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Hypoglycemic natural products with in vivo activities and their mechanisms:a review

Food Science and Human Wellness 2022年第5期11卷 1087-1100页

作者： Wenyi Ma longgao xiao Haiyang Liu xiaojiang Hao State Key Laboratory of Phytochemistry and Plant Resources in West China Yunnan Key Laboratory of Natural Medicinal ChemistryKunming Institute of BotanyChinese Academy of SciencesKunming 650201China University of Chinese Academy of Sciences Beijing 100049China

Diabetes mellitus(DM) is a metabolic disorder disease,and the number of diabetic patients will reach 578 million by 2030 ***,8 classes of small molecular drugs are used for treating ***,these drugs cannot completely meet patients ’ needs,due to diabetic complications need to be addressed along with diabetes,such as nephropathy,and cardiovascular ***,more types of drugs need to be provided for more ***,scientists still seek lead compounds with hypoglycemic *** products(NPs) are a reservoir of diverse structures and bioactivities with low toxicity and less side *** some of them show effects on diabetic complications,which is a significant idea for drug *** review aims to summarize natural products with hypoglycemic effects and their details,such as potential mechanisms,biological data,and particularly their advantages in treating *** the huge number of NPs was reported with anti-diabetic activity,and some of them need to be re-validated,this review focuses on the bioactive compounds with in vivo *** the end,the trend of natural products treating diabetes was *** hope this review provide a comprehensive and convincing summary,thus lending support to anti-diabetic natural products research.

关键词： Diabetes Natural products Hypoglycemic effects Mechanism

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Nutritional values,bioactive compounds and health benefits of purslane(Portulaca oleracea L.):a comprehensive review

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Food Science and Human Wellness 2024年第5期13卷 2480-2501页

作者： Yanxi Li longgao xiao Huan Yan Mingyi Wu xiaojiang Hao Haiyang Liu State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China University of Chinese Academy of Sciences Beijing 100049China Yunnan Characteristic Plant Extraction Laboratory Kunming 650106China

Portulaca oleracea L.,commonly known as purslane,is a worldwide weed species belonging to the family Portulacaceae and has been known as“Global Panacea”.As one of the most widely consumed green vegetables and medicinal plants around the world,it has recently been re-evaluated as a potential“new crop”due to the properties that differentiate it as one of the best vegetable sources of omega-3 fatty acid(α-linolenic acid),as well as a variety of nutrients and ***,emerging research has found that purslane exhibits health-promoting properties like anti-inflammatory,anti-hyperglycemic,antioxidant,neuroprotective,and *** findings suggest that this species possesses a potential using as a dietary supplement beyond potherb and traditional *** review systematically summarizes the up-to-date research carried out on purslane,including the nutritional compositions,bioactive compounds,and health benefits it exerts as well as limitations,challenges,and future directions of ***,we hope that this review would provide purslane with a comprehensive reference and future scope as functional and health-promoting food for disease prevention and treatment.

关键词： Purslane Nutritional compositions Bioactive compounds Polysaccharides Functional foods

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Eudesmane-guaiane sesquiterpenoid dimers from Aucklandia cos-tus trigger paraptosis-like cell death via ROS accumulation and MAPK hyperactivation

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Chinese Journal of Natural Medicines 2024年第11期22卷 1011-1019页

作者： xiao longgao ZHAO Yueqin DING xiao LIU Hui ZHU Guangyu LI Yanxi YAN Huan FANG Xin ZHAO Yuhan LIU Haiyang State Key Laboratory of Phytochemistry and Plant Resources in West China and Yunnan Key Laboratory of Natural Medicinal ChemistryKunming Institute of BotanyChinese Academy of SciencesKunming 650201China University of Chinese Academy of Sciences Beijing 100049China Yunnan Characteristic Plant Extraction Laboratory Kunming 650106China

Three novel sesquiterpenoid heterodimers,designated as auckcostusolides A-C(1-3),were isolated from Aucklandia costus *** structures of compounds 1-3 were elucidated through comprehensive spectroscopic analysis,with their absolute configurations established using a combination of X-ray single-crystal diffraction and electronic circular dichroism(ECD)***,compounds 1 and 2,despite sharing identical planar structures derived from two identical sesquiterpenoids,exhibited oppos-ite configurations at C-11 and C-8'.This configurational difference can be attributed to distinct Diels-Alder cycloaddition processes between the sesquiterpenoid ***,the cytotoxic effects of compounds 1-3 were evaluated against colorectal can-cer HCT116 cells,fibrosarcoma HT1080 cells,and hepatocellular carcinoma HepG2 *** 1-3 induced cell death was characterized by endoplasmic reticulum(ER)swelling and cytoplasmic vacuolization,typical morphological changes associated with *** studies revealed that compounds 1 and 3 triggered paraptosis-like cell death through the accumulation of react-ive oxygen species(ROS),activation of ER stress,and stimulation of the MAPK signaling pathway.

关键词： Aucklandia costus Sesquiterpenoid heterodimers Auckcostusolides A-CParaptosis MAPK signaling pathway

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基于PLUS模型的徐州市生态系统服务价值多情景模拟研究

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中国土地科学 2024年第4期38卷 125-134页

作者：肖建英戴津津方昕然李龙陈龙高中国矿业大学公共管理学院数字乡村服务研究中心江苏徐州221116 中国矿业大学中国资源型城市转型发展与乡村振兴研究中心江苏徐州221116

研究目的:分析2000—2020年徐州市生态系统服务价值变化规律,模拟多情景下徐州市2030年生态系统服务价值,为资源型城市转型发展提供参考。研究方法:当量因子法与PLUS模型。研究结果:(1)徐州市土地利用类型以耕地和建设用地为主,2000—2... 详细信息

研究目的:分析2000—2020年徐州市生态系统服务价值变化规律,模拟多情景下徐州市2030年生态系统服务价值,为资源型城市转型发展提供参考。研究方法:当量因子法与PLUS模型。研究结果:(1)徐州市土地利用类型以耕地和建设用地为主,2000—2020年耕地面积持续下降,湿地与水体面积先减后增。(2)2000—2020年徐州市生态系统服务价值先减后增。(3)在三种情景模拟中,生态系统服务价值均出现损失,调节服务价值损失最大,耕地、草地面积减少是生态系统服务价值减少的重要原因。城镇发展情景下,建设用地侵占其他地类速度加快,生态系统服务价值下降趋势最为明显。生态保护情景下,生态系统服务价值损失量最少。研究结论:资源型城市在未来发展中应均衡经济发展与生态保护,同时加强规划引领,促进资源型城市绿色转型发展。

关键词： PLUS模型多情景土地利用变化生态系统服务价值

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