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浅表流排水系统规划实践研究

中国给水排水 2024年第2期40卷 31-37页

作者：汤钟丁一鸣张亮俞露陆利杰蔡婳婳深圳市城市规划设计研究院股份有限公司广东深圳518028 中国市政工程华北设计研究总院有限公司北京分公司北京100044 中国城市规划设计研究院深圳分院广东深圳518000

浅表流排水系统作为一种创新型的排水理念,采用生态措施组织雨水径流于地表排放,因与地下污水管网系统分离建设,故可在提升排水系统生态效益的同时,实现雨污分流、降低运维费用和管养难度、便于雨水系统管理等城市水务建设管理诉求。基... 详细信息

浅表流排水系统作为一种创新型的排水理念,采用生态措施组织雨水径流于地表排放,因与地下污水管网系统分离建设,故可在提升排水系统生态效益的同时,实现雨污分流、降低运维费用和管养难度、便于雨水系统管理等城市水务建设管理诉求。基于浅表流排水理念,提出构建场地地表排水-市政明沟排水-河道绿廊排水三级浅表流排水体系的总体规划思路和分级规划策略,并以深圳市某片区规划设计实践为例,提出区域级浅表流排水系统规划建设方案,并进行综合效益分析。

关键词：雨污分流运营维护浅表流排水系统效益分析

Peripheral Artery Disease and Risk of Fibrosis Deterioration in Nonalcoholic Fatty liver Disease:A Prospective Investigation

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Biomedical and Environmental Sciences 2020年第4期33卷 217-226页

作者： ZHU Wen DENG Chan Juan XUAN li Ping DAI Hua jie ZHAO Zhi Yun WANG Tian Ge li Mian lu jie li XU Yu CHEN Yu Hong WANG Wei Qing BI Yu Fang XU Min State Key Laboratory of Medical Genomics Shanghai National Clinical Research Center for Endocrine and Metabolic DiseasesCollaborative Innovation Center of Systems BiomedicineShanghai Institute of Endocrine and Metabolic DiseasesDepartment of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

Objective liver fibrosis is an important predictor of mortality in nonalcoholic fatty liver disease(NAFLD).Peripheral artery disease(PAD)and liver fibrosis share many common metabolic *** aimed to explore the association between PAD and risk of fibrosis deterioration in NAFLD *** The study recruited 1,610 NAFLD patients aged≥40 years from a well-defined community at baseline in 2010 and followed up between August 2014 and May *** deterioration was defined as the NAFLD fibrosis score(NFS)status increased to a higher category at the follow-up *** was defined as an ankle-brachial index of*** During an average of 4.3 years’follow-up,618 patients progressed to a higher NFS *** was associated with 92%increased risk of fibrosis deterioration[multivariable-adjusted odds ratio(OR):1.92,95%confidence interval(CI):1.24,2.98].When stratified by baseline NFS status,the OR for progression from low to intermediate or high NFS was 1.74(95%CI:1.02,3.00),and progression from intermediate to high NFS was 2.24(95%CI:1.05,4.80).There was a significant interaction between PAD and insulin resistance(IR)on fibrosis deterioration(P for interaction=0.03).As compared with non-PAD and non-IR,the coexistence of PAD and IR was associated with a 3.85-fold(95%CI:2.06,7.18)increased risk of fibrosis *** PAD is associated with an increased risk of fibrosis deterioration in NAFLD patients,especially in those with *** coexistence of PAD and IR may impose an interactive effect on the risk of fibrosis deterioration.

关键词： Ankle-brachial index Nonalcoholic fatty liver disease Fibrosis deterioration NAFLD fibrosis score Insulin resistance

Machine learning for prediction of retained austenite fraction and optimization of processing in quenched and partitioned steels

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Journal of Iron and Steel Research International 2024年第8期31卷 2002-2013页

作者： Shuai Wang jie li li-yang Zeng Xun-wei Zuo Nai-lu Chen Yong-hua Rongg Shanghai Key Laboratory of Materials Laser Processing and Modification School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China

The metastable retained austenite(RA)plays a significant role in the excellent mechanical performance of quenching and partitioning(Q&P)steels,while the volume fraction of RA(V_(RA))is challengeable to directly predict due to the complicated relationships between the chemical composition and process(like quenching temperature(Qr)).A Gaussian process regression model in machine learning was developed to predict V_(RA),and the model accuracy was further improved by introducing a metallurgical parameter of martensite fraction(fo)to accurately predict V_(RA) in Q&P *** developed machine learning model combined with Bayesian global optimization can serve as another selection strategy for the quenching temperature,and this strategy is very effcient as it found the"optimum"Qr with the maximum V_(RA) using only seven consecutive *** benchmark experiment also reveals that the developed machine learning model predicts V_(RA) more accurately than the popular constrained carbon equilibrium thermodynamic model,even better than a thermo-kinetic quenching-partitioning-tempering-local equilibrium model.

