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Ab Initio Study of Mechanism of Forming a Si-heterocyclic Spiro-Sn-heterocyclic Ring Compound by Cycloaddition Reaction of Cl2Si=Sn: and Ethylene

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Chinese Journal of Structural Chemistry 2019年第5期38卷 673-678,667页

作者： TAN Xiao-Jun lu xiu-Hui School of Biological Science and Technology University of Jinan Jinan 250022 China School of Chemistry and Chemical Engineering University of Jinan Jinan 250022 China

X2Si=Sn:(X = H, Me, F, Cl, Br, Ph, Ar…) are new species of chemistry. The cycloaddition reaction of X2Si=Sn: is a new study field of stannylene chemistry. To explore the rules of cycloaddition reaction between X2Si=Sn: and the symmetric p-bonded compounds, the cycloaddition reactions of Cl2Si=Sn: and ethylene were selected as model reactions in this *** mechanism of cycloaddition reaction between singlet Cl2Si=Sn: and ethylene has been first investigated with the MP2/GENECP(C, H, Cl, Si in 6-311++G**;Sn in LanL2dz) method in this paper. From the potential energy profile, it could be predicted that the reaction has one dominant reaction channel. The reaction rule presented is that the 5p unoccupied orbital of Sn in Cl2Si=Sn: and the π orbital of ethylene forming a p→p donor-acceptor bond, resulting in the formation of an intermediate. Instability of the intermediate makes it isomerize to a four-membered Si-heterocyclic ring stannylene. Because the 5p unoccupied orbital of Sn atom in the four-membered Si-heterocyclic ring stannylene and the π orbital of ethylene form a p→p donor-acceptor bond, the four-membered Si-heterocyclic ring stannylene further combines with ethene to form another intermediate. Because the Sn atom in the intermediate shows sp3 hybridization after transition state, the intermediate isomerizes to a Si-heterocyclic spiro-Sn-heterocyclic ring compound. The research result indicates the laws of cycloaddition reaction between X2Si=Sn: and the symmetric π-bonded compounds. The study opens up a new research field for stannylene chemistry.

关键词： Cl2Si=Sn: four-membered Si-heterocyclic ring stannylene spiro-Sn-heterocyclic ring compound potential energy profile

Perilipin Gene 1237 T>C Polymorphism is not Associated with Obesity Risk in Northern Chinese Han Adults

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Biomedical and Environmental Sciences 2009年第5期22卷 442-447页

作者： DONG-SHENG HU JING XIE DA-HAI YU GuO-HENG XU JIE lu JIN-xiu yang CHUN-yang LI YAN-YAN LI Department of Epidemiology College of Public Health Zhengzhou University Zhengzhou 450001 Henan China Population Health Unit Centre for Eye Research Australia University of Melbourne Level 132 Gisborne Street East Melbourne VIC 3002 Australia Department of Evidence-Based Medicine and Division of Population Genetics Cardiovascular Institute and Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China Department of Physiology Beijing University Medical Sciences Center Beijing 100083 China

Objective To identify the association between PLIN 1237 polymorphism and obesity in Chinese Han adults. Methods A total of 994 adults （157 obese subjects, 322 overweight subjects, and 515 normal controls） were recruited from two rural communities. PLIN 1237 polymorphism was genotyped by polymerase chain reaction-restriction-fragment-length-polymorphism （PCR-RFLP）. Association between PLIN polymorphisms and obesity status was estimated by ordinal logistic regression. Results The three genotypes of,PLIN 1237 were detected with a percentage of 54.3%, 37.1%, and 8.6% in TT, TC, and CC genotypes, respectively. For the PLIN 1237 polymorphism locus, the frequency of alleles T and C was 0.73 and 0.27, respectively. The PLIN 1237 polymorphisms were in Hardy-Weinberg equilibrium. PLIN 1237 polymorphism was not associated with obesity. The odds ratio for overweight or obesity for the CC＋TC genotype was 0.8（0.4, 1.4） in women （P=-0.4） and 0.6 （0.3, 1.3） in men （P=-0.2） after adjustment for age, education, household income and alcohol consumption, smoking, and physicalactivity. Conclusion Chinese Han adults have a lower frequency of variant-allele C in PLIN1237. PLIN1237 T〉C polymorphism is not significantly associated with obesity in northern Chinese adults.

