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AB090. MOG1, the genetic modifier at 20q13, delays the age-at-onset of glaucoma by 8 to 10 years

Annals of Eye Science 2018年第1期 496-496页

作者： Vincent raymond Pascal Belleau rose Arseneault Stéphane Dubois Jean-louis Anctil Gilles Côté Marcel Amyot Fahed Elian Michael AWalter Québec Glaucoma Network Département d’ophtalmologie Centre de rechrechr du CHU de QuébecQuébecQCCanada

Background:Primary open-angle glaucoma(POAG)is a genetically complex disorder caused primarily by gene-gene *** identify these interactions,we studied the CA family,a large French-Canadian pedigree in which the myocilin K423E mutation(MYOCK423E)causes autosomal dominant glaucoma with diagnoses ranging from juvenile-onset OAG(JOAG)to late adult-onset POAG in the heterozygotes(HTZ).To explain this extreme variability,we hypothesized that a second gene,called a modifier,was interacting with MYOC,the primary disease *** goals were(I)to map the modifier on the human genome and;(II)to characterize the symptoms affected genetically by the *** symptoms are called ***:Three hundred seventy-five CA members were studied using four quantitative endophenotypes:age of maximal intra-ocular pressures(IOPmax),IOPs progression,progression of cup to disk ratios and age-at-onset(AAO)defined as age at which ocular hypertension(OHT)was first detected with IOP≥22 ***-wide linkage analysis was performed by genotyping 408 genetic markers in 184 CA *** unbiased pedigree-based algorithm was designed to identify the individuals who were double-mutants,i.e.,these individuals carried one MYOCK423E mutation(i.e.,they were HTZ,affected or not)and they also carry simultaneously a DNA mutation within the ***:Out of the 375 CA family members investigated,156 were HTZ for the MYOCK423E mutation.120 HTZ were affected with OAG or OHT with treatment while the remaining 36 HTZ were *** ranged from 7 to 63 years old;4 individuals over 50 years old were still *** preceded optic nerve damage in>98%of the HTZ carriers,confirming that AAO reflected the true severity of the *** modifier showed strong inherited effects on 2 of the 4 endophenotypes:AAO and *** next mapped with very high confidence the modifier locus for AAO at chromosome *** genotyping with additional markers refined th

关键词： Blindness genomics complex genetic disorder gene-gene interactions biostatistics

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血管造影示明显冠状动脉疾病患者的血中内皮祖细胞克隆数增加

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世界核心医学期刊文摘（心脏病学分册） 2007年第4期3卷 48-49页

作者： Güven H. Shepherd r.M. Bach r.G. D.C.Link 郭俊 Division of Oncology Washington University School of MedicineSt.LouisMOUnited States Dr.

目的:本研究旨在确定外周血中内皮祖细胞(EPC)和循环生血管细胞(CAC)数量是否与接受冠状动脉造影患者的冠状动脉疾病(CAD)及其严重程度相关。背景:先前研究提示。

关键词：祖细胞血管造影血管细胞循环血血运重建血管危险因素急性缺血细胞亚群负相关

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齿状核MrI T2加权低信号与多发性硬化症患者步行能力损伤有关

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世界核心医学期刊文摘（神经病学分册） 2005年第11期1卷 45-46页

作者： Tjoa C.W. Benedict r.H.B. Weinstock-Guttman B. r. Bakshi 周永 Departments of Neurology and radiology Brigham and Women’s Hospital Harvard Medical School 77 Avenue Louis Pasteur-HIM 730 Boston MA 02115 United States

Objectives: MrI T2 hypointensity in multiple sclerosis (MS)-gray matter, suggesting iron deposition, is associated with physical disability, disease course, lesion load, and brain atrophy. Ambulatory dysfunction limits quality of life; however correlation with conventional MrI remains poor. Methods: Normalized intensity on T2-weighted images was obtained in the basal ganglia, thalamus, red nucleus, and dentate nucleus in 47 MS patients and 15 healthy controls. Brain T1-hypointense and FLAIr-hype-rintense lesion volume, third ventricle width, brain parenchymal fraction and timed 25 foot walk (T25FW)-were measured in the MS group. results: T2 hypointensity was present throughout gray matter in MS vs. controls (all p rI variable significantly correlated with T25FW (Pearson r=-0.355, p=0.007) and was also the best MrI correlate of physical disability (EDSS) score in regression modeling (r=-0.463, r2=0.223, p=0.004). Conclusions: T2 hypointensity is present in subcortical gray matter nuclei in patients with MS vs. normal controls. Dentate nucleus T2 hypointensity is independently related to ambulatory impairment and disability, accounting for more variance than conventional lesion and atrophy measures. This study adds more weight to the notion that T2 hypointensity is a clinically relevant marker of tissue damage in MS.

