检索结果-南通市图书馆

Cyclooxygenase-2 expression is dependent upon epidermal growth factor receptor expression or activation in androgen independent prostate cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2008年第5期10卷 758-764页

作者： Rui-Peng Jia lu-wei xu Qi Su Jian-Hua Zhao Wen-Cheng Li Feng Wang Zheng xu Department of Urology Nanjing First Hospital Affiliated to Nanjing Medical University Nanjing 210006 China Department of Pathology Nanjing First Hospital Affiliated to NanjingMedical University Nanjing 210006 China Center Laboratory Nanjing First Hospital Affiliated to Nanjing Medical University Nanjing 210006 China

Aim： To investigate the expression of cyclooxygenase-2 （COX-2） and epidermal growth factor receptor （EGFR） and the possible mechanism in the development in androgen independent prostate cancer （AIPC）. Methods： Immunohistochemistry was performed on paraffin-embedded sections with goat polyclonal against COX-2 and mouse monoclonal antibody against EGFR in 30 AIPC and 18 androgen dependent prostate cancer （ADPC） specimens. The effect of epidermal growth factor （EGF） treatments on the expression of COX-2 and signal pathway in PC-3 and DU-145 cells was studied using reverse transcription-polymerase chain reaction （RT-PCR） and Western blot analysis. ELISA was used to measure prostaglandin E2 （PGE2） levels in the media of PC-3 and DU-145 incubated with EGF for 24 h. Results： COX-2 was positively expressed in AIPC and ADPC, which were predominantly in endochylema of prostate cancer （PCa） cells. Intense staining was seen in AIPC （80%） and in ADPC （55.5%）, but there was no significant association between the two groups. EGFR expression was also positive in the two groups （61.8% in ADPC and 90% in AIPC, P 〈 0.01）. A significant association was found between EGFR expression and a higher Gleason score （P 〈 0.05） or tumor stage （P 〈 0.05）. The expression of PGE2 was increased in PC-3 and DU-145 cells after being incubated with EGF. Both p38MAPK and PI-3K pathway were involved in the PC-3 cell COX-2 upregulation course. In DU- 145, only p38MAPK pathway was associated with COX-2 upregulation. Conclusion： EGFR activation induces COX-2 expression through PI-3K and/or p38MAPK pathways. COX-2 and EGFR inhibitors might have a cooperative anti-tumor effect in PCa.

关键词： cyclooxygenase-2 epidermal growth factor receptor prostatic neoplasms

Reduced expression of SK3 and IK1 channel proteins in the cavernous tissue of diabetic rats

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2010年第4期12卷 599-604页

作者： Jin-Hai Zhu Rui-Peng Jia lu-wei xu Jian-Ping Wu Zi-Zheng Wang Shu-Kui Wang Cheng-Jia Bo Department of Urology Nanjing First Hospital Affiliated to Nanjing Medical University Nanjing 210006 China Laboratory of Molecular Medicine Nanjing First Hospital Affiliated to Nanjing Medical University Nanjing 210006 China

The small （SK3） and intermediate （IK 1） conductance calcium-activated potassium channels could have key roles in the endothelium-dependent hyperpolarization factor pathway, which is believed to contribute to normal penile erection function. We aimed to investigate the expression of SK3 and IK1 in diabetic rodents. The experimental diabetes model was induced in 8-week-old male Sprague-Dawley rats （250-300 g） by a single administration of streptozotocin. Both the diabetes mellitus group （DM group, n = 20） and the control group （NDM group, n = 10） were injected with a low dose of apomorphine to allow for the measurement and comparison of the corresponding penile erections. The mRNA and protein expression levels of SK3 and IK1 were measured by reverse transcription polymerase chain reaction and western blot, respectively. Erectile function was significantly decreased in the DM group compared with control group （P 〈 0.05）. The mRNA and protein expression levels of SK3 and IK1 were reduced in the cavernous tissue of diabetic rats compared with the control group （P 〈 0.05）. Diabetes inhibits mRNA and protein expression of both SK3 and IK1 in the cavernous tissue of diabetic rats. This could play a key role in the development of erectile dysfunction in diabetic rats.

关键词： diabetes mellitus endothelium-dependent hyperpolarization factor erectile dysfunction IKI SK3

Intensity of stromal changes is associated with tumor relapse in clinically advanced prostate cancer after castration therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2014年第5期16卷 710-714,I0007,I0008页

作者： Jian-Ping Wu Wen-Bin Huang Hui Zhou lu-wei xu Jian-Hua Zhao Jia-Gen Zhu Jiang-Hao Su Hong-Bin Sun Department of Urology Nanjing Hospital Affiliated to Nanjing Medical University Nanjing China Department of Pathology Nanjing Hospital Affiliated to Nanjing Medical University Nanjing China

