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Stretch Bending of Z-section Stainless Steel Profile

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Journal of Iron and Steel Research International 2016年第6期23卷 525-530页

作者： Zheng-wei GU meng-meng lu Xin LI Hong XU State Key Laboratory of Automobile Materials Jilin University Changchun 130025 Jilin China Department of Materials Science and Engineering Jilin University Changchun 130025 Jilin China

The stretch bending properties of a new Z-section stainless steel profile were investigated by *** causes of the forming defects,such as section distortions and poor contour precision,were analyzed,and the corresponding controlling methods were *** results show that the main forming defects for the stretch bending of the Z-section profile were the flange sagging,the sidewall obliquing inward,the bottom surface upwarping,and the bad contour accuracy;the cross-section distortions were mainly induced by the shrinkage of the sidewall,which could be eliminated by increasing the sidewall height of the profile reasonably;the poor contour precision was mainly due to springback,which could be controlled by modifying the die surface based on the springback amount;for the investigated bending beam,the proper sidewall height compensation was 2mm,and the suitable die surface modification amount was 1.2times of the springback amount,when the elongation was 10% of the initial profile *** bending tests were conducted on a new type of die with adjustable bending surfaces,and high quality components were achieved,which verified the effectiveness of the defect controlling measures.

关键词： contour bending verified eliminated compensation stainless shrinkage modifying inward elongation

Consolidation solution for composite foundation considering a time-and depth-dependent stress increment along with three distribution patterns of soil permeability

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第4期12卷 268-277页

作者： meng-meng lu Kang-he XIE Chuan-xun LI Kun WANG State Key Laboratory for Geomechanics and Deep Underground Engineering School of Meehanics & Civil Engineering China University of Mining & Technology Xuzhou 221008 China MOE Key Laboratory of Soft Soils and Geoenvironmental Engineering Zhejiang University Hangzhou 310058 China

In actual engineering practice,the stress increment within a composite foundation caused by external loads may vary simultaneously with depth and *** addition,column installation always leads to a decay of soil permeability towards the ***,almost none of the consolidation theories for composite foundation comprehensively consider these factors until *** this reason,a stress increment due to external loads changing simultaneously with time and depth was incorporated into the analysis,and three possible variation patterns of soil's horizontal permeability coefficient were considered to account for the detrimental influence of column *** three patterns included a constant distribution pattern(Pattern I),a linear distribution pattern(Pattern II),and a parabolic distribution pattern(Pattern III).Solutions were obtained for the average excess pore water pressures and the average degree of consolidation *** several special cases were discussed in detail based on the general solution ***,comparisons were made,and the results show that the present solution is the most general rigorous solution in the literature,and it can be broken down into a number of previous *** consolidation rate is accelerated with the increase in the value of the top to the bottom stress *** consolidation rate calculated by the solution for Pattern I is less than that for Pattern II,which in turn is less than that for Pattern III.

关键词： Consolidation Composite foundation Stone column Permeability Ramp load Disturbance effect

Synthesis,Characterization　and　Catalytic　Activity　of　Polyoxometalates　Derived　from　α-P₂W₁₅O₅6⁽12

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Chemical Research in Chinese Universities 1998年第1期14卷 1-5页

作者： meng, lu Liu, Jing-fu NE Normal Univ Dept Chem Changchun 130024 Peoples R China

Ｓｙｎｔｈｅｓｉｓ，ＣｈａｒａｃｔｅｒｉｚａｔｉｏｎａｎｄＣａｔａｌｙｔｉｃＡｃｔｉｖｉｔｙｏｆＰｏｌｙｏｘｏｍｅｔａｌａｔｅｓＤｅｒｉｖｅｄｆｒｏｍα－Ｐ;Ｗ;Ｏ;６;ＬｉｇａｎｄＭＥＮＧＬｕ，ａｎｄＬＩＵＪｉｎｇ－ｆ... 详细信息

Ｓｙｎｔｈｅｓｉｓ，ＣｈａｒａｃｔｅｒｉｚａｔｉｏｎａｎｄＣａｔａｌｙｔｉｃＡｃｔｉｖｉｔｙｏｆＰｏｌｙｏｘｏｍｅｔａｌａｔｅｓＤｅｒｉｖｅｄｆｒｏｍα－Ｐ;Ｗ;Ｏ;６;ＬｉｇａｎｄＭＥＮＧＬｕ，ａｎｄＬＩＵＪｉｎｇ－ｆｕ(Ｄｅｐａ...

