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英夫利昔单抗治疗克罗恩病的有效性:一项随访15个月的多中心回顾性研究结果

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世界核心医学期刊文摘（胃肠病学分册） 2006年第9期2卷 31-32页

作者： Poupardin c. Lémann M. Gendre J.-P. B .coffin 张诗峰(译) 李文彬(校) 不详 service d' Hépato Gastro-Entérologie Hopital Louis Mourier 178 rue des Renouillers 92700 Colombes

Objectives-To evaluate prescription practices and response to infliximab treatment for crohn’s disease(cD).Patients and methods-The files of cD patients treated with at least one infusion of infliximab treated in gastroenterology units belonging to university teaching hospitals of the Parisian hospitals group(Assistance Publique-Hpitaux de Paris(AP-HP))during the year 2000 were analyzed ***-One hundred and thirty-seven patients(36.0 ±12.7 years,92 females)from 12 centers were *** for treatment was fistulae or perianal disease in 39%of patients,active crohn’s disease in 45and mixed conditions in 16%.Mean follow-up was 15.2 ±7.2 *** overall response rate was 85%.No predictive factor of sustained remission could be *** mean time to relapse was to 3.9 ±3.1 ***-eight patients were on maintenance therapy at the end of the follow-up;37%exhibiting progressive lost of response to *** therapy was added to infliximab in 78%of cases but response to infliximab was not modified by addition of immunosuppressive *** events,most frequently minor,were noted in 23%of the ***-This retrospective study confirms the efficacy and safety of infliximab in cD.

关键词：单抗治疗回顾性分析克罗恩病随访期多中心有效性总体反应率肛门周围疾病

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Decline in subarachnoid haemorrhage volumes associated with the first wave of the cOVID- 19 pandemic

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stroke & Vascular Neurology 2021年第4期6卷 542-552,I0026-I0032页

