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Unintended changes in ocular biometric parameters during a 6-month follow-up period after FS-LASIK and SMILE

Eye and Vision 2021年第1期8卷 75-82页

作者： Junjie Wang Bernardo t.lopes Hechen Li Riccardo Vinciguerra Si Cao Songan Wu Rong Zhu Qinmei Wang Xiaobo Zheng Fangjun Bao Ahmed Elsheikh Eye Hospital Wenzhou Medical UniversityWenzhou 325027ZhejiangChina the Institution of Ocular Biomechanics Wenzhou Medical UniversityWenzhou 325027ZhejiangChina School of Engineering University of LiverpoolLiverpool L693GHUK Humanitas San Pio X Hospital MilanItaly National Institute for Health Research(NIHR)Biomedical Research Centre for Ophthalmology Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of OphthalmologyLondonUK Beijing Advanced Innovation Center for Biomedical Engineering Beihang UniversityBeijingChina

Background:Corneal refractive surgery has become reliable for correcting refractive errors,but it can induce unintended ocular changes that alter refractive *** study is to evaluate the unintended changes in ocular biometric parameters over a 6-month follow-up period after femtosecond laser-assisted laser in situ keratomileusis(FS-LASIK)and small incision lenticule extraction(SMILE).Methods:156 consecutive myopic patients scheduled for FS-LASIK and SMILE were included in this *** corneal thickness(CCt),mean curvature of the corneal posterior surface(K_(pm)),internal anterior chamber depth(IACD)and the length from corneal endothelium to retina(ER)were evaluated before and after surgery over a 6-month ***:Both the FS-LASIK and SMILE groups(closely matched at the pre-surgery stage)experienced flatter Kpm,shallower IACD and decreased ER 1 week post-surgery(Pthese changes were larger in FS-LASIK than in SMILE *** the 1 week to 6 months follow up period,K_(pm),IACD and ER remained stable unlike CCt which increased significantly(Pthe FS-LASIK ***:During the follow up,the posterior corneal surface became flatter and shifted posteriorly,the anterior chamber depth and the length from the corneal endothelium to retina decreased significantly compared with the pre-surgery *** unintended changes in ocular biometric parameters were greater in patients undergoing FS-LASIK than *** changes present clear challenges for IOL power calculations and should be considered to avoid affecting the outcome of cataract surgery.

关键词： Posterior corneal surface Internal anterior chamber depth the length from corneal endothelium to retina FS-LASIK SMILE

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Review of ex-vivo characterisation of corneal biomechanics

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Medicine in Novel technology and Devices 2021年第3期11卷 40-46页

作者： JunJie Wang XiaoYu Liu FangJun Bao Bernardo t.lopes LiZhen Wang Ashkan Eliasy Ahmed Abass Ahmed Elsheikh Eye Hospital Wenzhou Medical UniversityWenzhouChina the Institution of Ocular Biomechanics Wenzhou Medical UniversityWenzhouChina Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina Beijing Advanced Innovation Centre for Biomedical Engineering Beihang UniversityBeijingChina School of Engineering University of LiverpoolLiverpoolUK Department of Ophthalmology Federal Univerisity of Sao Paulo(UNIFESP)Sao PauloBrazil National Institute for Health Research(NIHR)Biomedical Research Centre for Ophthalmology Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of OphthalmologyLondonUK

the evaluation of the corneal biomechanical behaviour has important clinical *** name a few,the accuracy of the intraocular pressure measurement,the study of corneal ectatic diseases and the assessment and optimisation of corneal surgical procedures are all highly influenced by corneal *** the last 45 years different ex-vivo methods were developed to study corneal biomechanical *** tissue maintenance,support,loading systems,as well as different monitoring strategies of corneal deformations were *** this review,the most important and commonly used methods are outlined,including strip extensiometry,inflation,compression,indentation and tissue separation *** particularities,applications,pros and cons and main applications are discussed.

关键词： Ex-vivo Corneal Biomechanics Experimental testing

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Review of in-vivo characterisation of corneal biomechanics

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Medicine in Novel technology and Devices 2021年第3期11卷 34-39页