关键词： Activity Polyoxometalates Catalytic

短链脂肪酸介导的肠骨轴在骨代谢中的研究进展

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食品科学 2025年第2期46卷 260-267页

作者：张萱杨雪李新科孟璐王加启郑楠中国农业科学院北京畜牧兽医研究所农业农村部奶及奶制品质量安全控制重点实验室北京100193 中国农业科学院北京畜牧兽医研究所农业农村部奶产品质量安全风险评估实验室(北京)北京100193

随着全球老龄化加剧,骨质疏松症等与年龄相关的骨骼代谢疾病发病率不断上升,寻求安全有效的治疗干预方法至关重要。目前肠道微生物及其代谢产物调节骨代谢已成为研究的热点。短链脂肪酸(short-chain fatty acids,SCFAs)如乙酸、丙酸和... 详细信息

随着全球老龄化加剧,骨质疏松症等与年龄相关的骨骼代谢疾病发病率不断上升,寻求安全有效的治疗干预方法至关重要。目前肠道微生物及其代谢产物调节骨代谢已成为研究的热点。短链脂肪酸(short-chain fatty acids,SCFAs)如乙酸、丙酸和丁酸等,能够通过肠-骨轴发挥骨形成和骨吸收的调节作用,对骨稳态调节具有一定的积极作用,并能改善炎症性骨丢失。本文综述SCFAs通过内分泌、免疫、改善营养吸收等途径调控骨代谢稳态,以期为老年代谢性骨病的预防和治疗提供科学依据。

关键词：肠-骨轴短链脂肪酸肠道微生物骨代谢骨质疏松症

Responsive Dual-Targeting Exosome as a Drug Carrier for Combination Cancer Immunotherapy

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Research 2021年第1期2021卷 1433-1444页

作者： Yuanyuan Fan Yingshun Zhou meng lu Haibin Si lu Li Bo Tang College of Chemistry Chemical Engineering and Materials ScienceCollaborative Innovation Center of Functionalized Probes for Chemical ImagingKey Laboratory of Molecular and Nano ProbesMinistry of EducationShandong Normal UniversityJinan 250014China

Recently,combination immunotherapy,which incorporates the activation of the immune system and inhibition of immune escape,has been proved to be a new powerful strategy for more efficient tumor suppression compared to ***,the major challenge is how to integrate multiple immune drugs together and efficiently convey these drugs to tumor *** a variety of nanomaterials have been exploited as carriers for targeting tumor issues and the delivery of multiple drugs,their potential toxicity,immune rejection,and stability are still controversial for clinical ***,we proposed endogenic exosomes as drug carriers to deliver two antibodies acting as tumor-targeting molecules and block checkpoint inhibitors with specific response to the tumor microenvironment and costimulatory molecules for further improvement of therapeutic *** versatile exosomes exhibit excellent biocompatibility and provide a combination immunotherapy platform with synergistic advantages of activation of immune response and inhibition of immune escape.

关键词： drugs versatile Dual

Predicting the D_(s)(*)D_(s)(*)bound states as the partners of X(3872)

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Science Bulletin 2021年第13期66卷 1288-1295,M0003,M0004页

作者： lu meng Bo Wang Shi-Lin Zhu Ruhr-Universität Bochum Fakultät für Physik und AstronomieInstitut für Theoretische Physik IID-44780 BochumGermany Center of High Energy Physics Peking UniversityBeijing 100871China School of Physics and State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijing 100871China

In this work,we investigate the SU(3)flavor symmetry,heavy quark spin symmetry and their breaking effects in the di-meson *** prove the existence of the[D_(s)(*)D_(s)(*)]^(0++),[D_(s)(*)D_(s)(*)]^(1++),and[D_(s)(*)D_(s)(*)]^(1++)bound states as the consequence of two prerequisites in the SU(3)flavor symmetry and heavy quark spin *** first prerequisite,the X(3872)as the weakly D*D=DD*bound state is supported by its mass and decay branching *** second prerequisite,the existence of the DsDs[D_(s)(*)D_(s)(*)]^(0++)bound state is supported by the lattice QCD calculation and the observation of X_(c0)(3930)by the LHCb *** hope the future experimental analyses can search for these bound states in the B→[D_(s)(*)D_(s)(*)]h processes(h denotes the light hadrons).The[D_(s)(*)D_(s)(*)]^(0++)bound state is also expected to be reconstructed in the J/ψФinal state in the B→//ψФK decay.

关键词： SU(3)flavor symmetry Hadronic molecule Xe3872T Tetraquark

Evolutionary mechanisms and practical significance of reproductive success and clonal diversity in unisexual vertebrate polyploids

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Science China(Life Sciences) 2024年第3期67卷 449-459页

作者： meng lu Li Zhou Jian-Fang Gui State Key Laboratory of Freshwater Ecology and Biotechnology Hubei Hongshan Laboratorythe Innovation Academy of Seed DesignInstitute of HydrobiologyChinese Academy of SciencesWuhan 430072China University of Chinese Academy of Sciences Beijing 100049China

