Peripheral Artery Disease and Risk of Fibrosis Deterioration in Nonalcoholic Fatty Liver Disease:A Prospective Investigation

作     者：ZHU Wen DENG Chan Juan XUAN Li Ping DAI Hua Jie ZHAO Zhi Yun WANG Tian Ge LI Mian LU Jie Li XU Yu CHEN Yu Hong WANG Wei Qing BI Yu Fang XU Min ZHU Wen;DENG Chan Juan;XUAN Li Ping;DAI Hua Jie;ZHAO Zhi Yun;WANG Tian Ge;LI Mian;LU Jie Li;XU Yu;CHEN Yu Hong;WANG Wei Qing;BI Yu Fang;XU Min

作者机构：State Key Laboratory of Medical GenomicsShanghai National Clinical Research Center for Endocrine and Metabolic DiseasesCollaborative Innovation Center of Systems BiomedicineShanghai Institute of Endocrine and Metabolic DiseasesDepartment of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China 

出 版 物：《Biomedical and Environmental Sciences》 (生物医学与环境科学（英文版）)

年 卷 期：2020年第33卷第4期

页      面：217-226页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Grants from the Ministry of Science and Technology of China[2018YFC1311705,2016YFC1305600,and 2016YFC1304904] the National Natural Science Foundation of China[81770842,81941017,and 81870604] the Shanghai Science and Technology Commission[YDZX20173100004881] the Shanghai Shen-Kang Hospital Development Center[SHDC12016202] 

主　　题：Ankle-brachial index Nonalcoholic fatty liver disease Fibrosis deterioration NAFLD fibrosis score Insulin resistance 

摘      要：Objective Liver fibrosis is an important predictor of mortality in nonalcoholic fatty liver disease(NAFLD).Peripheral artery disease(PAD)and liver fibrosis share many common metabolic *** aimed to explore the association between PAD and risk of fibrosis deterioration in NAFLD *** The study recruited 1,610 NAFLD patients aged≥40 years from a well-defined community at baseline in 2010 and followed up between August 2014 and May *** deterioration was defined as the NAFLD fibrosis score(NFS)status increased to a higher category at the follow-up *** was defined as an ankle-brachial index of*** During an average of 4.3 years’follow-up,618 patients progressed to a higher NFS *** was associated with 92%increased risk of fibrosis deterioration[multivariable-adjusted odds ratio(OR):1.92,95%confidence interval(CI):1.24,2.98].When stratified by baseline NFS status,the OR for progression from low to intermediate or high NFS was 1.74(95%CI:1.02,3.00),and progression from intermediate to high NFS was 2.24(95%CI:1.05,4.80).There was a significant interaction between PAD and insulin resistance(IR)on fibrosis deterioration(P for interaction=0.03).As compared with non-PAD and non-IR,the coexistence of PAD and IR was associated with a 3.85-fold(95%CI:2.06,7.18)increased risk of fibrosis *** PAD is associated with an increased risk of fibrosis deterioration in NAFLD patients,especially in those with *** coexistence of PAD and IR may impose an interactive effect on the risk of fibrosis deterioration.