检索结果-南通市图书馆

Sex-biased autophagy as a potential mechanism mediating sex differences in ischemic stroke outcome

Neural Regeneration Research 2023年第1期18卷 31-37页

作者： Brian Noh louise d.mccullough Jose F.Moruno-Manchon department of Neurology McGovern Medical School at the University of Texas Health Science Center at HoustonHoustonTXUSA

Stroke is the second leading cause of death and a major cause of disability worldwide,and biological sex is an important determining factor in stroke incidence and *** childhood through adulthood,men have a higher incidence of stroke compared with *** research has confirmed the beneficial effects of estrogen in experimental ischemic stroke but genetic factors such as the X-chromosome complement can also play an important role in determining sex differences in *** is a self-degrading cellular process orchestrated by multiple core proteins,which leads to the engulfment of cytoplasmic material and degradation of cargo after autophagy vesicles fuse with lysosomes or *** levels and the activity of components of these signaling pathways and of autophagy-related proteins can be altered during ischemic *** stroke activates autophagy,however,whether inhibiting autophagy after stroke is beneficial in the brain is still under a *** is a potential mechanism that may contribute to differences in stroke progression between the ***,the effects of manipulating autophagy may also differ between the *** that regulate autophagy in a sex-dependent manner in ischemic stroke remain *** this review,we summarize clinical and pre-clinical evidence for sex differences in *** briefly introduce the autophagy process and summarize the effects of gonadal hormones in autophagy in the brain and discuss X-linked genes that could potentially regulate brain ***,we review pre-clinical studies that address the mechanisms that could mediate sex differences in brain autophagy after stroke.

关键词： autophagy brain estrogen gonadal hormones neurodegeneration neuron stroke X-chromosome

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

differences in stroke damage in aged mice may not be due to differential cerebral blood flow dynamics

引用

Neuroimmunology and Neuroinflammation 2014年第1期1卷 13-14页

作者： Venugopal Reddy Venna louise d.mccullough department of Neuroscience University of Connecticut Health CenterFarmingtonCT 06030USA department of Neurology University of Connecticut Health CenterFarmingtonCT 06030USA The Stroke Center at Hartford Hospital HartfordCT 06102USA

INTROdUCTION Stroke is the leading cause of death and adult disability.[1-3]Aging is the most important nonmodifiable risk factor for stroke,and aged patients exhibit impaired stroke recovery.[4]Consistent with clinical data,findings from animal models have demonstrated that aged mice have higher mortality and worse outcomes when subjected to same duration of occlusion compared with young mice.

关键词： impaired damage mortality

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Psychiatric outcomes in outpatients affected by long COVId:A link between mental health and persistence of olfactory complaint

引用

World Journal of Psychiatry 2024年第4期14卷 507-512页

作者： Victoria Metelkina-Fernandez louise-Emilie dumas Clair Vandersteen david Chirio Auriane Gros Arnaud Fernandez Florence Askenazy Valeria Manera department of Psychiatry Nice University HospitalNice 06000France department of Child and Adolescent Psychiatry UniversitéCôte d’AzurNice 06200France ENT Head and Neck InstituteNice 06100France department of Infectiology Nice University HospitalNice 06200France department of Orthophony UniversitéCôte d’AzurNice 06100France Cobtek UniversitéCôte d’AzurNice 06100France