关键词：多发性硬化症 MrI T2加权步行能力齿状核病灶体积 EDSS FLAIr 基底神经节第三脑室铁沉积

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Gini系数在镜质体反射率量测分析上之应用

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石油实验地质 2001年第3期23卷 338-340页

作者：孙立中杨宗霖蔡龙王台中央大学地球物理所环境研究中心中央大学应用地质所

该研究主要利用Gini系数来探讨镜质体反射率量测上不均性的结果 ,由单一煤样之水洗样 (Y2 )及富集壳质组之样品 (Y3) ,与原始样 (Y1 )作Gini系数的比较。分析显示水洗样Y2 之镜质体反射率有向平均值集中的情形 ,而富集样Y3之Gini系数则... 详细信息

该研究主要利用Gini系数来探讨镜质体反射率量测上不均性的结果 ,由单一煤样之水洗样 (Y2 )及富集壳质组之样品 (Y3) ,与原始样 (Y1 )作Gini系数的比较。分析显示水洗样Y2 之镜质体反射率有向平均值集中的情形 ,而富集样Y3之Gini系数则有向平均值两端分布的趋势 ;向高值端的部分系受水洗的影响 ,而向低值端的发展 ,系受壳质组富集的影响。由Gini系数特性的研究可推广至已知再沉积材料之镜质体反射率的量测上 ,以取得一个可靠之Gini系数分布范围 ,作为将来分析样品时的参考。

关键词：量测分析镜质体反射率 Gini系数不均性煤级评估有机成熟度

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浅俯冲带缓慢动力变形与地震及海啸发生的自洽机理

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国际地震动态 2012年第7期33卷 9-9页

作者： Peter G Betts Wendy G Mason louis Moresi 张树良中国科学院国家科学图书馆兰州分馆中国科学院资源环境科学信息中心

2012年6月9日出版的《地球物理学研究通讯》（Geophysical research Letters）发表了美国圣地亚哥州立大学地质学系有关板块俯冲带地震及海啸发生机理研究的最新成果。该研究提出了浅俯冲带地震及其所引发海啸的＂自洽＂机制。

关键词：发生机理俯冲带海啸地震动力变形自洽地球物理学州立大学

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迟发的特发性震颤与痴呆相关

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世界核心医学期刊文摘(神经病学分册) 2006年第11期 57-57页

作者： Benito-Leóon J louis E.D Bermejo-Pareja F 郭俊 Avda. C. 73 portal 3 7 Izquierda E-28820 Coslada Madrid Spain Dr.

OBJECTIVE: To determine whether essential tremor (ET) is associated with prevalent dementia. METHODS: The authors identified all persons with dementia and ET in a population-based study in central Spain (the Neurological Disorders in Central Spain [NEDICES] Study). Dementia was diagnosed using the Diagnostic and Statistical Manual of Mental Disorders (4th ed.) criteria. rESULTS: Thirty-one (11.4%) of 273 ET cases had dementia vs 204 (6.0%) of 3,382 non-ET subjects (controls) (odds ratio [Or] = 2.00, 95%CI = 1.34 to 2.98, p = 0.001). In a model that adjusted for age, stroke, and educational level, Or = 1.35, 95%CI = 0.87 to 2.18, and p = 0.17. In an adjusted model, ET cases with tremor onset after age 65 were 70%more likely to be demented than were controls (Or = 1.70, 95%CI = 1.04 to 2.76, p = 0.03), whereas ET cases with tremor onset at age ≤65 and controls were equally likely to be demented (Or = 0.38, 95%CI = 0.09 to 1.73, p = 0.21). CONCLUSIONS: Older-onset essential tremor (ET) was associated with dementia. Prospective studies are required to elucidate the association between ET and dementia.

