Northwestern Polytechnical UniversityXi’an 710072China School of Automation Northwestern Polytechnical UniversityXi’an 710072China Key Laboratory of Flexible Electronics of Zhejiang Province Ningbo Institute of Northwestern Polytechnical UniversityNingbo 315103China

Piezoelectric actuators are a class of actuators that precisely transfer input electric energy into displacement,force,or movement outputs efficiently via inverse piezoelectric effect-based electromechanical *** types of piezoelectric actuators have sprung up and gained widespread use in various applications in terms of compelling attributes,such as high precision,flexibility of stoke,immunity to electromagnetic interference,and structural *** paper systematically reviews the piezoelectric materials,operating principles,representative schemes,characteristics,and potential applications of each mainstream type of piezoelectric ***,we intend to provide a more scientific and nuanced perspective to classify piezoelectric actuators into direct and indirect categories with several *** addition,this review outlines the pros and cons and the future development trends for all kinds of piezoelectric actuators by exploring the relations and mechanisms behind *** rich content and detailed comparison can help build an in-depth and holistic understanding of piezoelectric actuators and pave the way for future research and the selection of practical applications.

关键词： piezoelectric actuator piezoelectric effect amplified piezoelectric actuator ultrasonic actuator stepping actuator piezoelectric polymer

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Explicit results for ergodic properties of SDEs driven by cylindrical symmetric stable noises

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Science China Mathematics 2024年

作者： lu-Jing huang Jian Wang School of Mathematics and Statistics Fujian Normal University Key Laboratory of Analytical Mathematics and Applications (Ministry of Education) Fujian Normal University Fujian Key Laboratory of Analytical Mathematics and Applications Fujian Normal University Center for Applied Mathematics of Fujian Province Fujian Normal University

We consider the exponentially ergodic properties of systems of SDEs in Rndriven by cylindrical stable processes, potentially with different indices across different coordinates. Our approach is based on the well-known Foster-Lyapunov criteria and a careful selection of Lyapunov functions, alongside recent advances in regularity and transition density estimates for solutions to SDEs driven by L′evy processes with independent coordinates. These results are novel, even in the one-dimensional case. Notably, our findings suggest that multiplicative cylindrical stable processes can enhance the ergodicity of the system when the stable noise indices in all directions fall within [1, 2).

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Universal and efficient hybrid modeling and direct slicing method for additive manufacturing processes

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Advances in Manufacturing 2024年第2期12卷 300-316页

作者： Sen-Lin Wang Li-Chao Zhang Chao Cai Ming-Kai Tang Si Chen Jiang huang Yu-sheng Shi State Key Laboratory of Materials Processing and Die and Mould Technology Huazhong University of Science and TechnologyWuhan430074People’s Republic of China School of Machinery and Automation Wuhan University of Science and TechnologyWuhan430081People’s Republic of China

Model design and slicing contour generation in additive manufacturing(AM)data processing face challenges in terms of efficiency and scalability when stereolithography files generated by complex functionally graded structures have millions of *** paper proposes a hybrid modeling and direct slicing method for AM to efficiently construct and handle complex three-dimensional(3D)*** 3D solids,including conformal multigradient structures,were uniformly described using a small amount of data via signed distance *** hybrid representations were quickly discretized into numerous disordered directed lines using an improved marching squares *** establishing a directional HashMap to construct the topological relationship between lines,a connecting algorithm with linear time complexity is proposed to generate slicing contours for *** method replaces the mesh reconstruction and Boolean operation stages and can efficiently construct complex conformal gradient models of arbitrary topologies through hybrid ***,the time and memory consumption of direct slicing are much lower than those of previous methods when handling hybrid models with hundreds of millions of faces after mesh reconstruction.

关键词： Additive manufacturing(AM) Hybrid modeling Direct slicing Signed distance field

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Effect of Ti Particles on the Microstructure and Mechanical Properties of AZ91 Magnesium Matrix Composites

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Acta Metallurgica Sinica(English Letters) 2024年第3期37卷 513-524页

作者： lu Xiao Ting-Ting Liu Yue Chu Bo Song Jie Zhao Xian-Hua Chen Kai-Hong Zheng Fu-sheng Pan College of Materials Science and Engineering Chongqing UniversityChongqing 400044China lntelligent Manufacturing and Automobile School Chongqing College of Electronic EngineeringChongqing 401331China School of Materials and Energy Southwest UniversityChongqing 400715China Science and Technology Research Institute of CNNC 404 Co.LTD Gansu 735100China Institute of New Materials Guangdong Academy of SciencesGuangzhou 510650China

