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SARS-CoV-2 productively infects primary human immune system cells in vitro and in CoviD-19 patients

Journal of Molecular Cell Biology 2022年第4期14卷 51-64页

作者： Marjorie C.Pontelli italo A.Castro Ronaldo B.Martins Leonardo La Serra Flavio P.Veras Daniele C.Nascimento Camila M.Silva Ricardo S.Cardoso Roberta Rosales Rogério Gomes Thais M.Lima Juliano P.Souza Brenda C.Vitti Diego B.Caetite Mikhael H.F.de Lima Spencer D.Stumpf Cassandra E.Thompson louis-marie bloyet Juliana E Toller-Kawahisa Marcela C.Giannini Leticia P.Bonjorno Marial.F.Lopes Sabrina S.Batah Li Siyuan Rodrigo Luppino-Assad Sergio C.L.Almeida Fabiola R.Oliveira Maira N.Benatti Lorena L.F.Pontes Rodrigo C.Santana Fernando C.Vilar Maria Auxiliadora-Martins Pei-Yong Shi Thiago M.Cunha Rodrigo T.Calado JoséC.Alves-Filho Dario S.Zamboni Alexandre T.Fabro Paulo Louzada-Junior Rene D.R.Oliveira Sean P.J.Whelan Fernando Q.Cunha Eurico Arruda Virology Research Center Ribeirao Preto Medical SchoolUniversity of Sao Pauloibeirao PretoSao Paulo 14049-900.Brazil Center of Research in Inflammatory Diseases Ribeirao Preto Medical SchoolUniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil Department of Celland Molecular Biology Ribeirao Preto Medical SchoolUniversityof Sao PauloRibeirao PretoSao Paulo 14049-900 Brazil Regional Blood Centerof Ribeirao Preto Ribeirao Preto Medical ScholUniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil Department of Biochemistry&Molecular Biology the University of Texas Medical BranchGalvestonTX7755USA Divisions of Clinical lmmunology Infectious Diseases and Intensive Care UnitRibeirao Preto Medical Schooniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil Department of Pathology Ribeirao Preto Medical Scholniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil Department of Molecular Microbiology.Washington University in St.louis Saint LouisMO 63110USA

The severe acute respiratory syndrome coronavirus 2(SARS-CovV-2)infection is associated with a hyperinflammatory state and lymphocytopenia,a hallmark that appears as both signature and prognosis of disease severity *** cytokine storm and a sustained inflammatory state are commonly associated with immune cell depletion,it is still unclear whether direct SARS-Cov-2 infection of immune cells could also play a role in this scenario by harboring viral *** found that monocytes,as well as both B and T lymphocytes,were susceptible to SARS-Cov-2 infection in vitro,accumulating double-stranded RNA consistent with viral RNA replication and ultimately leading to expressive T cell *** addition,flow cytometry and immunofluorescence analysis revealed that SARS-Cov-2 was frequently detected in monocytes and B lymphocytes from coronavirus disease 2019(CoVID-19)*** rates of SARS-Cov-2-infected monocytes in peripheral blood mononuclear cells from CoVID-19 patients increased over time from symptom onset,with SARS-CoV-2-positive monocytes,B cells,and CD4+T lymphocytes also detected in postmortem lung *** results indicated that SARS-CoV-2 infection of blood-circulating leukocytes in covID-19 patients might have important implications for disease pathogenesis and progression,immune dysfunction,and virus spread within the host.

关键词： SARS-CoV-2 CoVID-19 lymphocytopenia peripheral blood mononuclear cell(PBMC) lymphocytes monocytes apoptosis

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Neuron Foundry Mach 8:A Concept of Multi-modal Neurosupportive Energy Therapy Device for Treating Neurodegenerative Disorders

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Brain Science Advances 2024年第1期10卷 6-38页

作者： Charles McGlynn Doni Dermawan Guia marie Canonizado School of Earth and Environment Rowan UniversityNJ 08028 New JerseyUnited States Applied Biotechnology Faculty of ChemistryWarsaw University of Technology00-661 WarsawPoland Saint louis University School of Medicine 2600 Baguio CityPhilippines

The prevalence of neurodegenerative disorders is rising as the population ages,and many ailments,such as depression,Parkinson’s disease,Alzheimer’s disease,autism spectrum disorder,and multiple sclerosis,have intricate underlying mechanisms that are still poorly *** Neuron Foundry Mach 8 is a multi-modal neuro-supportive energy therapy device designed to treat neurodegenerative disorders through daily *** device proposes to deliver safe and controlled energy therapy through multiple therapeutic pathways,including stimulating brain mitochondrial energy,supporting homeostasis within the brain’s immune system,increasing melatonin production within neuronal mitochondria,and triggering cellular communication through the brain’s white *** combining these unique energy-based treatments,this device holds promising potential for slowing,stopping,reversing,or at least reducing the effects of neurodegenerative diseases.

