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Seizure as the main presenting manifestation of three patients with acute glufosinate-ammonium poisoning

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第4期25卷 354-358页

作者： Ping wang Congying SONG xuan lu Yuanqiang lu Department of Emergency Medicine the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 3100030 China Zhejiang Key Laboratory for Diagnosis and Treatment of Physic chemical and Aging related Injuries Hangzhou 310003China Department of Geriatric Medicine the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China

Glufosinate-ammonium herbicides are the most widely used broad-spectrum,non-selective herbicides in the world.Glufosinate-ammonium is a structural analogue of glutamate(Glu)which can irreversibly inhibit the activity of glutamine synthetase(GS)and Glu decarboxylase in plants,thereby blocking the synthesis of glutamine(Gln)from Glu and ammonia(Hoerlein,1994).This causes the plants to die because of the nitrogen metabolism disorder and subsequent intracellular accumulation of ammonia.In humans,the characteristic features of glufosinate-ammonium herbicide poisoning include gastrointestinal symptoms and neurotoxicity(Watanabe and Sano,1998).

关键词： ammonium ammonia thereby

A benchmark-based method for evaluating hyperparameter optimization techniques of neural networks for surface water quality prediction

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Frontiers of Environmental Science & Engineering 2024年第5期18卷 13-27页

作者： xuan wang Yan Dong Jing Yang Zhipeng Liu Jinsuo lu School of Environmental and Municipal Engineering Xi’an University of Architecture and TechnologyXi’an710055China Shaanxi Key Laboratory of Environmental Engineering Xi’an University of Architecture and TechnologyXi’an710055China State Key Laboratory of Green Building in West China Xi’an University of Architecture and TechnologyXi’an710055China

Neural networks(NNs)have been used extensively in surface water prediction tasks due to computing algorithm improvements and data accumulation.An essential step in developing an NN is the hyperparameter selection.In practice,it is common to manually determine hyperparameters in the studies of NNs in water resources tasks.This may result in considerable randomness and require significant computation time;therefore,hyperparameter optimization(HPO)is essential.This study adopted five representatives of the HPO techniques in the surface water quality prediction tasks,including the grid sampling(GS),random search(RS),genetic algorithm(GA),Bayesian optimization(BO)based on the Gaussian process(GP),and the tree Parzen estimator(TPE).For the evaluation of these techniques,this study proposed a method:first,the optimal hyperparameter value sets achieved by GS were regarded as the benchmark;then,the other HPO techniques were evaluated and compared with the benchmark in convergence,optimization orientation,and consistency of the optimized values.The results indicated that the TPE-based BO algorithm was recommended because it yielded stable convergence,reasonable optimization orientation,and the highest consistency rates with the benchmark values.The optimization consistency rates via TPE for the hyperparameters hidden layers,hidden dimension,learning rate,and batch size were 86.7%,73.3%,73.3%,and 80.0%,respectively.Unlike the evaluation of HPO techniques directly based on the prediction performance of the optimized NN in a single HPO test,the proposed benchmark-based HPO evaluation approach is feasible and robust.

关键词： Neural networks Hyperparameter optimization Surface water quality prediction Bayes optimization Genetic algorithm

Dissolvable temporary barrier:a novel paradigm for flexible hydrogel patterning in organ-on-a-chip models

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Bio-Design and Manufacturing 2024年第2期7卷 153-166页

作者： Ding wang Qinyu Li Chenyang Zhou Zhangjie Li Kangyi lu Yijun Liu Lian xuan Xiaolin wang Department of Micro/Nano Electronics School of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Ophthalmology LKS Faculty of MedicineThe University of Hong KongHong Kong 999077China Institute of Medical Robotics Shanghai Jiao Tong UniversityShanghai 200240China National Key Laboratory of Advanced Micro and Nano Manufacture Technology Shanghai Jiao Tong UniversityShanghai 200240China National Center for Translational Medicine(Shanghai)SHU Branch Shanghai UniversityShanghai 200444China