BACKGROUNd Anosmia was one of the main symptoms of coronavirus disease 2019(COVId-19).A psychiatric history(i.e.,depression)may be an independent contributor to the risk of COVId-19 diagnosis,and COVId-19 survivors appear to have an increased risk of neuropsychiatric sequelae(bidirectional association).AIM To compare the rate of psychiatric disorder among post-COVId patients without anosmia vs patients with persistent olfactory *** We conducted a prospective case control study from March 2020 to May *** recruited at the ENT department of Nice University Hospital had a subjective olfactory complaint(visual analogue scale)for over 6 wk and a molecular or CT-proven severe acute respiratory syndrome coronavirus 2 diagnosis confirmed by ***-COVId patients without persistent olfactory disorders were recruited at the university hospital infectiology *** medical histories were collected by a psychiatrist during the *** Thirty-four patients with post-COVId-19 olfactory complaints were included in the first group of the *** percent of the patients were female(n=17).The group’s mean age was 40.5±12.9 *** control group included 32 participants,of which 34.4%were female(n=11),and had a mean age of 61.2±12.2 *** rate of psychiatric disorder among post-COVId patients with olfactory complaints was significatively higher(41.7%)than among patients without(18.8%)(χ2=5.9,P=0.015).CONCLUSION The presence of a psychiatric history may constitute a potential risk factor for the development of long COVId due to persistent *** therefore seems important to establish reinforced health monitoring after a COVId 19 infection in at-risk *** prospective,translational,and collaborative studies are needed to extrapolate these results to the general population.

关键词： COVId-19 Anosmia Psychiatry Stress Neuroplasticity Psychiatric history

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The risk of prostate cancer on incidental finding of an avid prostate uptake on 2-deoxy-2-[^(18)F]fluoro-d-glucose positron emission tomography/computed tomography for non-prostate cancer-related pathology:A single centre retrospective study

引用

Asian Journal of Urology 2024年第1期11卷 33-41页

作者： Anthony Franklin Troy Gianduzzo Boon Kua david Wong louise McEwan James Walters Rachel Esler Matthew J.Roberts Geoff Coughlina John W.Yaxley department of Urology The Wesley HospitalBrisbaneQLDAustralia Wesley Medical Research BrisbaneQLDAustralia School of Medicine The University of QueenslandBrisbaneQLDAustralia department of Radiology Wesley Medical ImagingBrisbaneQLDAustralia department of Urology Royal Brisbane and Women's HospitalBrisbaneQLDAustralia

Objective:To review the risk of prostate cancer(PCa)in men with incidentally reported increased intraprostatic uptake at 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography/computed tomography(18F-FdG PET/CT)ordered at department of Urology,The Wesley Hospital,Brisbane,QLd,Australia for non-PCa related ***:Retrospective analysis of consecutive men between August 2014 and August 2019 presenting to a single institution for 18F-FdG PET/CT for non-prostate related conditions was *** were classified as benign,indeterminate,or malignant depending of the results of prostate-specific antigen(PSA),PSA velocity,biopsy histopathology,and three-Tesla(3 T)multiparametric MRI(mpMRI)Prostate Imaging Reporting and data System score,or gallium-68-prostate-specific membrane antigen(68Ga-PSMA)PET/CT ***:Three percent(273/9122)of men demonstrated 18F-FdG avidity within the ***-five percent(231/273)were further investigated,including with PSA tests(227/231,98.3%),3 T mpMRI(68/231,29.4%),68Ga-PSMA PET/CT(33/231,14.3%),and prostate biopsy(57/231,24.7%).Results were considered benign in 130/231(56.3%),indeterminate in 31/231(13.4%),and malignant in 70/231(30.3%).PCa was identified in 51/57(89.5%)of the men who proceeded to biopsy,including 26/27(96.3%)men with Prostate Imaging Reporting and data System scores 4-5 mpMRI and six men with a positive 68Ga-PSMA PET/*** most common Gleason score on biopsy was greater than or equal to 4+5(14/51,27.5%).68Ga-PSMA PET/CT was concordant with the 18F-FdG findings in 26/33(78.8%).All 13 men with a positive concordant 18F-FdG,3 T mpMRI,and 68Ga-PSMA PET/CT had PCa on *** was no statistically significant difference in the 18F-FdG maximum standardized uptake value between the benign or malignant groups(5.7 vs.6.1;p=0.580).Conclusion:In this study,after an incidental finding of an avid intraprostatic lesion on 18F-FdG PET/CT,70 of the 231 cases(30.3%;0.8%of the entire cohort)had results c