作者： Thanh N Nguyen Diogo c Haussen Muhammad M Qureshi Hiroshi Yamagami Toshiyuki Fujinaka Ossama Y Mansour Mohamad Abdalkader Michael Frankel Zhongming Qiu Allan Taylor Pedro Lylyk Omer F Eker Laura Mechtouff Michel Piotin Fabricio Oliveira Lima Francisco Mont'Alverne Wazim Izzath Nobuyuki sakai Mahmoud Mohammaden Alhamza R Al-Bayati Leonardo Renieri salvatore Mangiafico David Ozretic Vanessa chalumeau saima Ahmad Umair Rashid syed Irteza Hussain seby John Emma Griffin John Thornton Jose Antonio Fiorot Rodrigo Rivera Nadia Hammami Anna M cervantes-Arslanian Hormuzdiyar H Dasenbrock Huynh Le Vu Viet Quy Nguyen steven Hetts Romain Bourcier Romain Guile Melanie Walker Malveeka sharma Don Frei Pascal Jabbour Nabeel Herial Fawaz Al-Mufti Atilla Ozcan Ozdemir Ozlem Aykac Dheeraj Gandhi chandril chugh charles Matouk Pascale Lavoie Randall Edgell Andre Beer-Furlan Michael chen Monika Killer-Oberpfalzer Vitor Mendes Pereira Patrick Nicholson Vikram Huded Nobuyuki Ohara Daisuke Watanabe Dong Hun shin Pedro sc Magalhaes Raghid Kikano santiago Ortega-Gutierrez Mudassir Farooqui Amal Abou-Hamden Tatsuo Amano Ryoo Yamamoto Adrienne Weeks Elena A cora Rotem sivan-Hoffmann Roberto crosa Markus Möhlenbruch simon Nagel Hosam Al-Jehani sunil A sheth Victor s Lopez Rivera James E siegler Achmad Fidaus sani Ajit s Puri Anna Luisa Kuhn Gianmarco Bernava Paolo Machi Daniel G Abud Octavio M Pontes-Neto Ajay K Wakhloo Barbara Voetsch Eytan Raz shadi Yaghi Brijesh P Mehta Naoto Kimura Mamoru Murakami Jin soo Lee Ji Man Hong Robert Fahed Gregory Walker Eiji Hagashi steve M cordina Hong Gee Roh Ken Wong Juan F Arenillas Mario Martinez-Galdamez Jordi Blasco Alejandro Rodriguez Vasquez Luisa Fonseca M Luis silva Teddy Y Wu simon John Alex Brehm Marios Psychogios William J Mack Matthew Tenser Tatemi Todaka Miki Fujimura Roberta Novakovic Jun Deguchi Yuri sugiura Hiroshi Tokimura Rakesh Khatri Michael Kelly Lissa Peeling Yuichi Murayama Hugh stephen Winters Johnny Wong Mohamed Teleb Jeremy Payne Hiroki Fukuda Kosuke Miyake Junsuke shimbo Yusuke sug Neurology RadiologyBoston Medical CenterBostonMassachusettsUSA Neurology Marcus Stroke&Neuroscience CenterGrady Memorial HospitalEmory University School of MedicineAtlantaGAUSA Radiology Radiation OncologyBoston University School of MedicineBostonMassachusettsUSA Neurology National Hospital Organization Osaka National HospitalOsakaJapan Neurosurgery National Hospital Organization Osaka National HospitalOsakaJapan Neurology Alexandria UniversityAlexandriaEgypt Radiology Boston Medical CenterBostonMassachusettsUSA Department of Neurology Xinqiao HospitalChongqingChina Neurosurgery University of Cape TownRondeboschWestern CapeSouth Africa Neurosurgery Interventional NeuroradiologyClinica La Sagrada FamiliaBuenos AiresArgentina Neuroradiologie Neurologie VasculaireHospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Neurologie Vasculaire Hospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Interventional Neuroradiology Fondation Ophtalmologique Adolphe de RothschildParisÎle-de FranceFrance Neurology Hospital Geral de FortalezaFortalezaBrazil Interventional Neuroradiology Hospital Geral de FortalezaFortalezaBrazil Neuroradiology Nottingham University Hospitals NHS TrustNottinghamUK Department of Neurosurgery Kobe City Medical Center General HospitalKobeHyogoJapan Interventional Neurovascular Unit University Hospital CareggiFirenzeToscanaItaly Neuroradiology University Hospital Centre ZagrebZagrebCroatia Interventional Neuroradiology Hopital BicetreLe Kremlin-BicetreFrance stroke and Interventional Neuroradiology Lahore General HospitalLahorePakistan Neurological Institute Cleveland Clinic Abu DhabiAbu DhabiUAE Department of Radiology Beaumont HospitalDublinIreland Neurology Stroke UnitHospital-Estadual CentralVitoriaBrazil Neuroradiology Instituto de Neurocirugia Dr AsengoSantiagoChile Interventional Neuroradiology Institut National de NeurologieTunisTunisia Neurology Boston Medical CenterBostonMassachusettsUSA Neurosurgery Boston Medical Center

Background During the cOVID-19 pandemic,decreased volumes of stroke admissions and mechanical thrombectomy were *** study’s objective was to examine whether subarachnoid haemorrhage(sAH)hospitalisations and ruptured aneurysm coiling interventions demonstrated similar *** We conducted a cross-sectional,retrospective,observational study across 6 continents,37 countries and 140 comprehensive stroke *** with the diagnosis of sAH,aneurysmal sAH,ruptured aneurysm coiling interventions and cOVID-19 were identified by prospective aneurysm databases or by International classification of Diseases,10th Revision,*** 3-month cumulative volume,monthly volumes for sAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period before(1 year and immediately before)and during the pandemic,defined as 1 March-31 May *** prior 1-year control period(1 March-31 May 2019)was obtained to account for seasonal *** There was a significant decline in sAH hospitalisations,with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic,representing a relative decline of 22.5%(95%cI−24.3%to−20.7%,psation of ruptured aneurysms declined with 1170-1035 procedures,respectively,representing an 11.5%(95%cI−13.5%to−9.8%,p=0.002)relative *** analysis was noted for aneurysmal sAH hospitalisation decline from 834 to 626 hospitalisations,a 24.9%relative decline(95%cI−28.0%to−22.1%,pcrease in ruptured aneurysm coiling was noted in low coiling volume hospitals of 41.1%(95%cI 32.3%to 50.6%,p=0.008)despite a decrease in sAH admissions in this *** There was a relative decrease in the volume of sAH hospitalisations,aneurysmal sAH hospitalisations and ruptured aneurysm embolisations during the cOVID-19 *** findings in sAH are consistent with a decrease in other emergencies,such as stroke and myocardial infarction.

