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Systemic immune-inflammation index,neutrophilto-lymphocyte ratio,and platelet-to-lymphocyte ratio in patients with type 2 diabetes at different stages of diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 877-882页

作者： Ying Gao Rong-Xin lu Yun Tang Xin-Yi Yang Hu Meng Chang-Lin zhao Yi-lu Chen feng Yan Qian Cao Department of Ophthalmology Sir Run Run HospitalNanjing Medical UniversityNanjing 211112Jiangsu ProvinceChina Department of Ophthalmology Affiliated Jinling HospitalMedical School of Nanjing UniversityNanjing 210002Jiangsu ProvinceChina Department of Thoracic Surgery the First Affiliated Hospital with Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina Medical School Nanjing UniversityNanjing 210093Jiangsu ProvinceChina Department of Ophthalmology Taikang Xianlin Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210046Jiangsu ProvinceChina

AIM:To investigate systemic immune-inflammation index(SII),neutrophil-to-lymphocyte ratio(NLR),and plateletto-lymphocyte ratio(PLR)levels in patients with type 2 diabetes at different stages of diabetic retinopathy(DR).METHODS:This retrospective study included 141 patients with type 2 diabetes mellitus(DM):45 without diabetic retinopathy(NDR),47 with non-proliferative diabetic retinopathy(NPDR),and 49 with proliferative diabetic retinopathy(PDR).Complete blood counts were obtained,and NLR,PLR,and SII were *** study analysed the ability of inflammatory markers to predict DR using receiver operating characteristic(ROC)*** relationships between DR stages and SII,PLR,and NLP were assessed using multivariate logistic ***:The average NLR,PLR,and SII were higher in the PDR group than in the NPDR group(P=0.011,0.043,0.009,respectively);higher in the NPDR group than in the NDR group(PluSION:The NLR,PLR,and SII may be used as predictors of DR.

关键词： diabetic retinopathy neutrophil-tolymphocyte ratio platelet-to-lymphocyte ratio systemic immune-inflammation index

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Diagnosis,treatment,and prevention of monkeypox in children:an experts'consensus statement

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World Journal of Pediatrics 2023年第3期19卷 231-242页

作者： Rong-Meng Jiang Yue-Jie Zheng Lei Zhou lu-zhao feng Lin Ma Bao-Ping Xu Hong-Mei Xu Wei Liu Zheng-De Xie Ji-Kui Deng Li-Juan Xiong Wan-Jun luo Zhi-Sheng Liu Sai-Nan Shu Jian-She Wang Yi Jiang Yun-Xiao Shang Miao Liu Li-Wei Gao Zhuang Wei Guang-Hua Liu Gang Liu Wei Xiang Yu-Xia Cui Gen lu Min lu Xiao-Xia lu Run-Ming Jin Yan Bai Le-Ping Ye Dong-Chi zhao A-Dong Shen Xiang Ma Qing-Hua lu feng-Xia Xue Jian-Bo Shao Tian-You Wang Zheng-Yan zhao Xing-Wang Li Yong-Hong Yang Kun-Ling Shen Diagnosis and Treatment Center of Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of Respiratory Shenzhen Children’s HospitalShenzhen 518038China Branch for Emerging Infectious Disease Public Health Emergency CenterChinese Center for Disease Control and PreventionBeijing 102206China School of Population Medicine&Public Health Chinese Academy of Medical Science/Peking Union Medical CollegeBeijing 100730China Department of Dermatology Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s Health(Beijing)Beijing 100045China Department of Respiratory Beijing Children’s HospitalCapital Medical UniversityNational Clinical Research Center for Respiratory DiseasesNational Center for Children’s Health(Beijing)Beijing 100045China Department of Infectious Diseases Children’s Hospital of Chongqing Medical UniversityChongqing 400014China Tianjin Children’s Hospital Children’s Hospital of Tianjin UniversityTianjin 300134China Beijing Key Laboratory of Pediatric Respiratory Infection Diseases Key Laboratory of Major Diseases in ChildrenMinistry of EducationNational Clinical Research Center for Respiratory DiseasesResearch Unit of Critical Infection in ChildrenChinese Academy of Medical Sciences2019RU016Laboratory of Infection and VirologyBeijing Pediatric Research InstituteBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s Health(Beijing)Beijing 100045China Department of Infectious Diseases Shenzhen Children’s HospitalShenzhen 518038China Department of Infectious Diseases Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Ofce of Infection Management Wuhan Children’s HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China Department of Neurology Wuhan Children’s HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China Department of Pediatrics Tongji