Spherical micro-Ti particle(TiP)-reinforced AZ91 magnesium alloy composites were fabricated by semi-solid stirring assisted ultrasonic vibration,which were then subjected to hot *** microstructure results showed that the addition of Ti particles refined the grain size and decreased the texture intensity of the as-extruded AZ91 *** Al3Ti phase with a thickness of 100 nm formed at the Ti/Mg interface,which had a non-coherent relationship with the magnesium *** as-extruded 1 vol.%TiP/AZ91 composite exhibited the best comprehensive mechanical properties,with yield strength,ultimate tensile strength,and elongation at break of 366 MPa,456 MPa,and 14.6%,respectively,which were significantly higher than those of the AZ91 ***,the addition of Ti particles can improve the strength and ductility of the AZ91 alloy,demonstrating the value of magnesium matrix composites for commercial applications.

关键词： Magnesium matrix composites Ti particles Interface Mechanical properties

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Metallothionein 1E Alleviates Cadmium-induced Renal Cytotoxicity through Promoting Mitochondrial Functional Recovery

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Biomedical and Environmental Sciences 2024年第1期37卷 117-121页

作者： WEN Si Hui LI lu Bei huang Hui Dan XIE Ying luO Lei Key Laboratory of Molecular Epidemiology of Hunan Province School of MedicineHunan Normal UniversityChangsha 410081HunanChina Department of Occupational Health Changsha Centre for Disease Control and PreventionChangsha 410004HunanChina The Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province Hunan Normal University School of MedicineChangsha 410013HunanChina

The pervasive utilization of industrial substances has escalated human exposure to cadmium(Cd),a metal associated with long-term negative health outcomes such as renal dysfunction,neurological disorders,and various cancers^([1]).Once ingested by humans,Cd interacts with cysteine-rich metallothioneins(MTs)which have metal-binding and antioxidant properties and is subsequently transported to the kidney^([2]).

关键词： Renal kidney cadmium

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Method for rapid warning and activity concentration estimates in online waterγ-spectrometry systems

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Nuclear Science and Techniques 2024年第3期35卷 1-12页

作者： Meng Wang Yi Gu Mao-Lin Xiong Liang-Quan Ge Qing-Xian Zhang Guo-Qiang Zeng Heng lu sheng-Liang Guo College of Nuclear Technology and Automation Engineering Chengdu University of TechnologyChengdu 610059China Applied Nuclear Technology in Geosciences Key Laboratory of Sichuan Province (Chengdu University of Technology)Chengdu 610059China Chengdu New Ray Technology Co.Ltd Chengdu 610052China

Onlineγ-spectrometry systems for inland waters,most of which extract samples in situ and in real time,are able to produce reliable activity concentration measurements for waterborne radionuclides only when they are distributed relatively uniformly and enter into a steady-state diffusion regime in the measurement *** protect residents’health and ensure the safety of the living environment,better timeliness is required for this measurement *** address this issue,this study established a mathematical model of the online waterγ-spectrometry system so that rapid warning and activity estimates can be obtained for water under non-steady-state(NSS)*** addition,the detection efficiency of the detector for radionuclides during the NSS diffusion process was determined by applying the computational fluid dynamics technique in conjunction with Monte Carlo *** this basis,a method was developed that allowed the online waterγ-spectrometry system to provide rapid warning and activity concentration estimates for radionuclides in *** analysis of the NSS-mode measurements of^(40)K radioactive solutions with different activity concentrations determined the optimum warning threshold and measurement time for producing accurate activity concentration estimates for *** experimental results show that the proposed NSS measurement method is able to give warning and yield accurate activity concentration estimates for radionuclides 55.42 and 69.42 min after the entry of a 10 Bq/L^(40)K radioactive solution into the measurement chamber,*** times are much shorter than the 90 min required by the conventional measurement ***,the NSS measurement method allows the measurement system to give rapid(within approximately 15 min)warning when the activity concentrations of some radionuclides reach their respective limits stipulated in the Guidelines for Drinking-water Quality of the WHO,suggesting that this method con

关键词： Water radioactivity monitoring Dynamic detection efficiency Rapid warning Activity estimation

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Transparent micropatterned conductive films based on highlyordered nanowire network

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Nano Research 2024年第5期17卷 4288-4297页

作者： Xin-Ran Zhang Hai-Tao Deng Xu Zeng Yi-Lin Wang Peng huang Xiao-sheng Zhang School of Integrated Circuit Science and Engineering University of Electronic Science and Technology of ChinaChengdu 611731China