Reactive stromal changes in prostate cancer （PCa） are likely involved in the emergence of castration-resistant PCa （CRPC）. This study was designed to investigate stromal changes in patients with clinically advanced PCa and analyze their prognostic significance. Prostate needle biopsies obtained from 148 patients before castration therapy were analyzed by Masson trichrome staining and immunohistochemical analysis of vimentin and desmin. Reactive stroma grading was inversely correlated with Gleason score. Stroma grade （Masson stain 82.8% vs 45.6%, P 〈 0.001） and vimentin expression （P = 0.005） were significantly higher, and desmin expression （P = 0.004） significantly lower, in reactive stroma of tumors with a Gleason score of 6-7 than in adjacent peritumoral tissue. Kaplan-Meier analysis showed a significant association between reactive stroma grade in tumors and the occurrence of CRPC in patients with a Gleason score of 6-7 （P= 0.009）. Furthermore, patients with higher vimentin or lower desmin expression had a shorter disease-free period. In multivariate analysis, only vimentin expression was a significant predictor of tumor relapse （hazard ratio 1.78, 95% confidence interval 1.12-10.26, P = 0.012）. These findings indicate that the intensity of reactive stroma is associated with castration responsiveness, especially in patients with a lower Gleason score where the abundant stroma component is most frequently found. High expression of vimentin in tumor stroma was independently associated with poor outcomes in patients with Gleason scores of 6-7, and may serve as a new prognostic marker in daily practice.

关键词： cancer-associated fibroblasts castration resistance prostate cancer reactive stroma vimentin

From waste to wealth:Coal tar residue derived carbon materials as low-cost anodes for potassium-ion batteries

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 464-475页

作者： Zhonghua lu Jun Shen Xin Zhang Lingcong Chao Liang Chen Ding Zhang Tao wei Shoudong xu College of Chemical Engineering and Technology Taiyuan University of TechnologyTaiyuan 030024China College of Chemistry Taiyuan University of TechnologyTaiyuan 030024China School of Chemical Engineering and Pharmacy Wuhan Institute of TechnologyWuhan 430205China School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212003China

Carbon materials are widely recognized as highly promising electrode materials for various energy storage system *** tar residues(CTR),as a type of carbon-rich solid waste with high value-added utilization,are crucially important for the development of a more sustainable *** this study,we employed a straightforward direct carbonization method within the temperature range of 700-1000℃to convert the worthless solid waste CTR into economically valuable carbon materials as anodes for potassium-ion batteries(PIBs).The effect of carbonization temperature on the microstructure and the potassium ions storage properties of CTR-derived carbons(CTRCs)were systematically explored by structural and morphological characterization,alongside electrochemical performances *** on the co-regulation between the turbine layers,crystal structure,pore structure,functional groups,and electrical conductivity of CTR-derived carbon carbonized at 900℃(CTRC-900H),the electrode material with high reversible capacity of 265.6m Ah·g^(-1)at 50 m A·g^(-1),a desirable cycling stability with 93.8%capacity retention even after 100 cycles,and the remarkable rate performance for PIBs were ***,cyclic voltammetry(CV)at different scan rates and galvanostatic intermittent titration technique(GITT)have been employed to explore the potassium ions storage mechanism and electrochemical kinetics of *** indicate that the electrode behavior is predominantly governed by surface-induced capacitive processes,particularly under high current densities,with the potassium storage mechanism characterized by an“adsorption-weak intercalation”*** work highlights the potential of CTR-based carbon as a promising electrode material category suitable for high-performance PIBs electrodes,while also provides valuable insights into the new avenues for the high value-added utilization of CTR.

关键词： coal tar residue carbon materials anode potassium-ion batteries high value-added

ORDERING OF BAINITE IN A Cu-Zn-Al ALLOY

在线全文

学校读者我要写书评

暂无评论

中国有色金属学会会刊：英文版 1993年第1期3卷 66-71页

作者： lu, wei Jiang, Bohong xu, Zuyao (T. Y. Hsu) Shanghai Jiaotong University, Shanghai 200030, China

The ordering of bainite is studied and compared with that of martensite in a Cu-20Zn-6Al(wt—％) alloy by X-ray analysis. Experilnental results show that in contrast with the diffraction pattern for 9R or 18R martensite, in which the (115) diffraction peak is distinguishable from the (■ 0 5), and the (1 2 10) from the (2 0 10), the (1 1 5) and (■ 0 5) or the (1 2 10) and (■0 10) diffraction peaks in the bainites formed from high temperature B2 or low temperature L2 parent phase overlap, and these phenomena do not change after prolonged aging or slow-cooling. The bainite structure is quite different from that of the martensite, i. e., the inheritance of the ordering of the parent phase would not occur, during bainite formation.

关键词： Cu-Zn-Al alloy marensite bainite ordering

基于CT的股骨有限元模型的建立及髋关节中空多孔假体植入后受力分布的初步研究(英文)

在线全文

学校读者我要写书评

暂无评论

生物化学与生物物理进展 2011年第11期38卷 1072-1078页

作者：吕大伟蔡胥王岩中国人民解放军总医院骨科北京100853

利用有限元分析的方法,对髋关节中空多孔假体植入后的受力分布改变进行研究,为改进中空多孔人工关节假体的设计提供依据.建立了股骨和假体三维有限元模型,应用有限元分析软件Ansys5.7模拟单腿负重状态,考察应力分布并进行比较.使用SPSS ... 详细信息

利用有限元分析的方法,对髋关节中空多孔假体植入后的受力分布改变进行研究,为改进中空多孔人工关节假体的设计提供依据.建立了股骨和假体三维有限元模型,应用有限元分析软件Ansys5.7模拟单腿负重状态,考察应力分布并进行比较.使用SPSS Statistics 17.0软件进行分析处理,绘制折线图.结果表明:a.开孔后张力侧最大压应力有所减小,开孔部位的应力水平变化不明显.b.与周围骨质形成连接后孔缘局部应力增加,张力侧受力改变不明显.c.短柄假体受力模式仍为远端应力集中;张力侧应力减小,开孔部位应力明显增加.d.下孔受力均大于上孔,受力方向基本一致.

