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Neural Regeneration Research 2025年第3期20卷 671-681页

作者： Angelid Pabon Jagannatham Naidu Bhupana Ching-On wong department of Biological Sciences Rutgers UniversityNewarkNJUSA

Cells undergo metabolic reprogramming to adapt to changes in nutrient availability, cellular activity, and transitions in cell states. The balance between glycolysis and mitochondrial respiration is crucial for energy production, and metabolic reprogramming stipulates a shift in such balance to optimize both bioenergetic efficiency and anabolic requirements. Failure in switching bioenergetic dependence can lead to maladaptation and pathogenesis. While cellular degradation is known to recycle precursor molecules for anabolism, its potential role in regulating energy production remains less explored. The bioenergetic switch between glycolysis and mitochondrial respiration involves transcription factors and organelle homeostasis, which are both regulated by the cellular degradation pathways. A growing body of studies has demonstrated that both stem cells and differentiated cells exhibit bioenergetic switch upon perturbations of autophagic activity or endolysosomal processes. Here, we highlighted the current understanding of the interplay between degradation processes, specifically autophagy and endolysosomes, transcription factors, endolysosomal signaling, and mitochondrial homeostasis in shaping cellular bioenergetics. This review aims to summarize the relationship between degradation processes and bioenergetics, providing a foundation for future research to unveil deeper mechanistic insights into bioenergetic regulation.

关键词： autophagy bioenergetics endolysosome energy production glycolysis metabolic reprogramming mitochondria

Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic lydia Jiménez-díaz Juan d.Navarro-lópez NeuroPhysiology&Behavior lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

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伤害监视系统在促进社区安全中的作用

疾病控制杂志 2007年第4期11卷 348-348页

作者： M Ming C B Chow Adela S F lai Y HChow Henry K HKwong Philip P WChoi Albert C Hlit louisa d l wong lars Gunnar Horte Princess Margaret Hospital Occupational safety and Health council Karolinski Insitiutet ( WHO collaboration centeron safety promotionin the community)

伤害是世界上主要的健康问题,其后果不尽相同,与社会分层、风险暴露和感受性不同有关.为保障个人、社区健康和福利,建立的伤害监视系统在整体小区安全促进中具有重要的位置.

关键词：人群监测

Polyethylene glycol has immunoprotective effects on sciatic allografts, but behavioral recovery and graft tolerance require neurorrhaphy and axonal fusion

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Neural Regeneration Research 2025年第4期20卷 1192-1206页

作者： Tyler A.Smith liwen Zhou Cameron l.Ghergherehchi Michelle Mikesh Cathy Z.Yang Haley O.Tucker JuliAnne Allgood Jared S.Bushman George d.Bittner department of Molecular Biosciences University of Texas at AustinAustinTXUSA department of Neuroscience University of Texas at AustinAustinTXUSA division of Pharmaceutical Sciences University of WyomingLaramieWYUSA

Behavioral recovery using(viable)peripheral nerve allografts to repair ablation-type(segmental-loss)peripheral nerve injuries is delayed or poor due to slow and inaccurate axonal ***,such peripheral nerve allografts undergo immunological rejection by the host immune *** contrast,peripheral nerve injuries repaired by polyethylene glycol fusion of peripheral nerve allografts exhibit excellent behavioral recovery within weeks,reduced immune responses,and many axons do not undergo Wallerian *** relative contribution of neurorrhaphy and polyethylene glycol-fusion of axons versus the effects of polyethylene glycol per se was unknown prior to this *** hypothesized that polyethylene glycol might have some immune-protective effects,but polyethylene glycol-fusion was necessary to prevent Wallerian degeneration and functional/behavioral *** examined how polyethylene glycol solutions per se affect functional and behavioral recovery and peripheral nerve allograft morphological and immunological responses in the absence of polyethylene glycol-induced axonal ***-type sciatic nerve injuries in outbred Sprague–dawley rats were repaired according to a modified protocol using the same solutions as polyethylene glycol-fused peripheral nerve allografts,but peripheral nerve allografts were loose-sutured(loose-sutured polyethylene glycol)with an intentional gap of 1–2 mm to prevent fusion by polyethylene glycol of peripheral nerve allograft axons with host *** to negative control peripheral nerve allografts not treated by polyethylene glycol and in contrast to polyethylene glycol-fused peripheral nerve allografts,animals with loose-sutured polyethylene glycol peripheral nerve allografts exhibited Wallerian degeneration for all axons and myelin degeneration by 7 days postoperatively and did not recover sciatic-mediated behavioral functions by 42 days *** morphological signs of rejection,such as col

关键词： allograft rejection axotomy macrophage myelin nerve repair polyethylene glycol(PEG) sciatic nerve T cell transplantation Wallerian degeneration

Altered expression of m^(1)A regulatory genes is associated with oncogenic pathways,overall survival,and infiltration of immune cells in diverse human cancers

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Genes & diseases 2023年第3期10卷 739-742页

作者： Renhua Song Justin J-l wong Epigenetics and RNA Biology Program Centenary Institute The University of SydneyCamperdown 2050Australia Faculty of Medicine and Health The University of SydneyCamperdown 2050Australia

Of over 170 types of RNA modifications discovered,N^(6)-methyladenosine(m^(6)A)is the most actively studied.m6A confers oncogenic potential,maintains cancer stem cells,and is associated with cancer-related outcomes.^(... 详细信息

关键词： cancer maintain immune

Framework for atomic-level characterisation of quantum computer arrays by machine learning

