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The study on the bottom friction and the breaking coefficient for typhoon waves in radial sand ridges—the Lanshayang Channel as an example

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Acta Oceanologica Sinica 2015年第3期34卷 99-107页

作者： xu Zhuo ZHANG wei lu Peidong CHEN Kefeng College of Harbor Coastal and Offshore Engineering Hohai University The Development Office of Yangtze River in Tongzhou District River and Harbor Department Nanjing Hydraulic Research Institute

Owing to the interactions among the complex terrain, bottom materials, and the complicate hydrodynam-ics, typhoon waves show special characteristics as big waves appeared at the high water level （HWL） and small waves emerged at low and middle water levels （LWL and MWL） in radial sand ridges （RSR）. It is as-sumed that the mud damping, sandy bed friction and wave breaking effects have a great influence on the typhoon wave propagation in this area. Under the low wave energy, a mud layer will form and transport into the shallow area, thus the mud damping effects dominate at the LWL and the MWL. And high Collins coef-ficient （c around 1） can be applied to computing the damping effects at the LWL and the MWL. But under the high wave energy, the bottom sediment will be stirred and suspended, and then the damping effects disappear at the HWL. Thus the varying Collins coefficient with the water level method （VCWL） is imple-mented into the SWAN to model the typhoon wave process in the Lanshayang Channel （LSYC） of the RSR, the observed wave data under “Winnie” （“9711”） typhoon was used as validation. The results show that the typhoon wave in the RSR area is able to be simulated by the VCWL method concisely, and a constant wave breaking coefficient （γ） equaling 0.78 is better for the RSR where wide tidal flats and gentle bed slopes exist.

关键词： typhoon wave radial sand ridges RSR mud damping effects varying Collins coefficient with the water level method wave breaking coefficient

Computational network pharmacological research of Chinese medicinal plants for chronic kidney disease

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Science China Chemistry 2010年第11期53卷 2337-2342页

作者： ZHU wei QIU XiaoHui xu XiaoJie lu ChuanJian Guangdong Hospital of Traditional Chinese Medicine Guangzhou 510006China College of Chemistry and Molecular Engineering Peking UniversityBeijing 100871China

The interaction between drug molecules and target proteins is the basis of pharmacological *** pharmacodynamic mechanism of Chinese medicinal plants for chronic kidney disease(CKD) was studied by molecular docking and complex network *** was found that the interaction network of components-proteins of Chinese medicinal plants is different from the interaction network of components-proteins of *** action mechanism of Chinese medicinal plants is different from that of *** also found the interaction network of components-proteins of tonifying herbs is different from the interaction network of components-proteins of evil expelling herbs using complex network research *** illuminates the ancient classification theory of Chinese medicinal *** computational approach could identify the pivotal components of Chinese medicinal plants and their key target proteins *** results provide data for development of multi-component Chinese medicine.

关键词： chronic kidney disease traditional Chinese medicine(TCM) molecular docking complex network

Morphology of platelet Golgi apparatus and their significance after acute cerebral infarction

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Neural Regeneration Research 2013年第23期8卷 2134-2143页

作者： wei lu Dong xu Ranran Tu Zhiping Hu Department of Neurology Second Xiangya HospitalCentral South University

Blood samples were harvested from the antecubital vein of 20 fasting patients with acute cerebral infarction at 1, 7 and 15 days after onset to prepare blood platelet suspension. Fasting antecubital vein blood was collected from an additional 20 normal adults as controls. Under transmission elec- tron microscope, platelet Golgi tubules and vesicles became significantly thickened, enlarged, and irregular after acute cerebral infarction. Alpha granules in platelets significantly reduced in number, especially 1 day after cerebral infarction. Under immunoelectron microscopy, a few alpha granules aggregated around Golgi tubules and vesicles after infarction. These results suggested that platelet Golgi apparatus displayed significant morphological changes, which were possibly associated with enhanced synthetic and secretory functions of activated platelets after acute cerebral infarction. This study used Golgi apparatus blocking agent Brefeldin A to block Golgi apparatus in an aim to study the effects of Golgi apparatus on CD40L expression on the surface of activated platelets. Flow cytometry revealed that CD40L expression on activated platelet surfaces decreased significantly when Golgi apparatus was blocked, which indicated that Golgi apparatus participated in the syn- thesis and transport of CD40L to the platelet surface.