A combination of hydrogels and microfluidics allows the construction of biomimetic three-dimensional(3D)tissue models in vitro,which are also known as organ-on-a-chipmodels.The hydrogel patterningwith awell-controlled spatial distribution is typically achieved by embedding sophisticated microstructures to act as a boundary.However,these physical barriers inevitably expose cells/tissues to a less physiologically relevant microenvironment than in vivo conditions.Herein,we present a novel dissolvable temporary barrier(DTB)strategy that allows robust and flexible hydrogel patterning with great freedom of design and desirable flow stimuli for cellular hydrogels.The key aspect of this approach is the patterning of a water-soluble rigid barrier as a guiding path for the hydrogel using stencil printing technology,followed by a barrier-free medium perfusion after the dissolution of the DTB.Single and multiple tissue compartments with different geometries can be established using either straight or curved DTB structures.The effectiveness of this strategy is further validated by generating a 3D vascular network through vasculogenesis and angiogenesis using a vascularized microtumor model.As a new proof-of-concept in vasculature-on-a-chip,DTB enables seamless contact between the hydrogel and the culture medium in closed microdevices,which is an improved protocol for the fabrication ofmultiorgan chips.Therefore,we expect it to serve as a promising paradigm for organ-on-a-chip devices for the development of tumor vascularization and drug evaluation in the future preclinical studies.

关键词： Dissolvable temporary barrier Hydrogel patterning Microfluidics Organ-on-a-chip Vascularization

Enantioselective Synthesis of Benzimidazole Atropisomers Featuring a N-N Axis

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Chinese Journal of Chemistry 2024年第7期42卷 711-718页

作者： Fang-Bei Ge Qi-Kun Yin Chuan-Jun lu xuan xuan Jia Feng Ren-Rong Liu College of Chemistry and Chemical Engineering Qingdao UniversityQingdaoShandong 266071China School of Pharmacy Key Laboratory of Mlecular Pharmacoogy and Drug EvaluationMinistry of EducationYantai Universit YantaiShandong 264005China

Atroposelective synthesis of N-N atropisomers is an emerging area but remains underexplored;in particular,the synthesis of N-N benzimidazole atropisomers is still unprecedented.Herein,the first enantioselective synthesis of N-N benzimidazole atropisomers via the palladium-catalyzed de novo construction of benzimidazole skeleton is presented.With readily available palladium catalyst and biphosphine ligand,a broad range of nonbiaryl benzimidazole and indole-benzimidazole atropisomers were conveniently ac-cessed in high yields and with excellent enantioselectivities.Significantly,these N-N benzimidazole atropisomers showed great anti-tumor activity and selectivity to breast cancer MCF-7 cells.The simple catalytic system,broad substrate scope,high enantioselectivi-ty,and good bioactivity make this approach highly attractive.

关键词： Asymmetric synthesis Atropisomerism Palladium Benzimidazole Antitumor

FAM53B promotes pancreatic ductal adenocarcinoma metastasis by regulating macrophage M2 polarization

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1479-1499页

作者： xuan-Zeng Pei Min Cai Da-Wei Jiang Song-Hai Chen Qing-Qing wang Hui-Min lu Yi-Fan lu Department of Hepatological Surgery The First Hospital of JiaxingJiaxing 314000Zhejiang ProvinceChina Department of General Surgery West China Hospital of Sichuan UniversityChengdu 610044Sichuan ProvinceChina

