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Localized Giant Cell Tumor of the Tendon Sheath: A Rare Case of Anterior Knee Pain

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Journal of Biosciences and Medicines 2019年第7期7卷 16-21页

作者： Bairi Cui Kumar Gurung Yuanming He Guo Song longhao jin Department of Orthopedic Surgery Yanbian University Hospital Yanji China Department of Orthopedic Surgery Community Hospital Itahari Nepal

This report describes a 61-year-old female with a giant cell tumor of the tendon sheath (GCT-TS). MRI showed that an elliptical abnormal signal was observed over the infrapatellar region of the right knee. We directly do arthroscopy to remove the tumor. An oval irregular mass of about 2.0 cm × 1.5 cm × 1 cm in the right knee joint was found. It was hard and had a dark red surface and the pedicle of the mass was connected with the joint capsule and infrapatellar fat pad. Nodular GCT-TS occurs less frequently in large joints than the small joints of the fingers and toes. The current report demonstrates the unique characteristics of the GCT-TS that extends around the ankle and invades the knee and proximal humerus.

关键词： Giant Cell Tumor of the Tendon Sheath (GCT-TS) Knee Arthroscopy

Comparison of Chondrogenic Ability between Mesenchymal Stem Cells and Buffy Coat <i>in Vitro</i>

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Journal of Biosciences and Medicines 2018年第3期6卷 86-94页

作者： longhao jin Zhongye Zhang Yanqun Liu Kumar Gurung Yongjun jin Yuanming He Yu jin Zhehu jin Department of Orthopedic Surgery Yanbian University Hospital Yanji City China Department of Orthopedic Surgery Songyuan Central Hospital Songyuan City China Department of Anatomy School of Medicine Yanbian University Yanji City China Department of Dermatology Yanbian University Hospital Yanji City China

Objective: In vitro comparison of chondrogenic differentiation ability of bone marrow extracted mesenchymal stem cells (MSCs) and buffy coat. Methods: MSCs of New Zealand white rabbits were cultured in vitro and adherent cells were passaged. The cells were inoculated on polyglycolic acid (PGA) scaffold (3 mm in diameter and 2 mm in height) liquid for 21 days. Under the same conditions, without subculture, buffy coat was directly inoculated into the cell scaffold. The degree of chondrogenic differentiation was compared by Safranin-Ostaining, histological scoring and biochemical functional detection. Results: The chondrogenic differentiation ability of the buffy coat group was better than that of the MSC group. Safranin-Ostain was stronger in buffy coat group than in MSC group. The Bern Score was also higher in the buffy coat group than in the MSC group and the total amount of sulfated glycosaminoglycans (GAGs) in buffy coat group was higher than that in MSC group. Conclusion: The chondrogenic differentiation ability of buffy coat is higher than that of MSC. Through this result, it was found buffy coat can also differentiate into sub-cartilage without stimulating growth factor. Thus, buffy coat can make a great source in artificial cartilage engineering.

关键词： Chondrogenic Buffy Coat Mesenchymal Stem Cells

The Application Prospect Autologous Bone Marrow Extract Buffy Coat in Cartilage Tissue Engineering: A Mini-Review

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Journal of Biosciences and Medicines 2019年第12期7卷 9-17页

作者： Zhiyu Li Zhongye Zhang Guo Song Shouyong Fu longhao jin Yanqun Liu Department of Orthopedic Surgery Yanbian University Hospital Yanji China Department of Orthopedic Surgery Songyuan Central Hospital Songyuan China

Cartilage injury is an important cause of osteoarthritis;however, there is no effective method of cartilage regeneration at present. Therefore, it would be of great value to explore and develop new methods of cartilage regeneration. In recent years, it has become a hot topic on repairing damaged cartilage by using tissue engineered cartilage domestic and abroad. It’s the key factor to success for getting cell source which is effective, applicable and easy to obtain in the technology of cartilage tissue engineering filed. This article summarizes the research progress of bone marrow extract buffy coat in cartilage tissue engineering.

关键词： Buffy Coat Cartilage Tissue Engineering

Surface-targeted functionalization of nickel-rich cathodes through synergistic slurry additive approach with multi-level impact using minimal quantity

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Nano Research 2024年第1期17卷 333-343页

作者： jing Zhang Jiapei Li longhao Cao Wenhua Cheng Ziyin Guo Xiuxia Zuo Chao Wang Ya-Jun Cheng Yonggao Xia Yudai Huang State Key Laboratory of Chemistry and Utilization of Carbon Based Energy Resources College of ChemistryXinjiang UniversityUrumqi 830017China Ningbo Institute of Materials Technology&Engineering Chinese Academy of SciencesNingbo 315201China School of Materials Science and Engineering Tongji UniversityShanghai 200240China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

