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The roles of bone remodeling in normal hematopoiesis and age-related hematological malignancies

Bone Research 2023年第2期11卷 273-291页

作者： Hengwei Zhang Jane LLiesveld Laura Mcalvi Brea clipe.Lianping Xing Michael WBecker Edward MSchwarz Shu-chi A.Yeh center for Musculoskeletal Research University of Rochester Medical Center601 Elmwood AveBox 665RochesterNY14642USA Department of Pathology and Laboratory Medicine University of Rochester Medical CenterRochesterNYUSA Wilmot cancer center University of Rochester Medical CenterRochesterNYUSA Department of Medicine Division of Hematology/Oncology and Bone Marrow Transplantation ProgramUniversity of Rochester Medical CenterRochesterNYUSA Department of Medicine Division of Endocrinology/MetabolismUniversity of Rochester Medical CenterRochesterNYUSA Department of Orthopaedics University of Rochester Medical CenterRochesterNYUSA Department of Medicine Division of Allergy/Immunology/RheumatologyUniversity of Rochester Medical CenterRochesterNYUSA Department of Biomedical Engineering University of RochesterNYUSA Department of Physiology/Pharmacology University of Rochester Medical CenterRochesterNYUSA

Prior research establishing that bone interacts in coordination with the bone marrow microenvironment(BMME)to regulate hematopoietic homeostasis was largely based on analyses of individual bone-associated cell *** advances in intravital imaging has suggested that the expansion of hematopoietic stem cells(HScs)and acute myeloid leukemia cells is restricted to bone marrow microdomains during a distinct stage of bone *** findings indicate that dynamic bone remodeling likely imposes additional heterogeneity within the BMME to yield differential clonal responses.A holistic understanding of the role of bone remodeling in regulating the stem cell niche and how these interactions are altered in age-related hematological malignancies will be critical to the development of novel *** advance this understanding,herein,we provide a synopsis of the cellular and molecular constituents that participate in bone turnover and their known connections to the hematopoietic ***,we elaborate on the coupling between bone remodeling and the BMME in homeostasis and age-related hematological malignancies and after treatment with bone-targeting *** then discuss unresolved questions and ambiguities that remain in the field.

关键词： remodeling homeostasis likely

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characterization of Lignin before and after Exposure to the Gastrointestinal Tract of Ruminants

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American Journal of Analytical chemistry 2016年第11期7卷 748-753页

作者： E. O. S. Saliba D. Pilo-Veloso N. M. Rodriguez E. A. capanema J. S. Saliba A. L. c. c. Borges L. c. Gonçalves I. Borges D. G. Jayme R. R. Silva Universidade Federal de Minas Gerais Belo Horizonte Brazil Wood and Paper Science Department North Carolina State University (NCSU) Raleigh USA

The aim of this study was to investigate the structural composition of lignin (lipe.) extracted from Eucalyptus grandis, before and after exposure to the gastrointestinal tract of ruminants. For this study lignin was ... 详细信息

The aim of this study was to investigate the structural composition of lignin (lipe.reg;) extracted from Eucalyptus grandis, before and after exposure to the gastrointestinal tract of ruminants. For this study lignin was isolated, purified and characterized using 1H and 13c Nuclear Magnetic Resonance Spectroscopy, nitrobenzene oxidation, functional groups analysis and gas chromatography with mass spectroscopy. To have a better understanding of lignin morphology and of its ultra structure, electron microscopy in wood cell wall was utilized. The lignin fecal samples showed similar 1H NMR spectrums and nitrobenzene oxidation products compared with lipe.reg;. The result of the microanalysis of lipe.reg;was similar to data shown in the literature. The ultra structure of lignin was similar to that of Bamboo (hard wood). The lignin isolated from feces of sheep was identical to the original lipe.reg;, which means that this product can be used as an external marker in protein digestibility in sheep.

关键词： Lignin Eucalyptus grandis Ruminant

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