关键词： energy therapy medical device multi-modal neuro-supportive energy neurodegenerative disorders Neuron Foundry Mach 8

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Investigation of Particle Breakdown in the Production of Composite Magnesium Chloride and Zeolite Based Thermochemical Energy Storage Materials

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Energy Engineering 2023年第10期120卷 2193-2209页

作者： louis F.marie Karina Sałek Tadhg S.O’Donovan HeriotWatt University Institute of MechanicalProcess and Energy EngineeringEdinburghUK

Composite thermochemical energy storage(TCES)represents an exciting field of thermal energy storage which could address the issue of seasonal variance in renewable energy ***,there are open questions about their performance and the root cause of some observed *** researchers have observed the breakdown of particles in their production phase,and in their *** study seeks to investigate the underlying cause of this *** and EDX analysis have been conducted on MgCl2 impregnated 13X zeolite composites of differing diameters,as well as LiX *** was done in order to study the level of impregnation of salt into the zeolite matrix,as well as the effect this impregnation process has on the morphology of the *** was conducted using ImageJ software to study the effect of the impregnation process on the diameter of the *** has been found that a by weight impregnation concentration of magnesium chloride of 11.90%for the LiX zeolite,and 7.59%and 5.26%for the large diameter 13X zeolite and the small diameter 13X zeolite respectively has been *** has been found that the impregnation process significantly affects themorphology of 13X zeolite particles,causing large fissures to form,and eventually resulting in the previously found breakdown of these *** has been verified that a primary factor influencing the breakdown of the 13X zeolite particles is the efflorescence and sub-fluorescence phenomena,which leads to a build-up of crystals in the zeolite *** has also been found that prolonged impregnation times and the use of high concentration salt solutions in the soaking process can induce significant crystal growth which also leads to the breakdown of these *** demonstrate that LiX zeolite is the optimum host matrix choice in these *** results will allow for the design of more resilient composite TCES particles.

关键词： Composites thermochemical energy storage salt-in-porous-matrix zeolites seasonal storage

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High-Harmonic Generation and Correlated Electron Emission from Relativistic Plasma Mirrors at 1 kHz Repetition Rate

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Ultrafast Science 2022年第3期2卷 19-27页

作者： Stefan Haessler marie Ouillé Jaismeen Kaur Maïmouna Bocoum Frederik Böhle Dan Levy louis Daniault Aline Vernier Jérôme Faure Rodrigo Lopez-Martens Laboratoire d’Optique Appliquée ENSTA ParisCNRSEcole PolytechniqueInstitut Polytechnique de Paris181 Chemin de la Hunière et des Joncherettes91120 PalaiseauFrance Ardop Engineering Citéde la Photonique11 Avenue de la CanteranneBât.Pléione33600 PessacFrance Department of Physics of Complex Systems Weizmann Institute of ScienceRehovot 7610001Israel

We report evidence for the first generation of XUV spectra from relativistic surface high-harmonic generation(SHHG)on plasma mirrors at a kilohertz repetition rate,emitted simultaneously with energetic *** spectra and electron angular distributions are measured as a function of the experimentally controlled plasma density gradient scale length Lg for three increasingly short and intense driving pulses:24 fs and a0=1:1,8 fs and a0=1:6,and finally 4 fs and a0≈2:1,where a0 is the peak vector potential normalized by mec/e with the elementary charge e,the electron rest mass me,and the vacuum light velocity *** all driver pulses,we observe correlated relativistic SHHG and electron emission in the range Lg∈½λ/20,λ/4,with an optimum gradient scale length of Lg≈λ/*** universal optimal Lg-range is rationalized by deriving a direct intensity-independent link between the scale length Lg and an effective similarity parameter for relativistic laser-plasma interactions.

关键词： Attosecond science and technology Attosecond light source High-harmonic generation

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Recent advances in gastrointestinal cancers

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World Journal of Gastroenterology 2021年第28期27卷 4493-4503页

作者： Natacha Bordry Christoforos Astaras marie Ongaro Nicolas Goossens Jean louis Frossard Thibaud Koessler Department of Oncology University Hospital of Geneva(HUG)Genève 1205Switzerland Divison of Gastroenterology and Hepatology University Hospital of Geneva(HUG)Genève 1205Switzerland

Gastrointestinal cancers occur in a total of eight different locations,each of them with a different standard of *** article is not an exhaustive review of what has been published in *** have concentrated on the thirteen phase III randomized studies that are *** these studies are oral presentations which have been given in one of the four major oncology congresses,namely American Society of Clinical Oncology(ASCO),ASCO gastrointestinal(GI),European Society of Medical Oncology(ESMO)and *** provide a concise view of these major trials and their main outcomes,and put these results into context.

