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Blockade of NMT1 enzymatic activity inhibits N-myristoylation of VILIP3 protein and suppresses liver cancer progression

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Signal Transduction and Targeted Therapy 2023年第2期8卷 716-729页

作者： Xiang-Peng Tan Yan He Jing Yang Xian Wei You-long Fan Guo-Geng Zhang Yi-Dong Zhu Zheng-Qiu Li hua-Xin Liao Da-Jiang Qin Xin-Yuan Guan Bin Li The First Affiliated Hospital of Jinan University Jinan UniversityGuangzhouChina Key Laboratory of Biological Targeting Diagnosis Therapy and Rehabilitation of Guangdong Higher Education Institutes and Key Laboratory of Protein Modification and DegradationThe Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina MOE Key Laboratory of Tumor Molecular Biology and National Engineering Research Center of Genetic Medicine College of Life Science and TechnologyJinan UniversityGuangzhouChina School of Pharmacy Jinan UniversityGuangzhouChina Department of Clinical Oncology The University of Hong KongHong KongChina

Hepatocellular carcinoma(HCC)is one of the most common malignant *** of the underlying mechanism of HCC progression and exploration of new therapeutic drugs are urgently ***,a compound library consisting of 419 FDA-approved drugs was taken to screen potential anticancer drugs.A series of functional assays showed that desloratadine,an antiallergic drug,can repress proliferation in HCC cell lines,cell-derived xenograft(CDX),patient-derived organoid(PDO)and patient-derived xenograft(PDX)models.N-myristoyl transferase 1(NMT1)was identified as a target protein of desloratadine by drug affinity responsive target stability(DARTS)and surface plasmon resonance(SPR)*** of NMT1 expression enhanced but NMT1 knockdown suppressed tumor growth in vitro and in *** labeling and mass spectrometry analyses revealed that Visinin-like protein 3(VILIP3)was a new substrate of NMT1 in protein N-myristoylation modification,and high NMT1 or VILIP3 expression was associated with advanced stages and poor survival in ***,desloratadine binds to Asn-246 in NMT1 and inhibits its enzymatic activity,disrupting the NMT1-mediated myristoylation of the VILIP3 protein and subsequent NFκB/Bcl-2 ***,this study demonstrates that desloratadine may be a novel anticancer drug and that NMT1-mediated myristoylation contributes to HCC progression and is a potential biomarker and therapeutic target in HCC.

关键词： drugs VILI allergic

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Heat Capacity of MgB3O3(OH)5 Solution by Microcalorimeter

Heat Capacity of MgB3O3(OH)5 Solution by Microcalorimeter

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中国化学会第五届全国热分析动力学与热动力学学术会议

作者： Yafei Guo fei Li long Li Tianlong Deng Tianjin Key Laboratory of Marine Resources and Chemistry College of Marine Science and Engineering at Tianjin University of Science and Technology

There are many different kinds of magnesium borates synthesized from various conditions or acquired naturally with different compositions,which can be used *** applications involve in ceramic industry,detergent industry,fire-retardants,lens solutions,super-conducting materials production,hydrocarbon catalysts,additive,or oils for friction reduction agents due to their superior properties such as high elastic coefficient,resistance to dust,and high resistance to *** addition,some hydrous magnesium borate minerals can also be used as neutron and gamma radiation shield materials,owing to the high content of boron and high quantity of crystal waters[1].The mineral of inderite(2MgO·3BO·15HO),associated with hydroboracite,was earliest found in the Yingjier Boron Deposit in the Former Soviet Union[2].Salt lakes located in the Qaidam Basin,China belong to a new-style of borate salt *** far,nine kinds of borates including six hydrated magnesium borate minerals of2MgO·3BO·15HO(inderite),2MgO·3BO·15HO(kurnakovite),2MgO·2BO·MgCl·14HO(chloropinnoite),MgO·BO·3HO(pinnoite),MgO·2BO·9HO(hungchaoite),MgO·3BO·7.5HO(mcallisterite),have been found in the Qaidam Basin[3].However,those valuable magnesium borates have not yet been effectively exploited for lacking the basic datum,particularly for the thermochemical properties of the borate species presented in aqueous solution to predict the thermochemical behavior of the salt lake *** the first,a series of heat capacities of the aqueous MgBO(OH)·5HO solutions in the concentration range from 0.0004770 to 0.02709 mol·kg at T = 298.15 K and p = 0.1 Mpa were determined by the BT2.15 microcalorimeter.A polynomial equation of the heat capacity versus the molality of magnesium borate was fitted through the polynomial *** the basis of Pitzer ion-interaction equation for the binary aqueous electrolytic solution,the apparent molar heat capacity model was used to fit the Pitzer single-salt parameter of inderite,β(0)J),β