关键词： neural regeneration brain injury Golgi apparatus CD40L alpha granules platelet ultrastructure cerebral infarction transport secretion Brefeldin A grants-supported paper neuroregeneration

Electrochemical impedance spectroscopy study on the corrosion of the weld zone of 3Cr steel welded joints in CO_2 environments

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International Journal of Minerals,Metallurgy and Materials 2015年第5期22卷 500-508页

作者： Li-ning xu Jin-yang Zhu Min-xu lu Lei Zhang wei Chang Corrosion and Protection Center Key Laboratory for Environmental Fracture (MOE) Institute for Advanced Materials and Technology University of Science and Technology Beijing CNOOC Research Institute

The welded joints of 3Cr pipeline steel were fabricated with commercial welding wire using the gas tungsten arc welding （GTAW） technique. Potentiodynamic polarization curves, linear polarization resistance （LPR）, electrochemical impedance spectroscopy （EIS）, scan- ning electron microscopy （SEM）, and energy-dispersive spectrometry （EDS） were used to investigate the corrosion resistance and the growth of a corrosion film on the weld zone （WZ）. The changes in electrochemical characteristics of the film were obtained through fitting of the EIS data. The results showed that the average corrosion rate of the WZ in CO2 environments first increased, then fluctuated, and finally de- creased gradually. The formation of the film on the WZ was divided into three stages： dynamic adsorption, incomplete-coverage layer forma- tion, and integral layer formation.

关键词： petroleum pipelines steel corrosion welded joints carbon dioxide electrochemical impedance spectroscopy

Green synthesis of MnO_x nanostructures and studies of their supercapacitor performance

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Science China Chemistry 2015年第4期58卷 627-633页

作者： wei Du Xiaoqian xu Di Zhang Qingyi lu Feng Gao State Key Laboratory of Coordination Chemistry Nanjing National Laboratory of Microstructures Coordination Chemistry Institute School of Chemistry and Chemical Engineering Nanjing University Department of Materials Science and Engineering Nanjing University

Manganese oxides with different crystalline phases and morphologies were prepared by calcining Mn CO3 precursors. The Mn CO3 precursors with different morphologies were obtained through a green route under hydrothermal conditions with orange pericarp extracting solution as the reducing agent. By calcining the precursor under different temperatures and atmospheres, Mn Ox with different stoichiometric ratios(i.e., Mn O, Mn O2, Mn2O3, and Mn3O4) can be obtained. Electrochemical studies reveal that among these manganese oxides, Mn O or Mn O2 are more suitable as supercapacitor working electrodes than Mn2O3 or Mn3O4. They exhibit high specific capacitance up to 296.6 F/g and also possess good cycling stability, which make them potential electrode materials for supercapacitors.

关键词： MnOx nanostructures green synthesis supercapacitor

Wet spinning of PVA composite fibers with a large fraction of multi-walled carbon nanotubes

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Progress in Natural Science:Materials International 2015年第5期25卷 445-452页

作者： Dengpan Lai Yizhe wei Liming Zou Yongjing xu Hongwei lu State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and Engineering Donghua University