关键词： Practice changing trials Immunotherapy Gastrointestinal cancers Gastrointestinal Gastric cancer

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Assessment of Radioactivity in Borehole Waters of the North Riviera Sodeci Catchment Field in Abidjan, Côte d’Ivoire

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World Journal of Nuclear Science and Technology 2022年第1期12卷 55-68页

作者： Epi Zita Tatiana Kocola Achi Bogbé Douo louis Huberson Gogon Koudou Djagouri marie Chantal Kouassi Goffri Laboratoire des Sciences de la Matière Environnement et de l’Energie Solaire (LASMES) Université Felix Houphouet Boigny Abidjan C&#244 te d’Ivoire Autorité de Radioprotection de Sureté et de sécurité Nucléaire Abidjan C&#244 te d’Ivoire Ecole Normale Superieure d’Abidjan Abidjan C&#244 te d’Ivoire

The radioactive isotopes of the decay series of uranium-238 (238U), thorium-232 (232Th) and potassium-40 (40K) occur naturally in varying amounts in groundwater. They are the subject of many measures, mainly because of the risk they represent from a public health point of view. The purpose of this study is to measure the radioisotope content of borehole waters from the north riviera (NR) catchment field of the Ivorian drinking water distribution company (SODECI). These measurements will make it possible to assess the absolute levels of radioisotopes in the water from SODECI’s boreholes used directly for drinking or swimming, and possibly the associated risk from a public health point of view. To achieve this, a sampling campaign from the seven functional boreholes and the control or treatment tower took place in July 2018 at the NR well field. The analysis of radionuclides by gamma spectrometry was carried out in the laboratory of the Radiation Protection Institute (RPI) of the Ghana Atomic Energy Commission (GAEC). The naturally occurring radionuclides identified during the borehole water samples analysis are 238U, 232Th, and 40K. The results reveal that the specific activities of uranium vary from 0.45 ± 0.18 Bq/L to 0.55 ± 0.17 Bq/L with an average of 0.49 ± 0.15 Bq/L. Those of thorium vary from 0.66 ± 0.14 Bq/L to 0.78 ± 0.18 Bq/L with an average of 0.72 ± 0.16 Bq/L and potassium of 4.14 ± 0.53 Bq/L at 5.87 ± 0.60 Bq/L with an average of 5.32 ± 0.58 Bq/L.

关键词： North Rivera (NR) Catchment Field Drilling Water Natural Radionuclides Uranium Thorium Potassium

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Trifluoromethyl radical triggered radical cyclization of N-benzoyl ynamides leading to isoindolinones

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Science China Chemistry 2019年第11期62卷 1542-1546页

作者： Maud Cassé Christian Nisole Héloise Dossmann Yves Gimbert Jean-marie Fourquez Laure Haberkorn Cyril Ollivier louis Fensterbank Sorbonne Université CNRSInstitut Parisien de Chimie MoléculaireIPCM75005 ParisFrance Institut de Recherches Servier 78290 Croissy-sur-SeineFrance Département de Chimie Moléculaire CNRSUniversitéGrenoble Alpes38610 GièresFrance

Under photocatalytic reductive conditions,trifluoromethyl radical addition onto an ynamide followed by cyclization on a benzoyl moiety produces diverse isoindolinone platforms with good *** selectivity of the radical cyclization,N-benzoyl vs.N-benzyl as radical acceptor and the E/Z ratio of isomers have been rationalized by modeling.

关键词： ynamides trifluoromethylation photocatalysis cascade reactions tandem processes isoindolinones modeling

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Effect of High-Speed Solar Winds Turbulence Upstream of the Earth’s Magnetosphere: Case of the Outer Minima of Solar Cycles 20, 21, 22, 23 and 24

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Open Journal of Applied Sciences 2023年第7期13卷 1145-1162页

作者： Inza Gnanou Salfo Kabore Aristide marie Frédéric Gyebre Christian Zoundi Jean-louis Zerbo Frédéric Ouattara É cole Normale Supérieure Koudougou Burkina Faso Department of Physics Laboratoire de Recherche en énergétique et Météorologie de l’Espace (LAREME) Université Norbert ZONGO Koudougou Burkina Faso Department of Physics Laboratoire de Matériaux d’Héliophysique et Environnement (LaMHE) Université Nazi BONI Bobo-Dioulasso Burkina Faso

