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Multiple neurofibromas plus fibrosarcoma with familial NF1 pathogenicity:A case report

World Journal of Clinical Cases 2020年第7期8卷 1306-1310页

作者： Yang Wang Xiao-Fan lu lu-lu Chen Ying-Wei Zhang Bing Zhang Department of Radiology The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008Jiangsu ProvinceChina Research Center of Biostatistics and Computational Pharmacy China Pharmaceutical UniversityNanjing 210009Jiangsu ProvinceChina Department of Respiration The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008Jiangsu ProvinceChina

BACKGROUND Neurofibromatosis(NF)is a genetic disease consisting of seven types,of which types 1 to 4 are caused by a dominant autosomal gene mutation;such disease sometimes arises in patients with NF type ***,it remains unclear whether the origin of neurofibrosarcoma is directly linked to the incidence of NF type 1,as no reports have been published on this ***,we report a case of NF1-positive multiple neurofibromas with malignant fibrosarcomatous transformation in the pleural *** SUMMARY A 51-year-old male was admitted to our hospital due to fever accompanied by coughing,chest tightness and asthma for more than one *** preliminary diagnosis was NF type 1,which was pathologically confirmed by a subsequent thoracoabdominal subcutaneous *** definitive diagnosis was neurofibrosarcoma with a pathogenic NF1 *** patient refused surgery and chemoradiotherapy,and died two months *** is a genetic disease consisting of seven types,of which types 1 to 4 are caused by a dominant autosomal gene *** case reported belongs to the class of NF1-positive dominant *** is a malignant tumor derived from cells surrounding the peripheral ***,due to the lack of previous reports,it remains unclear whether the origin of neurofibrosarcoma is directly linked to the incidence of NF type *** We report the first case of NF1-positive multiple neurofibromas with malignant fibrosarcomatous transformation in the pleural cavity.

关键词： Multiple neurofibromas Fibrosarcoma Neurofibromatosis type 1 pathogenicity Pseudochylothorax Pleural cavity Case report

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Why is pollen in Camellia oleifera inedible to honeybees?

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Journal of Integrative Plant Biology 2024年第11期66卷 2307-2309页

作者： Jannathan Mamut Wei-Bing Zhang lu-lu Tang Xinjiang Key Laboratory for Ecological Adaptation and Evolution of Extreme Environment Biology College of Life SciencesXinjiang Agricultural UniversityÜrümqi 830052China College of Life Sciences Central South UniversityChangsha 410083China

The evolutionary transition from bee-to bird-pollinated plants is usually associated with multiple modifications in floral traits,such as color,size,nectar and pollen presentation mode (Thomson and Wilson,2008).Compared to bee-adapted flowers,bird-flowers usually produce a larger volume of nectar with a lower sugar concentration(Sun et al.,2017).

关键词： traits flowers sugar

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Cerebellar Degeneration-related Antigen 1 Is Ubiquitously Expressed in Human Epidermis and Dermis

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Current Medical Science 2020年第3期40卷 570-573页

作者： lu-lu WANG Maria GSHWANDTNER Leopold ECKHART Erwin TSCHACHLER Department of Dermatology Research Division of Biology and Pathobiology of the SkinMedical University of ViennaViennaA-1090Austria Department of Pediatrics The University of Hong Kong-Shenzhen HospitalShenzhen518053China

Cerebellar degeneration-related antigen 1(CDR1)was described to be expressed in the nervous system and in different types of cancer *** the present study,we demonstrate that CDR1 is in addition ubiquitously expressed in human epidermis,dermis and isolated skin *** CDR1 mRNA and protein were detected in human skin-derived mast cells,melanocytes,fibroblasts and keratinocytes,suggesting that CDR1 does not have a neuron-specific function.

关键词： cerebellar degeneration-related antigen 1 skin keratinocyte mast cell

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Complex structure of human Hsp90~N and a novel small inhibitor FS5

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Nuclear Science and Techniques 2020年第3期31卷 74-84页

作者： Rui Liu Xiao-lu lu Xian-Hua Huang Wei He Jing-Jing Duan Jin Zhang Jian Li School of Basic Medical Sciences Nanchang UniversityNanchang 330031China College of Pharmaceutical Sciences Gannan Medical UniversityGanzhou 341000China Human Aging Research Institute(HARI) School of Life SciencesNanchang UniversityNanchang 330031China Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases Ministry of EducationGannan Medical UniversityGanzhou 341000China