PVA composites fibers with a large fraction of multi-walled carbon nanotubes modified by both covalent and non-covalent functionalization were produced by a wet-spinning *** XQ-1 tensile tester,thermogravimetric analysis,scanning electron microscopy,differential scanning calorimetry,and wide-angle X-ray diffraction were used to characterize the properties of PVA/MWNT composite *** TGA results suggested that MWNTs content in composite fibers were ranged from 5.3 wt%to 27.6 wt%.The mechanical properties of PVA/MWNT composite fibers were obviously superior to pure PVA *** Young's modulus of composite fibers enhanced with increasing the content of MWNTs,and it rised gradually from 6.7 GPa for the pure PVA fiber to 12.8 GPa for the composite fibers with 27.6 wt%***,the tensile strength increased gradually from 0.39 GPa for the pure PVA fiber to 0.74 GPa for the composite fibers with 14.4 wt%***,the tensile strength of the composite fibers decreased as the MWNTs content up to 27.6 wt%.SEM results indicated that the MWNTs homogeneously dispersed in the composite fibers,however some agglomerates also existed when the content of MWNTs reached27.6 wt%.DSC results proved strong interfacial interaction between MWNTs and PVA chain,which benefited composite fibers in the efficient *** characterization showed that the orientation of PVA molecules declined from 94.1%to 90.9%with the increasing of MWNTs *** good dispersibility of MWNTs throughout PVA matrix and efficient stress-transfer between MWNTs and PVA matrix may contributed to significant enhancement in the mechanical properties.

关键词： Multi-walled carbon nanotubes(MWNTs) Poly(vinyl alcohol)(PVA) Wet-spinning Composite fibers

Structure and quality controlled growth of InAs nanowires through catalyst engineering

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Nano Research 2014年第11期7卷 1640-1649页

作者： ZhiZhang Zhenyu lu Hongyi xu Pingping Chen wei lu Jin Zou Materials Engineering The University of Queensland St. Lucia Queensland 4072 Australia National Laboratory for Infrared Physics Shanghai Institute of Technical Physics Chinese Academy of Sciences 500 Yu-Tian Road Shanghai 200083 China Centre for Microscopy and Microanalysis The University of Queensland St. Lucia Queensland 4072 Australia

In this study, the structure and quality controlled growth of InAs nanowires using Au catalysts in a molecular beam epitaxy reactor is presented. By tuning the indium concentration in the catalyst, defect-free wurtzite structure and defect-free zinc blende structure InAs nanowires can be induced. It is found that these defect-free zinc blende structure InAs nanowires grow along 〈110〉 directions with four low-energy {111} and two {110} side-wall facets and adopt the （111） catalyst/nanowire interface. Our structural and chemical characterization and calculations identify the existence of a catalyst supersaturation threshold for the InAs nanowire growth. When the In concentration in the catalyst is sufficiently high, defect-free zinc blende structure InAs nanowires can be induced. This study provides an insight into the manipulation of crystal structure and structure quality of III-V semiconductor nanowires through catalyst engineering.

关键词： structure quality InAs nanowires molecular beam epitaxy (MBE) Au catalysts

Stretch Bending of Z-section Stainless Steel Profile

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Journal of Iron and Steel Research International 2016年第6期23卷 525-530页

作者： Zheng-wei GU Meng-meng lu Xin LI Hong xu State Key Laboratory of Automobile Materials Jilin University Changchun 130025 Jilin China Department of Materials Science and Engineering Jilin University Changchun 130025 Jilin China

The stretch bending properties of a new Z-section stainless steel profile were investigated by *** causes of the forming defects,such as section distortions and poor contour precision,were analyzed,and the corresponding controlling methods were *** results show that the main forming defects for the stretch bending of the Z-section profile were the flange sagging,the sidewall obliquing inward,the bottom surface upwarping,and the bad contour accuracy;the cross-section distortions were mainly induced by the shrinkage of the sidewall,which could be eliminated by increasing the sidewall height of the profile reasonably;the poor contour precision was mainly due to springback,which could be controlled by modifying the die surface based on the springback amount;for the investigated bending beam,the proper sidewall height compensation was 2mm,and the suitable die surface modification amount was 1.2times of the springback amount,when the elongation was 10% of the initial profile *** bending tests were conducted on a new type of die with adjustable bending surfaces,and high quality components were achieved,which verified the effectiveness of the defect controlling measures.

关键词： contour bending verified eliminated compensation stainless shrinkage modifying inward elongation

Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing Wu wei Wu Ying Wang Yan Sun Lingxiao Deng Melissa Walker Chen Chen Heqiao Dai Qi Han Ying Ding Yongzhi Xia George Smith Rui Li Nai-Kui Liu Xiao-Ming xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation