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Pseudohyperkalemia with Myelofibrosis after Splenectomy

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Chinese Medical Sciences Journal 2016年第4期31卷 258-260页

作者： Sheng-li Liu lu-wei zhang Jun Tian Center of Kidney Transplantation and Hemodialysis Qilu Hospital of Shandong University

SEUDOHYPERKALEMIA refers the serum potassiumlevel is higher than plasma potassium due tovarious reasons in vitro monitoring, but actualpotassium level in vivo is at the normal range. Aseries of inappropriate clinical interventions due to initialfailure to recognize it may actually decrease potassiumlevel，which could cause life-threatening condition. Here wereport a patient with myelofibrosis who occurred spurioushyperkalemia after splenectomy, aiming at emphasizingthe importance of recognizing pseudodyperkalemia.

关键词： pseudohyperkalemia serum potassium plasma potassium myelofibrosis splenectomy

Efficacy and safety of carrimycin in ten patients with severe pneumonia following solid organ transplantation

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World Journal of Clinical Cases 2024年第15期12卷 2542-2550页

作者： Xian-Quan Cui lu-wei zhang Peng Zhao Jing-Jing Feng Department of Organ Transplantation Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina Department of Blood Purification Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina

BACKGROUND The number of patients undergoing solid organ transplantation has increased ***,infections in solid organ transplant recipients can have a severe effect on patient survival owing to the continued use of *** is a novel macrolide antibiotic produced by genetically engineered streptomyces spiramyceticus harboring a 4’’-O-isovaleryltransferase gene(ist)from streptomyces *** has good antibacterial and antiviral ***,no relevant studies have been conducted on the efficacy and safety of carrimycin in patients with severe pneumonia(SP)after solid organ *** To explore the efficacy and safety of carrimycin in patients with SP after solid organ transplantation to provide a medication reference for clinical *** In March 2022,ten patients with SP following solid-organ transplantation were treated at our hospital between January 2021 and March *** the condition was critical and difficult to control with other drugs,carrimycin was *** ten patients'clinical features and treatment protocols were retrospectively analyzed,and the efficacy and safety of carrimycin for treating SP following solid organ transplantation were *** All ten patients were included in the *** etiological agent detection,there were three cases of fungal pneumonia,two cases of bacterial pneumonia,two cases of Pneumocystis pneumonia,and three cases of mixed *** treatment with carrimycin,the disease in seven patients significantly improved,the course of the disease was significantly shortened,fever was quickly controlled,chest computed tomography was significantly improved,and oxygenation was significantly ***,the patients were discharged after *** patient died of acute respiratory distress syndrome,and two patients discontinued *** Carrimycin is a safe and effective treatment modality for SP following soli

关键词： Carrimycin Organ transplantation Severe pneumonia Immunosuppressant Infection Antiviral drugs

Transarterial chemoembolization combined with radiofrequency ablation in the treatment of hepatocellular carcinomas larger than 5 cm

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Hepatoma Research 2019年第4期5卷 33-41页

作者： Yi Yang Zhuo-Min Lv Min Yan Hong-Xin zhang Yong Long wei-lu zhang Department of Pain Treatment Tangdu Hospital of the Fourth Military Medical UniversityXi’an 710038China Department of Epidemiology Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environmentthe Fourth Military Medical UniversityXi’an 710032China

Aim:This meta-analysis was designed to compare the effectiveness of the combination of transarterial chemoembolization(TACE)and radiofrequency ablation(RFA)*** of TACE alone in hepatocellular carcinoma(HCC)tumors larger than 5 ***:PUBMED,CNKI,and CBM were searched for all related randomized controlled trials(RCTs)up until October 22,*** studies were identified that compared TACE with *** alone for HCC *** response rate,the proportion of patients with either complete or partial shrinkage of tumors,and survival rate were the major evaluation ***:Meta-analysis data revealed that TACE with RFA showed significantly better tumor response rate(risk ratio(RR)=1.452,95%confidence interval(CI):1.308-1.610,P<0.001)and 1-year overall survival rate(RR=1.412,95%CI:1.249-1.596,P<0.001)than that of TACE alone ***:The data of our study indicates that TACE combined with RFA in the treatment of HCC larger than 5 cm is an effective comprehensive interventional therapy.

