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Periodontitis as a promoting factor of T2D: current evidence and mechanisms

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International Journal of Oral Science 2023年第2期15卷 217-228页

作者： Yuan Su Leilei Ye Chen Hu Yanli Zhang Jia Liu longquan shao Stomatology Center Shunde HospitalSouthern Medical University(The First People's Hospital of Shunde)FoshanChina Stomatological Hospital School of StomatologySouthern Medical University Department of Stomatology Nanfang HospitalSouthern Medical UniversityGuangzhouChina

Periodontitis is an infectious disease caused by an imbalance between the local microbiota and host immune ***,periodontitis is closely related to the occurrence,development,and poor prognosis of T2D and is recognized as a potential risk factor for *** recent years,increasing attention has been given to the role of the virulence factors produced by disorders of the subgingival microbiota in the pathological mechanism of T2D。

关键词： prognosis tit Periodon

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Perlecan and synaptophysin changes in denervated skeletal muscle

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Neural Regeneration Research 2012年第17期7卷 1293-1298页

作者： Kai Ma Zhifeng Huang Jianfeng Ma longquan shao Huiming Wang Yanliang Wang Department of Oral and Maxillofacial Surgery Affiliated Hospital of Stomatology Medical College of Zhejiang University Hangzhou 310006 Zhejiang Province China Department of Oral and Maxillofacial Surgery Affiliated Hospital of Stomatology Wenzhou Medical College Wenzhou 325027 Zhejiang Province China School of Pharmacy Wenzhou Medical College Wenzhou 325000 Zhejiang Province China Department of Stomatology Nanfang Hospital Southern Medical University Guangzhou 510515 Guangdong Province China

The present study observed sciatic nerve and gastrocnemius muscle changes in denervated rats using morphology methods, and assessed expression of perlecan, an extracellular matrix component, which is located at the skeletal muscle cell surface as acetylcholine esterase, as well as synaptophysin, a synaptic marker. Results showed degeneration and inflammation following transection of the sciatic nerve. In addition, the sciatic nerve-dominated skeletal muscle degenerated with mild inflammation, indicating that skeletal muscle atrophy primarily contributed to denervation-induced nutritional disturbances. With prolonged injury time （1-4 weeks post-injury）, perlecan expression gradually decreased and reached the lowest level at 4 weeks, but synaptophysin expression remained unchanged after denervation. Results suggested that perlecan expression was more sensitive to denervation and reflected regional extracellular matrix changes following denervation.

关键词： perlecan synaptophysin extracellular matdx acetylcholine esterase neuromuscular junction denervated skeletal muscle sciatic nerve neural regeneration

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A bioactive glass functional hydrogel enhances bone augmentation via synergistic angiogenesis,self-swelling and osteogenesis

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Bioactive Materials 2023年第4期22卷 201-210页

作者： Fujian Zhao Zhen Yang Huacui Xiong Yang Yan Xiaofeng Chen longquan shao Stomatological Hospital Southern Medical UniversityGuangzhou510280China Department of Biomedical Engineering School of Materials Science and EngineeringSouth China University of TechnologyGuangzhou510641China National Engineering Research Center for Tissue Restoration and Reconstruction South China University of TechnologyGuangzhou510006China Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering Guangzhou510515China

Bone augmentation materials usually cannot provide enough new bone for dental implants due to the material degradation and mucosal *** use of hydrogels with self-swelling properties may provide a higher bone augmentation,although swelling is generally considered to be a disadvantage in tissue ***,a double-crosslinked gelatin-hyaluronic acid hydrogels(GH)with self-swelling properties were ***,niobium doped bioactive glasses(NbBG)was dispersed in the hydrogel network to prepare the GH-NbBG *** composite hydrogel exhibited excellent biocompatibility and the addition of NbBG significantly improved the mechanical properties of the *** vivo results found that GH-NbBG synergistically promoted angiogenesis and increased bone augmentation by self-swelling at the early stage of *** addition,at the late stage after implantation,GH-NbBG significantly promoted new bone formation by activating RUNX2/Bglap signaling ***,this study reverses the self-swelling disadvantage of hydrogels into advantage and provides novel ideas for the application of hydrogels in bone augmentation.