关键词： Q&P steel Retained austenite fraction Machine learning Quenching temperature Gaussian process regression model

Contemporary strategies and approaches for characterizing composition and enhancing biofilm penetration targeting bacterial extracellular polymeric substances

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Journal of Pharmaceutical Analysis 2024年第4期14卷 506-524页

作者： Lan lu Yuting Zhao Mingxing li Xiaobo Wang jie Zhu li liao Jingya Wang Key Laboratory of Medicinal and Edible Plants Resources Development of Sichuan Education Department Sichuan Industrial Institute of AntibioticsSchool of PharmacyChengdu UniversityChengdu610000China Meishan Pharmaceutical Vocational College School of PharmacyMeishanSichuan620200China Laboratory of Molecular Pharmacology Department of PharmacologySchool of PharmacySouthwest Medical UniversityLuzhouSichuan646000China Hepatobiliary Surgery Langzhong People's HospitalLangzhongSichuan646000China

Extracellular polymeric substances(EPS)constitutes crucial elements within bacterial biofilms,facili-tating accelerated antimicrobial resistance and conferring defense against the host's immune *** precise and effective antibiofilm approaches and strategies,tailored to the specific charac-teristics of EPS composition,can offer valuable insights for the creation of novel antimicrobial ***,in turn,holds the potential to mitigate the alarming issue of bacterial drug *** analysis of EPS compositions relies heavily on colorimetric approaches with a significant bias,which is likely due to the selection of a standard compound and the cross-interference of various EPS *** the pivotal role of EPS in biofilm functionality,it is imperative for EPS research to delve deeper into the analysis of intricate compositions,moving beyond the current focus on polymeric *** ne-cessitates a shift from heavy reliance on colorimetric analytic methods to more comprehensive and nuanced analytical *** this study,we have provided a comprehensive summary of existing analytical methods utilized in the characterization of EPS ***,novel strategies aimed at targeting EPS to enhance biofilm penetration were explored,with a specific focus on high-lighting the limitations associated with colorimetric ***,we have outlined the challenges faced in identifying additional components of EPS and propose a prospective research plan to address these *** review has the potential to guide future researchers in the search for novel compounds capable of suppressing EPS,thereby inhibiting biofilm *** insight opens up a new avenue for exploration within this research domain.

关键词： Analytic strategies and approaches Composition characterization Extracellular polymeric substances(EPS) Promoting biofilm penetration

Effect of moxibustion on expression profile of miRNAs in Tripterygium glycoside-induced decreased ovarian reserve

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Journal of Traditional Chinese Medicine 2024年第4期44卷 745-752页

作者： SHEN jie YIN Yaoli li Hongxiao lu Ge ZHU Yaoyao QIN Yantong JIN Xun CHENG jie SHEN Meihong College of Acupuncture and Tuina Nanjing University of Chinese MedicineNanjing 210023China

OBJECTIVE:To explore the possible regulatory mechanism of microRNA(miRNA)in moxibustion treatment for decreased ovarian reserve(DOR).METHODS:The DOR model was constructed by intragastrical Tripterygium glycoside suspension administration,and moxibustion therapy was simultaneously *** morphological ovarian changes were observed by hematoxylin and eosin *** miRNA expression profile was detected by RNA sequencing,and bioinformatics analysis was *** software 3.6.1 was used to establish a regulatory network and differentially expressed miRNAs were verified by reverse transcription quantitative polymerase chain reaction(RT-qPCR).RESULTS:Decreased number of mature follicles,increased atresia follicles,and abnormal granulosa cell morphology were observed in the model group compared with the control *** moxibustion group demonstrated increased mature follicles,decreased atretic follicles,and significantly decreased abnormal morphology of granulosa cells compared with the model ***,RNA sequencing results manifested significantly up-regulated miRNA expressions(miR-92b-3p,miR-26-5p_R+1_1ss10TC,miR-206-3p,miR-9993b-3p_1ss6GA,miR-7857-3p_R-1,miR-219a-2-3p_1ss10GC,miR-3968-p5_1ss10AT,and PC-5p-6478_1795)and down-regulated miR-664-2-5p_R+1 in the model group,compared with the control group,and the moxibustion group reversed abnormal disorder levels of these ***,these differentially expressed miRNAs were mainly involved in the phosphatidylinositol-3-kinase/protein kinase B signaling pathway and nuclear factor erythropoietin-2-related factor 2/heme oxygenase 1 signaling ***,network and RT-qPCR verification revealed miR-9993b-3p_1ss6GA as the most critical ***:This experiment proved the effectiveness of moxibustion in improving the ovarian reserve of rats by regulating miRNA expression,especially miR-9993b-3p_1ss6GA.

