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纳米酶在生物检测和癌症治疗中的应用

西南大学学报（自然科学版） 2024年第6期46卷 17-28页

作者：谭龙飞傅仕艳梅林刘映岐中国科学院理化技术研究所北京100190 陆军军医大学军事预防医学系重庆400038 陆军军医大学边防卫勤训练大队新疆昌吉831200 西南大学医院重庆400715

纳米酶是2022年度化学领域十大新兴技术之一.它如同天然酶一样,能够在温和条件下催化酶底物,呈现出与天然酶类似的酶促反应动力学和反应机制,并且可以作为天然酶的替代物应用于疾病的检测及治疗.在免疫检测方面,纳米酶可以作为信号放大... 详细信息

纳米酶是2022年度化学领域十大新兴技术之一.它如同天然酶一样,能够在温和条件下催化酶底物,呈现出与天然酶类似的酶促反应动力学和反应机制,并且可以作为天然酶的替代物应用于疾病的检测及治疗.在免疫检测方面,纳米酶可以作为信号放大器或传统酶的替代品,提高检测的灵敏度和特异性.而在肿瘤微环境治疗中,通过特异性响应肿瘤微环境中弱酸性、缺氧和过表达过氧化氢及谷胱甘肽等条件来辅助癌症治疗.此外,纳米酶还可与多种外部刺激包括磁场、辐射、光、超声和微波等结合,实现多种方式协同检测治疗.该研究总结了纳米酶的合成方法、分类及催化原理以及纳米酶的生物医学应用,展望了其应用前景.

关键词：纳米酶催化原理生物医学应用

Preparation and enhanced properties of ZrMOF@CdTe nanoparticles with high-density quantum dots

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Frontiers of Materials Science 2020年第2期14卷 155-162页

作者： Xin LIU Xiangling REN longfei tan Wenna GUO Zhongbing HUANG Xianwei MENG College of Materials Science and Engineering Sichuan UniversityChengdu 610065China Laboratory of Controllable Preparation and Application of Nanomaterials CAS Key Laboratory of CryogenicsTechnical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China

ZrMOF@CdTe nanoparticles(NPs)with high fluorescence were synthe-sized by hydrothermal *** morphology,particle size distribution,compositions,fluorescence properties and stability of the synthesized ZrMOF@CdTe were analyzed via the characterization by TEM,ICP-AES and fluorescence spectrophotometry,and the effects of the reaction time and pH value on the fluorescent property of ZrMOF@CdTe NPs were *** results show that ZrMOFs could maintain its morphology and structure well during the process of loading CdTe quantum *** the increase of the loading reaction time,the red-shifted emission peaks of ZrMOF@CdTe NPs appear,and their fluorescence gradually changes from green to red *** the increase of the pH value and temperature of the hydrothermal reaction,the fluorescence of ZrMOF@CdTe NPs was also consistent with the red-shifted *** fluorescent property of ZrMOF@CdTe NPs could be remained for more than 3 ***,ZrMOF@CdTe NPs synthesized by the hydrothermal method have the characteristics of simple operation,adjustable fluorescent color and high stability,and the potential application in the fields of biological detection and sensing is expected.

关键词： hydrothermal synthesis ZrMOF@CdTe nanoparticles quantum dots metal-organic framework

新质生产力背景下BIM的价值体现及其在建筑产品全生命周期的应用

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绿色建造与智能建筑 2024年第9期 81-86页

作者：尚文婧金占勇于光旭谭龙飞北京建筑大学城市经济与管理学院北京100044

新质生产力的崛起为建筑行业带来了新的机遇和挑战,BIM技术作为这一变革的核心工具,正逐渐在建筑行业中展现出其巨大的潜力和价值。本文深入探讨了建筑信息模型(BIM)技术在建筑行业设计、生产、施工和运维阶段的具体应用,并总结了BIM技... 详细信息

新质生产力的崛起为建筑行业带来了新的机遇和挑战,BIM技术作为这一变革的核心工具,正逐渐在建筑行业中展现出其巨大的潜力和价值。本文深入探讨了建筑信息模型(BIM)技术在建筑行业设计、生产、施工和运维阶段的具体应用,并总结了BIM技术在新质生产力下的创新发展和价值体现。

关键词：新质生产力建筑信息模型可视化应用

Preparation and properties of covalent organic framework nanoparticles with high drug loading

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Frontiers of Materials Science 2021年第3期15卷 465-470页

作者： Jian ZOU Xiangling REN longfei tan Zhongbing HUANG Li GOU Xianwei MENG College of Biomedical Engineering Sichuan UniversityChengdu 610065China Laboratory of Controllable Preparation and Application of Nanomaterials CAS Key Laboratory of CryogenicsTechnical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China

With the rapid development of nanotechnology,nano-drug carrier systems in biomedicine have received extensive attention from *** adsorbing or coating the drug in/on a nano-sized carrier,this system improves the drug’s stability and selectivity in the body,reducing the toxicity and side effects of the *** these carrier systems have broad application prospects in the field of biomedicine.A common nano-drug carrier system includes inorganic nano-carriers,organic nano-carriers,and metal *** nano-carriers have the advantages of good stability,controllable size,larger specific surface area,and unique photothermal electromagnetic properties.

