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Endocrine radionuclide scintigraphy with fusion single photon emission computed tomography/computed tomography

World Journal of Radiology 2016年第6期8卷 635-655页

作者： Ka-Kit Wong Arpit Gandhi Benjamin L Viglianti lorraine m fig Domenico Rubello milton D Gross Division of Nuclear medicine Department of RadiologyUniversity of Michigan Nuclear medicine Service VA Ann Arbor Healthcare System Radiology Service VA Ann Arbor Healthcare System Department of Nuclear medicine RadiologyNeuro RadiologyMedical PhysicsSanta Maria della Misericordia Hospital

AIm: To review the benefits of single photon emission computed tomography(SPECT)/computed tomography(CT) hybrid imaging for diagnosis of various endocrine ***: We performed mEDLINE and Pub med searches using the terms: "SPECT/CT"; "functional anatomic mapping"; "transmission emission tomography"; "parathyroid adenoma"; "thyroid cancer"; "neuroendocrine tumor"; "adrenal"; "pheochromocytoma"; "paraganglioma"; in order to identify relevant articles published in English during the years 2003 to 2015. Reference lists from the articles were reviewed to identify additional pertinent articles. Retrieved manuscripts(case reports, reviews, meta-analyses and abstracts) concerning the application of SPECT/CT to endocrine imaging were analyzed to provide a descriptive synthesis of the utility of this ***: The emergence of hybrid SPECT/CT camera technology now allows simultaneous acquisition of combined multi-modality imaging, with seamless fusion of three-dimensional volume datasets. The usefulness of combining functional information to depict the biodistribution of radiotracers that map cellular processes of the endocrine system and tumors of endocrine origin, with anatomy derived from CT, has improved the diagnostic capability of scintigraphy for a range of disorders of endocrine gland function. The literature describes benefits of SPECT/CT for ^(99m)Tc-sestamibi parathyroid scintigraphy and ^(99m)Tc-pertechnetate thyroid scintigraphy, ^(123)I- or ^(131)I-radioiodine for staging of differentiated thyroid carcinoma, ^(111)In- and ^(99m)Tclabeled somatostatin receptor analogues for detection of neuroendocrine tumors, ^(131)I-norcholesterol(NP-59) scans for assessment of adrenal cortical hyperfunction, and ^(123)I- or ^(131)I-metaiodobenzylguanidine imaging for evaluation of pheochromocytoma and ***: SPECT/CT exploits the synergism between the functional information from radiopharmaceutical imaging and anatomy from CT, translating

关键词： Parathyroid adenoma Neuroendocrine tumor Single photon emission computed tomography/ computed tomography Single photon emission computed tomography-computed tomography Thyroid cancer Pheochromocytoma Paraganglioma

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Drought events influence nutrient canopy exchanges and green leaf partitioning during senescence in a deciduous forest

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Forest Ecosystems 2024年第1期11卷 110-119页

作者： J.Touche C.Calvaruso P.De Donato m.-P.Turpault INRAE BEFF-54000NancyFrance UmR 7359 GeoRessourcesFaculte des Sciences-Campus des Aiguillettes54506Vandoeuvre Les NancyFrance EcoSustain Environmental Engineering OfficeResearch and DevelopmentKanfen57330France

The increase in the frequency and intensity of drought events expected in the coming decades in Western Europe may disturb forest biogeochemical cycles and create nutrient deficiencies in *** possible origin of nutrient deficiency is the disturbance of the partitioning of the green leaf pool during the leaf senescence period between resorption,foliar leaching and senesced ***,the effects of drought events on this partitioning and the consequences for the maintenance of tree nutrition are poorly *** experiment in a beech forest in meuse(France)was conducted to assess the effect of drought events on nutrient canopy exchanges and on the partitioning of the green leaf pool during the leaf senescence *** aim was to identify potential nutritional consequences of droughts for *** nutrient dynamics,including resorption,chemistry of green and senesced leaves,foliar absorption and leaching in mature beech stands from 2012 to 2019 allowed us to compare the nutrient exchanges for three nondry and three dry years(i.e.,with an intense drought event during the growing season).During dry years,we observed a decrease by almost a third of the potassium(K)partitioning to resorption(*** efficiency),thus reducing the K reserve in trees for the next growing *** result suggests that with the increased drought frequency and intensity expected for the coming decades,there will be a risk of potassium deficiency in trees,as already observed in a rainfall exclusion experiment on the same study *** foliar leaching and higher parititioning to the senesced leaves for K and phosphorus(P)were also *** addition,a slight increase in nitrogen(N)resorption efficiency occurred during dry years which is more likely to improve tree *** calcium(Ca)negative resorption decreased,with no apparent consequence in our study *** results show that nutrient exchanges in the canopy and the partitioning of the green leaf