LiNi0.8Co0.1Mn0.1O_(2)(NCM811),a Ni-rich layered oxide,is a promising cathode material for high-energy density lithium-ion batteries(LIBs).However,its structural instability,caused by adverse phase transitions and continuous oxygen release,as well as deteriorated interfacial stability due to excessive electrolyte oxidative decomposition,limits its widespread *** address these issues,a new concept is proposed that surface targeted precise functionalization(STPF)of the NCM811 cathode using a synergistic slurry additive(SSA)*** approach involves coating the NCM811 particle surface with 3-aminopropyl dimethoxy methyl silane(3-ADMS),followed by the precise deposition of ascorbic acid via an acid-base *** slurry additives induce the formation of an ultra-thin spinel surface layer and a stable cathode–electrolyte interface(CEI),which enhances the electrochemical kinetics and inhibits crack *** STPF strategy implemented by the SSA approach significantly improves the cyclic stability and rate performance of the NCM811 cathode in both half-cell and full-cell *** work establishes a promising strategy to enhance the structural stability and electrochemical performance of nickel-rich cathodes and provides a feasible route to promote practical applications of high-energy density lithium-ion battery technology.

关键词： nickel-rich cathode slurry additive lithium-ion battery cathode–electrolyte interface ascorbic acid phase transition

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新渣系碱性焊条发尘量及发尘速率

焊接学报 2007年第6期28卷 77-80页

作者：孟工戈金龙浩赵国华杨拓宇哈尔滨理工大学材料学院哈尔滨150040 哈药集团医药有限公司哈尔滨150020

基于均匀设计的思想方法安排试验,研究多种药皮辅料对焊条发尘量和发尘速率的影响规律。选定9种药皮辅料作为自变量,并把每个自变量分成6个水平,共做了24个焊条小样。记录焊接过程中焊条的发尘量和发尘速率,并在计算机上进行数据的统计... 详细信息

基于均匀设计的思想方法安排试验,研究多种药皮辅料对焊条发尘量和发尘速率的影响规律。选定9种药皮辅料作为自变量,并把每个自变量分成6个水平,共做了24个焊条小样。记录焊接过程中焊条的发尘量和发尘速率,并在计算机上进行数据的统计处理。分析结果给出了自变量与因变量之间的数学模型和趋势图。结果表明,多种药皮辅料对发尘量的影响呈交互作用的形式,其中氟化钡与萤石、钛白粉与碳酸钡、金红石与萤石、铝镁粉与铁粉之间的交互作用都会使发尘量增加,而钛白粉与金红石的联合作用则会使发尘量降低。发尘速率也有相类似的结果。

关键词：碱性焊条发尘量发尘速率均匀设计

Phenylalanine deprivation inhibits multiple myeloma progression by perturbing endoplasmic reticulum homeostasis

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3493-3512页

作者： longhao Cheng Xiaoxue Wang Aijun Liu Ying Zhu Hu Cheng Jiangling Yu Lili Gong Honglin Liu Guolin Shen Lihong Liu Institute of Clinical Medical Sciences ChinaeJapan Friendship HospitalCapital Medical UniversityBeijing 100029China Department of Pharmacy ChinaeJapan Friendship HospitalBeijing 100029China Beijing Chao-Yang Hospital Capital Medical UniversityBeijing 100020China Institute of Chemicals Safety Chinese Academy of Inspection and QuarantineBeijing 100020China

Amino acid metabolic remodeling is a hallmark of cancer,driving an increased nutritional demand for amino *** acids are pivotal for energetic regulation,biosynthetic support,and homeostatic maintenance to stimulate cancer ***,the role of phenylalanine in multiple myeloma(MM)remains ***,we demonstrate that phenylalanine levels in MM patients are decreased in plasma but elevated in bone marrow(BM)*** the treatment,phenylalanine levels increase in plasma and decrease in *** suggests that changes in phenylalanine have diagnostic value and that phenylalanine in the BM microenvironment is an essential source of nutrients for MM *** requirement for phenylalanine by MM cells exhibits a similar *** phenylalanine utilization suppresses MM cell growth and provides a synergistic effect with Bortezomib(BTZ)treatment in vitro and murine ***,phenylalanine deprivation induces excessive endoplasmic reticulum stress and leads to MM cell apoptosis through the ATF3eCHOPeDR5 *** with ATF3 significantly affects phenylalanine deprivation *** conclusion,we have identified phenylalanine metabolism as a characteristic feature of MM metabolic *** is necessary for MM proliferation,and its aberrant demand highlights the importance of lowphenylalanine diets as an adjuvant treatment for MM.