关键词： diagnosis representing subarachnoid

Nature:研究利用单细胞分析阐明癌症干细胞在脑癌中的关键角色

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现代生物医学进展 2017年第6期17卷 I0003-I0003页

作者： Itay Tirosh, Andrew s. Venteicher, christine Hebert, Leah E. Escalante, Keren Yizhak, Jonathan M. Fisher, christopher Rodman, Mariella G. Filbin, cyril Neftel, Jackson Nyman, Benjamin Izar, Joshua M. Francis, Kenneth J. Livak, Dave Gennert, Rahul satija, Todd R. Golub, Miguel N. Rivera, Gad Getz, Orit Rozenblatt-Rosen, Bradley E. Bernstein, Aviv Regev Mario L. suv agrave Andrew s. Venteicher, christine Hebert, Leah E. Escalante, Keren Yizhak, Mariella G. Filbin, cyril Neftel, Niyati Desai, christina c. Luo, Aanand A. Patel, Maristela L. Onozato, Nicolo Riggi, Ravindra Mylvaganam, A. John Iafrate, Matthew P. Frosch, Miguel N. Rivera, Gad Getz, Bradley E. Bernstein, David N. louis Mario L. suv agrave Andrew s. Venteicher, Anoop P. Patel, Brian V. Nahed, William T. curry, Robert L. Martuza Daniel P. cahill christopher Mount Michelle Monje Mariella G. Filbin Todd R. Golub Joshua M. Francis Todd R. Golub Aviv Regev Broad Institute of Harvard and MIT Cambridge Massachusetts 02142 USA Department of Pathology and center for cancer Research Massachusetts General Hospital and Harvard Medical School Boston Massachusetts 02114 USA Department of Neurosurgery Massachusetts General Hospital and Harvard Medical School Boston Massachusetts 02114 USA Departments of Neurology Neurosurgery Pediatrics and Pathology Stanford University School of Medicine Stanford California 94305 USA Department of Pediatric Oncology Dana-Farber Cancer Institute and Children’s Hospital Cancer Center Boston Massachusetts 02215 USA Department of Medical Oncology Dana-Farber Cancer Institute Boston Massachusetts 02215 USA Howard Hughes Medical Institute Koch Institute Department of Biology MIT Cambridge Massachusetts 02139 USA

近日。来自麻省总医院、博德研究所及哈佛大学的研究人员通过联合研究，在单细胞水平上对脑瘤基因组进行了分析。他们发现。癌症干细胞或许能够诱发少突神经胶质瘤的发生，少突神经胶质瘤是一种缓慢发展但却非常难以治愈的脑癌，相关研... 详细信息

近日。来自麻省总医院、博德研究所及哈佛大学的研究人员通过联合研究，在单细胞水平上对脑瘤基因组进行了分析。他们发现。癌症干细胞或许能够诱发少突神经胶质瘤的发生，少突神经胶质瘤是一种缓慢发展但却非常难以治愈的脑癌，相关研究刊登于Nature杂志上。同时研究者还首次在人类脑瘤样本中鉴别出了癌症干细胞及其分化的后代细胞。

关键词：干细胞单细胞分析癌症脑瘤神经胶质瘤键角利用研究人员

Preface to the special Issue on Flexible and Wearable sensors for Robotics and Health

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Journal of semiconductors 2019年第11期40卷 2-2页