关键词：特发性震颤迟发 ET

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Le Fresnoy国立当代艺术工作室

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城市环境设计 2016年第1期 78-85页

作者： Bernard Tschumi Francois Gillet Mark Haukos Tom Kowalski robert Young Jim Sullivan Yannis Aesopos Douglas Gauthier Eric Liftin robert Moric Sheri Olsen Jordan Parnass Tsuto Sakamoto Henning Ehrhardt Jean-Francois Erhel Véronique Descharrèires Vincent Tehvenon Paul H.Huchard louis Choulet

法国Le Fresnoy国立当代艺术工作室的竞赛目标是创造一个能为电影、录像和电子传媒等艺术提供展出、表演和制作场地的跨领域设施。将不同门类的艺术置于同一个项目中是教学层面的一次大胆尝试,目的是在不同领域的交叉地带催生实验与创... 详细信息

法国Le Fresnoy国立当代艺术工作室的竞赛目标是创造一个能为电影、录像和电子传媒等艺术提供展出、表演和制作场地的跨领域设施。将不同门类的艺术置于同一个项目中是教学层面的一次大胆尝试,目的是在不同领域的交叉地带催生实验与创新。该项目位于法国北部的老工业城市图尔昆,基地选在市内一处建于20世纪20年代的废弃建筑,这里曾集

关键词：当代艺术工作室 Le Fresnoy

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Toxic Effects of Seed Methanolic Extracts of Endemic Albizia Species （Fabaceae） from Madagascar on Animals

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Journal of Life Sciences 2014年第8期8卷 676-689页

作者： Hanitra ranjana randrianarivo Anjarasoa ravo razafindrakoto Holy Christiane ratsimanohatra Lovarintsoa Judicael randriamampianina Clara Fredeline rajemiarimoelisoa Lolona ramamonjisoa David ramanitrahasimbola Danielle Aurore Doll rakoto Victor louis Jeannoda Laboratory of Applied Biochemistry to Medical Sciences Fundamental and Applied Biochemistry Department Faculty of SciencesUniversity of Antananarivo PO Bo 906 Antananarivo 101 Madagascar Department of Pharmacy Faculty of Medicine PO Box 375 Antananarivo 101 Madagascar National Tree Seed Centre (SNGF) PO Box 5091 Antananarivo 101 Madagascar

In order to find natural compounds of interest such as pesticides and therapeutic molecules, toxicological properties of seed methanolic extracts (SME) of nine Malagasy Albizia species were investigated. Toxicity was assessed on living animals by intraperitoneal and oral route, and pharmacological effects on isolated organs. All SME induced various disorders in mice but the signs of the nervous system disturbs were the earliest and the most often observed. The main organ lesions, examined on histological sections, induced vasodilatation, inflammatory infiltrate of neutrophil polymorphonuclears and hemorrhagic areas. At low concentrations (until 20 μg/mL), A. masikororum and A. viridis provoked on isolated auricular a positive inotrope effect followed by a progressive inhibition of the contraction and a complete atrial arrhythmia. Besides, A. viridis and A. bernieri induced some hepatic functional impairment after a chronic treatment during one month. Albizia greveana with a LD50 of 1.13-2 mg/kg was the most toxic and Albizia bernieri the least one with a LD50 of 52 mg/kg. Alkaloids and/or saponins, the major chemical groups found by phytochemical screening on these extracts, could be responsible of their toxicity.

关键词：马达加斯加甲醇提取物毒性效应活体动物合欢种子物种中性粒细胞

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基于单片机的CO气体报警器的设计

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电脑知识与技术 2021年第25期17卷 176-178,183页

作者：蒋鹏飞徐静杨浩古天乐刘添强吴占财新疆农业大学计算机与信息工程学院新疆乌鲁木齐830000

在现代生活中,人们用车的频率愈来愈频繁,在冬季和夏季当汽车停止不动而车内还使用空调冷气或暖气时,发动机所排出的一氧化碳很容易泄漏到车厢内,危及人们的生命财产安全。本设计采用MQ-7气体传感器来检测气体,用单片机控制声光报警装... 详细信息

在现代生活中,人们用车的频率愈来愈频繁,在冬季和夏季当汽车停止不动而车内还使用空调冷气或暖气时,发动机所排出的一氧化碳很容易泄漏到车厢内,危及人们的生命财产安全。本设计采用MQ-7气体传感器来检测气体,用单片机控制声光报警装置进行报警和LCD160A显示检测气体浓度。该设计提高了检测气体的灵敏度同时可随时显示室内CO浓度,以便人们观察。复位电路设置报警的初始值方便人们使用且提高了人们在的日常生活的安全性。

关键词：一氧化碳检测报警单片机气体传感器

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EGFr Expression Is Unreliable to Decide for Cetuximab Treatment in Patients with Metastatic Colorectal Cancer: results from “ErBITUX-OUEST”

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Open Journal of Internal Medicine 2016年第2期6卷 56-67页