Heat shock proteins(Hsps)are a family of abundantly expressed ATP-dependent chaperone ***90 is an eminent member of Hsp *** far,two primary functions have been described for Hsp90:first,as a regulator of conformational change of some protein kinases and nuclear hormone receptors,and the other as an indispensable factor in cellular stress ***90 has an essential number of interaction proteins since it participates in almost every biological process and its importance is ***90 has an inextricable relationship in the pathogenesis of cancer,especially in the proliferation and irradiation of cancer cells,thus being a notable cancer *** the discovery of geldanamycin,the first inhibitor of Hsp90,from the bacterial species Streptomyces hygroscopicus,even more attention has been focused toward *** structure-based inhibitors of Hsp90 have been designed to develop an innovative method to defeat ***,already designed inhibitors have various deficiencies,such as hepatotoxicity,poor aqueous solubility,instability,and non-ideal oral *** on the aforementioned reasons and to achieve an optimal performance and fewer side effects,we designed a novel inhibitor of Hsp90,called FS5,and resolved the crystal structure of the Hsp90^N-FS5 complex(1.65 A°,PDB code 5XRB).Furthermore,we compared the complexes Hsp90^N,Hsp90^N-GDM,and Hsp90^N-ATP and suggest that the inhibitor FS5 may compete with ATP for binding to Hsp90,which can be regarded as a potential strategy for the development of novel cancer drugs in the future.

关键词： Heat shock protein 90 Complex crystal structure Interactions Anti-tumor drugs X-ray diffraction

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Automatic Video Segmentation Based on Information Centroid and Optimized SaliencyCut

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Journal of Computer Science & Technology 2020年第3期35卷 564-575页

作者： Hui-Si Wu Meng-Shu Liu lu-lu Yin Ping Li Zhen-Kun Wen Hon-Cheng Wong College of Computer Science and Software Engineering Shenzhen UniversityShenzhen 518060China Department of Computing The Hong Kong Polytechnic UniversityHong Kong 999077China Faculty of Information Technology Macao University of Science and TechnologyMacao 999078China

We propose an automatic video segmentation method based on an optimized SaliencyCut equipped with information centroid(IC)detection according to level balance principle in physical *** the existing methods,the image information of another dimension is provided by the IC to enhance the video segmentation ***,our IC is implemented based on the information-level balance principle in the image,and denoted as the information pivot by aggregating all the image information to a *** effectively enhance the saliency value of the target object and suppress the background area,we also combine the color and the coordinate information of the image in calculating the local IC and the global IC in the *** saliency maps for all frames in the video are calculated based on the detected *** applying IC smoothing to enhance the optimized saliency detection,we can further correct the unsatisfied saliency maps,where sharp variations of colors or motions may exist in complex ***,we obtain the segmentation results based on IC-based saliency maps and optimized *** method is evaluated on the DAVIS dataset,consisting of different kinds of challenging *** with the state-of-the-art methods are also conducted to evaluate our *** visual results and statistical comparisons demonstrate its advantages and robustness for automatic video segmentation.

关键词： automatic video segmentation information centroid saliency detection optimized SaliencyCut

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Formation and biocorrosion behavior of Zr-Al-Co-Nb bulk metallic glasses

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Chinese Science Bulletin 2012年第14期57卷 1723-1727页

作者： lu XuYang HUANG lu PANG ShuJie ZHANG Tao Key Laboratory of Aerospace Materials and Performance （Ministry of Education） School of Materials Science and Engineering BeihangUniversity Beijing 100191 China

Ni-and Cu-free Zr-Al-Co-Nb glassy alloys with different Nb and Co contents were synthesized by melt spinning and copper mold *** effects of Nb addition to partially replace Co in the Zr55Al20Co25 glassy alloy on the glass-forming ability,thermal properties,in-vitro biocorrosion behavior and surface wettability of the metallic glasses were *** addition of Nb up to 5 at.% slightly decreased the supercooled liquid region and the glass-forming ability(GFA),the alloys could be casted in a bulk glassy rod form with diameters up to *** Zr-Al-Co-Nb glassy alloys were spontaneously passivated with low passive current densities in phosphate buffered saline and Hanks' *** of "toxic" Co by Nb is effective in improved the corrosion resistance of the Zr-Al-Co glassy *** contact angle measurements showed that Nb addition increased the hydrophilicity of the glassy alloys,which may enhance cell adhesion of the alloys in biomedical applications.

关键词：大块金属玻璃腐蚀行为生物玻璃形成能力铌非晶合金锆铝

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Tri-functionalized polypropylene separator by rGO/MoO_(2) composite for high-performance lithium–sulfur batteries

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Rare Metals 2021年第10期40卷 2810-2818页

作者： Kun Xu Xin Liang lu-lu Wang Yong Wang Ju-Feng Yun Yi Sun Hong-Fa Xiang School of Materials Science and Engineering Engineering Research Center of High Performance Copper Alloy Materials and ProcessingMinistry of EducationHefei University of TechnologyHefei 230009China