作者： Zhiyong Fan Johnny c Ho chuan Wang Yun-Ze Long Huan Liu Hong Kong University of science and Technology city University of Hong Kong Washington University in st.louis Qingdao University Huazhong University of science and Technology

Flexible and wearable sensors that can acquire signals of pressure,temperature,optical input,chemical environment as well as human body physiological and biological parameters,are of critical importance for robotics and health,in which these sensors are hence in urgent *** the fundamental side,there are still substantial challenges on how to design and fabricate materials with biocompatibility,robustness and excellent mechanical flexibility,as well as to achieve sensor devices with high performance,low power consumption and good system integration *** in practical applications,there are also obstacles on the integration of various kinds of sensors with flexible substrates,signal processing and power supply *** the fast development of Internet of Things(IoT),smart sensors will as well be interconnected to form sensor networks,providing big data for our future intelligent *** these would deliver a profound socioeconomic impact to our society.

关键词： hence smart IoT

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δ-OPIOID REcEPTOR ADAPTATION IN NEUROBLAsTOMA cELLs

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中国药物依赖性通报 1993年第2期2卷 77-77页

作者： D-M.chuang M.Belcheva J.Barg J.Rowinski W.G.clark c.A.Gloeckner A.Ho X-M.Gao c.J.coscia section on Molecular Neurobiology BPB NIMH National Institute of Health Bethesda MD20892 USA E. A. Doisy Department of Biochemistry Molecular Biology St. Louis University School of Medicine St. Louis MO 63104 USA

The mechanisms underlying tolerance and dependence arising from chronic opioid exposure are poorly understood. However, the development of neuroblastoma and neurohybrid cell culturea, has provided a simplified model ... 详细信息

关键词： REcEPTOR cELLs IN

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急性冠状动脉综合征后接受β受体阻断剂治疗的患者中β2肾上腺素能受体基因型与生存率的关系

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世界核心医学期刊文摘(心脏病学分册) 2006年第3期 22-23页

作者： Lanfear D. E. Jones P. G. Marsh s. H.L.McLeod 王亭忠 Washington University School of Medicine Campus Box 8069 660 S Euclid Ave St Louis MO 63110 United States Dr.

context: Previous data support an association between polymorphisms of the β1-and β2-adrenergic receptors(ADRB1 and ADRB2) and surrogate end points of response to β-adrenergic blocker therapy. However, no associations between these polymorphisms and mortality have been demonstrated. Objective: To evaluate the effect of ADRB1 Arg389Gly(1165 cG), ser49Gly(145 AG), and ADRB2 Gly16Arg(46 GA), Gln27Glu(79 cG) genotypes on survival among patients discharged with prescribed β-blockers after an acute coronary syndrome(Acs). Design, setting, and Patients: Prospective cohort study of 735 Acs patients admitted to 2 Kansas city, Mo, medical centers between March 2001 and October 2002; 597 patients were discharged with β-blocker therapy. Main Outcome Measure: Multivariable-adjusted time to all-cause 3-year mortality. Results: There were 84 deaths during follow-up. There was a significant association between ADRB2 genotype and 3-year mortality among patients prescribed β -blocker therapy. For the 79 cG polymorphism, Kaplan-Meier 3-year mortality rates were 16% (35 deaths), 11% (27 deaths), and 6% (4 deaths) for the cc, cG, and GG genotypes, respectively(P=.03; adjusted hazard ratios AHRs , 0.51 95% confidence interval {cI}, 0.30-0.87 for cG vs cc and 0.24(95% cI, 0.09-0.68) for GG vs cc, P=.004). For the ADRB2 46 GA polymorphism, 3-year Kaplan-Meier mortality estimates were 10% (17 deaths), 10% (28 deaths), and 20% (20 deaths) for the GG, GA, and AA genotypes, respectively(P=.005; AHRs, 0.48 95% cI, 0.27-0.86 for GA vs AA and 0.44 95% cI, 0.22-0.85 for GG vs AA, P=.02). No mortality difference between genotypes was found among patients not discharged with β -blocker therapy for either the 79 cG or 46 GA polymorphisms(P=.98 and P=.49, respectively). The ADRB2 diplotype and compound genotypes were predictive of survival in patients treated with β -blockers(P=.04 and P=.002; AHRs, 5.36 95% cI, 1.83-15.69 and 2.41 95% cI,0.86-6.74 for 46 A homozygous and composite heterozygous vs 79