关键词： Heat capacity inderite Aqueous solution

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碳关税视阈下中国产业结构的调整

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福建师范大学学报（哲学社会科学版） 2011年第5期 20-26页

作者：杨飞龙福建师范大学经济学院福建福州350108

碳关税虽然还存有争议,但随着国际社会对环境保护和低碳经济发展的重视,最终被WTO认可的可能性大。碳关税的开征对我国高碳产业势必形成冲击,但也为我国调整优化出口结构、产业结构,发展低碳经济,实现跨越式发展提供了机会。我国应该加... 详细信息

碳关税虽然还存有争议,但随着国际社会对环境保护和低碳经济发展的重视,最终被WTO认可的可能性大。碳关税的开征对我国高碳产业势必形成冲击,但也为我国调整优化出口结构、产业结构,发展低碳经济,实现跨越式发展提供了机会。我国应该加速高碳产业转型,促进新兴低碳产业崛起,开征碳税和利用清洁发展机制,实现国家产业整体向低能耗、低排放、高附加值、高技术含量转化,构建以低碳为主的产业结构。

关键词：碳关税外贸出口产业结构

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Down-regulation of the Smad signaling by circZBTB46 via the Smad2-PDLIM5 axis to inhibit type I collagen expression

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Journal of Geriatric Cardiology 2023年第6期20卷 431-447页

作者： Jing YU Wen-Zhao YAN Xin-hua ZHANG Bin ZHENG Wen-Sen PAN Zhan YANG Hong ZHANG Zi-Yuan NIE Ying MA Yang BAI long ZHANG Dan-Dan FENG Jin-Kun WEN Department of Biochemistry and Molecular Biology Hebei Medical UniversityShijiazhuangChina Second Department of Respiratory and Critical Care Medicine the Second Hospital of Hebei Medical UniversityShijiazhuangChina Department of Infectious Diseases the Third Hospital of Hebei Medical UniversityShijiazhuangChina Institution of Chinese Integrative Medicine Hebei Medical UniversityShijiazhuangChina Department of Urology the Second Hospital of Hebei Medical UniversityShijiazhuangChina Department of Hematology the Second Hospital of Hebei Medical UniversityShijiazhuangChina Department of Biochemistry and Molecular Biology Binzhou Medical UniversityYantaiChina