关键词： Transarterial chemoembolization radiofrequency ablation hepatocellular carcinoma meta-analysis

Raman scattering study of magnetic layered MPS_3 crystals(M = Mn, Fe, Ni)

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Chinese Physics B 2019年第5期28卷 226-231页

作者： Yi-Meng Wang Jian-Feng zhang Cheng-He Li Xiao-Li Ma Jian-Ting Ji Feng Jin He-Chang Lei Kai Liu wei-lu zhang Qing-Ming zhang Department of Physics Renmin University of China Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Department of Engineering and Applied Sciences Sophia University School of Physical Science and Technology Lanzhou University

We report a comprehensive Raman scattering study on layered MPS_3(M = Mn, Fe, Ni), a two-dimensional magnetic compound with weak van der Waals interlayer coupling. The observed Raman phonon modes have been well assigned by the combination of first-principles calculations and the polarization-resolved spectra. Careful symmetry analysis on the angle-dependent spectra demonstrates that the crystal symmetry is strictly described by C_(2h)but can be simplified to D_(3d) with good accuracy. Interestingly, the three compounds share exactly the same lattice structure but show distinct magnetic structures. This provides us with a unique opportunity to study the effect of different magnetic orders on lattice dynamics in MPS_3. Our results reveal that the in-plane Nel antiferromagnetic(AF) order in MnPS_3 favors a spin–phonon coupling compared to the in-plane zig-zag AF in NiPS_3 and FePS_3. We have discussed the mechanism in terms of the folding of magnetic Brillouin zones. Our results provide insights into the relation between lattice dynamics and magnetism in the layered MPX_3(M = transition metal, X = S, Se) family and shed light on the magnetism of monolayer MPX_3 materials.

关键词： Raman scattering two-dimensional magnetic van der Waals materials lattice dynamics magnetism

Efficacy and safety of stereotactic body radiation therapy combined with transarterial chemoembolization for Chinese intermediate-to advanced-stage hepatocellular carcinoma patients: a systematic review and meta-analysis

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Hepatoma Research 2019年第5期5卷 37-46页

作者： Shou-Jie Zhao Bai-Shu Dai Zhong-Jun Shao Xi-Lin Du wei-lu zhang Yong Long Department of General Surgery Tangdu Hospital of the Fourth Military Medical UniversityXi’an 710038China Department of Epidemiology the Fourth Military Medical UniversityXi’an 710032China

Aim:According to the current guidelines,transarterial chemoembolization(TACE)remains the first-line therapies for hepatocellular carcinoma(HCC)patients at Barcelona Clinic Liver Cancer(BCLC)B-stage and sorafenib is a small molecule target drug for BCLC *** clinical practice,clinicians have attempted to use stereotactic body radiation therapy(SBRT)plus TACE for treating intermediate-to advanced-stage ***,the therapeutic effects are still *** meta-analysis was conducted to elucidate the validity and safety of the combination therapy of SBRT plus TACE in the patients with intermediate-to advanced-stage ***:PubMed,MEDLINE,Web of Science,China Biology Medicine,Chinese Knowledge resources integrated and Chinese Scientific Journal Full-Text Database was searched from their inception date to November *** survival rates(half-year,one-year and two-year)were analyzed and compared between the observation groups and the control *** negative conversion rate of AFP and the total effective rate were also *** ratios(RR)and 95%CI were calculated to express therapeutic effects. ;Results:A total of 1,210 patients from 13 eligible studies were *** cooperation of TACE and SBRT notably ameliorated the whole survival rates of half-year,one-year,two-year,the negative conversion rate of AFP,and the total effective rate,compared with TACE or SBRT monotherapy[RR(the total effective rate),1.412,95%CI:1.309-1.523,P<0.001],[RR(half-year survival rate),1.196,95%CI:1.121-1.276,P<0.001],[RR(one-year survival rate),1.327,95%CI:1.236-1.424,P<0.001],[RR(two-year survival rate),1.479,95%CI:1.284-1.703,P<0.001]and[RR(negative conversion rate of AFP),1.756,95%CI:1.502-2.059,P<0.001].Sensitivity analysis supported the above ***:Combination therapy of SBRT and TACE provides survival benefits in intermediate-to advanced-stage HCC patients compared to monotherapy of SBRT or TACE.

关键词： Transcatheter arterial chemoembolization hepatocellular carcinoma stereotactic body radiation therapy meta-analysis

Permanence and Periodic Solution of an Impulsive Delay Two-prey One-predator System with Variable Coefficients

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Chinese Quarterly Journal of Mathematics 2009年第2期24卷 267-273页

作者： LIU Yan-wei lu Kai-zhang Department o.f Mathematics Zhoakou Normal University Zhoukou 466001 China

two-prey one-predator system with a special Holling-Ⅱ functional response is discussed. That w-periodic solution of the predator extinction is global asymptotically stable is proved by some new methods. Furthermore, by the comparison theorem of impulsive differential equation, the sufficient conditions are derived for the permanence and the existence of periodic solution of the system.