关键词： Natural drought Beech forest Canopy Resorption Foliar leaching Senesced leaves Nutrition

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Intelligent Solution System for Cloud Security Based on Equity Distribution:model and Algorithms

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Computers, materials & Continua 2024年第1期78卷 1461-1479页

作者： Sarah mustafa Eljack mahdi Jemmali mohsen Denden mutasim Al Sadig Abdullah m.Algashami Sadok Turki Department of Computer Science and Information College of Science at ZulfiMajmaah UniversityAl-Majmaah11952Saudi Arabia Department of Computer Science College of Computing and InformaticsUniversity of SharjahSharjahUnited Arab Emirates Higher Institute of Computer Science and mathematics University of MonastirMonastir5000Tunisia mars Laboratory University of SousseSousseTunisia Department of Logistic and maintenance UFR MIM at MetzUniversity of LorraineMetzFrance Department of Computer and Information Technologies College of Telecommunicationand Information Riyadh CTITechnical and Vocational Training Corporation TVTCRiyadh12464Saudi Arabia Department of Computer Science Higher Institute of Applied Sciences of SousseSousse UniversitySousse4000Tunisia

In the cloud environment,ensuring a high level of data security is in high *** planning storage optimization is part of the whole security process in the cloud *** enables data security by avoiding the risk of data loss and data *** development of data flow scheduling approaches in the cloud environment taking security parameters into account is *** our work,we propose a data scheduling model for the cloud *** is made up of three parts that together help dispatch user data flow to the appropriate *** first component is the Collector Agent whichmust periodically collect information on the state of the network *** second one is the monitoring agent which must then analyze,classify,and make a decision on the state of the link and finally transmit this information to the *** third one is the scheduler who must consider previous information to transfer user data,including fair distribution and reliable *** should be noted that each part of the proposedmodel requires the development of its *** this article,we are interested in the development of data transfer algorithms,including fairness distribution with the consideration of a stable link *** algorithms are based on the grouping of transmitted files and the iterative *** proposed algorithms showthe performances to obtain an approximate solution to the studied problem which is an NP-hard(Non-Polynomial solution)*** experimental results show that the best algorithm is the half-grouped minimum excluding(HmE),with a percentage of 91.3%,an average deviation of 0.042,and an execution time of 0.001 s.

关键词： Cyber-security cloud computing cloud security algorithms heuristics

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Natural Convection of a Power-Law Nanofluid in a Square Cavity with a Vertical Fin

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Fluid Dynamics & materials Processing 2024年第9期20卷 2091-2108页

作者： Amira m’hadbi mohammed El Ganaoui Haïkel Ben Hamed Amenallah Guizani Khalid Chtaibi LERmAB Department of Transition and Energy Efficiency ProfessionsIUT H Poincaréde LongwyUniversity of LorraineLongwy54400France LPT Center for Energy Research and Technologies(Borj Cedria2084)University of Tunis El ManarTunis1068Tunisia LTI Department of Mechanical Engineering and ProductionIUTUniversity of Picardie Jules-VerneAmiens80025France