BACKGROUND Our study investigated the role of FAM53B in regulating macrophage M2 polarization and its potential mechanisms in promoting pancreatic ductal adenocarcinoma(PDAC)metastasis.AIM To further investigate the role of FAM53B in regulating macrophage M2 polarization and its potential mechanism in promoting PDAC metastasis.Our goal is to determine how FAM53B affects macrophage M2 polarization and to define its underlying mechanism in PDAC metastasis.METHODS Cell culture and various experiments,including protein analysis,immunohisto-chemistry,and animal model experiments,were conducted.We compared FAM53B expression between PDAC tissues and healthy tissues and assessed the correlation of FAM53B expression with clinical features.Our study analyzed the role of FAM53B in macrophage M2 polarization in vitro by examining the expression of relevant markers.Finally,we used a murine model to study the role of FAM53B in PDAC metastasis and analyzed the potential underlying mechanisms.RESULTS Our research showed that there was a significant increase in FAM53B levels in PDAC tissues,which was linked to adverse tumor features.Experimental findings indicated that FAM53B can enhance macrophage M2 polarization,leading to increased anti-inflammatory factor release.The results from the mouse model further supported the role of FAM53B in PDAC metastasis,as blocking FAM53B prevented tumor cell invasion and metastasis.CONCluSION FAM53B promotes PDAC metastasis by regulating macrophage M2 polarization.This discovery could lead to the development of new strategies for treating PDAC.For example,interfering with the FAM53B signaling pathway may prevent cancer spread.Our research findings also provide important information for expanding our understanding of PDAC pathogenesis.

关键词： FAM53B Pancreatic ductal adenocarcinoma Tumor metastasis Macrophage polarization

Construction of Cu-Zn Co-doped layered materials for sodium-ion batteries with high cycle stability

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Chinese Chemical Letters 2024年第5期35卷 441-446页

作者： Xiping Dong xuan wang Zhixiu lu Qinhao Shi Zhengyi Yang xuan Yu Wuliang Feng Xingli Zou Yang Liu Yufeng Zhao Institute for Sustainable Energy&College of Sciences Shanghai UniversityShanghai 200444China Key Laboratory for Advanced Technology in Environmental Protection of Jiangsu Province Yancheng Institute of TechnologyYancheng 224051China State Key Laboratory of Advanced Special Steel&Shanghai Key Laboratory of Advanced Ferrometallurgy&School of Materials Science and Engineering Shanghai UniversityShanghai 200444China

Due to its high operational voltage and energy density,P2-type Na_(0.67)Ni_(0.3)Mn_(0.7)O_(2) has become a leading cathode material for sodium-ion batteries(SIBs),which is an ideal option for large-scale energy storage.However,the practical application of P2-type Na_(0.67)Ni_(0.3)Mn_(0.7)O_(2) is limited by the capacity constraints and unwanted phase transitions,presenting significant challenges to the widespread application of SIBs.To address these challenges and optimize the electrochemical properties of the P2 phase cathode material,this study proposes a Cu and Zn co-doped strategy to improve the electrochemical performance.The incorporation of Cu/Zn can stabilize the P2-phase structure against P2-O2 phase transitions,thus enhancing its electrochemical properties.The as-obtained P2-type Na0.67[Ni_(0.3)Mn_(0.58)Cu_(0.09)Zn_(0.03)]O_(2) cathode material shows an impressive cycling stability,maintaining 80%capacity retention after 1000 cycles at 2 C.The cyclic voltammetry(CV)tests show that the Cu^(2+)/Cu^(3+)redox reaction is also involved in charge compensation during the charge/discharge process.

关键词： Sodium-ion batteries Cathode material Cycle performance Cu/Zn co-doped P2-type Na_(0.67)Ni_(0.3)Mn_(0.7)O_(2)

Collective Molecular Machines: Multidimensionality and Reconfigurability

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Nano-Micro Letters 2024年第8期16卷 309-340页

作者： Bin wang Yuan lu Department of Chemical Engineering Tsinghua UniversityBeijing 100084People’s Republic of China Key Laboratory of Industrial Biocatalysis Ministry of EducationTsinghua UniversityBeijing 100084People’s Republic of China

Molecular machines are key to cellular activity where they are involved in converting chemical and light energy into efficient mechanical work.During the last 60 years,designing molecular structures capable of generating unidirectional mechanical motion at the nanoscale has been the topic of intense research.Effective progress has been made,attributed to advances in various fields such as supramolecular chemistry,biology and nanotechnology,and informatics.However,individual molecular machines are only capable of producing nanometer work and generally have only a single functionality.In order to address these problems,collective behaviors realized by integrating several or more of these individual mechanical units in space and time have become a new paradigm.In this review,we comprehensively discuss recent developments in the collective behaviors of molecular machines.In particular,collective behavior is divided into two paradigms.One is the appropriate integration of molecular machines to efficiently amplify molecular motions and deformations to construct novel functional materials.The other is the construction of swarming modes at the supramolecular level to perform nanoscale or microscale operations.We discuss design strategies for both modes and focus on the modulation of features and properties.Subsequently,in order to address existing challenges,the idea of transferring experience gained in the field of micro/nano robotics is presented,offering prospects for future developments in the collective behavior of molecular machines.

