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Basic and clinical aspects of osteoporosis in inflammatory bowel disease

World Journal of Gastroenterology 2007年第46期13卷 6156-6165页

作者： lorena rodríguez-bores JosuéBarahona-Garrido Jesús K Yamamoto-Furusho IBD Clinic Department of GastroenterologyInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán.Vasco de Quiroga 15 colonia Sección ⅩⅥTlalpanCP 14000México

Low bone mineral density and the increased risk of fracture in gastrointestinal diseases have a multifactorial pathogenesis. Inflammatory bowel disease （IBD） has been associated with an increased risk of osteoporosis and osteopenia and epidemiologic studies have reported an increased prevalence of low bone mass in patients with IBD. Certainly, genetics play an important role, along with other factors such as systemic inflammation, malnutrition, hypogonadism, glucocorticoid therapy in IBD and other lifestyle factors. At a molecular level the proinflammatory cytokines that contribute to the intestinal immune response in IBD are known to enhance bone resorption. There are genes influencing osteoblast function and it is likely that LRP5 may be involved in the skeletal development. Also the identification of vitamin D receptors （VDRs） and some of its polymorphisms have led to consider the possible relationships between them and some autoimmune diseases and may be involved in the pathogenesis through the exertion of its immunomodulatory effects during inflammation. Trying to explain the physiopathology we have found that there is increasing evidence for the integration between systemic inflammation and bone loss likely mediated via receptor for activated nuclear factor kappa-B （RANK）, RANK-ligand, and osteoprotegerin, proteins that can affect both osteoclastogenesis and T-cell activation. Although glucocorticoids can reduce mucosal and systemic inflammation, they have intrinsic qualities that negatively impact on bone mass. It is still controversial if all IBD patients should be screened, especially in patients with preexisting risk factors for bone disease. Available methods to measure BMD include single energy x-ray absorptiometry, DXA, quantitative computed tomography （QCT）, radiographic absorptiometry, and *** is the establish method to determine BMD, and routinely is measured in the hip and the lumbar spine. There are several treatments options that have

关键词： Inflammatory bowel disease Osteoporosis

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Novel genetic markers in inflammatory bowel disease

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World Journal of Gastroenterology 2007年第42期13卷 5560-5570页

作者： lorena rodríguez-bores Gabriela C Fonseca Marco A Villeda Jesús K Yamamoto-Furusho IBD Clinic Department of Gastroenterology Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Vasco de Quiroga 15 colonia Sección XVI Tlalpan CP 14000 México

Genetic factors play a significant role in determining inflammatory bowel disease(IBD)*** data support genetic contribution to the pathogenesis of IBD,which include familial aggregation,twin studies,racial and ethnic differences in disease *** studies have identified several susceptibility genes contained in different genomic regions named IBD1 to *** oligomerization domain(NOD2)and human leukocyte antigen(HLA)genes are the most extensively studied genetic regions(IBD1 and IBD3 respectively)in *** of the NOD2 gene are associated with Crohn's disease(CD)and several HLA genes are associated with ulcerative colitis(UC)and *** like receptors(TLRs)have an important role in the innate immune response against infections by mediating recognition of pathogen-associated microbial *** single-nucleotide polymorphisms(SNPs)in molecules involved in bacterial recognition seems to be essential to define genetic backgrounds at risk of ***,numerous new genes have been identified to be involved in the genetic susceptibility to IBD:NOD1/Caspase-activation recruitment domains 4(CARD4),Chemokine ligand 20(CCL20),IL-11,and IL-18 among *** characterization of these novel genes potentially will lead to the identification of therapeutic agents and clinical assessment of phenotype and prognosis in patients with IBD.