关键词： Perilipin Polymorphism Obesity

Dual-AAV split prime editor corrects the mutation and phenotype in mice with inherited retinal degeneration

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Signal Transduction and Targeted Therapy 2023年第3期8卷 1186-1197页

作者： Kaiqin She Yi Liu Qinyu Zhao xiu Jin Yiliu yang Jing Su Ruiting Li Li Song Jianlu Xiao Shaohua Yao Fang lu Yuquan Wei yang yang Department of Ophthalmology West China HospitalSichuan UniversityChengduSichuanChina State Key Laboratory of Biotherapy and Cancer Center West China HospitalSichuan University and Collaborative Innovation CenterChengduSichuanChina

The prime editor(PE)can edit genomes with almost any intended changes,including all 12 possible types of base substitutions,small insertions and deletions,and their combinations,without the requirement for double strand breaks or exogenous donor *** demonstrates the possibility of correcting a variety of disease-causing mutations and might expand the therapeutic application of gene *** this study,PE was optimized based on a dual-adeno-associated virus(AAV)split-intein system in vitro by screening different split sites and split *** found that splitting PE before amino acid 1105(Ser)of SpCas9 with Rma intein resulted in the highest on-target *** orientations of pegRNA and nicking sgRNA in the AAV vector were further *** test the in vivo performance of the optimized dual-AAV split-PE3,it was delivered by subretinal injection in rd12 mice with inherited retinal disease Leber congenital *** prime editors corrected the pathogenic mutation with up to 16%efficiency in a precise way,with no detectable off-target edits,restored RPE65 expression,rescued retinal and visual function,and preserved *** findings establish a framework for the preclinical development of PE and motivate further testing of PE for the treatment of inherited retinal diseases caused by various mutations.

关键词： editor degeneration precise

Soil macroaggregates and organic-matter content regulate microbial communities and enzymatic activity in a Chinese Mollisol

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Journal of Integrative Agriculture 2019年第11期18卷 2605-2618页

作者： CHEN Xu HAN Xiao-zeng YOU Meng-yang YAN Jun lu Xin-chun William RHorwath ZOU Wen-xiu Key Laboratory of Mollisols Agroecology Northeast Institute of Geography and AgroecologyChinese Academy of SciencesHarbin 150081P.R.China Biogeochemistry and Nutrient Cycling Laboratory Department of LandAir and Water ResourcesUniversity of California DavisCA 95616USA

The formation and turnover of macroaggregates are critical processes influencing the dynamics and stabilization of soil organic carbon(SOC).Soil aggregate size distribution is directly related to the makeup and activity of microbial *** incubated soils managed for>30 years as restored grassland(GL),farmland(FL)and bare fallow(BF)for 60 days using both intact and reduced aggregate size distributions(intact aggregate distribution(IAD)lucose,alanine or inorganic N,to reveal activity and microbial community structure as a function of aggregate size and *** a 60-day incubation period,the highest phospholipid fatty acid(PLFA)abundance was on day 7 for bacteria and fungi,on day 15 for *** majority of the variation in enzymatic activities was likely related to PLFA *** had higher microbial abundance and enzyme *** reducing macroaggregates(>0.25 mm)by 34.7%in GL soil with no substrate additions increased the abundance of PLFAs(average increase of 15.7%)and activities of β-glucosidase(increase of 17.4%)and N-acetyl-β-glucosaminidase(increase of 7.6%).The addition of C substrates increased PLFA abundance in FL and BF by averages of 18.8 and 33.4%,respectively,but not in GL *** results show that the effect of habitat destruction on microorganisms depends on the soil aggregates,due to a release of bioavailable C,and the addition of substrates for soils with limited nutrient *** protection of SOC is promoted by larger size soil aggregate structures that are important to different aggregate size classes in affecting soil C stabilization and microbial community structure and activity.

关键词： soil macroaggregates soil organic carbon PLFAs enzyme activity microbial community Mollisol

Ab initio Study of Anharmonic Force Field and Spectroscopic Constants for Germanium Dichloride

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Chinese Journal of Chemical Physics 2016年第6期29卷 657-662,I0001页

作者： Wei-xiu Pang Yun-bin Sun Jian-jun Zhao Yi lu KeyLaboratoryofMagnetismandMaEneticMaterialsatUniversitiesofInnerMongoliaAutonomousRegion DepartmentofPhysicsBaotouNormalUniversityBaotou014030China

Ab initio study of the equilibrium structure, spectroscopy constants, and anharmonic force field for several isotopomers of germanium dichloride （70GeCl2, 72GECl2, and 76GeCl2） have been carried out at the MP2 and CCSD（T） levels of theory using cc-pVTZ basis set. The cal- culated geometries, rotational constants, vibration-rotation interaction constants, harmonic frequencies, anharmonic constants, quartic and sextic centrifugal distortion constants, cubic and quartic force constants are compared with experimental data. For small mass differences of the Ge isotopes, the isotopic effects for germanium dichloride are much weaker. The agreements are satisfactory for these two methods, but the deviations of CCSD（T） results are slightly larger than that of MP2, because of CCSD（T）＇s inadequate treatment of electron correlation in hypervalent Cl atom.

