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Chinese Chemical Letters 1990年第2期1卷 149-152页

作者： Ji liang SHI Yuan Chao ZHANG Li jun XIA Xi Kui JIANG Shanghai Institute of Organic Chemistry,Academia Sinica,345 Ling Ling lu,Shanghai 200032,China

The speculation that a flat molecule without a side-chain might not readily undergo the hydrophobicity-driven process of aggregation has been shown to be a plausible proposition by the fact that pyrene molecules do no... 详细信息

关键词： FORM EtOH

A write buffer design based on stable and area-saving embedded SRAM for flash applications

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Science China(Technological Sciences) 2015年第2期58卷 357-361页

作者： CAO Hua Min HUO Zong liang WANG Yu LI Ting LIU Jing JIN Lei JIANG Dan-Dan ZHANG Deng jun LI Di LIU Ming Institute of Microelectronics Chinese Academy of Sciences College of Communication Engineering Chengdu University of Information Technology Guangdong Berg Micro Co. Ltd.

This paper presents an embedded SRAM design for write buffer applications in flash *** write buffer is implemented with a newly proposed self-adaptive timing control circuit,an area-saving sense-latch circuit and 6 T SRAM cell units.A 2 kb SRAM macro with the area of 135μm×180μm is implemented in and applied to a 128 Mb NOR flash memory with the SMIC 65 nm NOR flash memory *** simulation and chip test results show that the SRAM write buffer is beneficial to high-density flash memory design.

关键词： write buffer embedded SRAM flash 65 nm technology 2 kb 128 Mb

Donor hepatic artery reconstruction based on human embryology:A case report

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World Journal of Gastrointestinal Surgery 2023年第8期15卷 1825-1830页

作者： He-Zhao Zhang jun-Hui lu Zhi-Yong Shi Ya-Rong Guo Wen-Hao Shao Fan-Xiu Meng Rui Zhang An-Hong Zhang jun Xu Faculty of Graduate Studies Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina Department of Hepatopancreatobiliary Surgery First Hospital of Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina Department of Oncology First Hospital of Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina

BACKGROUND Embryonic hepatic artery anatomy simplifies its identification during liver *** to the donor hepatic artery can cause complications in this *** hepatic artery's complex anatomy in adults makes this step challenging;however,during embryonic development,the artery and its branches have a simpler *** restoring the embryonic hepatic artery anatomy,surgeons can reduce the risk of damage and increase the procedure's success *** approach can lead to improved patient outcomes and lower complication *** SUMMARY In this study,we report a case of donor liver preparation using a donor hepatic artery preparation based on human *** the preparation of the hepatic artery,we restored the anatomy of the celiac trunk,superior mesenteric artery,and their branches to the state of the embryo at 5 *** allowed us to dissect the variant hepatic artery from the superior mesenteric artery and left gastric artery during the *** implanting the donor liver into the recipient,we observed normal blood flow in the donor hepatic artery,main hepatic artery,and variant hepatic artery,without any *** Donor hepatic artery preparation based on human embryology can help reduce the incidence of donor hepatic artery injuries during liver transplantation.

关键词： Donor hepatic artery Abnormality of artery Liver transplantation Embryonic development Anatomical relationship Case report

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手性多取代环戊二烯配体的合成及应用

有机化学 2020年第6期40卷 1792-1793页

作者：梁昊汪君中山大学化学学院广州510275

2012年, Cramer小组[1]与Rovis和Ward小组[2]几乎同时报道了手性环戊二烯(Cp)铑催化剂可以高效、高对映选择性地实现不对称碳氢键活化反应.其中,前者使用的是甘露醇衍生的具有手性骨架的Cp铑催化剂,而后者则是利用生物素(biotin)与亲和... 详细信息

2012年, Cramer小组[1]与Rovis和Ward小组[2]几乎同时报道了手性环戊二烯(Cp)铑催化剂可以高效、高对映选择性地实现不对称碳氢键活化反应.其中,前者使用的是甘露醇衍生的具有手性骨架的Cp铑催化剂,而后者则是利用生物素(biotin)与亲和素(avidin)的强结合作用,将非手性五甲基Cp铑络合物牢固绑定在人工酶的手性空腔中,进而形成手性催化剂.