BACKGROUND Abnormal type I collagen(COL1)expression is associated with the development of many cardiovascular *** TGF-beta/Smad signaling pathway and circRNAs have been shown to regulate COL1 gene expression,but the underlying molecular mechanisms are still not fully *** Gain-and loss-of-function experiments were prformed to study the effect of circZBTB46 on the expression of alpha 2 chain of type I collagen(COL1A2).Co-immunoprecipitation assay was performed to observe the interaction between two *** immunoprecipitation assay and biotin pull-down assay were performed to observe the interaction of circZBTB46 with *** In this study,we investigated the role of circZBTB46 in regulating COL1A2 expression in human vascular smooth muscle cells(VSMCs).We found that circZBTB46 is expressed in VSMCs and that TGF-beta inhibits circZBTB46 formation by downregulating KLF4 expression through activation of the Smad signaling ***46 inhibits the expression of COL1A2 induced by ***,circZBTB46 mediates the interaction between Smad2 and PDLIM5,resulting in the inhibition of Smad signaling and the subsequent downregulation of COL1A2 ***,we found that the expression of TGFbeta and COL1A2 is decreased,while circZBTB46 expression is increased in human abdominal aortic aneurysm tissues,indicating that circZBTB46-mediated regulation of TGF-beta/Smad signaling and COL1A2 synthesis in VSMCs plays a crucial role in vascular homeostasis and aneurysm *** CircZBTB46 was identified as a novel inhibitor of COL1 synthesis in VSMCs,highlighting the importance of circZBTB46 and PDLIM5 in regulating TGF-beta/Smad signaling and COL1A2 expression.

关键词： PDLIM5 Smad2 homeostasis

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南昌市NDVI时空演化特征及其气候驱动因子分析

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森林工程 2024年第5期40卷 50-61页

作者：徐悦李佳潼郭齐韵李慧珊吴华西藏大学工学院拉萨850013 高原地表环境遥感监测联合实验室拉萨850000 南昌市气象局南昌330008

揭示南昌市植被覆盖的演化特征和确定影响其变化趋势的主要气候驱动因子,为其长期稳定、良性发展和积极应对后续的气候变化提供指导。采用2000—2020年南昌市的NDVI月度数据、气温、降水和气压等10个气象驱动因子,利用单样本K-S(Kolmogo... 详细信息

揭示南昌市植被覆盖的演化特征和确定影响其变化趋势的主要气候驱动因子,为其长期稳定、良性发展和积极应对后续的气候变化提供指导。采用2000—2020年南昌市的NDVI月度数据、气温、降水和气压等10个气象驱动因子,利用单样本K-S(Kolmogorov-Smirnov)检验、弗里德曼检验、肯德尔和谐系数检验法等非参数检验法和随机森林分析方法,对不同驱动因子的重要性进行研究。结果表明,1)在2000—2020年南昌市的NDVI呈波动下降趋势,该峰值出现在2000年,谷值则在2010年;2)城市整体植被覆盖呈现四周高中间低的空间分布规律,北部和西部地区的NDVI值相对较高且下降速率缓慢,中部的东湖区和青山湖区等NDVI值相对较低且有明显下降趋势;3)植被覆盖的极大平均值出现在每年8月,受温度的影响最显著,而风向的影响最不显著,降水的影响有一定的时滞性,植被覆盖变化应结合多要素的共同驱动作用来决定。

关键词：归一化植被指数非参数检验随机森林气候变化驱动分析。

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Is ABP1 an Auxin Receptor Yet？

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Molecular Plant 2011年第4期4卷 635-640页

作者： Jing-hua Shi Zhen-Biao Yang Center for Plant Cell Biology Department of Botany and Plant Sciences University of California Riverside CA 92521 USA

AUXIN BINDING PROTEIN 1 （ABP1） has long been proposed as an auxin receptor to regulate cell expansion. The embryo lethality of ABP1-null mutants demonstrates its fundamental role in plant development, but also hinders investigation of its involvement in post-embryonic processes and its mode of action. By taking advantage of weak alleles and inducible systems, several recent studies have revealed a role for ABP1 in organ development, cell polarization, and shape formation. In addition to its role in the regulation of auxin-induced gene expression, ABP1 has now been shown to modulate non-transcriptional auxin responses. ABP1 is required for activating two antagonizing ROP GTPase signaling pathways involved in cytoskeletal reorganization and cell shape formation, and participates in the regulation of clathrinmediated endocytosis to subsequently affect PIN protein distribution. These exciting discoveries provide indisputable evidence for the auxin-induced signaling pathways that are downstream of ABP1 function, and suggest intriguing mechanisms for ABPl-mediated polar cell expansion and spatial coordination in response to auxin.