关键词： β受体阻断剂急性冠状动脉综合征基因型遗传型肾上腺素能受体患者生存率

EGFR Expression Is Unreliable to Decide for cetuximab Treatment in Patients with Metastatic colorectal cancer: Results from “ERBITUX-OUEsT”

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Open Journal of Internal Medicine 2016年第2期6卷 56-67页

作者： Jean-Philippe Metges Erick Gamelin Alain Volant Olivier capitain Jean-François Ramée Jean-Luc Raoul Jean-Yves Douillard Pierre-Luc Etienne Isabelle cumin Olivier Dupuis Roger Faroux Marie-Aude coulon Philippe Deguiral Karine Bideau Nacr Eddine Achour Alain Gourlaouen corinne Alleaume Annie Wdowik Laurent Miglianico Yann Touchefeu Vincent Klein Alain Penchet Ludovic Rosenfeld Daniel Martin claire stampfli Jean-Jacques Auger Alain Bargain Murielle Broyer-Petit Jérome chettrit louis-Rémi De Ybarlucea serge Eloit Pierre Marie Girardot Nathalie Heresbach christian Laboisse Eric Lavoine Gilles Lemasson claire Magois sophie Michalak Norbert Padilla Joseph Politis Frédéric staroz Bruno Turlin Arnaud Uguen Viorel Vasiliu Véronique Verriele Fanny Marhuenda Delphine Déniel Lagadec christian Riché Françoise Grudé Observatoire dédié au cancer des régions Bretagne et Pays de la Loire France centre Hospitalier Régional Universitaire (cHRU) Brest France Institut de cancérologie de l’Ouest (IcO) Paul Papin Angers France centre catherine de sienne Nantes France cRLcc Eugène Marquis Rennes France IcO René Gauducheau Nantes France centre cARIO-HcPA Plérin France centre Hospitalier Bretagne sud (cHBs) Lorient France clinique Victor Hugo Le Mans France centre Hospitalier Départemental (cHD) La Roche-sur-Yon France cH Le Mans France clinique Mutualiste de l’Estuaire Saint-Nazaire France cHIc Quimper France clinique Pasteur Lanroze Brest France cH MORLAIX France cH Saint-Brieuc France cHBA Vannes France cHP Saint-Grégoire France cHU Nantes France Hopital Privé Océane Vannes France clinique saint-Michel et sainte-Anne Quimper France Pole santé sarthe et Loire La Flèche France Polyclinique du Maine Laval France Polyclinique sud Quimper France cH Laval France Polyclinique cesson sévigné France Laboratoire d’anatomie et de cytologie pathologiques Cholet France cabinet d’anatomie et de cytologie pathologiques Saint-Malo France Laboratoire d’anatomie et de cytologie pathologiques Lorient France Institut d’histopathologie Nantes France Laboratoire de Pathologie Médicale Laval France ARMOR Pathologie Plérin France Laboratoire d’anatomie et de cytologie pathologiques Rennes France Laboratoire d’anatomie et de cytologie pathologiques Angers France Laboratoire Analyses Biologie Glasgow Brest France cHU Angers France centre d’anatomie et de cytologie pathologiques Le Mans France cabinet d’anatomie et de cytologie pathologiques Vannes France Laboratoire d’anatomie et de cytologie pathologiques Quimper France cHU Rennes France