关键词：铑催化剂手性催化剂铑络合物对映选择性环戊二烯五甲基人工酶亲和素

Mesenchymal stem cell therapy for liver fibrosis need“partner”:Results based on a meta-analysis of preclinical studies

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World Journal of Gastroenterology 2024年第32期30卷 3766-3782页

作者： Yan Xu Xue-Song Wang Xiao-Lei Zhou Wen-Ming lu Xing-Kun Tang Yu Jin jun-Song Ye Subcenter for Stem Cell Clinical Translation First Affiliated Hospital of Gannan Medical UniversityGanzhou 341000Jiangxi ProvinceChina School of Rehabilitation Medicine Gannan Medical UniversityGanzhou 341000Jiangxi ProvinceChina Ganzhou Key Laboratory of Stem Cell and Regenerative Medicine Gannan Medical UniversityGanzhou 341000Jiangxi ProvinceChina Department of Medical Genetics School of MedicineTongji UniversityShanghai 200092China Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases Ministry of EducationGannan Medical UniversityGanzhou 341000Jiangxi ProvinceChina

BACKGROUND The efficacy of mesenchymal stem cells(MSCs)in treating liver fibrosis has been demonstrated in several clinical ***,their low survival and liver implantation rates remain *** recent years,a large number of studies in animal models of liver fibrosis have shown that MSCs combined with drugs can improve the efficacy of MSCs in the treatment of liver fibrosis alone and inhibit its progression to end-stage liver *** has inspired new ways of thinking about treating liver *** To investigate the effectiveness and mechanisms of MSCs combined with drugs in treating liver *** Data sources included four electronic databases and were constructed until January *** subjects,interventions,comparators,outcomes,and study design principle were used to screen the literature,and the quality of the literature was evaluated to assess the risk of *** randomised controlled trials were selected,and the final 13 studies were included in the final *** A total of 13 studies were included after *** analysis showed that MSCs combined with drug therapy significantly improved liver function,promoted the repair of damaged liver tissues,reduced the level of liver fibrosis-related indexes,and effectively ameliorated hepatic fibrosis by modulating the hepatic inflammatory microenvironment,promoting the homing of MSCs,and regulating the relevant signaling pathways,and the treatment efficacy was superior to MSCs ***,the combined treatment statistics showed no amelioration in serum albumin levels(standardized mean difference=0.77,95%confidence interval:-0.13 to 1.68,P=0.09).CONCluSION In conclusion,MSCs combined with drugs for treating liver fibrosis effectively make up for the shortcomings of MSCs in their therapeutic ***,due to the different drugs,the treatment mechanism and effect also ***,more randomized controlled trials are needed to compare the therapeutic effic

关键词： drugs alone partner

Grape Skin Polyphenols （GSPs） Inhibit the Migration of Mouse Mammary Carcinoma 4T1 Cells in Vitro

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Clinical oncology and cancer researeh 2011年第1期8卷 33-37页

作者： Qiu-yu CHEN Zhi-qiang liang Tao SUN Xiang-jun SUN College of Agriculture and Biology Shanghai Jiaotong University Shanghai 200240 China College of Food Science and Engineering Shanxi Agricultural University Shanxi 030800China

OBJECTIVE 1） To study the efficacy of GSPs on the migration of highly metastatic mammary carcinoma cells and 2） To investigate inhibition *** Cell migration was assessed using a 24-well transwell assay. Cells with different concentrations of GSPs were suspended （5×105 cell/mL） in RPMI 1640 media in the upper chamber, and RPMI 1640 media with 10% FBS was supplemented in the lower chamber. Then, cells were allowed to migrate for 24 *** GSPs inhibited the migration of 4T1 cells in a dosedependent manner. The migration of 4T1 cells was obviously inhibited by GSPs, even at a very low concentration （5 μg/mL）,and was totally inhibited when the concentration was 20 μg/***, 20 μg/mL of GSPs inhibited cell viability by only 11.4% and induced early apoptosis by only 5.6% compared with a percentage of 4.0% in control cells. GSPs suppressed the activation of PDK1,Akt and Erk1/2 in a dose-dependent *** GSPs significantly inhibit the migration of highly metastatic mammary carcinoma 4T1 cells in vitro. This inhibition is independent of decreased cell viability or apoptosis induction. The inhibition of migration by GSPs is involved in blocking the PI3k/Akt and MAPK pathways.