作者： Bernardo t.lopes FangJun Bao JunJie Wang XiaoYu Liu LiZhen Wang Ahmed Abass Ashkan Eliasy Ahmed Elsheikh School of Engineering University of LiverpoolLiverpoolUK Department of Ophthalmology Federal Univerisity of Sao Paulo(UNIFESP)Sao PauloBrazil Eye Hospital Wenzhou Medical UniversityWenzhouChina the Institution of Ocular Biomechanics Wenzhou Medical UniversityWenzhouChina Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina Beijing Advanced Innovation Centre for Biomedical Engineering Beihang UniversityBeijingChina National Institute for Health Research(NIHR)Biomedical Research Centre for Ophthalmology Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of OphthalmologyLondonUK

the study of corneal biomechanics in vivo has been evolving fast in recent *** an organised corneal structure is necessary for its transparency,resistance to occasional external insults and bearing the intraocular pressure(IOP),which several clinically relevant events can *** review focuses on three techniques that are available for clinical use,namely the Ocular Response Analyzer(Reichert Ophthalmic Instruments,Buffalo,NY,USA),the Corvis St(Oculus Optikgerate GmbH,Wetzlar,Germany)and the Brillouin Optical Scattering System(Intelon Optics Inc.,Lexington,MA,USA).the principles and the main parameters of each device are discussed along with their strategies to improve accuracy in the IOP measurement,corneal ectasia diagnosis,evaluation of corneal cross-linking procedures,and planning of corneal refractive surgeries.

关键词： Corneal biomechanics Corneal diagnosis Intraocular pressure Corneal ectasia Corneal cross linking

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Biomechanical diagnostics of the cornea

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Eye and Vision 2020年第1期7卷 87-98页

作者： Louise Pellegrino Gomes Esporcatte Marcella Q.Salomão Bernardo t.lopes Paolo Vinciguerra Riccardo Vinciguerra Cynthia Roberts Ahmed Elsheikh Daniel G.Dawson Renato Ambrósio Jr Rio de Janeiro Corneal tomography and Biomechanics Study Group Rio de JaneiroBrazil Instituto de Olhos Renato Ambrósio Rua Conde de Bonfim 211/712Rio de JaneiroRJ 20520-050Brazil Department of Ophthalmology Hospital São Vicente de PauloRio de JaneiroBrazil Brazilian Study Group of Artificial Intelligence and Corneal Analysis–BrAIN Rio de Janeiro&MaceióBrazil Department of Ophthalmology Federal University of São PauloSão PauloBrazil Instituto Benjamin Constant Rio de JaneiroBrazil School of Engineering University of LiverpoolLiverpool L693GHUK Department of Biomedical Science Humanitas UniversityRozzanoItaly Eye Center Humanitas Clinical and Research CenterRozzanoItaly Department of Ophthalmology Humanitas San Pio X HospitalMilanItaly Department of Ophthalmology and Visual Science Department of Biomedical EngineeringThe Ohio State UniversityColumbusOHUSA School of Biological Science and Biomedical Engineering Beihang UniversityBeijingChina NIHR Biomedical Research Centre for Ophthalmology Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of OphthalmologyLondonUK the University of Florida Department of Ophthalmology GainesvilleFLUSA Department of Ophthalmology Federal University the State of Rio de Janeiro(UNIRIO)Rio de JaneiroBrazil

Corneal biomechanics has been a hot topic for research in contemporary ophthalmology due to its prospective applications in diagnosis,management,and treatment of several clinical conditions,including glaucoma,elective keratorefractive surgery,and different corneal *** clinical biomechanical investigation has become of great importance in the setting of refractive surgery to identify patients at higher risk of developing iatrogenic ectasia after laser vision *** review discusses the latest developments in the detection of corneal ectatic *** developments should be considered in conjunction with multimodal corneal and refractive imaging,including Placido-disk based corneal topography,Scheimpflug corneal tomography,anterior segment tomography,spectral-domain optical coherence tomography(SD-OCt),very-high-frequency ultrasound(VHF-US),ocular biometry,and ocular wavefront *** ocular response analyzer(ORA)and the Corvis St are non-contact tonometry systems that provide a clinical corneal biomechanical *** recently,Brillouin optical microscopy has been demonstrated to provide in vivo biomechanical *** integration of tomographic and biomechanical data into artificial intelligence techniques has demonstrated the ability to increase the accuracy to detect ectatic disease and characterize the inherent susceptibility for biomechanical failure and ectasia progression,which is a severe complication after laser vision correction.

关键词： Corneal biomechanics Corneal ectasia Corneal imaging

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患儿血清胃蛋白酶原、血清胃泌素、胃黏膜组织学和幽门螺杆菌毒力因子的关系

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世界核心医学期刊文摘（胃肠病学分册） 2006年第11期2卷 45-46页

作者： lopes A.I. Palha A. lopes t. 张诗峰 Gastroenterology Unit Paediatric Department University Hospital Santa Maria Lisbon Portugal Dr.