Monkeypox is a zoonotic *** the first human monkeypox case was detected in 1970,it has been prevalent in some countries in central and western *** May 2022,monkeypox cases have been reported in more than 96 non-endemic countries and regions *** of September 14,2022,there have been more than 58,200 human monkeypox cases,and there is community *** cessation of smallpox vaccination in 1980,which had some cross-protection with monkeypox,resulted in a general lack of immunity to monkeypox,which caused global concern and *** of Sep-tember 14,2022,there are four monkeypox cases in China,including three in Taiwan province and one in Hong Kong *** foreign studies have shown that children are vulnerable to monkeypox and are also at high risk for severe disease or *** order to improve pediatricians'understanding of monkeypox and achieve early detection,early diagno-sis,early treatment,and early disposal,we have organized national authoritative experts in pediatric infection,respiratory,dermatology,critical care medicine,infectious diseases,and public health and others to formulate this expert consensus,on the basis of the latest"Clinical management and infection prevention and control for monkeypox"released by The World Health Organization,the"guidelines for diagnosis and treatment of monkeypox(version 2022)"issued by National Health Commission of the People's Republic of China and other relevant *** the development of this consensus,multidisciplinary experts have repeatedly demonstrated the etiology,epidemiology,transmission,clinical manifestations,laboratory examinations,diagnosis,differential diagnosis,treatment,discharge criteria,prevention,disposal process,and key points of prevention and control of suspected and confirmed cases.

关键词： Children Consensus Diagnosis Monkeypox Prevention Treatment

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Exploring the relevance between load-bearing capacity and surface friction behavior based on a layered hydrogel cartilage prototype

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Friction 2024年第8期12卷 1757-1770页

作者： Yunlei ZHANG Weiyi zhao Xiaoduo zhao Jinshuai ZHANG Bo YU Shuanhong MA feng ZHOU State Key Laboratory of Solid lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China College of Materials Science and Opto-Electronic Technology University of Chinese Academy of SciencesBeijing 100049China Shandong Laboratory of Yantai Advanced Materials and Green Manufacture Yantai Zhongke Research Institute of Advanced Materials and Green Chemical EngineeringYantai 264006China

Cartilage is well lubricated over a lifetime and this phenomenon is attributed to both of the surface hydration lubrication and the matrix load-bearing *** hydrogels with a layered structure are designed to mimic cartilage as potential *** many studies have concentrated on improving surface hydration to reduce friction,few have experimentally detected the relationship between load-bearing capacity of hydrogels and their interface friction *** this work,a bilayer hydrogel,serving as a cartilage prototype consisted of a top thick hydrated polymer brush layer and a bottom hydrogel matrix with tunable modulus was designed to investigate this *** coefficient of friction(COF,μ)is defined as the sum of interfacial component(μInt)and deformation/hysteresis component(μHyst).The presence of the top hydration layer effectively dissipates contact stress and reduces the interface interaction(μInt),leading to a stable and low *** contribution of mechanical deformation(μHyst)during the sliding shearing process to COF can be significantly reduced by increasing the local mechanical modulus,thereby enhancing the load-bearing *** results show that the strategy of coupling surface hydration layer with a high load-bearing matrix can indeed enhance the lubrication performance of hydrogel cartilage prototypes,and implies a promising routine for designing robust soft matter lubrication system and friction-control devices.

关键词： soft contact hydration,deformation load-bearing friction control

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Self assembled electron blocking and lithiophilic interface towards dendrite-free solid-state lithium battery

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Chinese Chemical Letters 2024年第4期35卷 220-225页

作者： Caixia Li Yi Qiu Yufeng zhao Wuliang feng Institute for Sustainable Energy&College of Sciences Shanghai UniversityShanghai 200444China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Nankai UniversityTianjin 300071China