关键词： ovarian reserve moxibustion microRNAs mechanics

Photocatalytic in situ H_(2)O_(2) production and activation for enhanced ciprofloxacin degradation over CeO_(2)-Co_(3)O_(4)/g-C_(3)N_(4):key role of CeO_(2)

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Rare Metals 2024年第6期43卷 2695-2707页

作者： Hong-jie Zhu Yi-Kai Yang Ming-Hui li lu-Ning Zou Hai-Tao Zhao Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology School of Chemistry and Chemical Engin College of Ecology and Environment Anhui Normal UniversityWuhu241002China liaocheng Yilu Advanced Materials Co. LtdLiaocheng 252000China

The abused ciprofloxacin antibiotics have caused significant environmental *** oxidative degradation of ciprofloxacin exhibits promising efficacy,it often entails excessive energy ***,it is necessary to explore an effective and ecologically sustainable degradation ***,we demonstrated that g-C_(3)N_(4) decorated with the coordinated CeO_(2)and Co_(3)O_(4)(CeO_(2)-Co_(3)O_(4)/CN)exhibited effective ciprofloxacin photodegradation via in situ H_(2)O_(2) production and activation *** indicate that the introduced CeO_(2) enhances the transference of photogenerated electrons to O_(2) by adjusting the oxygen vacancy of photocatalyst,thereby increasing the generation of superoxide radicals,which in turn generate H_(2)O_(2),resulting in a 22.4-fold increase in H_(2)O_(2) generation over g-C_(3)N_(4).Moreover,the in situ H_(2)O_(2)generation facilitated by CeO_(2) is confirmed to be essential for ciprofloxacin degradation via CeO_(2)-Co_(3)O_(4)/CN,as it provides enough oxidant for Co_(3)O_(4) to activate into hydroxyl radicals for the pollutants ***,CeO_(2)-Co_(3)O_(4)/CN achieves a ciprofloxacin degradation ratio of 97.7%within 80 *** study introduces a novel approach that combines H_(2)O_(2) generation and activation,offering an innovative perspective for achieving clean and efficient purification of antibiotic-contaminated water.

关键词： CeO_(2) In situ H_(2)O_(2)generation Ciprofloxacin degradation Photocatalyst

Association of Visit-to-Visit Variabilities in Metabolic Factors with Chronic Kidney Disease in Chinese Adults living in Shanghai

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Biomedical and Environmental Sciences 2021年第10期34卷 761-772页

作者： li ling WANG Fei XU Min lu jie li ZHAO Zhi Yun li Mian WANG Tian Ge WANG Shuang Yuan BI Yu Fang XU Yu CAI Wei Min NING Guang Department of Clinical Pharmacy and Pharmaceutical Management School of PharmacyFudan UniversityShanghai 201203China Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai National Clinical Research Center for Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR ChinaShanghai National Center for Translational MedicineRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

Objective This study aimed to examine the association of visit-to-visit variabilities in metabolic factors with chronic kidney disease(CKD)in Shanghai community *** We used data from a cohort study of community residents who participated in three examinations in 2008,2009,and 2013,*** plasma glucose(FPG)level,blood pressure(BP),and lipid levels were determined in 2,109 participants at all three visits,and CKD was evaluated between the second and the third ***-to-visit variabilities in metabolic factors were described by coefficients of variation(CV)at three visits.A variability score was calculated by adding the numbers of metabolic factors with a high variability defined as the highest quartile of *** was defined as the estimated glomerular filtration ratelic BP(OR=1.62,95%CI 1.04–2.50),and 85%for low-density lipoprotein cholesterol(OR=1.85,95%CI 1.23–2.80).Furthermore,the risk of CKD increased significantly with an increasing variability *** with participants with score 0,participants with scores of 1,2,and 3 were associated with 58%(OR=1.58,95%CI 1.08–2.32),121%(OR=2.21,95%CI 1.40–3.49),and 548%(OR=6.48,95%CI 3.18–13.21)higher risks of CKD,*** The visit-to-visit variabilities in metabolic factors were significantly associated with the risks of CKD in Shanghai community residents.