关键词： Multiple myeloma Phenylalanine Amino acid metabolism Nutrient deprivation Cancer therapy Endoplasmic reticulum stress ATF3 Apoptosis

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双小钢板固定尺桡骨干骨折

中国矫形外科杂志 2023年第1期31卷 81-83页

作者：刘恒宇马东宝李林金龙浩延边大学附属医院(延边医院)关节外科吉林延吉136200

[目的]探讨双小钢板(掌骨钢板)治疗尺桡骨干骨折的临床疗效。[方法] 2019年3月—2021年3月对16例尺桡骨干骨折患者采用双掌骨钢板固定,评价临床与影像资料。[结果]所有患者均顺利完成手术,术中均无严重并发症。随访时间平均(19.4±3.2)... 详细信息

[目的]探讨双小钢板(掌骨钢板)治疗尺桡骨干骨折的临床疗效。[方法] 2019年3月—2021年3月对16例尺桡骨干骨折患者采用双掌骨钢板固定,评价临床与影像资料。[结果]所有患者均顺利完成手术,术中均无严重并发症。随访时间平均(19.4±3.2)个月。与术后3个月相比,术后6个月前臂旋前ROM、前臂旋后ROM显著增加(P<0.05),DASH评分及G-E评级结果显著改善(P<0.05),G-E评级术后6个月优良率100%。至末次随访时,所有患者均骨性愈合,无固定物松动和断裂情况发生。[结论]双掌骨钢板固定具有体积小、血运破坏小等优势,可有效治疗尺桡骨干骨折。

关键词：尺桡骨干骨折双掌骨钢板术后恢复并发症

Luminescence-activated Pt(Ⅳ)prodrug for in situ triggerable cancer therapy

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Chinese Chemical Letters 2024年第7期35卷 383-387页

作者： Huijie An Chen Yang Zhihui Jiang Junjie Yuan Zhongming Qiu longhao Chen Xin Chen Mutu Huang Linlang Huang Hongju Lin Biao Cheng Hongjiang Liu Zhiqiang Yu General Hospital of Southern Theatre Command PLAGuangzhou 510010China The 925th Hospital of The Chinese People's Liberation Army Guiyang 550025China The 903rd Hospital of The People's Liberation Army Hangzhou 310007China The Second Hospital of Hebei Medical University Shijiazhuang 050000China The Tenth Affiliated Hospital of Southern Medical University(Dongguan people's hospital) Dongguan 523018China

Anticancer platinum prodrugs that can be controllably activated are highly desired for personalized precision medicine and patient compliance in cancer ***,the clinical application of platinum(Ⅳ)prodrugs(Pt(Ⅳ))is restricted by tissue penetration of external ***,we report a novel Pt(Ⅳ)activation strategy based on endogenous luminescence of tumor microenvironment responsiveness,which completely circumvents the limitation of external *** designed Pt(Ⅳ)–Lu,a mixture of trans,trans,trans-[Pt(N_(3))_(2)(OH)_(2)(py)_(2)]and luminol(Lu),has controllable activation property:it remains inert in reductant environment and normal tissues,but under tumor microenvironment,Lu will be oxidized to produce blue luminescence,which rapidly reduce Pt(Ⅳ)to Pt(Ⅱ)without the need of any external ***(Ⅳ)–Lu shows excellent responsive antitumor ability both in vitro and in *** to cisplatin,the median lethal dose in BALB/c mice increased by an order of *** results suggest that Pt(Ⅳ)–Lu exhibits highly controllable activation property,superior antitumor activity,and good biosafety,which may provide a novel strategy for the design of platinum prodrugs.

关键词： Tumor microenvironment Endogenous luminescence Platinum(Ⅳ)prodrug Activation strategy Antitumor Biosafety

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双股射流撞击雾化的无网格MPS法数值研究

工程热物理学报 2024年第5期45卷 1385-1394页

作者：崔龙豪孙一颉周子棋孙中国席光西安交通大学能源与动力工程学院西安710049

为研究质量流量和撞击角对双股射流撞击雾场的影响规律,采取移动粒子半隐式(MPS)法对双股射流撞击雾化过程进行数值模拟,针对数值模拟结果提出了用于液滴空间弥散状态研究的染色法并对雾场进行后处理分析。首先通过对泊肃叶流动和方形... 详细信息

为研究质量流量和撞击角对双股射流撞击雾场的影响规律,采取移动粒子半隐式(MPS)法对双股射流撞击雾化过程进行数值模拟,针对数值模拟结果提出了用于液滴空间弥散状态研究的染色法并对雾场进行后处理分析。首先通过对泊肃叶流动和方形液滴变圆的模拟,验证了充分发展速度进口模型和表面张力模型的正确性:随后通过分析质量流量和撞击角对雾化特性参数的影响,得到了典型工况下雾化后液膜生成并破碎为液丝、液丝发展为液滴的全过程。最终得到结论:质量流量从5g/s增加到25g/s,液滴平均粒径减少80.00%,雾化角增加42.13%;撞击角从30°增加到90°,液滴平均粒径减少94.22%,雾化角增加59.95%;当质量流量为20g/s,撞击角为75°时,雾化场能达到相对最优的状态。

关键词：移动粒子半隐式方法双股射流雾化过程