The popularity of lithium–sulfur batteries has been increasing gradually due to their ultrahigh theoretical specific capacity and energy density. Nevertheless, they also have lots of drawbacks to be overcome, such as poor conductivity, severe volume expansion, and serious“shuttle effect”. In this work, reduced graphene oxide/molybdenum dioxide(rGO/MoO_(2)) composite is synthesized and applied to modify polypropylene separator. The modified polypropylene separator introduces synergistic tri-functions of physical adsorption, chemical interaction and catalytic effects, which can inhibit the“shuttle effect” and enhance the electrochemical performances of lithium-sulfur batteries. In the prepared r GO/MoO_(2) composite, the polar MoO_(2) chemically adsorbs the intermediate lithium polysulfide, while the rGO with good electrical conductivity not only acts as a physical barrier to prevent diffusion of polysulfide ions, but also improves the conversion efficiency of active material intercepted on the separator. As a consequence, the battery assembled with rGO/MoO_(2) modified polypropylene separator exhibits a reversible capacity of 757.5 mAh·g^(-1) after 200 cycles at0.2 C with a negligible capacity decay of 0.207% per cycle,which indicates a good long-period cycling stability. Furthermore, the rate performance and self-discharge suppression are also improved by introducing modified polypropylene separator. It shows that rGO/MoO_(2) composite is a promising material for separator modification in lithium-sulfur batteries.

关键词： rGO/MoO_(2)composite Li–S batteries Separator modification Shuttle effect

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The functions and applications of A7R in anti-angiogenic therapy, imaging and drug delivery systems

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Asian Journal of Pharmaceutical Sciences 2019年第6期14卷 595-608页

作者： lu lu Hongyuan Chen Dake Hao Xinke Zhang Fengshan Wang Key Laboratory of Chemical Biology(Ministry of Education) Institute of Biochemical and Biotechnological DrugSchool of Pharmaceutical SciencesShandong UniversityJinan 250012China Department of General Surgery Shandong University Affiliated Shandong Provincial HospitalJinan 250021China Department of Surgery UC Davis Health Medical CenterSacramento 95817USA Key Laboratory of Chemical Biology(Ministry of Education) Department of PharmacologySchool of Pharmaceutical SciencesShandong UniversityJinan 250012China

Vascular endothelial growth factor receptor 2(VEGFR-2)and neuropilin-1(NRP-1)are two prominent antiangiogenic *** are highly expressed on vascular endothelial cells and some tumor ***,targeting VEGFR-2 and NRP-1 may be a potential antiangiogenic and antitumor strategy.A7R,a peptide with sequence of Ala-Thr-Trp-Leu-Pro-Pro-Arg that was found by phage display of peptide libraries,can preferentially target VEGFR-2 and NRP-1 and destroy the binding between vascular endothelial growth factor 165(VEGF165)and VEGFR-2 or *** peptide is a new potent inhibitor of tumor angiogenesis and a targeting ligand for cancer *** review describes the discovery,function and mechanism of the action of A7R,and further introduces the applications of A7R in antitumor angiogenic treatments,tumor angiogenesis imaging and targeted drug delivery *** this review,strategies to deliver different drugs by A7R-modified liposomes and nanoparticles are highlighted.A7R,a new dual targeting ligand of VEGFR-2 and NRP-1,is expected to have efficient therapeutic or targeting roles in tumor drug delivery.

关键词： A7R Vascular endothelial growth factor receptor 2 Neuropilin-1 Antiangiogenesis Tumor angiogenesis imaging Drug delivery

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A New Clustering Algorithm for Categorical Attributes

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International Journal of Minerals,Metallurgy and Materials 2000年第4期14卷 318-322页

作者： Songfeng lu, Zhengding lu (College of Computer Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China) College of Computer Science and Technology Huazhong University of Science and Technology Wuhan 430074 China

In traditional data clustering, similarity of a cluster of objects is measured by distance between objects. Such measures are not appropriate for categorical data. A new clustering criterion to determine the similarity between points with categorical attributes is pre- sented. Furthermore, a new clustering algorithm for categorical attributes is addressed. A single scan of the dataset yields a good clus- tering, and more additional passes can be used to improve the quality further.

关键词： data mining clustering similarity Information

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Synthesis and Crystal Structure of a New Mononuclear Cadmium(Ⅱ) Cryptate Derived from the Condensation of Tri(2-aminoethyl)amine with Glyoxal

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Chinese Journal of Structural Chemistry 2005年第11期24卷 1276-1280页

作者： CHEN Hua XU Xing-You GAO Jian YANG Xu-Jie lu lu-De WANG Xin Materials Chemistry Laboratory Nanjing Universityof Science and Technology Nanjing 210094 China Department of Chemical Engineering Huahai Institute of Technology Lianyungang 222005 China

A new mononuclear cadmium（Ⅱ） cryptate has been synthesized by [2＋3] Schiff base condensation of tri（2-aminoethyl）amine with glyoxal in the presence of Cd（ClO4）2·6H2O. The crystal structure, spectral characterization and molar conductivity show that cadmium（Ⅱ） is sixcoordinated （N6） into a distorted octahedral geometry.

关键词： mononuclear cadmium cryptate synthesis crystal structure

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