The poor interfacial contact is one of the biggest challenges that solid-state lithium batteries suffer *** the solid-state electrolyte surface energy by transforming the interface from lithiophobic to lithiophilic is effective to promote the interfacial contact, but electronic conductive interphases usually increase the risk of electron attack, thus leading to uncontrollable Li dendrite growth. Herein, we propose a self-assembled thermodynamic stable Li I interphase to simultaneously improve the interfacial contact between the garnet electrolyte Li_7La_(3)Zr_(2)O_(12)(LLZO) and Li anode, and prohibit the electron attack. The direct contact between LLZO and Li and the high temperature Li melting process was ascribed to Zr4+reduction, which facilitated Li dendrite formation and propagation. With the modification of the high lithiophilic I_(2) thin film, the area specific interfacial resistance of LLZO/Li was reduced from 1525 Ω/cm^(2) to 57 Ω/cm^(2). More importantly, LLZO was protected from being reduced due to the outstanding electronic insulativity of the Li I interphase, which leaded to a high critical current density of 1.2/7.0 m A/cm^(2) in the time/capacity-constant modes, respectively.

关键词： Li_7La_(3)Zr_(2)O_(12) LiI interphase Interfacial contact Li dendrite Thermodynamic stable

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Health diagnosis of ultrahigh arch dam performance using heterogeneous spatial panel vector model

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Water Science and Engineering 2024年第2期17卷 177-186页

作者： Er-feng zhao Xin Li Chong-shi Gu The National Key Laboratory of Water Disaster Prevention Hohai UniversityNanjing 210098China NationalEngineering Research Centerof Water Resources Eficient Utilization and Engineering Safety Hohai UniversityNanjing 20098China

Currently,more than ten ultrahigh arch dams have been constructed or are being constructed in *** control is essential to long-term operation of these *** study employed the flexibility coefficient and plastic complementary energy norm to assess the structural safety of arch dams.A comprehensive analysis was conducted,focusing on differences among conventional methods in characterizing the structural behavior of the Xiaowan arch dam in ***,the spatiotemporal characteristics of the measured performance of the Xiaowan dam were explored,including periodicity,convergence,and time-effect *** findings revealed the governing mechanism of main ***,a heterogeneous spatial panel vector model was developed,considering both common factors and specific factors affecting the safety and performance of arch *** model aims to comprehensively illustrate spatial heterogeneity between the entire structure and local regions,introducing a specific effect quantity to characterize local deformation ***,the proposed model was applied to the Xiaowan arch dam,accurately quantifying the spatiotemporal heterogeneity of dam ***,the spatiotemporal distri-bution characteristics of environmental load effects on different parts of the dam were reasonably *** of the model prediction enhances its credibility,leading to the formulation of health diagnosis criteria for future long-term operation of the Xiaowan *** findings not only enhance the predictive ability and timely control of ultrahigh arch dams'performance but also provide a crucial basis for assessing the effectiveness of engineering treatment measures.

关键词： Ultrahigh arch dam Structural performance Deformation behavior Diagnosis criterion Panel data model

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The economic burden of influenza-associated outpatient visits and hospitalizations in China: a retrospective survey

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Infectious Diseases of Poverty 2015年第1期4卷 371-381页

作者： Juan Yang Mark Jit Kathy S.Leung Ya-ming Zheng lu-zhao feng Li-ping Wang Eric H.Y.Lau Joseph T.Wu Hong-jie Yu Key Laboratory of Surveillance and Early-warning on Infectious Disease Division of Infectious DiseaseChinese Center for Disease Control and Prevention155 Changbai RoadChangping DistrictBeijing 102206China Modelling and Economics Unit of Public Health in England LondonUK Department of Infectious Disease Epidemiology London School of Hygiene and Tropical MedicineLondonUK WHO Collaborating Centre for Infectious Disease Epidemiology and Control School of Public HealthLi Ka Shing Faculty of MedicineThe University of Hong Kong2/F North WingPatrick Manson Building7 Sassoon RoadPok Fu LamHong Kong Special Administrative RegionChina