Objective. Serum pepsinogens and gastrin have been proposed as markers of gastritis, but have seldom been studied in children. In this study the aim was to identify host-and Helicobacter pylori-related factors linked to variations in serum gastrin, PGI, PGⅡ, and to evaluate the potential of these biomarkers for diagnosing gastritis, whether H. pylori-associated or not. Material and methods. Ninety-two dyspeptic children referred for endoscopy (peptic ulcer exclusion) were included in the study. H. pylori status (urease, culture, histology) was assessed, and genotype determined (PCR) in H. pylori-positive subjects. Serum gastrin, PGI and PGⅡ levels were measured by standard radioimmunoassay (RIA). Results. PGI and PGⅡ levels were significantly higher in H. pylori-positive subjects (p = 0.007; p = 0.012, respectively). Gastrin levels were significantly higher in H. pylori-negative subjects (p = 0.035). PGI and PGⅡ were associated significantly with higher antrum inflammation scores (p = 0.002; p = 0.016, respectively); only PGI was associated with age, after controlling for inflammation (p = 0.033) and for activity (p = 0.037). the contribution of virulence factors could not be assessed owing to the low number of virulent strains. After multivariate analysis, only antrum inflammation was independently associated with PGI level (p = 0.012). Receiver operating characteristic (ROC) analysis showed a low PGI and PGⅡ discriminant power for predicting antrum inflammation. Conclusions. Pepsinogen levels as measured in this study seem predominantly to reflect antral inflammation, but they are not an effective screening test for gastritis (H. pylori-positive or -negative) in dyspeptic children.

关键词：血清胃蛋白酶原血清胃泌素胃黏膜组织毒力因子组织学方法胃镜检查消化性溃疡尿素酶菌株数

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Evolution of Pre-Columbian Metallurgy from the North of Peru Studied with a Portable Non-invasive Equipment Using Energy-Dispersive X-Ray Fluorescence

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材料科学与工程（中英文B版） 2011年第1期1卷 48-81页

作者： Roberto Cesareo Angel Bustamante D Julio Fabian S Sandra Zambrano A Walter Alva Luis Chero del Carmen Espinoza C Rosendo Rodriguez R Marco Seclen F Fidel Gutierrez V E.B. Ldvano Gonzales A. Marcia A. Rizzutto Enrico Poli Cristiane Calza Marcelino dos Anjos Ricardo t. lopes Giovanni E. Gigante Gabriel M. Ingo Cristina Riccucci Carlos Elera Izumi Shimada Victor Curay Castillo G and Fabio lopes Dipartimento di Matematica e Fisica Universith di Sassari Sassari Italy Universidad Nacional Mayor de San Marcos Lima Peri4 Museo ＂tumbas Reales de Sip6n ＂ Lambayeque Perlt Instituto de Fisica Universidade de S6o Paulo SP Brasil Asociaci6n cultural e Museo Enrico Poli Lima Peru COPPE Universidade Federal do Rio de Janeiro Rio de Janeiro Brasil Dipartimento di Energetica Universith di Roma ＂La Sapienza ＂ Rome Italy lstituto Studio dei Materiali Nanostrutturati-CNR Area Ricerca RM1-Montelibretti Rome Italy Museo de Sic6n Ferrahqfe Perit Istituto Nacional de Cultura Piura Peru Universidade Estadual de Londrina Londrina PR Brasil

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Inflow and outflow permeability tests in a very soft clay under low stresses

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第8期16卷 3270-3283页

作者： J.W.S.Vargas F.A.B.Danziger F.R.lopes t.Lunne Federal University of Rio de Janeiro Rio de JaneiroBrazil Norwegian Geotechnical Institute OsloNorway

In situ inflow and outflow permeability tests with the BAt probe at SarapuíII soft clay test site are presented.A description of the BAt permeability test is provided,discussing its advantages and shortcomings,especially in the case of very soft clays under low *** pressures were monitored during probe installation and were found to be slightly lower than piezocone u2 pore pressures,consistent with the position of the *** role of filter tip saturation was investigated after the usual saturation procedure provided an unsatisfactory pore pressure response during probe *** show that the vacuum saturation procedure provides adequate response during installation and increases the reliability of the coefficient of permeability determination in early *** inflow and outflow tests yielded similar results,indicating that careful execution of the test can lead to good test repeatability regardless of the loading *** sequences of alternated inflow and outflow tests have yielded similar results,indicating that soil reconsolidation and filter clogging were negligible in the tests *** are presented concerning the relationship between index parameters and the in situ coefficient of permeability for SarapuíII clay,which plot outside the range of existing databases.