关键词： Prostatecancer Positionemission tomography Multiparametric magneticresonance imaging Prostatebiopsy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Myosin binding protein C:Structural abnormalities in familial hypertrophic cardiomyopathy

引用

Cell Research 2004年第2期14卷 95-110页

作者： Cecily E OAKLEY,Brett d HAMBLY,Paul MG CURMI,louise J BROWN department of Pathology University of Sydney NSW 2006 Australia department of Pathology University of Sydney NSW 2006 Australia Initiative for Biomolecular Structure School of Physics University of New South Wales NSW 2052 and Centre for Immunology St Vincent's Hospital and University of New South Wales Sydney NSW 2010 Australia. Initiative for Biomolecular Structure School of Physics University of New South Wales NSW 2052 and Centre for Immunology St Vincent's Hospital and University of New South Wales Sydney NSW 2010 Australia.

The muscle protein myosin binding protein C (MyBPC) is a large multi-domain protein whose role in the sarcomere is complex and not yet fully understood. Mutations in MyBPC are strongly associated with the heart disease familial hypertrophic cardiomyopathy (FHC) and these experiments of nature have provided some insight into the intricate workings of this protein in the heart. While some regions of the MyBPC molecule have been assigned a function in the regulation of muscle contraction, the interaction of other regions with various parts of the myosin molecule and the sarcomeric proteins, actin and titin, remain obscure. In addition, several intra-domain interactions between adjacent MyBPC molecules have been identified. Although the basic structure of the molecule (a series of immunoglobulin and fibronectin domains) has been elucidated, the assembly of MyBPC in the sarcomere is a topic for debate. By analysing the MyBPC sequence with respect to FHC-causing mutations it is possible to identify individual

关键词： myosin binding protein C hypertrophic cardiomyopathy sarcomeric proteins immunoglobulin superfamily mutations.

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Non-invasive means of measuring hepatic fat content

引用

World Journal of Gastroenterology 2008年第22期14卷 3476-3483页

作者： Sanjeev R Mehta E louise Thomas Jimmy d Bell desmond G Johnston Simon d Taylor-Robinson division of Medicine Imperial College London St Mary's Campus Praed Street London W2 1NY United Kingdom Imaging Sciences depart-ment Division of Clinical Sciences Imperial College London Hammersmith Campus Du Cane Road London W12 OHS United Kingdom

Hepatic steatosis affects 20% to 30% of the general adult population in the western world. Currently, the technique of choice for determining hepatic fat deposition and the stage of fibrosis is liver biopsy. However, it is an invasive procedure and its use is limited, particularly in children. It may also be subject to sampling error. Non-invasive techniques such as ultrasound, computerised tomography (CT), magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (1H MRS) can detect hepatic steatosis, but currently cannot distinguish between simple steatosis and steatohepatitis, or stage the degree of fibrosis accurately. Ultrasound is widely used to detect hepatic steatosis, but its sensitivity is reduced in the morbidly obese and also in those with small amounts of fatty infiltration. It has been used to grade hepatic fat content, but this is subjective. CT can detect hepatic steatosis, but exposes subjects to ionising radiation, thus limiting its use in longitudinal studies and in children. Recently, magnetic resonance (MR) techniques using chemical shift imaging have provided a quantitative assessment of the degree of hepatic fatty infiltration, which correlates well with liver biopsy results in the same patients. Similarly, in vivo 1H MRS is a fast, safe, non-invasive method forthe quantification of intrahepatocellular lipid (IHCL) levels. Both techniques will be useful tools in future longitudinal clinical studies, either in examining the natural history of conditions causing hepatic steatosis (e.g. non-alcoholic fatty liver disease), or in testing new treatments for these conditions.