关键词： coating stability loading

Enhanced antibacterial activity of silica nanorattles with ZnO combination nanoparticles against methicillin-resistant Staphylococcus aureus

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Science Bulletin 2017年第17期62卷 1207-1215页

作者： Qianqian Chai Qiong wu Tianlong Liu longfei tan Changhui Fu Xiangling Ren Yue Yang Xianwei Meng Laboratory of Controllable Preparation and Application of Nanomaterials CAS Key Laboratory of CryogenicsTechnical Institute of Physics and ChemistryChinese Academyof SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Silica nanorattles(SNs) with zinc oxide(ZnO) combination nanoparticles are reported to inhibit methicillin-resistant Staphylococcus aureus(MRSA) for the first time. SNs loaded with ZnO nanoparticles,which can produce free radicals, can cause severe damage to bacteria. ZnO nanoparticles not only provide free radicals in the combined nanostructures, which can inhibit the growth of bacteria, but also form nanorough surfaces with an irregular distribution of spikes on the SNs, which can enhance their adhesion to bacteria. Nanorough silica shell surfaces maintain the high activity and stability of small-sized ZnO nanoparticles and gather ZnO nanoparticles together to enhance production, which improves the efficiency of free radicals against the cytomembranes of bacterial cells. The enhanced adhesion of ZnO@SN nanoparticles to MRSA cells shortens the effective touching distance between free radicals and MRSA, which also improves antibacterial activity. As we expected, the ZnO@SN nanoparticles exhibit a better antibacterial effect than free ZnO nanoparticles against MRSA in vitro and in vivo. We also demonstrate that SNs loaded with ZnO nanoparticles can accelerate wound healing in MRSA skin inflammation models. This method of multilevel functionalization will be potentially applicable to the antibacterial field.

关键词： Silica nanorattles ZnO nanoparticles Methicillin-resistant Staphylococcus aureus(MRSA) Rough surface Reactive oxygen species

High-yield preparation of robust gold nanoshells on silica nanorattles with good biocompatiblity

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Science Bulletin 2016年第4期61卷 282-291页

作者： Changhui Fu Chaofeng He longfei tan Shunhao Wang Lu Shang Linlin Li Xianwei Meng Huiyu Liu Laboratory of Controllable Preparation and Application ofNanomaterials Technical Institute of Physics and ChemistryChinese Academy of Sciences Beijing 100190 China University of Chinese Academy of Sciences Beijing 100049China Beijing Institute of Nanoenergy and Nanosystems ChineseAcademy of Sciences Beijing 100083 China National Center for Nanoscience and Technology (NCNST) Beijing 100083 China Beijing Key Laboratory of Bioprocess College of Life Scienceand Technology Beijing University of Chemical TechnologyBeijing 100029 China

Although gold nanoshells are widely considered as one of the promising photothermal nanomaterials used for biomedicine, the high cost, low yield and poor stability severely limit their potential application in clinical ***, robust gold nanoshells on silica nanorattles(GSNs)were easily prepared in a high yield by an improved seedmediated method employing polyvinylpyrrolidone(PVP) as a stabilizing and capping agent. The present method is very simple, effective and reproducible and can well control the growth process of gold nanoshells. The as-prepared GSNs have a narrow size distribution(tandard deviation). Furthermore, the utilization rate of Au in the solution used for the growth of gold nanoshells increases by 70 %than that in previous method. The resultant GSNs have a good structural stability after placing over 6 months due to the protection of PVP. More importantly, in vivo and in vitro toxic studies indicate that the GSNs have good biocompatibility. We believe that our preparation method will remarkably promote the use of gold nanoshells for biomedicine.

关键词： Gold nanoshells Silica nanorattlesPolyvinylpyrrolidone (PVP) High yield Biocompatibility

Nanoscale metal organic frameworks inhibition of pyruvate kinase of M2

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Chinese Chemical Letters 2021年第10期32卷 3087-3089页

作者： Xiangling Ren Xinyuan Huang Qiong Wu longfei tan Changhui Fu Yi Chen Xianwei Meng Laboratory of Controllable Preparation and Application of Nanomaterials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China CAS Key Laboratory of Cryogenics Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Tumor cells usually show abnormally high glycolysis rate to maintain the dynamic balance of *** growth of tumor cells can be affected by inhibiting the activity of pyruvate kinase(especially M2-type isozyme,PKM2),the rate limiting enzyme of *** is helpful to the treatment of ***,metal organic frameworks(MOFs) were found to inhibit the activity of *** ZIF-8 was synthesized by standing and ultrasonic method,*** ZIF-8 has the performance of inhibiting *** research showed that the inhibition ability was attributed to zinc ion in ***,the IC_(50) of ZIF-8 on PKM2 was one percent of that of zinc *** novel enzyme inhibitor is expected to be used in cancer therapy.