关键词： Anharmonic force field Spectroscopic constants Germanium dichloride

The Root Operator on Invariant Subspaces of the Weighted Bergman Space

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Journal of Mathematical Research and Exposition 2010年第1期30卷 54-66页

作者： Xiao yang ZHOU xiu Ying SHI Yu Feng lu School of Mathematical Science Dalian University of Technology Liaoning 116024 P. R. China School of Continuing Education Chifeng University Inner Mongolia 024000 P. R. China

In this paper, for an invariant subspace I of the weighted Bergman space, the weighted root operator is defined. We study the weighted root operator and obtain its fundamental properties when the invariant subspace I ... 详细信息

关键词： root operator index weighted Bergman space invariant subspace.

Periodic Solutions to a Kind of Second Order Neutral Functional Differential Equation in the Critical Case

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Acta Mathematica Sinica,English Series 2005年第5期21卷 1149-1158页

作者： Shi Ping lu Wei Gao GE Zu xiu ZHENG Department of Mathematics Anhui Normal University Wuhu 241000 P. R. China Department of Applied Mathematics Beijing Institute of Technology Beijing 100081 P. R. China Department of Mathematics Anhui University Hefei 230039 P. R. China

In this paper, the authors consider the existence of periodic solutions for a kind of second neutral functional differential equation as follows：（x（t） - cx（t -τ）＂ = g（t, x（t - μ（t）））＋ e（t）,in the critical case ｜c｜ = 1. By employing Mawhin＇s continuation theorem and some analysis techniques, some new results are obtained.

关键词： Periodic solution Mawhin's continuation theorem Neutral functional differential equation in the critical case

Deformation Temperature and Lamellar Thickness Dependency of FormⅠto Form Ⅲ Phase Transition in Syndiotactic Polypropylene during Tensile Stretching

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Chinese Journal of Polymer Science 2014年第9期32卷 1210-1217页

作者： Ying lu Ying-ying Sun Ran Chen xiu-hong Li 门永锋 State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences University of Chinese Academy of Sciences SSRF Shanghai Institute of Applied Physics Chinese Academy of Sciences

Phase transition from form Ⅰ to form Ⅲ in syndiotactic polypropylene crystallized at different conditions during tensile deformation at different temperatures was investigated by using in situ synchrotron wide angle X-ray diffraction technique. In all cases, the occurrence of this phase transition was observed. The onset strain of this transition was found to be crystalline thickness decided by crystallization temperature and drawing temperature dependent. The effect of drawing temperature on this phase transition is understood by the changes in mechanical properties with temperature. Moreover, crystalline thickness dependency of the phase transition reveals that this form Ⅰ to from Ⅲ phase transition occurs first in those lamellae with their normal along the stretching direction which have not experienced stress induced melting and recrystallization.

关键词： Tensile deformation Phase transition Syndiotactic polypropylene WAXD.

Synthesis and Antibacterial Activities of 1,4-Disubstituted Phenyl-5-(halo-2-hydroxyphenyl)imino-1,2,3-triazole

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Chemical Research in Chinese Universities 2012年第3期28卷 424-429页

作者： ZHAO Xu lu Jun-rui XIN Chun-wei lu Bo-wei BAO xiu-rong LI Jian-fa LIU Ya yang Xu-yun YUAN Yi College of Chemistry and Chemical Engineering Tianjin University of TechnologyTianjin 300384P.R.China College of Chemistry Nankai UniversityTianjin 300071P.R.China

According to the superposition principle of reinforcement of biological activities, 24 novel 1,4- disubstituted phenyl-5-（halo-2-hydroxyphenyl）imino-l,2,3-triazoles was synthesized and characterized by 1H NMR, ^13C NMR, elemental analysis and IR. All the target compounds were screened for their antibacterial potential in vitro against Monilia albican, Escherichia coli and Staphylococcus aureus. It was shown that all the compounds possessed efficient antibacterial activities at a concentration of 0.1 mg/mL, even at a concentration of 0.01 mg/mL, some of the compounds still exhibited antibacterial activities against Escherichia coli and Monilia albican. At last, the struc- ture-activity relationship was discussed based on the antibacterial results.

关键词： 1,4-Disubstituted phenyl-5-(halo-2-hydroxyphenyl)imino-l,2,3-triazole Antibacterial activity Structure-activity relationship