The behavior of non-Newtonian power-law nanofluids under free convection heat transfer conditions in a cooled square enclosure equipped with a heated fin is investigated *** particular,the impact of nanofluids,composed of water and Al_(2)O_(3),TiO_(2),and Cu nanoparticles,on heat transfer enhancement is *** aim of this research is also to analyze the influence of different parameters,including the Rayleigh number(Ra=10^(4)-10^(6)),nanoparticle volume fraction(φ=0%-20%),non-Newtonian power-law indexes(n=0.6-1.4),and fin dimensions(Ar=0.3,0.5,and 0.7).Streamlines and isotherms are used to depict flow and related heat transfer *** indicate that thermal performance improves with increasing Rayleigh number,regardless of the nanoparticle type or nanofluid rheological *** suggests that the buoyancy force has a significant impact on heat transfer,particularly near the heat *** Nusselt number is more sensitive to variations in Cu nanoparticle volume fractions compared to Al₂O₃and TiO₂.moreover,the average Nusselt numbers for power-law nanofluids with n1)are greater(smaller)than for Newtonian fluids due to the decrease(increase)in viscosity with increasing(decreasing)shear rate,at the same values of Rayleigh number Ra owing to the amplification(attenuation)of the convective ***,the most substantial enhancement is observed with Cu-water shear-thinning nanofluid,where the Nusselt number increases by 136%when changing from Newtonian to shear thinning behavior and by 154.9%when adding 16%nanoparticle volume ***,an even larger increase of 57%in the average Nusselt number is obtained on increasing the fin length from 0.3 to 0.7.

关键词： Heat transfer nanofluid non-Newtonian fluid natural convection

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A cluster-randomized trial comparing two SWITCH implementation support strategies for school wellness intervention effectiveness

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Journal of Sport and Health Science 2023年第1期12卷 87-96页

作者： Richard R.Rosenkranz Philip m.Dixon David A.Dzewaltowski Gabriella m.mcLoughlin Joey A.Lee Senlin Chen Spyridoula Vazou lorraine m.Lanningham-Foster Doug A.Gentile Gregory J.Welk Department of Food NutritionDietetics&HealthKansas State UniversityManhattanKS 66506USA Department of Statistics Snedecor HallIowa State UniversityAmesIA 50011-1210USA Department of Health Promotion University of NebraskaOmahaNE 68198-4365USA Implementation Science Center for Cancer Control and Prevention Research Center Brown SchoolWashington University in St.LouisSt.LouisMO 63130USA Division of Public Health Sciences(Department of Surgery) Washington University School of MedicineWashington University in St.LouisSt.LouisMO 63130USA Department of Health Sciences University of Colorado Colorado SpringsColorado SpringsCO 80918USA Department of Kinesiology Iowa State UniversityAmesIA 50011-4008USA Department of Food Science&Human Nutrition Iowa State UniversityAmesIA 50011USA Department of Psychology Iowa State UniversityAmesIA 50011-1041USA

Background:The School Wellness Integration Targeting Child Health(SWITCH)intervention has demonstrated feasibility as an implementation approach to help schools facilitate changes in students’physical activity(PA),sedentary screen time(SST),and dietary intake(DI).This study evaluated the comparative effectiveness of enhanced(individualized)implementation and standard(group-based)***:Twenty-two Iowa elementary schools participated,with each receiving standardized training(wellness conference and webinars).Schools were matched within region and randomized to receive either individualized or group implementation *** PA,SST,and DI outcomes of 1097 students were assessed at pre-and post-intervention periods using the Youth Activity *** mixed models evaluated differential change in outcomes by condition,for comparative effectiveness,and by ***:Both implementation conditions led to significant improvements in PA and SST over time(pmprove commensurately(p value range:0.02‒0.05).There were no differential changes between the group and individualized conditions for PA(p=0.51),SST(p=0.19),or DI(p=0.73).There were no differential effects by gender(i.e.,non-significant condition-by-gender interactions)for PA(p_(for interaction)=0.86),SST(p_(for interaction)=0.46),or DI(p_(for interaction)=0.15).Effect sizes for both conditions equated to approximately 6 min more PA per day and approximately 3 min less sedentary ***:The observed lack of difference in outcomes suggests that group implementation of SWITCH is equally effective as individualized implementation for building capacity in school wellness ***,the lack of interaction by gender suggests that SWITCH can be beneficial for both boys and *** research is needed to understand the school-level factors that influence implementation(and outcomes)of SWITCH.