关键词： Metal organic frameworks Pyruvate kinase Glycolysis Lactate dehydrogenase Inhibition

Chemical chaperone delivered nanoscale metal–organic frameworks as inhibitor of endoplasmic reticulum for enhanced sensitization of thermo-chemo therapy

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Chinese Chemical Letters 2022年第3期33卷 1604-1608页

作者： Xiaoyan Ma Qiong Wu longfei tan Changhui Fu Xiangling Ren Qijun Du Lufeng Chen Xianwei Meng Laboratory of Controllable Preparation and Application of Nanomaterials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China Graduate School of Bio-Applications and Systems Engineering Tokyo University of Agriculture and TechnologyKokyo 184-8588Japan CAS Key Laboratory of Cryogenics Technical Institute of Physics and ChemistryBeijing 100190China First Clinical Medical School and First Hospital Shanxi Medical UniversityTaiyuan 030001China

Thermotherapy and chemotherapy have received extensive attention to tumor treatment. However, thermal tolerance and drug resistance severely limit clinical effect of tumor therapy owing to endoplasmic reticulum(ER) stress. Reducing thermal tolerance and drug resistance of tumors is an urgent challenge to be solved. In this work, we design a nanoplatform of PBA-Dtxl@MIL-101 as an ER inhibitor. Amino functionalized Fe-metal organic framework(MIL-101) nanoparticles are synthesized as p H and microwave(MW) dual stimuli-responsive drug delivery system. Then, the chemical chaperones of 4-phenylbutyric acid(PBA) and antineoplastic drug Docetaxel(Dtxl) were successfully loaded into MIL-101 nanoparticles to form PBA-Dtxl@MIL-101 nanoparticles. Furthermore, PBA-Dtxl@MIL-101 nanoparticles exhibit inhibitor effect of ER stress through upregulating caspase 9 proteins and reduce thermal tolerance by downregulating HSP 90. It was demonstrated that the therapy sensitized by PBA-Dtxl@MIL-101 nanoparticles obviously destroyed tumor cells, showing simultaneously enhanced thermo-chemo therapy.

关键词： Metal–organic frameworks Biodegradable Chemotherapy Thermotherapy Microwave

Fabrication of microwave-sensitized nanospheres of covalent organic framework with apatinib for tumor therapy

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Chinese Chemical Letters 2023年第5期34卷 427-432页

作者： Qijun Du Jian Zou Zhongbing Huang Shimei Li longfei tan Xiangling Ren Guangfu Yin Yongfa Zheng Xianwei Meng College of Biomedical Engineering Sichuan UniversityChengdu 610065China Laboratory of Controllable Preparation and Application of Nanomaterials CAS Key Laboratory of CryogenicsTechnical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China Sichuan Kangcheng Biotechnology Co. Ltd.Chengdu 610041China Department of Oncology Renmin Hospital of Wuhan UniversityWuhan 430060China

A new nanocomposite of hollow covalent organic framework(COF)conjugated with the apatinib(AP)and loading microwave-sensitizer(ionic liquid,IL)was prepared by layer by layer(LBL)method and hyaluronic acid(HA)coating,named as COF-AP-IL@*** loading rate in COF hollow-spheres(~30 nm shell thickness)was~40.3%,due to the interactions of hydrogen andπ-πbonds between AP and COF shell,and acidic environment destroyed COF structure,promoting AP *** sensitization of loaded IL in COF hollow-spheres could enhance the microwave heat-effect,and combined AP therapeutic ability,leading to their higher inhibitation on tumor,due to targeting ability of HA and the local release of apatinib.88.9%of inhibition rate of COF-AP-IL@HA under microwave on the in vivo tumor was significantly higher than those without microwave(12.3%)and COF-IL@HA with microwave(37.5%),indicating a synergism of sensitized microwave hyperthermia and AP therapy on the reduced expression of VEGF via the downregulation pathway of hypoxia inducible *** results indicated that COF-AP-IL@HA was potential to the application in the combination therapy of tumor of the sensitized microwave hyperthermia and apatinib.

关键词： Covalent organic framework Antiangiogenesis Tumor therapy Microwave hyperthermia Hollow spheres