Background:The seasonal influenza vaccine coverage rate in China is only 1.9%.There is no information available on the economic burden of influenza-associated outpatient visits and hospitalizations at the national level,even though this kind of information is important for informing national-level immunization policy ***:A retrospective telephone survey was conducted in 2013/14 to estimate the direct and indirect costs of seasonal influenza-associated outpatient visits and hospitalizations from a societal *** participants were laboratory-confirmed cases registered in the National Influenza-like Illness Surveillance Network and Severe Acute Respiratory Infections Sentinel Surveillance Network in China in ***-reported costs from the survey were validated by a review of hospital accounts for a small sample of the ***:The study enrolled 529 outpatients(median age:eight years;interquartile range[IQR]:five to 20 years)and 254 inpatients(median age:four years;IQR:two to seven years).Among the outpatients,22.1%(117/529)had underlying diseases and among the inpatients,52.8%(134/254)had underlying *** average total costs related to influenza-associated outpatient visits and inpatient visits were US$155(standard deviation,SD US$122)and US$1,511(SD US$1,465),*** medical costs accounted for 45 and 69%of the total costs related to influenza-associated outpatient and inpatient visits,*** influenza outpatients,the mean cost per episode in children aged below five years(US$196)was higher than that in other age groups(US$129–153).For influenza inpatients,the mean cost per episode in adults aged over 60 years(US$2,735)was much higher than that in those aged below 60 years(US$1,417–1,621).Patients with underlying medical conditions had higher costs per episode than patients without underlying medical conditions(outpatients:US$186 ***$146;inpatients:US$1,800 ***$1,189).In the baseline ana

关键词： Influenza Cost analysis China

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A Novel Multi-Stream Fusion Network for Underwater Image Enhancement

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China Communications 2024年第2期21卷 166-182页

作者： Guijin Tang Lian Duan Haitao zhao feng Liu Jiangsu Key Laboratory of Image Processing and Image Communication Nanjing University of Posts and TelecommunicationsNanjing 210003China Jiangsu Key Laboratory of Wireless Communications Nanjing University of Posts and TelecommunicationsNanjing 210003China

Due to the selective absorption of light and the existence of a large number of floating media in sea water, underwater images often suffer from color casts and detail blurs. It is therefore necessary to perform color correction and detail restoration. However,the existing enhancement algorithms cannot achieve the desired results. In order to solve the above problems, this paper proposes a multi-stream feature fusion network. First, an underwater image is preprocessed to obtain potential information from the illumination stream, color stream and structure stream by histogram equalization with contrast limitation, gamma correction and white balance, respectively. Next, these three streams and the original raw stream are sent to the residual blocks to extract the features. The features will be subsequently fused. It can enhance feature representation in underwater images. In the meantime, a composite loss function including three terms is used to ensure the quality of the enhanced image from the three aspects of color balance, structure preservation and image smoothness. Therefore, the enhanced image is more in line with human visual ***, the effectiveness of the proposed method is verified by comparison experiments with many stateof-the-art underwater image enhancement algorithms. Experimental results show that the proposed method provides superior results over them in terms of MSE,PSNR, SSIM, UIQM and UCIQE, and the enhanced images are more similar to their ground truth images.

关键词： image enhancement multi-stream fusion underwater image

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Life's essential 8 and risk of subclinical atherosclerosis progression: a prospective cohort study

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Journal of Geriatric Cardiology 2024年第7期21卷 751-759页

作者： Shi-Yu ZHOU Fang-Chao LIU Shu-feng CHEN Jian-Xin LI Jie CAO Ke-Yong HUANG Zheng-Hao TANG feng-Chao LIANG Dong-Sheng HU Lian-Cheng zhao Ying LI Jian-feng HUANG Xiang-feng lu Bin lu Dong-feng GU Department of Epidemiology&Key Laboratory of Cardiovascular Epidemiology State Key Laboratory of Cardiovas-cular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina School of Public Health and Emergency Management School of Medi-cineSouthern University of Science and TechnologyShenzhenChina Department of Epidemiology and Health Stat-istics School of Public HealthZhengzhou UniversityZhengzhouChina Department of Biostatistics and Epidemi-ology School of Public HealthShenzhen University Health Science CenterShenzhenChina Department of Radi-ology State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina

