Toxic Effects of Seed Methanolic Extracts of Endemic Albizia Species （Fabaceae） from Madagascar on Animals
Toxic Effects of Seed Methanolic Extracts of Endemic Albizia Species （Fabaceae） from Madagascar on Animals作者机构：Laboratory of Applied Biochemistry to Medical Sciences Fundamental and Applied Biochemistry Department Faculty of SciencesUniversity of Antananarivo PO Bo 906 Antananarivo 101 Madagascar Department of Pharmacy Faculty of Medicine PO Box 375 Antananarivo 101 Madagascar National Tree Seed Centre (SNGF) PO Box 5091 Antananarivo 101 Madagascar
出 版 物：《Journal of Life Sciences》 (生命科学（英文版）)
年 卷 期：2014年第8卷第8期
页 面：676-689页
学科分类：1007[医学-药学(可授医学、理学学位)] 0907[农学-林学] 07[理学] 090705[农学-野生动植物保护与利用] 09[农学] 0713[理学-生态学] 10[医学]
主 题：马达加斯加 甲醇提取物 毒性效应 活体动物 合欢 种子 物种 中性粒细胞
摘 要：In order to find natural compounds of interest such as pesticides and therapeutic molecules, toxicological properties of seed methanolic extracts (SME) of nine Malagasy Albizia species were investigated. Toxicity was assessed on living animals by intraperitoneal and oral route, and pharmacological effects on isolated organs. All SME induced various disorders in mice but the signs of the nervous system disturbs were the earliest and the most often observed. The main organ lesions, examined on histological sections, induced vasodilatation, inflammatory infiltrate of neutrophil polymorphonuclears and hemorrhagic areas. At low concentrations (until 20 μg/mL), A. masikororum and A. viridis provoked on isolated auricular a positive inotrope effect followed by a progressive inhibition of the contraction and a complete atrial arrhythmia. Besides, A. viridis and A. bernieri induced some hepatic functional impairment after a chronic treatment during one month. Albizia greveana with a LD50 of 1.13-2 mg/kg was the most toxic and Albizia bernieri the least one with a LD50 of 52 mg/kg. Alkaloids and/or saponins, the major chemical groups found by phytochemical screening on these extracts, could be responsible of their toxicity.
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