关键词： Hormonal regulation hormone biology receptors signal transduction cell signaling.

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大坝气幕隔震效果的数值模拟分析

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四川大学学报（工程科学版） 2005年第2期37卷 38-42页

作者：隆文非刘浩吾四川大学水电学院四川成都610065

为了探讨气幕的防震及隔震效果,针对水利工程中常采用的拱坝,对有无气幕的情况做了对比研究。为了评价气幕厚度和隔震效果的关系,对不同的气幕厚度,通过数值模拟分析,提出了气幕的适宜厚度。结果表明:坝前气幕厚度与动水压力、坝体位移... 详细信息

为了探讨气幕的防震及隔震效果,针对水利工程中常采用的拱坝,对有无气幕的情况做了对比研究。为了评价气幕厚度和隔震效果的关系,对不同的气幕厚度,通过数值模拟分析,提出了气幕的适宜厚度。结果表明:坝前气幕厚度与动水压力、坝体位移等有关。对于强烈震动情况,气幕在减轻大坝所承受的动水压力、从而抑制大坝发生较大位移的作用比较明显。因此,气幕技术在水利工程建设和大坝自身安全保障上有很好的推广前景。

关键词：气幕隔震气幕厚度拱坝动水压力

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Thermodynamic potential and phase diagram for multiferroic bismuth ferrite(BiFeO_(3))

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npj Computational Materials 2017年第1期3卷 284-293页

作者： Dmitry V.Karpinsky Eugene A.Eliseev fei Xue Maxim V.Silibin Alexandra Franz Maya D.Glinchuk Igor O.Troyanchuk Sergey A.Gavrilov Venkatraman Gopalan long-Qing Chen Anna N.Morozovska Scientific-Practical Materials Research Centre of NAS of Belarus P.Brovki str.19 Minsk 220072Belarus National Research University of Electronic Technology“MIET” Bld.1Shokin sq.ZelenogradMoscow 124498Russia Institute for Problems of Materials Science National Academy of Sciences of UkraineKrzhizhanovsky str.3 Kyiv 03680Ukraine Department of Materials Science and Engineering Pennsylvania State UniversityUniversity Park State CollegePA 16802USA Helmholtz Center Berlin Hahn-Meitner-Platz 1Berlin 14109Germany Institute of Physics National Academy of Sciences of Ukraine46pr.Nauky Kyiv 03028Ukraine

We construct a Landau-Ginzburg thermodynamic potential,and the corresponding phase diagram for pristine and slightly doped bismuth ferrite,a ferroelectric antiferromagnet at room *** potential is developed based on new X-ray and neutron diffraction experiments complementing available *** demonstrate that a strong biquadratic antiferrodistortive-type coupling is the key to a quantitative description of Bi_(1−x)La_(x)FeO_(3) multiferroic phase diagram including the temperature stability of the antiferromagnetic,ferroelectric,and antiferrodistortive phases,as well as for the prediction of novel intermediate structural ***,we show that“rotomagnetic”antiferrodistortive-antiferromagnetic coupling is very important to describe the ferroelectric polarization and antiferrodistortive tilt behavior in the R3c phase of BiFeO_(3).The Landau-Ginzburg thermodynamic potential is able to describe the sequence of serial and trigger-type phase transitions,the temperature-dependent behavior of the order parameters,and the corresponding susceptibilities to external *** can also be employed to predict the corresponding ferroelectric and antiferrodistortive properties of Bi_(1−x)La_(x)FeO_(3) thin films and nanoparticles by incorporating the gradient and surface energy terms that are strongly dependent on the shape,size,and preparation method.