关键词： Children Implementation science Obesity prevention Physical activity School health

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Going only half the way:cell cycle exit after the G1 restriction point

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Signal Transduction and Targeted Therapy 2024年第1期9卷 1-2页

作者： Lisa muller Tony Gutschner mechthild Hatzfeld Department of Pathobiochemistry Institute of Molecular MedicineMartin Luther University Halle-WittenbergCharles Tanford Protein Research CenterHalleGermany Department of RNA Biology and Pathogenesis Institute of Molecular MedicineMartin Luther University Halle-WittenbergCharles Tanford Protein Research CenterHalleGermany

In a recent article published in Nature,James *** et *** that cyclin A2 levels determine whether cells will make an entrance into mitosis or whether cells will leave the cell cycle after having passed the G1/restriction(R)-point implicating that the decision is fully reversible(fig.1).This ground-breaking study could impact future approaches for cancer treatment by targeting the mitotic clock.

关键词： point cycle

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Oxidative stress-induced mitochondrial dysfunction in a normal colon epithelial cell line

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World Journal of Gastroenterology 2017年第19期23卷 3427-3439页

作者： Nandakumar Packiriswamy Kari F Coulson Susan J Holcombe lorraine m Sordillo Department of Large Animal Clinical Sciences College of Veterinary Medicine Michigan State University

AIm To determine how a normal human colon cell line reacts to microbial challenge as a way to study oxidative stress-induced responses associated with inflammatory bowel *** Normal human colon epithelial cells(ATCC?CRL.1790?)were stimulated with either heat killed *** or heat killed murine cecal contents(HKC)and examined for several relevant biomarkers associated with inflammation and oxidative stress including cytokine production,mitochondrial autophagy and oxidant ***α,IL-1βand IL-8 protein concentrations were measured within the *** microscopy was performed to quantify the production of reactive oxygen species(ROS)using an oxidation responsive fluorogenic *** morphology and mitochondrial membrane potential was assessed by dual staining using COXIV antibody and a dye concentrating in active *** ROS scavenger was used to determine the source of ROS in stimulated *** was detected by staining for the presence of autophagic *** controls for autophagy and ROS/RNS experiments were treated with rapamycin and *** morphology,ROS production and autophagy microscopy experiments were analyzed using a custom acquisition and analysis microscopy software(Image J).RESULTS Exposing CRL.1790 cells to microbial challenge stimulated cells to produce several relevant biomarkers associated with inflammation and oxidative *** killed cecal contents treatment induced a 10-12fold increase in IL-8 production by CRL.1790 cells compared to unstimulated controls at 6 and 12 h(Pmulation resulted in a4-5 fold increase in IL-8 compared to the unstimulated control cells at each time point(Pmulated robust ROS production at 6(Pmitochondrial morphologic abnormalities were detected at 6 and12 h based on reduced mitochondrial circularity and decreased mitochondrial membr

关键词：结肠癌房间线 CRL.1790 房间发炎线粒体微生物引起的刺激 Interleukin-8 Autophagy

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Impact of sarcopenia on tumor response and survival outcomes in patients with hepatocellular carcinoma treated by trans-arterial (chemo)-embolization

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World Journal of Gastroenterology 2022年第36期28卷 5324-5337页

作者： Gael Roth Yann Teyssier maxime Benhamou mélodie Abousalihac Stefano Caruso Christian Sengel Olivier Seror Julien Ghelfi Arnaud Seigneurin Nathalie Ganne-Carrie Elia Gigante lorraine Blaise Olivier Sutter Thomas Decaens Jean-Charles Nault Univ.Grenoble-Alpes Grenoble 38058France Department of Hepatology Gastroenterology and Digestive OncologyCHU Grenoble AlpesGrenoble 38043France Institute for Advanced Biosciences INSERM U1209/CNRS UMR 5309Grenoble 38043France Department of Radiology CHU Grenoble AlpesGrenoble 38043France Department of Radiology CHU Avicenne-APHPBobigny 93000France Functional Genomics of Solid Tumors Laboratory Centre de Recherche des Cordeliers-INSERM UMR 1138InsermUniversitéParisParis 75006France Unitéde Formation et de Recherche Santémédecine et Biologie Humaine UniversitéParis NordParis 93430France Service d'Epidémiologie et Evaluation médicale CHU Grenoble AlpesGrenoble 38043France Department of Hepatology CHU Avicenne-APHPBobigny 93000France