关键词：有限元分析生物力学髋关节假体

AlN/InN和AlN/GaN超晶格能带结构研究

在线全文

学校读者我要写书评

暂无评论

物理学报 2011年第8期60卷 693-702页

作者：芦伟徐明魏屹何林四川师范大学固体物理研究所成都610101

利用Krnig-Penney模型和形变势理论,从理论上探讨了纤锌矿型AlN/InN和AlN/GaN超晶格系统的能带结构及不同应变模式对能带结构的影响,计算得到了能带结构随各亚层参量变化的一般性规律、超晶格的能量色散关系、应变造成的影响以及不同... 详细信息

利用Krnig-Penney模型和形变势理论,从理论上探讨了纤锌矿型AlN/InN和AlN/GaN超晶格系统的能带结构及不同应变模式对能带结构的影响,计算得到了能带结构随各亚层参量变化的一般性规律、超晶格的能量色散关系、应变造成的影响以及不同亚层厚度的系统禁带宽度和导带第一子禁带宽度.研究发现,通过改变亚层厚度可以从不同形式设计能带结构,应变会改变系统禁带宽度,使带阶和子能带明显窄化,价带结构趋于复杂甚至生成准能带结构.与实验结果对比后发现,该模型适于模拟窄势阱结构超晶格,而对于宽势阱则必须考虑内建电场的作用.

关键词： AlN/InN和AlN/GaN超晶格 Krnig-Penney模型应变子能带

基于区域标记法的代价敏感支持向量机在股票预测中的研究

在线全文

学校读者我要写书评

暂无评论

四川大学学报（自然科学版） 2018年第2期55卷 277-282页

作者：秦璐李旭伟四川大学计算机学院成都610065

针对传统股票预测中单点标记法的缺陷,提出了区域标记法,区域标记法可以为训练分类器提供更多有用信息,在一定程度上减轻了类别不平衡的问题,也更能满足实际任务的需求.同时,构建了一个RCS-Trader模型,该模型使用了代价敏感的支持向量机... 详细信息

针对传统股票预测中单点标记法的缺陷,提出了区域标记法,区域标记法可以为训练分类器提供更多有用信息,在一定程度上减轻了类别不平衡的问题,也更能满足实际任务的需求.同时,构建了一个RCS-Trader模型,该模型使用了代价敏感的支持向量机和FS度量进行优化,相比于传统股票预测方法,RCS-Trader模型的效果更好,投资回报率更高.

关键词：区域标记法股票预测支持向量机代价敏感

Controllable synthesis of biomimetic wood stem nanoporous high entropy oxides catalysts for oxygen evolution reaction

在线全文

学校读者我要写书评

暂无评论

Nano Research 2025年第1期18卷 107-117页

作者： wei Wang weiqi Wang Huihui Wang Xing lu Jinwen Zhang Yunzhuo lu School of Materials Science and Engineering Dalian Jiaotong UniversityDalian 116028China School of Intelligence and Electronic Engineering Dalian Neusoft University of InformationDalian 116023China Guangdong Key Laboratory of Materials and Equipment in Harsh Marine Environment Guangzhou Maritime UniversityGuangzhou 510725China

Bubbles generated during the oxygen evolution reaction(OER)in water splitting readily adhere to the electrode surface,thereby impeding contact between the electrolyte and the active sites,thereby increasing the ***,it is imperative to elucidate the bubble release behavior and engineer electrodes that facilitate faster bubble *** this study,inspired by the wood stem of the Norway spruce,we synthesized a gradient nanoporous high-entropy oxide(GNP-HEO)electrode with a controllable pore *** GNP-HEO,featuring a well-controlled gradient in pore size,is achieved through a straightforward strategy combining selective laser melting with selective phase *** unique gradient nanoporous structure not only facilitates bubble release but also diminishes the bubble shielding effect in OER,thereby enhancing electrocatalytic *** affect interaction of Al,Co,Cr,Fe,and Ni,coupled with the gradient nanoporous structure,yields exceptional OER performance,evidenced by an overpotential of 250 mV at a current density of 50 mA/cm^(2) and a Tafel slope of 38.0 mV/dec in 1 M *** functional theory calculations confirm that the GNPHEO adheres to the adsorbate evolution mechanism reaction pathway and exhibits significant *** work highlights a promising approach for the design and synthesis of high-performance OER electrocatalysts.

关键词： oxygen evolution reaction high-entropy oxides selective phase dis-solution selective laser melting gradient nanoporous