关键词： Chronic kidney disease Cohort Metabolic factor Visit-to-visit variability

Primary study on imaging in transient ischemic attacks

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Chinese Medical Journal 2005年第21期118卷 1812-1816页

作者： lu jie li Kun-cheng HUA Yang Department of Radiology Xuanwu Hospital Capital University of Medical Sciences Beijing 100053 China

Background Although transient ischemic attacks （TIA） is a clinical diagnosis, imaging findings are important for its diagnosis and treatment. This study evaluated the value and limitations of conventional CT, CT cerebral perfusion imaging and transcranial Doppler sonography （TCD） in patients with TIA. Methods Conventional CT, CT cerebral perfusion imaging and TCD were performed in 20 patients with TIA. After regular CT examination, d-0-second dynamic scans were performed on selected slice, while 40 ml of nonionic contrast materials was bolus-injected through antecubital vein with power injector. These dynamic images were processed with the perfusion software package on workstation. Cerebral blood flow （CBF） and time to peak （3~FP） were measured in specific regions of the brain. TCD was also performed in 20 patients with TIA. Comparative analysis was made on the basis of the results of conventional CT, CT cerebral perfusion imaging and *** In the 20 patients with TIA, conventional CT turned out to be normal. However, persisting abnormal perfusion changes corresponding to clinical symptoms were found in 13 cases with the prolonged TFP. The other 7 cases were normal. TFP of the affected side （ 11.6 ± 3.0） s was significantly prolonged （ t =4. 782 ,P 〈0. 01 ） in comparison with the contralateral side （8.8 ± 1.5 ） s. The difference in CBF was not statistically significant （t = 1. 912, P =0. 073） between the affected side [ （223.9 ±19.6） ml ·min^-1 ·L^-1 ] and the contralateral side [ （227.7 ± 19. 8） ml · min^-1· L^-1 ] . TCD revealed severe stenosis or occlusion of the carotid artery in 10 patients, arteriosclerosis in 6 patients, blood speed decrease in 2 patients, vasospasm in 1 patient. Conclusions Conventional CT can exclude intracerebral diseases. Perfusion CT provides valuable hemodynamic information and shows the extent of perfusion disturbances. TCD can demonstrate abnormalities of the involved arteries in patients with TIA. The combination of these three

关键词： transient ischemic attacks computerized tomography perfusion transcranial Doppler sonography

Two-dimensional flow vector measurement based on all-fiber laser feedback frequency-shifted multiplexing technology

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Photonics Research 2024年第7期12卷 1371-1378页

作者： LEI ZHANG JIAliANG LV YUNKUN ZHAO jie li KEYAN liU QI YU HONGTAO li BENli YU liANG lu Information Materials and Intelligent Sensing Laboratory of Anhui Province Anhui UniversityHefei 230601China Key Laboratory of Opto-Electronic Information Acquisition and Manipulation of Ministry of Education Anhui UniversityHefei 230601China School of Physics and Optoelectronic Engineering Anhui UniversityHefei 230601China School of Optics and Photonics Beijing Institute of TechnologyBeijing 100081China

The decomposition and identification of signals are crucial for flow vector acquisition in a multi-dimensional measurement. Here, we proposed a two-dimensional(2D) flow vector measurement system based on all-fiber laser feedback frequency-shifted multiplexing technology. The reliable performance of the system is characterized by experimental verification and numerical simulation. An orthogonal dual-beam structure is employed to eliminate the impact of an unknown incident angle in the practical application. Meanwhile, the vector velocity signals in 2D can be decomposed into one-dimensional(1D) scalar signals by adopting the frequency-shifted multiplexing,which makes it easy to obtain the vector information and velocity distribution of fluid motion through the self-mixing interference frequency spectrum.

关键词： fiber shifted flow