关键词： Molecular machines Collective control Collective behaviors DNA Biomolecular motors

Regulating ion transport behaviors toward dendrite-free potassium metal batteries:recent advances and perspectives

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Rare Metals 2024年第4期43卷 1435-1460页

作者： lu-Kang Zhao xuan-Wen Gao Tian-Zhen Ren Da wang Da-Wei wang Zhao-Meng Liu Hong Chen Wen-Bin luo School of Metallurgy Northeastern University School of Chemical Engineering The University of New South Wales

With abundant potassium resources and high capacity,potassium metal batteries(PMBs) present a compelling option for the next generation of energy storage technology.However,PMBs suffer from an unstable anode interface caused by uncontrolled dendrite growth,which results in unsatisfactory cyclability and safety concerns.Extensive investigations suggest that significant progress has been made in enhancing the interfacial stability of PMBs.The various effective strategies for stabilizing interfaces can ultimately be attributed to the regulation of the sluggish ion transfer kinetics and irregular deposition,i.e.,the arrangement of ion transport behaviors at the interface.Rational modulation of ions transport rate and ions deposition directions makes it possible to obtain a dendrite-free and smooth deposition plane.Herein,the influencing factors and action mechanism of K+interface transport behaviors are discussed to understand the nature of material design for constructing stable anode interfaces,including regulating the solvation and desolvation structures,accelerating K+transport kinetics and controlling K+deposition direction.In addition,the deficiencies and prospects of the research on electrolyte,separators and designed electrode involved in the manufacturing and testing and ion transport process of PMBs are discussed.This review is expected to provide some possible directions for constructing dendrite-free interfaces in advanced PMBs-related research and offer significant insights for prospective experimental research and commercial applications.

关键词： Ion transport rate Ion transport direction Interface Potassium metal batteries Dendrites growth

Comparative analysis between single-train passing and double-train intersection in a tunnel

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第5期25卷 429-442页

作者： Jianming DU Qian FANG xuan ZHANG Hualao wang Bridge and Tunnel Research Center Research Institute of Highway Ministry of TransportBejing 100088China Tunnel and Underground Engineering Research Center of Ministry of Education Beijing Jiaotong UniversityBeijing 00044China

Aerodynamic pressure significantly impacts the scientific evaluation of tunnel service performance.The aerodynamic pressure of two trains running in a double-track tunnel is considerably more complicated than that of a single train.We used the numerical method to investigate the difference in aerodynamic pressure between a single train and two trains running in a double-track tunnel.First,the numerical method was verified by comparing the results of numerical simulation and on-site monitoring.Then,the characteristics of aerodynamic pressure were studied.Finally,the influence of various train-tunnel factors on the characteristics of aerodynamic pressure was investigated.The results show that the aerodynamic pressure variation can be divided into stage I:irregular pressure fluctuations before the train tail leaves the tunnel exit,and stage II:periodic pressure declines after the train tail leaves the tunnel exit.In addition,the aerodynamic pressure simultaneously jumps positively or drops negatively for a single train or two trains running in double-track tunnel scenarios.The pressure amplitude in the two-train case is higher than that for a single train.The maximum positive peak pressure difference(P_(STP))and maximum negative peak pressure difference(P_(STN))increase as train speed rises to the power from 2.256 to 2.930 in stage I.The P_(STP) and P_(STN) first increase and then decrease with the increase of tunnel length in stage I.The P_(STP) and P_(STN) increase as the blockage ratio rises to the power from 2.032 to 2.798 in stages I and II.

关键词： Railway tunnel Aerodynamic effect Pressure characteristic Train speed Tunnel length Blockage ratio