BACKGROUND At the diagnosis of hepatocellular carcinoma(HCC),more than 90%of HCC patients present cirrhosis,a clinical condition often associated to *** is an indirect marker of malnutrition assessable on computed tomography(CT).AIm To evaluate the prognostic value of sarcopenia in patients with HCC treated by trans-arterial(chemo)-*** Patients with HCC treated by a first session of trans-arterial(chemo)embolization and an available CT scan before treatment were *** was assessed using skeletal muscle index at baseline and at the first radiological *** response was recorded after the first session of treatment using *** Of 225 patients treated by trans-arterial bland embolization(n=71)or trans-arterial chemoembolization(n=154)for HCC between 2007 and 2013,Barcelona Clinic of Liver Cancer stage was A,B,and C in 27.5%,55%,and 16.8%of cases,*** was present in 57.7%of the *** with sarcopenia presented a higher rate of progressive disease(19%vs 8%,P=0.0236),a shorter progression-free survival(8.3 vs 13.2 mo,P=0.0035),and a shorter median overall survival(19.4 mo vs 35.5 mo,P=0.0149)compared with non-sarcopenic ***,patients whose sarcopenia appeared after first transarterial treatment had the worst prognosis(P=0.0004).CONCLUSION Sarcopenia is associated with tumor progression and poor survival outcomes after trans-arterial(chemo)-embolization for HCC.

关键词： Hepatocellular carcinoma Transarterial chemoembolization Bland embolization Sarcopenia Skeletal muscle index

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Downscaling future climate scenarios to fine scales for hydrologic and ecological modeling and analysis

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Ecological Processes 2012年第1期1卷 109-123页

作者： lorraine E Flint Alan L Flint U.S.Geological Survey Placer Hall6000 J St.SacramentoCA 95819USA

Introduction:Evaluating the environmental impacts of climate change on water resources and biological components of the landscape is an integral part of hydrologic and ecological investigations,and the resultant land and resource management in the twenty-first *** of both climate and simulated hydrologic parameters on ecological processes are relevant at scales that reflect the heterogeneity and complexity of *** present,simulations of climate change available from global climate models[GCms]require downscaling for hydrologic or ecological ***:Using statistically downscaled future climate projections developed using constructed analogues,a methodology was developed to further downscale the projections spatially using a gradient-inverse-distancesquared approach for application to hydrologic modeling at 270-m spatial ***:This paper illustrates a methodology to downscale and bias-correct national GCms to subkilometer scales that are applicable to fine-scale environmental *** scenarios were chosen to bracket the range of future emissions put forth by the Intergovernmental Panel on Climate ***-scale applications of downscaled datasets of ecological and hydrologic correlations to variation in climate are ***:The methodology,which includes a sequence of rigorous analyses and calculations,is intended to reduce the addition of uncertainty to the climate data as a result of the downscaling while providing the fine-scale climate information necessary for ecological *** results in new but consistent data sets for the US at 4 km,the southwest US at 270 m,and California at 90 m and illustrates the utility of fine-scale downscaling to analyses of ecological processes influenced by topographic complexity.

关键词： downscaling climate change spatial scale scenarios

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IT-Software SmEs in China, Technology Transfer from Universities and Entrepreneurship, a Successful Nexus？

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Frontiers of Business Research in China 2014年第1期8卷 18-48页

作者： Jianghong Cao m. John Foster lorraine Watkins-mathys Kingston-Business School Kingston University Kingston Upon Thames KT2 7LB UK

Drawing on the empirical work of a broader study, this paper examines whether technology is being successfully transferred from universities to the IT-sottware SmEs present in China, and the effectiveness of entrepreneurship in effecting such transfers. A conceptual framework was generated to guide the investigation. Data were elicited using a detailed questionnaire which generated 53 usable responses; follow-up interviews with 17 of the 53 respondents; and four interviews with relevant government officials （civil servants from the ministry of Science and Technology and state-owned banks）. There were three main fmdings. Chinese software SmEs tend to be reluctant to adopt new technologies from local tmiversities; there is a lack of common purpose between the parties; and entrepreneurs who did undertake such technology transfer felt the process was badly impeded by the lack of available finance, and expressed fears about poor protection of intellectual property rights in China. The majority of the sample firms acted opportunistically, taking advantage of the benefits offered under government schemes to earn rapid returns mainly using extant technologies. These conclusions suggest that the Chinese government＇s policies in this area of technology transfer have had only limited success.

关键词： entrepreneurship technology transfer universities IT-software,SmE China

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