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npj Computational Materials 2020年第1期6卷 1513-1520页

作者： Muhammad Usman Yi Zheng wong Charles d.Hill lloyd C.l.Hollenberg Center for Quantum Computation and Communication Technology University of MelbourneParkvilleVIC 3010Australia School of Physics University of MelbourneParkvilleVIC 3010Australia School of Computing and Information Systems Melbourne School of EngineeringUniversity of MelbourneParkvilleVIC 3010Australia School of Mathematics and Statistics University of MelbourneParkvilleVIC 3010Australia

Atomic-level qubits in silicon are attractive candidates for large-scale quantum computing;however,their quantum properties and controllability are sensitive to details such as the number of donor atoms comprising a qubit and their precise *** work combines machine learning techniques with million-atom simulations of scanning tunnelling microscopic(STM)images of dopants to formulate a theoretical framework capable of determining the number of dopants at a particular qubit location and their positions with exact lattice site precision.A convolutional neural network(CNN)was trained on 100,000 simulated STM images,acquiring a characterisation fidelity(number and absolute donor positions)of>98% over a set of 17,600 test images including planar and blurring noise commensurate with experimental *** formalism is based on a systematic symmetry analysis and feature-detection processing of the STM images to optimise the computational *** technique is demonstrated for qubits formed by single and pairs of closely spaced donor atoms,with the potential to generalise it for larger donor *** method established here will enable a high-precision post-fabrication characterisation of dopant qubits in silicon,with high-throughput potentially alleviating the requirements on the level of resources required for quantum-based characterisation,which will otherwise be a challenge in the context of large qubit arrays for universal quantum computing.

关键词： quantum character donor

Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： laura Huggon Emma l.Clayton UK dementia Research Institute at King’s College london LondonUK department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T d)and amyo t rophic lateral sclerosis(AlS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTd affecting neurons of the frontal and temporal lobes,and AlS affecting upper and lower motor neurons),these two diseases are complexly *** and AlS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

Interference with the formation of the epididymal microenvironment——a new strategy for male contraception?

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Asian Journal of Andrology 2000年第1期2卷 39-45页

作者： X.d.Gong G.P.H.leung B.l.Y.Cheuk P.Y.d.wong department of Phsiology The Chinese University of Hong Kong Shatin N. T. Hong Kong ChinaDepartment of Phsiology The Chinese University of Hong Kong Shatin N. T. Hong Kong ChinaDepartment of Phsiology The Chinese University of Hong Kong Shatin N. T. Hong Kong ChinaDepartment of Phsiology The Chinese University of Hong Kong Shatin N. T. Hong Kong China

The cystic fibrosis transmembrane conductance regulator (CFIR) or the small conductance cAMP-activated chlo-ride channel encoded by the CFTR gene has been shown to play an important role in the formation of the epididymalfluid microenvironment. Recent work in our laboratory has shown that this protein is also expressed by developing germcells indicating a role of this protein in spermatogenesis. In view of the fact that the CFTR gene has a far reaching andwidespread effect on human reproduction, understanding the role of CFTR in the male reproductive tissues and its inter-vention by pharmacological agents can open a new avenue of research into the development of novel male contracep-tives. (Asian J Androl 2000; 2: 39 - 45 )

关键词： epididymis cyclooxygenase contraception cystic fibrosis transmembrane conductance regulator

STRUCTURE ANd SURFACE STUdIES OF Mg_xZn_(1-x)O FIlMS GROWN BY PUlSEd lASER dEPOSITION

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Acta Metallurgica Sinica(English letters) 2005年第3期18卷 237-241页

作者： l.Zhuang K.H.wong departmentofAppliedPhysics TheHongKongPolytechnicUniversityKowloonHongKongChina

The structural and surface properties of high-quality epitaxial cubic MgxZn1-xO films deposited by pulsed laser deposition (Pld) were studied by X-ray diffracti on and atomic force microscopy respectively. For films of about 500nm thick, sca ns over a 30μm × 30μm area revealed a surface roughness Ra of about 100nm. Th is relatively large surface roughness is primarily attributed to the particulate and outgrowth during the Pld process. A good epitaxial growth on laAlO3 (lAO ) (100) substrates, however has been obtained for composition x = 0.9, 0.7 and 0 .5 with the heteroepitaxial relationship of (100)■∥(100)lAO (out-of-plane) and (011)■∥(010)lAO (in-plane). These structural qualities suggest that cubic Mgx Zn1-xO alloys films have good potential in a variety of optoelectronic device ap plications.

关键词： pulsed laser deposition thin film XRd MgxZn1-xO

Combinatorial genetics methods for discovering high-order regulatory combinations and engineering genetic drivers for neural differentiation

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Neural Regeneration Research 2021年第12期16卷 2403-2404页

作者： dawn G.l.Thean Alan S.l.wong laboratory of Combinatorial Genetics and Synthetic Biology School of Biomedical SciencesThe University of Hong KongPokfulamHong Kong Special Administrative RegionChina department of Electrical and Electronic Engineering The University of Hong KongPokfulamHong Kong Special Administrative RegionChina

diving into the search for effective cell differentiation factors:Researchers are still striving to find better therapeutics to revert or slow down the progression of neurological disorders such as Parkinson’s disease,Alzheimer’s disease,and Huntington’s *** disorders are the result of neuronal cell death in different parts of the *** or treatments used to relieve the symptoms in patients have not been well *** do not recover the damaged neural tissues and can result in unwanted side effects.

关键词： Huntington neural Alzheimer