关键词： grape skin polyphenols (GSPs) mammary carcinoma cells migration inhibition mechanism

新生儿呼吸窘迫综合征合并呼吸机相关肺炎患儿预后影响因素及生存预测

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中国妇幼健康研究 2025年第1期36卷 19-24页

作者：曲海新梁俊霞袁二伟刘璐郭卫平时丽霞河北北方学院附属第一医院新生儿科河北张家口075000 河北北方学院附属第一医院儿科河北张家口075000

目的探究新生儿呼吸窘迫综合征(RDS)合并呼吸机相关肺炎(VAP)患儿在血小板/淋巴细胞比率(PLR)、嗜酸性粒细胞/淋巴细胞比值(ELR)和红细胞分布宽度/白蛋白比值(RAR)水平的变化与其对预后的影响,并评估其联合预测的能力。方法选取2021年8... 详细信息

目的探究新生儿呼吸窘迫综合征(RDS)合并呼吸机相关肺炎(VAP)患儿在血小板/淋巴细胞比率(PLR)、嗜酸性粒细胞/淋巴细胞比值(ELR)和红细胞分布宽度/白蛋白比值(RAR)水平的变化与其对预后的影响,并评估其联合预测的能力。方法选取2021年8月至2023年8月于河北北方学院附属第一医院收治的120例患RDS的新生儿为研究对象,根据是否发生VAP分为VAP组22例和非VAP组98例,根据病情严重程度VAP组进一步分为低危组7例、中危组8例和高危组7例。对VAP组患儿进行28天预后状况随访,根据随访结果分为生存组16例和死亡组6例。使用全自动血液分析仪进行血常规检测,计算出PLR、ELR、RAR水平。采用多因素Logistic回归分析RDS并发VAP患儿预后的影响因素。应用受试者工作特征(ROC)曲线分析RDS并发VAP新生儿PLR、ELR、RAR水平与预后的关系。结果与非VAP组相比,VAP组患儿中PLR、ELR、RAR水平显著升高(t=5.580、7.970、11.603,P<0.05)。与低危组相比,高危组患儿中PLR水平显著升高(F=5.950,P<0.05)。与低危组相比,中危组和高危组患儿中ELR、RAR水平依次显著升高(F=14.788、20.248,P<0.05)。与生存组相比,死亡组PLR(t=3.501,P=0.002)、ELR(t=5.502,P<0.05)、RAR(t=3.646,P=0.002)水平显著升高。PLR[OR=2.744(1.772~4.248)]、ELR[OR=3.285(1.714~6.297)]、RAR[OR=1.894(1.485~2.415)]水平为RDS并发VAP患儿预后的危险因素(P<0.05)。与PLR、ELR、RAR单独预测相比,三者联合预测RDS并发VAP新生儿预后的曲线下面积(AUC)0.917(95%CI:0.718~0.991)显著升高(Z PLR~PLR+ELR+RAR=3.575,P<0.001;Z ELR~PLR+ELR+RAR=3.319,P<0.001;Z RAR~PLR+ELR+RAR=4.582,P<0.001)。结论RDS并发VAP新生儿PLR、ELR、RAR水平显著升高,与病情严重程度有关,是影响新生儿预后的重要因素,三者联合检测能够提高对RDS并发VAP新生儿预后的预测价值。

关键词：呼吸窘迫综合征呼吸机相关性肺炎新生儿血小板/淋巴细胞比率嗜酸性粒细胞/淋巴细胞比值红细胞分布宽度/白蛋白比值预后

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Analysis and Design of Vector Control for VSC-HVDC Connected to Weak Grids

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CSEE Journal of Power and Energy Systems 2017年第2期3卷 115-124页

作者： Guanglu Wu jun liang Xiaoxin Zhou Yalou Li Agusti Egea-Alvarez Gen Li Hongying Peng Xing Zhang State Key Laboratory of Power Grid Safety and Energy Conservation(China Electric Power Research Institute) Beijing 100192China School of Engineering Cardiff UniversityCardiffCF243AAUK

Voltage source converter based high voltage direct current transmission(VSC-HVDC)is considered one of the most suitable technologies to integrate renewable ***,connecting VSC to a weak grid is challenging since traditional vector control tends to become unstable under high power demand *** this paper,an improved vector control method is proposed wherein a feed forward branch based on steady state and small signal analysis of the VSC system is added under weak grid *** feed forward branch promotes faster reactive power response,thus enhancing the stability of the VSC *** the improved vector control uses the same inner loop as traditional vector control,the proposed method allows for the ability to retain fault current suppression ***,the control parameters of the outer loop of the improved vector control need not vary according to the variation of the operating points,which makes it easy to *** feed forward branch is implemented by solving a nonlinear equation or through use of a look-up *** influence of the estimation errors of short circuit ratio(SCR)on the control performance is also *** effectiveness of the improved vector control is demonstrated through small signal model analysis and time domain simulations.