Highly turbulent environment, the solar wind is a stream of very energetic particles mainly made of protons and electrons. During its trip in the interplanetary space, this solar flow becomes more accelerated during the outer minima (descending phases) of the solar cycles and can therefore influence all of humanity and its technology. These disturbances lead to socio-economic consequences requiring a precise knowledge of the climate variability. Using a statistical approach, we evaluate the response of the Earth’s magnetosphere to the High-Speed Solar Winds (HSSW) forcing during the peaks of the last five outer minima. To do so, 1UA data of solar wind and magnetic field parameters were extracted from OMNI browser. Analysis of the energetic solar plasma particles shows that strong geomagnetic field variations can occur even in the absence of large solar disturbances. While the normalized reconnection rate was estimated to be ~21% of the total variance of the magnetospheric variables, the upstream of the magnetic cavity was perturbed 80% of the time with large energies recorded. As a result, Earth’s magnetosphere becomes denser (i.e., more drag), which is a problem for spacecraft. Thus, the coupled solar wind-magnetosphere system follows scale-invariant dynamics and is in a state far from equilibrium. Our analysis provides insight into the main cause of geomagnetic storms with more than 97% of HSSW imposed in the range 300 - 850 km/s. These high-speeds lead to auroras that can disrupt electrical and communication systems.

关键词： Solar Wind Outer Minimum Magnetosphere Geomagnetic Field Solar Disturbances

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Production of human polyclonal antibodies by transgenic animals

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Advances in Bioscience and Biotechnology 2011年第3期2卷 138-141页

作者： louis-marie Houdebine 不详

Polyclonal antibodies collected from the blood of animals and humans experimentally immunised or spontaneously immunised respectively can be injected into patients to protect them against pathogens, toxins, tumours etc. This approach is severely limited by the availability of human polyclonal antibodies of interest. Moreover, polyclonal antibodies from animals are recognised as antigens by patients and are thus rapidly rejected and inactivated. To circumvent this problem, animals (essentially rabbits, chicken, pigs and cows) are being genetically engineered. Their immunoglobulin genes are being inactivated and the corresponding human immunoglobulin genes are being transferred to them. These animals will be immunized and it is expected that large amounts of pure human polyclonal antibodies will be extracted from their blood to be administered to patients. The possible acceptability problem of this approach is under a case study of the European Union Pegasus project.

关键词： Human Polyclonal Antibodies Transgenic Animals Acceptability

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Total Indicative Dose Determination in Water from the North Riviera Well Field of SODECI in Abidjan, Cote d’Ivoire

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Journal of Environmental Protection 2023年第12期14卷 1006-1015页

作者： Epi Zita Tatiana Kocola Achi Bogbé Douo louis Huberson Gogon N’Guessan Guy Léopold Oka Antonin Aka Koua marie Chantal Kouassi Goffri Laboratoire des Sciences de la Matiè re Environnement et de l’Energie Solaire (LASMES) Universit&eacute F&eacute lix Houphou&eumlt Boigny Abidjan C&ocircte d’Ivoire Autorité de Radioprotection de S&ucircret&eacute et de S&eacute curit&eacute Nucl&eacute aire Abidjan C&ocircte d’Ivoire Institut de Recherche en Energies Renouvelables (IREN) Universit&eacute Nangui Abrogoua Abidjan C&ocircte d’Ivoire Acadé mie des Sciences des Arts des Cultures d’Afrique (ASCAD) Abidjan C&ocircte d’Ivoire

The Uranium-238 (238U), Thorium-232 (232Th) families and Potassium-40 (40K) are of terrestrial origin and contribute generally to an individual’s external exposure through our presence in this environment. They also contribute to the internal exposure through the ingestion of products and beverages such as water that are close to the earth. The aim of this work is to determine the committed effective dose or Total Indicative Dose (TID) due to gamma radioactivity of the borehole water from the Nord Riviera (NR) well field operated by the Côte d’Ivoire Water Distribution Company (SODECI) for the supply of drinking water to part of the population of Abidjan. In addition, the populations, with their habits, could use these borehole waters directly as drinking water. To this end, water samples from the seven (07) functional boreholes were collected and analyzed on a gamma spectrometry chain, equipped with an HPGe detector in the laboratory of the Radiation Protection Institute (RPI) of the GHANA Atomic Energy Commission (GAEC). The results of the specific activities of 238U, 232Th and 40K obtained were transcribed into TID. As the natural radioactivity of the borehole water is high [1], the TIDs calculated from the activity results of the natural radionuclides238U, 232Th, and 40K vary for the seven boreholes from 0.150 to 0.166 mSv/yr with an average of 0.161 ± 0.034 mSv/yr. The TID of the control tower, where the borehole water is mixed and treated for household use, is equal to 0.136 ± 0.03 mSv/yr. The TIDs obtained are therefore all slightly greater than the WHO reference dose value of 0.1 mSv/yr. But all remain below the UNSCEAR reference dose of 0.29 mSv/yr.

关键词： North Rivera (NR) Well Field Borehole Water Natural Radioactivity Gamma Spectrometry Total Indicative Dose Committed Annual Effective Dose

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