关键词： Adipose tissue Ectopic fat Hepatic fat Insulin resistance Ultrasound Computerised tomography Magnetic resonance imaging Magnetic resonance spectroscopy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A high incidence of non-cavity nesting in an introduced population of House Sparrows suggests that the species should not be constrained by cavity-nest site availability

引用

Avian Research 2017年第4期8卷 202-209页

作者： Elizabeth louise Sheldon Simon Charles Griffith department of Biological Sciences Macquarie UniversitySydneyNSW 2109Australia

Background: The House Sparrow(Passer domesticus) has undergone dramatic population declines in many parts of *** has been widely hypothesised that a lack of cavity nest sites has contributed to this *** the idea of the House Sparrow being nest site limited is somewhat incompatible with the long history of nest site plasticity in the ***: The nest-site selection in a population of non-native House Sparrows introduced to Australia from Europe just over 150 years ago was *** prevalence of non-cavity nesting was quantified,and nest-site selection in terms of landscape and nesting structure were ***: Flexible nesting behaviors were reported over a range of different landscapes and a surprisingly high rate of nesting in vegetation(43%) was *** nests found in vegetation were not in cavities,but were woven into the foliage and supported by branches and ***: The high rate of vegetation nesting indicates that in this introduced population,the House Sparrow is unlikely to be constrained by cavity-nest site *** high degree of nest site plasticity in the Australian population may suggest that European House Sparrows have the potential to shift away from their proclivity for cavity *** work in Europe should examine the incidence of non-cavity nesting in House Sparrows more closely,and perhaps reconsider the idea that House Sparrows are nest-site constrained.

关键词： Passer domesticus Cavity nests House Sparrow decline Nesting plasticity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Evidence for the involvement of NOd2 in regulating colonic epithelial cell growth and survival

引用

World Journal of Gastroenterology 2008年第38期14卷 5834-5841页

作者： Sheena M Cruickshank louise Wakenshaw John Cardone Peter d Howdle Peter J Murray Simon R Carding Molecular and Cellular Biology University of Leeds Leeds LS2 9JT United Kingdom Faculty of Life Sciences University of Manchester Manchester M13 9PT United Kingdom Institute of Molecular and Cellular Biology University of Leeds Leeds LS2 9JT United Kingdom The Institute of Food Research Norwich Research Park Norwich NR4 7UA United Kingdom Institute of Molecular and Cellular Biology University of Leeds Leeds LS2 9JT United Kingdom Section of Medicine Surgery & Anaesthesia Leeds Institute of Molecular Medicine University of Leeds Leeds LS2 9JT United Kingdom department of Infectious diseases St. Jude Children's Research Hospital Memphis TN 38105 United States

AIM: To investigate the function of NOd2 in colonic epithelial cells (CEC). METHOdS: A combination of in vivo and in vitro analyses of epithelial cell turnover in the presence and absence of a functional NOd2 protein and, in response to enteric Salmonella typhimurium infection, were used. shRNA interference was also used to investigate the consequences of knocking down NOd2 gene expression on the growth and survival of colorectal carcinoma cell lines. RESULTS:In the colonic mucosa the highest levels of NOd2 expression were in proliferating crypt epithelial cells. Muramyl dipeptide (MdP), that is recognized by NOd2, promoted CEC growth in vitro . By contrast,the growth of NOd2-deficient CECs was impaired. In vivo CEC proliferation was also reduced and apoptosis increased in Nod2-/- mice, which were also evident following enteric Salmonella infection. Furthermore, neutralization of NOd2 mRNA expression in human colonic carcinoma cells by shRNA interference resulted in decreased survival due to increased levels of apoptosis. CONCLUSION: These findings are consistent with the involvement of NOd2 protein in promoting CEC growth and survival. defects in proliferation by CECs in cases of Cd may contribute to the underlying pathology of disrupted intestinal homeostasis and excessive inflammation.