关键词： ferrite ferroelectric diagram

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多单体强风暴影响下的一次强降水超级单体演变特征分析

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气象 2024年第8期50卷 966-980页

作者：陈磊王福侠尉英华花家嘉何丽华侯书勋中国气象局雄安大气边界层重点开放实验室河北雄安新区071800 河北省气象与生态环境重点实验室石家庄050021 河北省唐山市气象台唐山063000 河北省气象台石家庄050021 天津市气象台天津300074

利用天津多普勒天气雷达资料、常规探测资料、地面自动站资料、ERA5再分析资料和VDRAS数据等,对2017年6月19日发生在冀东地区由多单体强风暴引领下的一次罕见的强降水超级单体风暴进行分析,重点探讨了超级单体风暴的演变特征和维持机制... 详细信息

利用天津多普勒天气雷达资料、常规探测资料、地面自动站资料、ERA5再分析资料和VDRAS数据等,对2017年6月19日发生在冀东地区由多单体强风暴引领下的一次罕见的强降水超级单体风暴进行分析,重点探讨了超级单体风暴的演变特征和维持机制。结果表明,海风锋和多单体强风暴的阵风锋及其所围成的低层“舌”状高温、高湿区为超级单体风暴形成提供了较好的动力和热力条件,当对流单体移入“舌”区之后,快速发展为超级单体并一直沿着多单体强风暴的出流边界向东南方向移动。缓慢减弱的多单体强风暴所提供的相对“稳定”的阵风锋不仅为超级单体发展和维持提供了长时间的动力条件,而且还为其移动提供了引导作用,这对于强对流天气短时临近预警有很好的指示意义。在超级单体形成之初,受多单体强风暴冷池出流影响,近地面偏南风转为较强的偏东风,中尺度环境配置发生了明显改变,0~6 km垂直风切变增大到27 m·s^(-1)且0~3 km垂直风切变增大到17~19 m·s^(-1)是中气旋形成的主要原因;其次,辐合线上较强的垂直涡度平流也有利于中气旋形成和维持。此次超级单体中气旋始于低层,通过VDRAS数据得到的0~3 km低层垂直风切变始终维持在20 m·s^(-1)左右,斜压涡生作用明显,为超级单体的发展和维持提供了较大的、长时间的水平涡度输入。超级单体形成和发展成熟阶段,风暴相对螺旋度(SRH)在140~171 m^(2)·s^(-2),大部分时段在150 m^(2)·s^(-2)以上,而在超级单体形成之前和接近消散阶段,SRH明显小于150 m^(2)·s^(-2),表明SRH对于超级单体发生发展有较为明确的指示意义。此次过程冷池出流先于超级单体形成,使得入流区辐合抬升加强,有利于超级单体的发展和维持,另外超级单体中不断有单体从母暴中分裂并减弱东移,一定程度上削弱了超级单体的强烈发展,使得下沉出流不至于过强而造成阵风锋快速远离,冷池始终维持一定的强度,同时多单体强风暴的阵风锋又给超级单体提供了稳定的0~3 km的垂直风切变(始终维持在20 m·s^(-1)左右),造成了超级单体前端的风切变和冷池强度保持了长时间的平衡,最终使超级单体长时间维持“稳定态”。综上所述,中尺度环境提供的适当垂直风切变等与风暴发展保持平衡是超级单体长时间维持自组织状态的主要原因。

关键词：超级单体中气旋阵风锋垂直风切变

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Does a low solar cycle minimum hint at a weak upcoming cycle?

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Research in Astronomy and Astrophysics 2010年第10期10卷 950-955页

作者： Zhan-Le Du hua-Ning Wang Key Laboratory of Solar Activity National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China

The maximum amplitude （Rm） of a solar cycle, in the term of mean sunspot numbers, is well-known to be positively correlated with the preceding minimum （Rmin）. So far as the long term trend is concerned, a low level of Rmin tends to be followed by a weak Rm, and vice versa. We found that the evidence is insufficient to infer a very weak Cycle 24 from the very low Rmin in the preceding cycle. This is concluded by analyzing the correlation in the temporal variations of parameters for two successive cycles.

关键词： Sun activity -- Sun general -- sunspots

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