Unisexual reproduction is generally relevant to polyploidy, and unisexual vertebrates are often considered an evolutionary “dead end” due to the accumulation of deleterious mutations and absence of genetic diversity. However, some unisexual polyploids have developed strategies to avoid genomic decay, and thus provide ideal models to unveil unexplored evolutionary mechanisms, from the reproductive success to clonal diversity creation. This article reviews the evolutionary mechanisms for overcoming meiotic barrier and generating genetic diversity in unisexual vertebrates, and summarizes recent research advancements in the polyploid Carassius complex. Gynogenetic gibel carp(Carassius gibelio) is a unique amphitriploid that has undergone a recurrent autotriploidy and has overcome the bottleneck of triploid sterility via gynogenesis. Recently, an efficient strategy in which ploidy changes, including from amphitriploid to amphitetraploid, then from amphitetraploid to novel amphitriploid, drive unisexual-sexual-unisexual reproduction transition and clonal diversity has been *** on this new discovery, multigenomic reconstruction biotechnology has been used to breed a novel strain with superior growth and stronger disease resistance. Moreover, a unique reproduction mode that combines both abilities of ameiotic oogenesis and sperm-egg fusion,termed as ameio-fusiongensis, has been discovered, and it provides an efficient approach to synthesize sterile allopolyploids. In order to avoid ecological risks upon escape and protect the sustainable property rights of the aquaculture seed industry, a controllable fertility biotechnology approach for precise breeding is being developed by integrating sterile allopolyploid synthesis and gene-editing *** review provides novel insights into the origin and evolution of unisexual vertebrates and into the attempts being made to exploit new breeding biotechnologies in aquaculture.

关键词： unisexual vertebrates polyploidy reproduction transition clonal diversity precise breeding genomic reconstruction controllable fertility

Knocking-Out OsPDR7 Triggers Up-Regulation of OsZIP9 Expression and Enhances Zinc Accumulation in Rice

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Rice science 2023年第1期30卷 36-49页

作者： meng lu TANG Mingfeng ZHU Yuxing TAN Longtao Key Laboratory of Agro-ecological Processes in Subtropical Region Institute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125China University of Chinese Academy of Sciences Beijing 100049China Institute of Agricultural Quality Standard and Testing Technology Chongqing Academy of Agricultural SciencesChongqing 401329China

Zinc(Zn) is an essential trace mineral that is required for plant growth and development. A number of protein transporters, which are involved in Zn uptake, translocation and distribution, are finely regulated to maintain Zn homeostasis in plant. In this study, we functionally characterized an ATP-binding cassette(ABC) transporter gene, OsPDR7, which is involved in Zn homeostasis. Os PDR7 encodes a plasma membrane-localized protein that is expressed mainly in the exodermis and xylem in the rice ***7 mutants resulted in higher Zn accumulation compared with the wild type. Heterogeneous expression of OsPDR7 in a yeast mutant rescued the Zn-deficiency phenotype, implying transport activity of OsPDR7 to Zn in yeast. However, no ZIP genes except for OsZIP9 showed change in expression profile in the ospdr7 mutants, which suggested that OsPDR7 maintains cellular Zn homeostasis through regulating Os ZIP9 expression. RNA-Seq analysis further revealed a set of differentially expressed genes between the wild type and ospdr7 mutants that allowed us to propose a possible OsPDR7-associated signaling network involving transporters, hormone responsive genes, and transcription factors. Our results revealed a novel transporter involved in the regulation of Zn homeostasis and will pave the way toward a better understanding of the fine-tuning of gene expression in the network of transporter genes.

关键词： OsPDR7 OsZIP9 zinc metal accumulation rice ATP-binding cassette transporter

Theoretical Characterization of Indentation Depth-Dependent Creep Behavior of CoCrFeNiAl_(0.3) High-Entropy Alloy

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Acta Mechanica Solida Sinica 2023年第1期36卷 55-64页

作者： lu meng Weiling Cui Buyun Su Xuefeng Shu Gesheng Xiao Institute of Applied Mechanics College of Mechanical and Vehicle EngineeringTaiyuan University of TechnologyTaiyuan 030024China Shanxi Key Laboratory of Material Strength and Structural Impact Taiyuan 030024China College of Biomedical Engineering Taiyuan University of TechnologyTaiyuan 030024China

The effects of indentation loading depth and dynamic pre-compression on the creep behavior of CoCrFeNiAl_(0.3) high-entropy alloy(HEA)were studied through a series of indentation creep *** show that the creep displacement,creep stress exponent and creep strain rate are all sensitive to loading depth.A phenomenological model based on the holding time and loading depth was established by studying the characteristic relation between the loading depth and the creep displacement of CoCrFeNiAl_(0.3) *** phenomenological model was used to analyze the creep behavior of the alloy under dynamic pre-compression(i.e.,dynamic compressive deformation caused by Hopkinson bar impact).

关键词： High-entropy alloy Creep behavior Phenomenological model Indentation depth-dependence Dynamic pre-compression