关键词： Permeability test Soft clay BAt probe Inflow and outflow tests

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the nest architecture of the ant, Pheidole oxyops Forel, 1908 （Hymenoptera： Formicidae）

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Insect Science 2007年第5期14卷 437-442页

作者： LUIZ C. FORtI ROBERtO S. CAMARGO RICARDO t. FUJIHARA JULIANE F. S. lopes Laboratorio de Insetos Sociais-Praga Departamento de Producao Vegetal - Setor Defesa Fitossanitaria FCA/UNESP Botucatu SP Comportamento e Ecologia Animal Instituto de Ciencias Biologicas Universidade Federal de Juiz de Fora Campus Universitario Martelos Juiz de Fora MG Brazil

Pheidole oxyops builds subterranean nests, with an external architecture that is distinctive and easily recognizable by its wide and specific entrance hole, measuring up to 12.2 cm in diameter, denoting a pitfall-trap. In order to study the nests＇ internal architecture, seven nests were excavated; four were identified with neutral talc, while the others were cast in cement and then excavated. Measurements were made in order to gain a better understand- ing of their structures, and a photographic documentation was obtained as well. the excavations revealed that the nests are perpendicular relative to the ground, beginning with a cylindrical channel with a mean length of 13.5 cm, containing irregular formations, and whose diameter becomes progressively narrower until the first chamber is formed. As the channel continues, dish-like chambers appear, interconnected by channels that become progressively narrower and longer, while the chambers are arranged at greater distances from each other as nest depth increases. Both channels and chambers are located on the vertical projection of the entrance hole. Nests may reach a depth of up to 5.09 m, with a number of chambers ranging between 4 and 14.

关键词： chambers nest architecture Pheidole pitfall-trap

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Solar-stellar astrophysics and dark matter

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Research in Astronomy and Astrophysics 2012年第8期12卷 1107-1138页

作者： Sylvaine turck-Chize Ilídio lopes CEA/IRFU/Service d'Astrophysique AIMCE Saclay91191 Gif sur YvetteFrance Centro Multidisciplinar de Astrofísica Instituto Superior TcnicoUniversidade Tcnica de LisboaAv.Rovisco Pais1049-001 LisboaPortugal Departamento de Física Escola de Ciência e TecnologiaUniversidade de vora Colgio Luis António Verney7002-554 voraPortugal

In this review, we recall how stars contribute to the search for dark matter and the specific role of the Sun. We describe a more complete picture of the solar interior that emerges from neutrino detections, gravity and acoustic mode measurements of the Solar and Heliospheric Observatory （SOHO） satellite, becoming a reference for the most common stars in the Universe. the Sun is a unique star in that we can observe directly the effect of dark matter. the absence of a signature related to Weakly Interacting Massive Particles （WIMPs） in its core disfavors a WIMP mass range below 12 GeV. We give arguments to continue this search on the Sun and other promising cases. We also examine another dark matter candidate, the sterile neutrino, and infer the limitations of the classical structural equations. Open questions on the young Sun, when planets formed, and on its present internal dynamics are finally dis- cussed. Future directions are proposed for the next decade： a better description of the solar core, a generalization to stars coming from seismic missions and a better under- standing of the dynamics of our galaxy which are all crucial keys for understanding dark matter.

关键词： stellar evolution: theory -- elementary particles -- helioseismology --dark matter -- early solar-planet relationship

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白鲷高豆粕饲料中添加糖酶可提高养分利用率

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饲料博览 2016年第10期26卷 53-53页

作者： Magalh?es R lopes t Martins N Rosales P D Couto A Ferreira P P teles A O Peres H

试验旨在探讨高豆粕(SBM)/低鱼粉(FM)的白鲷鱼(鲷科)饲料中添加非淀粉糖酶(NSPase)复合酶对其性能的影响。四组等氮(36%CP)、等脂(18%CL)饲粮按2×2方阵设计,包括15%FM/32%SBM或5%FM/42%SBM两种豆粕、鱼粉比例,添加或不添加NSPase复合... 详细信息

试验旨在探讨高豆粕(SBM)/低鱼粉(FM)的白鲷鱼(鲷科)饲料中添加非淀粉糖酶(NSPase)复合酶对其性能的影响。四组等氮(36%CP)、等脂(18%CL)饲粮按2×2方阵设计,包括15%FM/32%SBM或5%FM/42%SBM两种豆粕、鱼粉比例,添加或不添加NSPase复合酶。共12组,每组15条鱼(平均体重58 g),为期10周。试验检测了各组日粮的表观消化率、FM两组的采食量、生长性能、饲料效率、体成分、消化率、远端小肠和肝组织形态学以及消化酶活性无显著差异。然而,补充NSPase能显著增加饲料消化率,提高蛋白质、能量利用率,5%FM组的作用效果高于15%FM组。随着NSPase的添加,体成分和脂肪含量也随之提高,粪氮和能量的损失减少。此外,在5%FM组添加NSPase能促进淀粉酶和脂肪酶活性,但对蛋白酶活性无影响。试验结果表明,饲料中缺乏FM时,白鲷性能表现更好。高植物性饲料中添加NSPase可提高饲料的营养利用效率,并有助于减少粪便产生。

关键词：豆粕饲料养分利用率糖酶鲷科表观消化率试验检测生长性能消化酶活性

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