关键词： Colon Epithelial cells NOd2 Growth

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of nutritional counselling on hepatic,muscle and adipose tissue fat content and distribution in non-alcoholic fatty liver disease

引用

World Journal of Gastroenterology 2006年第36期12卷 5813-5819页

作者： E louise Thomas Audrey E Brynes Gavin Hamilton Nayna Patel Adam Spong Robert d Goldin Gary Frost Jimmy d Bell Simon d Taylor-Robinson The Robert Steiner MR Unit MRC Clinical Sciences Centre department of Nutrition and dietetics The Robert Steiner MR Unit MRC Clinical Sciences Centre Faculty of Medicine Imperial College London Hammersmith Hospital Du Cane Rd London W12 0HS United Kingdom and Histopathology Department Faculty of Medicine Imperial College London St Mary's Hospital Praed Street London W2 1NY United Kingdom Faculty of Medicine Faculty of Medicine Imperial College London St Mary's Hospital Praed Street London W2 1NY United Kingdom

AIM： To assess the effectiveness of the current UK clinical practice in reducing hepatic fat （IHCL）.METHOdS： Whole body MRI and IH MRS were obtained, before and after 6 mo nutritional counselling, from liver, soleus and tibialis muscles in 10 subjects with non-alcoholic fatty liver disease （NAFLd）.RESULTS： A 500 Kcal-restricted diet resulted in an average weight loss of 4% （-3.4 kg,） accompanied by significant reductions in most adipose tissue （AT） depots, including subcutaneous （-9.9%）, abdominal subcutaneous （-10.2%） and intra-abdominal- AT （-11.4%）. Intramyocellular lipids （IMCL） were significantly reduced in the tibialis muscle （-28.2%）. decreases in both IHCL （-39.9%） and soleus IMCL （-12.2%） content were also observed, although these were not significant. Several individuals showed dramatic decreases in IHCL, while others paradoxically showed increases in IHCL content. Changes in body composition were accompanied by improvements in certain liver function tests： serum aspartate aminotransferase （AST） and alanine aminotransferase （ALT）. Significant correlations were found between decreases in IHCL and reductions in both intra-abdominal and abdominal subcutaneous AT. Improvements in liver function tests were associated with reductions in intra-abdominal AT, but not with changes in IHCL. CONCLUSION： This study shows that even a very modest reduction in body weight achieved through lifestyle modification can result in changes in body fat depots and improvements in LETs.

关键词： Intra-abdominal adipose tissue Intrahepatic fat Intramyocellular lipids Weiqht loss Magnetic resonance imaging

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Psychometric validation of satisfaction with simulated clinical learning experience evaluation e corrections(SSCLEE-C)

引用

International Journal of Nursing Sciences 2016年第1期3卷 58-62页

作者： desiree A.dı´az Reagan louise deborah Shelton William d.Barta University of Central Florida USA University of Connecticut School of Nursing USA School of Nursing Center for Correctional Health Networks-CCHNetUSA Center for Correctional Health Networks-CCHNet USA

Purpose:This study sought to modify a 19-item instrument designed to measure nursing students'satisfaction with a simulated learning experience for use in a correctional system to measure nurse satisfaction with simulated learning experiences;and to establish validity for the modified *** measures were available for use in a correctional setting,and few instruments were available to measure nurse satisfaction with simulation ***/methodology:One hundred and ninety-eight correctional nurses responded to the original 19-item five-point Likert scale *** data were used for an exploratory and confirmatory factor ***:A 3-factor solution accounting for 62%of the *** 3 factors:Fidelity,Objectives,and Problem solving were supported by *** 9-itemCFA exhibited desirable psychometric properties:Rootmeansquare error of approximation(RMSEA)=.046;Akaike Information Criterion(AIC)=76.95;Comparative Fit Index(CFI)=*** model χ^(2)=30.95(ns).Alpha reliability estimates of the three factors were 0.70,0.70 and ***/value:The Satisfaction with Simulated Clinical Learning Experience Evaluation-Corrections(SSCLEE-C)is the only instrument available for ongoing assessment of correctional nurse satisfaction with simulated clinical learning experiences.

关键词： Simulation Satisfaction Correctional nurses Instrument development

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：