关键词： Bioactive glass Bone formation Osteogenesis Angiogenesis

Concentrated growth factor regulates the macrophage-mediated immune response

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Regenerative Biomaterials 2021年第6期8卷 59-68页

作者： Haiyun Luo Wenjing Liu Yachuan Zhou Xiao Jiang Yeungyeung Liu Qin Yang longquan shao Department of Endodontics Stomatological HospitalSouthern Medical University366 Jiangnan Avenue SouthGuangzhou 510280China Department of Prosthodontics Stomatological HospitalSouthern Medical UniversityGuangzhou 510280China State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Department of Cariology and Endodontics West China Hospital of StomatologySichuan UniversityNO.143rd Section of Ren Min Nan Rd.Chengdu 610041China Department of Oral Medicine Stomatological HospitalSouthern Medical UniversityGuangzhou 510280China Department of Periodontics Stomatological HospitalSouthern Medical UniversityGuangzhou 510280China

Concentrated growth factor(CGF)is a promising regenerative material that serves as a scaffold and adjunct growth factor for tissue *** host immune response,particularly macrophage activity,plays a critical role in injury repair and tissue ***,the biological effect of CGF on the immune response is not *** enrich the theoretical groundwork for clinical application,the present study examined the immunoregulatory role of CGF in macrophage functional activities in *** CGF scaffold appeared as a dense fibrin network with multiple embedded leukocytes and platelets,and it was biocompatible with *** bioactive factors in the CGF extract enhanced THP-1 monocyte recruitment and promoted the maturation of suspended monocytes into adherent *** extract also promoted THP-1 macrophage polarization toward the M2 phenotype with upregulated CD163 expression,as detected by cell morphology and surface marker expression.A cytokine antibody array showed that CGF extract exerted a regulatory effect on macrophage functional activities by reducing secretion of the inflammatory factor interleukin-1b while inducing expression of the chemokine regulated on activation,normal T cell expressed and ***,the AKT signaling pathway was activated,and an AKT inhibitor partially suppressed the immunomodulatory effect of *** findings reveal that CGF induces a favorable immune response mediated by macrophages,which represents a promising strategy for functional tissue regeneration.

关键词： concentrated growth factor immune response macrophage signaling pathway

Optimizing mechanical property and cytocompatibility of the biodegradable Mg-Zn-Y-Nd alloy by hot extrusion and heat treatment

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Journal of Materials Science & Technology 2019年第1期35卷 6-18页

作者： Yiyuan Kang Beining Du Yueming Li Baojie Wang Liyuan Sheng longquan shao Yufeng Zheng Tingfei Xi Shenzhen Institute Peking University Nanfang Hospital Southern Medical University Institute of Metal Research Chinese Academy of Sciences

The Mg-Zn-Y-Nd alloy is a new type of degradable material for biomedical application. In the present study, Mg-6Zn-1.2Y-0.8Nd alloy was fabricated, and then extrusion and heat treatment were conducted to optimize its mechanical properties and cytocompatibility. The microstructure observation, mechanical property, degradation behavior and cytocompatibility tests were conducted on the Mg-Zn-Y-Nd alloy with three different states: as-cast(alloy C), as-extruded(alloy E) and extruded + heat treated(alloy EH).The results show that alloy C consists of coarse grains and continuous secondary phases. The extrusion process has caused incomplete recrystallization, and results in a mixed grain structure of elongated grains and small equiaxed grains(alloy E). The heat treatment process has promoted the recrystallization and homogenized the grain structure(alloy EH). Both the strength and ductility of the alloy has been improved by extrusion, but the following heat treatment has decreased the strength and increased the *** degradation behavior of the alloy C and E alloys does not show much difference, but improves slightly in alloy EH, because the heat treatment has homogenized the microstructure and released the residual stress in the alloy. The directly and indirectly cell viability tests indicate that alloy EH exhibits the best cytocompatibility, which should be ascribed to its relative uniform degradation and low ion releasing rate. In summary, the combination of hot extrusion and heat treatment could optimize the mechanical property and cytocompatibility of the Mg-Zn-Y-Nd alloy together, which is beneficial for the future application of the alloy.