Transparent conductive films that are based on nanowire networks are essential to construct flexible,wearable,and even stretchable ***,large-scale precise micropatterning,especially with regard to the controllability of the organizing orientation of nanowires,is a critical ***,we proposed a liquid film rupture self-assembly approach for manufacturing transparent conductive films with microstructure arrays based on a highly ordered nanowire *** large-scale microstructure conductive films were fabricated through air-liquid interface self-assembly and liquid film rupture *** typical micropattern morphologies,including square,hexagon,circle,serpentine,etc.,were prepared to reveal the universal applicability of the proposed *** homogeneity and controllability of this approach were verified for multiple *** the assembly cycles increasing,the optical transmittance decreases *** addition,theoretical model analysis is carried out,and the analytical formula of the speed of the film moving with the surface tension and the density of the liquid film is ***,the feasibility of this approach for piezoresistive strain sensors is *** fabrication approach demonstrated a cost-effective and efficient method for precisely arranging nanowires,which is useful in transparent and wearable applications.

关键词： flexible electronics transparent conductive network micropatterning nanowires micro electromechanical systems(MEMS)

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Bending Failure Mode and Prediction Method of the Compressive Strain Capacity of A Submarine Pipeline with Dent Defects

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China Ocean Engineering 2024年第4期38卷 636-647页

作者： HOU Fu-heng JIA lu-sheng CHEN Yan-fei ZHANG Qi ZHONG Rong-feng WANG Chun-sha School of Mechanical and Transportation Engineering China University of PetroleumBeijingBeijing 102249China CNOOC Research Institute Ltd.Beijing 100028 China

A dent is a common type of defects for submarine *** submarine pipelines,high hydrostatic pressure and internal pressure are the main *** pipelines bend due to complex subsea conditions,the compression strain capacity may be *** into the local buckling failure and accurate prediction of the compressive strain capacity are important.A finite element model of a pipeline with a dent is *** buckling failure under a bending moment is investigated,and the compressive strain capacity is *** effects of different parameters on pipeline local buckling are *** results show that the dent depth,external pressure and internal pressure lead to different local buckling failure modes of the pipeline.A higher internal pressure indicates a larger compressive strain capacity,and the opposite is true for external *** the ratio of external pressure to collapse pressure of intact pipeline is greater than 0.1,the deeper the dent,the greater the compressive strain capacity of the *** as the ratio is less than 0.1,the opposite is *** the basis of these results,a regression equation for predicting the compressive strain capacity of a dented submarine pipeline is proposed,which can be referred to during the integrity assessment of a submarine pipeline.

关键词： submarine pipeline dent defect bending load local buckling compressive strain capacity

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CsABF3-activated CsSUT1 pathway is implicated in pre-harvest water deficit inducing sucrose accumulation in citrus fruit

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Horticultural Plant Journal 2024年第1期10卷 103-114页

作者： Xiaochuan Ma Yuanyuan Chang Feifei Li Junfeng Yang Li Ye Tie Zhou Yan Jin Ling sheng Xiaopeng lu College of Horticulture Hunan Agricultural UniversityChangshaHunan 410128China National Center for Citrus Improvement ChangshaHunan 410128China Institute of Horticulture Hunan Academy of Agricultural ScienceChangshaHunan 410125China

Pre-harvest water deficit(PHWD)plays an important role in sugar accumulation of citrus ***,the mechanism is not known ***,it was confirmed that PHWD promoted sucrose accumulation of citrus fruit,but had limited effect on fructose,glucose and total acid.A sucrose transporter,Cs SUT1,which localizes to the plasma membrane,was demonstrated to function in sucrose transport induced by *** to wild-type,Cs SUT1 overexpression in citrus calli stimulated sucrose,fructose and glucose accumulation,while its silencing in juice sacs reduced sucrose *** sugar accumulation in transgenic lines enhanced plant drought tolerance,and resulted in decreased electrolyte leakage,malondialdehyde and hydrogen peroxide contents,as well as increased superoxide dismutase activity and proline *** abscisic acid(ABA)-responsive transcription factor,Cs ABF3,was found with a same expression pattern with Cs SUT1 under *** one-hybrid,electrophoretic mobility shift assay and dual-luciferase assays all revealed that Cs ABF3 directly bound with the Cs SUT1 promoter by ABA responsive *** Cs ABF3 was overexpressed in citrus calli,the sucrose,fructose and glucose concentration increased ***,transgenic studies demonstrated that Cs ABF3 could affect sucrose accumulation by regulating Cs ***,this study revealed a regulation of Cs ABF3 promoting Cs SUT1 expression and sucrose accumulation in response to *** results provide a detail insight into the quality formation of citrus fruit.

关键词： Citrus Water deficit Pre-harvest Sucrose CsABF3 CsSUT1

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