Purpose: Although controversial, assessment of epidermal growth factor receptor (EGFR) expression is required for the approved indications of cetuximab in metastatic colorectal cancer (mcRc). With the objective of improving patient selection, “ERBITUX-OUEsT” study aimed at analyzing EGFR status in a large cohort of mcRc patients who received cetuximab without preliminary EGFR screening, and assessing the correlation between EGFR status and response to treatment retrospectively. Patients and methods: 332 patients treated with Irinotecan cetuximab based regimen after progression on irinotecan or oxaliplatin therapy were included. EGFR status was assessed using three available immunohistochemistry (IHc) tests and in situ hybridization in case of negativity. clinical outcomes of EGFR-positive and EGFR-non-detected (or considered as negative with at least one test) patients were compared. Results: Of the 332 samples centrally screened, 194 were classified as full-positive (i.e., EGFR-positive for all three tests), 86 as full-negative, and 52 as discordant. One third of the 131 negative samples with FDA approved test should be reclassified as positive with at least one of the two others tests. Regarding results from FDA approved test only, neither objective response rate (ORR), progression-free survival (PFs) nor overall survival (Os) differed significantly between EGFR-negative and EGFR-positive patients (P = 0.788, 0.326 and 0.888, respectively). similarly, comparison of full-negative to other groups did not show any significant difference in terms of ORR (P = 0.507), PFs (P = 0.222) or Os (P = 0.686). conclusion: These data strongly argue against mcRc patients selection for cetuximab treatment based on EGFR expression as measured by currently available IHc technics.

关键词： Metastatic colorectal cancer cetuximab EGFR Expression

活体小鼠前哨淋巴结和淋巴管无创性靛青绿二维显像——体积光谱光声成像及平面荧光成像

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国际医学放射学杂志 2010年第4期 372-372页

作者： c.Kim 李宁 Department of Biomedical Engineering Washington University School of MedicineOne Brookings DrCampus Box 1097St.LouisMO 63130-4899

目的利用无创性靛青绿(IcG)二维成像显示活体小鼠前哨淋巴结(sLN)及淋巴管。包括体积光谱光声成像测量(光吸收测量)及平面荧光成像(荧光散射测量)。材料与方法经动物保护

关键词：前哨淋巴结淋巴管淋巴系统光声成像小鼠小家鼠荧光成像活体无创性

心脏手术中的脑电图（EEG）及脑电双频指数（BIs）监测

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麻醉与镇痛 2013年第6期9卷 68-81页

作者： Miklos D. Kertai, MD, PhD Elizabeth L. Whitlock, MD, Msc Michael s. Avidan, MBBch 俞结晶(译) 肖洁(校) 王祥瑞(校) Duke University Medical center Durham North Carolina and Semmelweis University Budapest Hungary Washington University school of Medicine St. Louis Missouri 不详

心脏手术对于麻醉医生来说存在特别的挑战。术中除了基本的和高级的监测措施，麻醉医生会考虑应用普通的或经过处理的脑电图（electroencephalography，EEG）监测患者的脑功能状态。有力证据显示，与普通监测相比，术中合并经处理的EEG... 详细信息

心脏手术对于麻醉医生来说存在特别的挑战。术中除了基本的和高级的监测措施，麻醉医生会考虑应用普通的或经过处理的脑电图（electroencephalography，EEG）监测患者的脑功能状态。有力证据显示，与普通监测相比，术中合并经处理的EEG电双频指数（bispectralindex，BIs）监测可有效降低术中知晓的发生率。也有与之冲突的证据显示，心脏手术麻醉应用BIs可改善“快通道麻醉”，减少麻醉药的使用和及早发现脑缺血。最近一项大样本研究显示，对于预防术中知晓，BIs监测并不优于呼气末麻醉药浓度监测。目前有众多麻醉学文献关注综合EEG监测，包括一些非专用的处理后的指数。研究表明，通过专业训练，麻醉医生可以从普通的EEG轨迹采集到有用的数据。本综述中，我们对心脏手术人群术中BIs和额叶EEG监测的优势和局限性加以阐述。

关键词：脑电双频指数浓度监测心脏手术脑电图手术中 EEG监测 BIs监测麻醉医生