BACKGROUND Previous studies have demonstrated the benefits of ideal cardiovascular health(CVH) in reducing cardiovascular ***,its role in subclinical atherosclerosis(SA) progression remains *** aim to examine the association of CVH,estimated by the American Heart Association's new Life's Essential 8(LE8),with the progression of *** This prospective cohort study was conducted among 972 asymptomatic Chinese participants and followed up for5.7 *** LE8 score(range,0–100) consisted of blood pressure,lipids,glucose,body mass index,smoking status,diet health,physical activity and sleep health was evaluated in 1998 and 2008–*** of SA was determined by carotid plaque and coronary artery calcification(CAC) in 2008–2009 and 2013–***-binomial regression model was used to estimate the association of LE8 score with SA *** Each 10 points increment in LE8 score was associated with 15.2%(RR:0.848,95% CI:0.797–0.902),17.7%(RR:0.823,95% CI:0.766–0.884) and 12.0%(RR:0.880,95% CI:0.845–0.916) lower risks of carotid plaque,CAC and overall SA progression,*** with participants with non-ideal CVH at both visits,the participants with ideal CVH at both visits had39.1%(RR:0.609,95% CI:0.494–0.752),41.0%(RR:0.590,95% CI:0.456–0.764) and 29.7%(RR:0.703,95% CI:0.598–0.825) lower risks of carotid plaque,CAC and overall SA progression,*** Higher LE8 scores were associated with lower risks of SA ***,long-term maintenance of optimal CVH was more beneficial to prevent SA progression.

关键词： atherosclerosis prospective cardiovascular

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Zircon Hf Isotope Mapping for Understanding Crustal Architecture and Its Controls on Mineralization during Early Cretaceous in the Southern Great Xing'an Range,NE China

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Journal of Earth Science 2024年第1期35卷 41-50页

作者： feng Yuan Huanan Liu Shengjin zhao Mingjing Fan State Key Laboratory of Geological Processes and Mineral Resources Collaborative Innovation Center for Exploration of Strategic Mineral ResourcesSchool of Earth ResourcesChina University of GeosciencesWuhan 430074China State Key Laboratory of Geological Processes and Mineral Resources School of Earth Sciences and ResourcesChina University of GeosciencesBeijing100083China No.10 Institute of Geological Exploration Inner Mongolia Bureau of Geology and Mineral ResourcesChifeng 024000China Key Laboratory of Metallogeny and Mineral Assessment Institute of Mineral ResourcesChinese Academy of Geological SciencesBeijing 100037China

Voluminous Early Cretaceous granitoids and associated large-scale ore deposits are distributed within the southern Great Xing'an Range(SGXR),NE *** on previously published geochronology and zircon Hf-isotope data,Hf isotope mapping is undertaken to improve our understanding of crustal architecture and its controls on ore *** ore-related Early Cretaceous granitoids were sourced predominantly from juvenile crust,with the involvement of variable proportions of ancient crustal *** crustal architecture,as inferred from Hf isotopic contour maps,indicates two distinct Hf isotopic domains in SGXR,including(1)a higher-ε_(Hf)(+7 to+11)juvenile crust containing minor ancient crustal material,and(2)a lower-ε_(Hf)(+2 to+6)juvenile crust containing a greater proportion of ancient crustal *** Hf isotopic maps identify links between crustal architecture and regional *** deposits and other deposits with significant Cu production are restricted mainly to the higher-ε_(Hf)juvenile crustal regions in the northern and eastern *** dominated by other metals(e.g.,Mo,Sn,W,Pb,Zn,and Ag)occur mainly in the lower-ε_(Hf)juvenile crustal regions in the southern and western *** between juvenile crust-derived melts and ancient crustal components played an important role on the distribution of various ore metals.

关键词： Hf isotope mapping crustal architecture large-scale Early Cretaceous granitoids distribution of ore deposits southern Great Xing'an Range zircon

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Prediction of undeformed chip thickness distribution and surface roughness in ultrasonic vibration grinding of inner hole of bearings

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第4期25卷 311-323页

作者： Yanqin LI Daohui XIANG Guofu GAO feng JIAO Bo zhao School of Mechanical and Power Engineering Henan Polytechnic UniversityJiaozuo 454000China

Ultrasonic vibration grinding differs from traditional grinding in terms of its material removal *** randomness of grain-workpiece interaction in ultrasonic vibration grinding can produce variable chips and impact the surface roughness of ***,previous studies used iterative method to calculate the unformed chip thickness(UCT),which has low computational *** this study,a symbolic difference method is proposed to calculate the *** UCT distributions are obtained to describe the stochastic interaction characteristics of ultrasonic grinding ***,the UCT distribution characteristics under different machining parameters are ***,a surface roughness prediction model is established based on the UCT ***,the correctness of the model is verified by *** study provides a quick and accurate method for predicting surface roughness in longitudinal ultrasonic vibration grinding.

关键词： Ultrasonic vibration grinding Undeformed chip thickness(UCT) Distribution characteristics Surface roughness

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