作者： Jean-Philippe Metges Erick Gamelin Alain Volant Olivier Capitain Jean-François ramée Jean-Luc raoul Jean-Yves Douillard Pierre-Luc Etienne Isabelle Cumin Olivier Dupuis roger Faroux Marie-Aude Coulon Philippe Deguiral Karine Bideau Nacr Eddine Achour Alain Gourlaouen Corinne Alleaume Annie Wdowik Laurent Miglianico Yann Touchefeu Vincent Klein Alain Penchet Ludovic rosenfeld Daniel Martin Claire Stampfli Jean-Jacques Auger Alain Bargain Murielle Broyer-Petit Jérome Chettrit louis-rémi De Ybarlucea Serge Eloit Pierre Marie Girardot Nathalie Heresbach Christian Laboisse Eric Lavoine Gilles Lemasson Claire Magois Sophie Michalak Norbert Padilla Joseph Politis Frédéric Staroz Bruno Turlin Arnaud Uguen Viorel Vasiliu Véronique Verriele Fanny Marhuenda Delphine Déniel Lagadec Christian riché Françoise Grudé Observatoire dédié au Cancer des régions Bretagne et Pays de la Loire France Centre Hospitalier régional Universitaire (CHrU) Brest France Institut de Cancérologie de l’Ouest (ICO) Paul Papin Angers France Centre Catherine de Sienne Nantes France CrLCC Eugène Marquis Rennes France ICO rené Gauducheau Nantes France Centre CArIO-HCPA Plérin France Centre Hospitalier Bretagne Sud (CHBS) Lorient France Clinique Victor Hugo Le Mans France Centre Hospitalier Départemental (CHD) La Roche-sur-Yon France CH Le Mans France Clinique Mutualiste de l’Estuaire Saint-Nazaire France CHIC Quimper France Clinique Pasteur Lanroze Brest France CH MORLAIX France CH Saint-Brieuc France CHBA Vannes France CHP Saint-Grégoire France CHU Nantes France Hopital Privé Océane Vannes France Clinique Saint-Michel et Sainte-Anne Quimper France Pole Santé Sarthe et Loire La Flèche France Polyclinique du Maine Laval France Polyclinique Sud Quimper France CH Laval France Polyclinique Cesson Sévigné France Laboratoire d’anatomie et de cytologie pathologiques Cholet France Cabinet d’anatomie et de cytologie pathologiques Saint-Malo France Laboratoire d’anatomie et de cytologie pathologiques Lorient France Institut d’histopathologie Nantes France Laboratoire de Pathologie Médicale Laval France ArMOr Pathologie Plérin France Laboratoire d’anatomie et de cytologie pathologiques Rennes France Laboratoire d’anatomie et de cytologie pathologiques Angers France Laboratoire Analyses Biologie Glasgow Brest France CHU Angers France Centre d’anatomie et de cytologie pathologiques Le Mans France Cabinet d’anatomie et de cytologie pathologiques Vannes France Laboratoire d’anatomie et de cytologie pathologiques Quimper France CHU rennes France

Purpose: Although controversial, assessment of epidermal growth factor receptor (EGFr) expression is required for the approved indications of Cetuximab in metastatic colorectal cancer (mCrC). With the objective of improving patient selection, “ErBITUX-OUEST” study aimed at analyzing EGFr status in a large cohort of mCrC patients who received cetuximab without preliminary EGFr screening, and assessing the correlation between EGFr status and response to treatment retrospectively. Patients and methods: 332 patients treated with Irinotecan Cetuximab based regimen after progression on irinotecan or oxaliplatin therapy were included. EGFr status was assessed using three available immunohistochemistry (IHC) tests and in situ hybridization in case of negativity. Clinical outcomes of EGFr-positive and EGFr-non-detected (or considered as negative with at least one test) patients were compared. results: Of the 332 samples centrally screened, 194 were classified as full-positive (i.e., EGFr-positive for all three tests), 86 as full-negative, and 52 as discordant. One third of the 131 negative samples with FDA approved test should be reclassified as positive with at least one of the two others tests. regarding results from FDA approved test only, neither objective response rate (Orr), progression-free survival (PFS) nor overall survival (OS) differed significantly between EGFr-negative and EGFr-positive patients (P = 0.788, 0.326 and 0.888, respectively). Similarly, comparison of full-negative to other groups did not show any significant difference in terms of Orr (P = 0.507), PFS (P = 0.222) or OS (P = 0.686). Conclusion: These data strongly argue against mCrC patients selection for Cetuximab treatment based on EGFr expression as measured by currently available IHC technics.

关键词： Metastatic Colorectal Cancer Cetuximab EGFr Expression

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