关键词： Genetic Inflammatory bowel disease Human leukocyte antigen Nucleotide oligomerizationdomain Toll like receptors Susceptibility

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放射状角膜切开术——美国经验分析

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国际眼科纵览 1982年第3期 156-157页

作者： bores LD 孙书琛龙沛之

手术治疗屈光不正的兴趣,尤其对于近视,正在日益增加。近25-30年来发展了多种手术。Sato(1953)首次报告了放射状切开角膜实质层以使角膜中央部变平的方法。因为切口是由前房进入角膜,术后出现角膜水肿。1979年Fyodorov等报道60例从角膜... 详细信息

手术治疗屈光不正的兴趣,尤其对于近视,正在日益增加。近25-30年来发展了多种手术。Sato(1953)首次报告了放射状切开角膜实质层以使角膜中央部变平的方法。因为切口是由前房进入角膜,术后出现角膜水肿。1979年Fyodorov等报道60例从角膜表面做放射状切口,术后裸眼视力极好。本文为美国国家放射状角膜切开研究组(National Radial Keratotomy Study Group)对223例400只近视眼治疗的结果,术后观察时间至少为1年。患者均为-2～-11D非进行性近视,散光小于1.5 D。年龄18-63岁。不包括青光眼、糖尿病、能影响角膜伤口愈合的角膜病、外眼病或全身病患者。手术前后均测量了角膜曲度、眼压、屈光和角膜厚度。角膜中央区平均厚度为0.56mm,傍中央区为0.64mm。手术用表面麻醉,在显微镜下用微型刀进

关键词：放射状角膜缘切开术美国美利坚合众国北美洲

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Asterohyptis stellulata: Phytochemistry and wound healing activity

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Food Bioscience 2022年第6期50卷 2067-2076页

作者： Nallely Álvarez-Santos Edgar Antonio Estrella-Parra José del Carmen Benítez-Flores Rocío Serrano-Parrales Tomás Ernesto Villamar-Duque Martha Angelica Santiago-Santiago María del Rosario González-Valle José Guillermo Avila-Acevedo Ana María García-bores Phytochemistry Laboratory UBIPROSuperior Studies Faculty (FES)-IztacalaNational Autonomous University of Mexico (UNAM)Tlalnepantla de BazMexico State54090Mexico Postgraduate Biological Sciences Postgraduate Studies UnitNational Autonomous University of Mexico (UNAM)CoyoacanMexico City04510Mexico Histology Laboratory 1 UMFSuperior Studies Faculty (FES)-IztacalaNational Autonomous University of Mexico (UNAM)Tlalnepantla de BazMexico State54090Mexico Natural Products Bioactivity Laboratory UBIPROSuperior Studies Faculty (FES)-IztacalaNational Autonomous University of Mexico (UNAM)Tlalnepantla de BazMexico State54090Mexico Bioterium Superior Studies Faculty (FES)-IztacalaNational Autonomous University of Mexico (UNAM)Tlalnepantla de BazMexico State54090Mexico Plant Physiology Laboratory UBIPROFES-IztacalaUNAMTlalnepantla de BazMexico State54090Mexico

Wound healing is a fast and efficient process. However, several factors can inhibit healing, causing scars and chronic wounds. This affects patients in their physical integrity, economic and emotional stability. Many plants that are used in wound healing treatment have antioxidant/anti-inflammatory activity through ROS regulation and antibacterial activity. Asterohyptis stellulata is used for wound treatment. Nonetheless, this activity has not been evaluated and its secondary metabolites are unknown. Therefore, the objective of this study was to analyze its phytochemical composition and evaluate the healing activity of A. stellulata. For the identification of secondary metabolites, the following were carried out: phytochemical screening, quantification of total phenols, and HPLC/MS analysis. The antibacterial and antioxidant activities were also determined. Next, to evaluate the healing activity of topical application of A. stellulata, the extract was mixed with the Beeler base to form an emulsion and an irritability test was performed. The emulsion was evaluated on incisional wounds of CD1 et/et mice, with tests of tensile strength, total re-epithelialization time, wound closure speed, and histological analysis. The phytochemical analysis showed that A. stellulata has phenolic compounds, two quercetin derivatives and a glycoside rosmarinic acid as main compounds. The extract exhibited medium antibacterial and antioxidant activities. A. stellulata emulsion was non-irritating, promoted closure speed of wound (1.479 ± 0.043 mm/day), increased tensile strength (980 ± 89.44 g), and histological analysis showed it promoted mice skin regeneration, compared to the controls (Recoveron® and Beeler base). This study confirms the traditional use of the A. stellulata.

关键词： Asterohyptis stellulata Phytochemistry Skin regeneration Wound healing

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