关键词： Improved vector control VSC-HVDC weak AC grids

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初速度对被撞船舷侧结构影响

大连理工大学学报 2008年第1期48卷 90-94页

作者：马骏陶亮大连理工大学船舶工程学院辽宁大连116024

采用ANSYS/LS-DYNA建立了两船发生侧向对中垂直碰撞的非线性有限元模型,模型中考虑了材料非线性、几何非线性等因素;并以所建立的非线性有限元模型为基础,对被撞船舷侧结构碰撞性能进行了仿真研究,得到了碰撞力和能量随碰撞船位移变化... 详细信息

采用ANSYS/LS-DYNA建立了两船发生侧向对中垂直碰撞的非线性有限元模型,模型中考虑了材料非线性、几何非线性等因素;并以所建立的非线性有限元模型为基础,对被撞船舷侧结构碰撞性能进行了仿真研究,得到了碰撞力和能量随碰撞船位移变化的关系曲线,重点研究了碰撞船初速度的影响.数值仿真结果表明,不同的碰撞船初速度会导致被撞船舷侧结构产生不同形式的变形和不同程度的损伤.同时,通过仿真计算得到了某一确定碰撞情景下被撞船舷侧内、外壳破裂的临界速度,可以为海事部门制定海上限速避碰规则提供依据.

关键词：船舶碰撞数值仿真非线性有限元结构损伤临界速度

Cervical spondylotic myelopathy with syringomyelia presenting as hip Charcot neuroarthropathy:A case report and review of literature

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World Journal of Clinical Cases 2022年第3期10卷 1077-1085页

作者： Yu lu jun-Yi Xiang Cheng-Yu Shi Ju-Bao Li Hai-Chao Gu Chang Liu Guo-Yu Ye Department of Orthopedics Yunnan Provincial Hospital of Traditional Chinese MedicineKunming 650000Yunnan ProvinceChina Department of Management and Economics Kunming University of Science and TechnologyKunming 650000Yunnan ProvinceChina Department of Sleep Center The First People's Hospital of Yunnan ProvinceKunming 650000Yunnan ProvinceChina

BACKGROUND Charcot neuroarthropathy(CN)is a systemic disease characterized by progressive bone loss and destruction,which is usually closely related to diabetes,HIV,***,CN caused by syringomyelia accounts for only 5%of CN cases;the shoulder and elbow are most often involved,and the hip joint is rarely *** a rare factor,cervical spondylotic myelopathy(CSM)can be associated with syringomyelia,which is scarcely reported in the ***,we present the first case report to date of CN of the hip caused by syringomyelia secondary to *** SUMMARY We describe a 76-year-old male patient who was diagnosed with CSM due to neck pain and weakness of limbs 16 years *** years ago,he noticed recurrent swelling of the right hip with pain and was diagnosed with degenerative ***,however,his symptoms gradually worsened,and because of progressive pain,destabilization and weakness of the right hip,he was admitted to our *** systematic physical,radiographic and laboratory examinations,we finally reached a diagnosis:CN of the right hip associated with syringomyelia secondary to *** comprehensive evaluation of the patient's condition,we performed right total hip *** the follow-up,the patient felt well clinically and could walk independently with a knee *** We suggest a possible etiological association between CSM and syringomyelia,which may reflect a potential pathogenesis of *** encourage clinicians to actively carry out a detailed medical history and comprehensive physical and imaging examinations in patients with joint lesions,especially chronic shoulder neck pain,to rule out the possibility of this association,which plays a crucial role in the early diagnosis of *** may no longer be an absolute contraindication to surgical treatment of *** selection of the surgical strategy can markedly improve the clinical symptoms and quality of life of patients.

关键词： Cervical spondylotic myelopathy Syringomyelia Hip Charcot neuroarthropathy Case report