关键词： Mg-Zn-Y-Nd alloy Microstructure Mechanical property Biodegradable behavior Biocompatibility

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NIR-II emissive dye based polymer nanoparticle targeting EGFR for oral cancer theranostics

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Nano Research 2022年第7期15卷 6288-6296页

作者： Mingjian Ling Rui Sun Guang Li Madiha Zahra Syeda Wen Ma Ziyi Mai longquan shao Longguang Tang Zhiqiang Yu School of Pharmaceutical Sciences Guangdong Provincial Key Laboratory of New Drug ScreeningSouthern Medical UniversityGuangzhou 510632China Nanfang Hospital Southern Medical UniversityGuangzhou 510515China Department of Obstetrics and Gynecology The Third Affiliated Hospital of Southern Medical UniversityGuangzhou 510632China Department of Pharmacology and Department of Respiratory and Critical Care Medicine of the Second Affiliated Hospital Zhejiang University School of MedicineKey Laboratory of Respiratory Disease of Zhejiang ProvinceHangzhou 310009China The Fourth Affiliated Hospital International Institutes of MedicineZhejiang University School of MedicinJinhua 322000China

Oral cancer is a common malignant tumor of the head and neck,and surgery combined with radiotherapy and chemotherapy is the primary treatment ***,a positive resection margin that may lead to recurrence after surgery has always been a critical issue to ***,radiotherapy and chemotherapy also have shortcomings such as resistance to chemotherapy and radiation,lack of targeting,and severe side ***,exploring new methods of tumor surgical navigation and tumor treatment is of great significance for oral ***,the emerging near-infrared II(NIR-II,1,000–1,700 nm)region fluorescent imaging has revolutionized surgical navigation,a high tumor-targeting fluorescent probe remains ***,while emerging photothermal therapy(PTT)can overcome chemoradiotherapy’s shortcomings and achieve precise treatment of tumors,its clinical application is still limited by the lack of high photothermal conversion efficiency,high photothermal stability,and highly penetrating ***,a NIR-II dye SQ890 is developed for tumor imaging and PTT of oral *** assembling into nanoparticles(NPs)and being modified with epithelial growth factor receptor(EGFR)-targeting peptides GE11,SQ890 NPs-Pep can specifically accumulate in tumor sites via active targeting,and realize photoacoustic/NIR-II fluorescence dual-modality imaging-guided PTT of oral cancer.

关键词： near-infrared(NIR-II)imaging oral cancer theranostics epithelial growth factor receptor(EGFR) photothermal therapy

Design and evaluation of a novel sub-scaffold dental implant system based on the osteoinduction of micro-nano bioactive glass

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Biomaterials Translational 2020年第1期1卷 82-88页

作者： Fujian Zhao Zhen Yang Lu Liu Dafu Chen longquan shao Xiaofeng Chen Stomatological Hospital Southern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Biomedical Engineering School of Materials Science and EngineeringSouth China University of TechnologyGuangzhouGuangdong ProvinceChina National Engineering Research Center for Tissue Restoration and Reconstruction South China University of TechnologyGuangzhouGuangdong ProvinceChina Laboratory of Bone Tissue Engineering Beijing Laboratory of Biomedical MaterialsBeijing Research Institute of Orthopaedics and TraumatologyBeijing Jishuitan HospitalBeijingChina