关键词： impulsive delay comparison principle variable coefficients

Relationship between endothelial cell protein C receptor gene 6936A/G polymorphisms and deep venous thrombosis

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Chinese Medical Journal 2011年第1期124卷 72-75页

作者： CHEN Xu-dong TIAN lu LIMing JIN wei zhang Hong-kun ZHENG Cheng-fei Department of Vascular Surgery First Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang 310003 China

Background Deep venous thrombosis （DVT） can result in pulmonary embolism, a fatal complication that is due to the dislodgement and movement of a blood clot （thrombus） from a limb into the lungs. Genetic risk factors related to DVT development include mutations in coagulation proteins, especially the endothelial protein C receptor （EPCR）, a component of the anticoagulation protein C （PC） pathway. The objective of the present study was to analyze the relationship between the 6936A/G polymorphism in the EPCR gene and the occurrence of DVT. Methods This study involved 65 patients with DVT and 71 age- and gender-matched healthy controls. Peripheral blood samples were collected from all subjects. Plasma levels of soluble EPCR （sEPCR） were measured by enzyme-linked immunosorbent assay. Genomic DNA was extracted and EPCR gene product was amplified by a standard PCR reaction. Gene product bands were sequenced to identify EPCR gene polymorphisms. Results In the control group, the level of sEPCR in subjects with 6936AG genotype was significantly higher than that in subjects with 6936AA genotype （（0.97_＋0.32） pg/ml vs. （0.61_＋0.24） pg/ml, P 〈0.01）. Similarly in the DVT group, the level of sEPCR in subjects with the 6936AG were greater than that in subjects with the 6936AA genotype （（0.87_-K）.21） pg/ml vs. （0.50-＋0.18） pg/ml, P 〈0.01）. The sEPCR level in DVT patients was significantly higher than that in healthy controls （（0.68_--K）.32） pg/ml vs. （0.54_--K）.22） pg/ml, P 〈0.05）. The 6936AG genotype frequency in DVT patients was significantly higher than that in healthy controls （P 〈0.05）. In contrast, the 6936AA genotype frequency in DVT patients was lower than that in healthy controls （P 〈0.05）. Subjects carrying 6936AG had an increased risk of thrombosis （OR=2.75, 95% CI： 1.04-7.30, P 〈0.05）. Conclusions EPCR gene 6936A/G polymorphism is associated with increased plasma levels of sEPCR. Subjects carrvinq 6936AG likely have an increased risk of thrombosis.

关键词： deep venous thrombosis endothelial cell protein C receptor polymorphisms

RADIATION FROM THE CRYOGENIC CALIBRATION LOAD FOR MICROWAVE RADIOMETERS

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Journal of Electronics(China) 1998年第2期15卷 182-186页

作者： lu Ying Guo wei zhang Zuyin(Huazhong University of Science and Technology, Wuhan 430074) Huazhong University of Science and Technology Wuhan

A styrofoam layer is introduced to the cryogenic calibration load for microwave radiometers in order to keep the antenna at ambient temperature while calibrating. Obviously the insulation layer has nonuniform temperature profile. A novel approach based on the transmission-line theory is presented to calculate the emission from the load. According to the sample calculation through this new approach, the contribution of the insulation layer to the load radiation can not be neglected.

关键词： Cryogenic calibration load Layered media Brightness temperature

Aquaporin-4 deficiency attenuates acute lesions but aggravates delayed lesions and microgliosis after cryoinjury to mouse brain

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Neuroscience Bulletin 2012年第1期28卷 61-68页

作者： Wen-Zhen Shi Chun-Zhen Zhao Bing Zhao Xiao-Liang Zheng San-Hua Fang Yun-Bi lu wei-Ping zhang Zhong Chen Er-Qing wei Department of Pharmacology and Institute of Neurobiology School of Medicine Zhejiang University Hangzhou 310058China

Objective To determine whether aquaporin-4 （AQP4） regulates acute lesions, delayed lesions, and the associated microglial activation after cryoinjury to the brain. Methods Brain cryoinjury was applied to AQP4 knockout （KO） and wild-type mice. At 24 h and on days 7 and 14 after cryoinjury, lesion volume, neuronal loss, and densities of microglia and astrocytes were determined, and their changes were compared between AQP4 KO and wild-type mice. Results Lesion volume and neuronal loss in AQP4 KO mice were milder at 24 h following cryoinjury, but worsened on days 7 and 14, compared to those in wild-type mice. Besides, microglial density increased more, and astrocyte proliferation and glial scar formation were attenuated on days 7 and 14 in AQP4 KO mice. Conclusion AQP4 deficiency ameliorates acute lesions, but worsens delayed lesions, perhaps due to the microgliosis in the late phase.

关键词： aquaporin-4 gene deficiency cryoinjury microglia astrocyte