Alveolar ridge atrophy brings great challenges for endosteal implantation due to the lack of adequate vertical bone mass to hold the *** overcome this limitation,we developed a novel dental implant design:sub-scaffold dental implant system(SDIS),which is composed of a metal implant and a micro-nano bioactive glass *** implant system can be directly implanted under mucous membranes without adding any biomolecules or destroying the alveolar *** evaluate the performance of the novel implant system in vivo,SDISs were implanted into the subepicranial aponeurosis space of Sprague–Dawley *** 6 weeks,the SDIS and surrounding tissues were collected and analysed by micro-CT,scanning electron microscopy and *** results showed that SDISs implanted into the sub-epicranial aponeurosis had integrated with the skull without any mobility and could stably support a ***,this design achieved alveolar ridge augmentation,as active osteogenesis could be observed outside the cortical *** that the microenvironment of the sub-epicranial aponeurosis space is similar to that of the alveolar ridge,SDISs have great potential for clinical applications in the treatment of atrophic alveolar *** study was approved by the Animal Care Committee of Guangdong Pharmaceutical University(approval No.2017370).

关键词： alveolar ridge augmentation micro-nano bioactive glass osteoinduction sub-scaffold dental implant system

Electrochemically derived nanographene oxide activates endothelial tip cells and promotes angiogenesis by binding endogenous lysophosphatidic acid

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Bioactive Materials 2022年第3期7卷 92-104页

作者： Wenjing Liu Haiyun Luo Qinwei Wei Jia Liu Junrong Wu Yanli Zhang Lili Chen Wencai Ren longquan shao Stomatological Hospital Southern Medical UniversityGuangzhou510280China Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering Guangzhou510515China Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang110016China Stomatology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China

Graphene oxide(GO)exhibits good mechanical and physicochemical characteristics and has extensive application prospects in bone tissue ***,its effect on angiogenesis is unclear,and its potential toxic effects are heavily ***,we found that nanographene oxide(NGO)synthesized by one-step water electrolytic oxidation is smaller and shows superior ***,NGO significantly enhanced angiogenesis in calvarial bone defect areas in vivo,providing a good microenvironment for bone *** tip cell differentiation is an important step in the initiation of *** verified that NGO activates endothelial tip cells by coupling with lysophosphatidic acid(LPA)in serum via strong hydrogen bonding interactions,which has not been *** addition,the mechanism by which NGO promotes angiogenesis was systematically ***-coupled LPA activates LPAR6 and facilitates the formation of migratory tip cells via Hippo/Yes-associated protein(YAP)independent of reactive oxygen species(ROS)stimulation or additional complex *** results provide an effective strategy for the application of electrochemically derived NGO and more insight into NGO-mediated angiogenesis.

关键词： Nanographene oxide Lysophosphatidic acid Hydrogen bonding Endothelial tip cell Hippo signalling

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5种全瓷底层材料相对透明率的对比测定

稀有金属材料与工程 2009年第S2期38卷 827-829页

作者：邵龙泉温宁张薇薇邓斌南方医科大学解放军总医院

对比测定了EmpressⅡ100、Vita In-Ceram AL2色瓷沉积氧化铝、Z21色瓷沉积氧化锆、Cercon base color氧化锆、Cercon base氧化锆及Vita牙本质瓷A2色的相对透明率。结果表明,Vita牙本质瓷A2色的相对透明率为0.6231,而5组全瓷底层材料试样... 详细信息

对比测定了EmpressⅡ100、Vita In-Ceram AL2色瓷沉积氧化铝、Z21色瓷沉积氧化锆、Cercon base color氧化锆、Cercon base氧化锆及Vita牙本质瓷A2色的相对透明率。结果表明,Vita牙本质瓷A2色的相对透明率为0.6231,而5组全瓷底层材料试样为0.8083～0.9885;组间差异具有统计学意义。按相对透明率数值从低到高排序为EmpressⅡ100<瓷沉积氧化铝AL2色

关键词：牙科陶瓷相对透明率氧化铝氧化锆