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Communicat.ons in Computat.onal Physics 2008年第8期4卷 611-623页

作者： V.I.Sotnikov V.V.Ivanov R.Presura J.N.Leboeuf o.G.onishchenko B.V.oliver B.Jones t.A.Mehlhorn C.Deeney University of Nevada at Reno NV 89523USA JNL Scientific Casa GrandeAZ 85222USA Institute of Physics of Earth 123995MoscowRussia Sandia Nat.onal Laboratories NM 87123USA Department.of Energy WashingtonDC 20585USA

Flute mode turbulence plays an important role in numerous applicat.ons,such as tokamak,Z-pinch,space and ast.ophysical *** a low beta plasma flute oscillat.ons are elect.ostatic and in the nonlinear stage they produce large scale density structures co-mingling with short scale *** scale structures are responsible for the enhanced transport across the magnetic field and appearance of short scales leads to ion heating,associated with the ion *** the present paper nonlinear equat.ons which describe the nonlinear evolut.on of the flute modes treated as compressible elect.omagnetic oscillat.ons in a finite beta inhomogeneous plasma with nonuniform magnetic field are derived and solved *** this purpose the 2D numerical code FLUtE was *** results show that even in a finite beta plasma flute mode instability can develop along with format.on of large scale structures co-existing with short scale perturbat.ons in the nonlinear stage.

关键词： Flute instability plasma turbulence nonlinear cascades

基于区间二型t-S模糊模型的网络控制系统的输出反馈预测控制

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自动化学报 2019年第3期45卷 604-616页

作者：唐晓铭邓梨虞继敏屈洪春重庆邮电大学自动化学院工业物联网协同创新中心重庆400065 重庆邮电大学工业物联网与网络化控制教育部重点实验室重庆400065

针对干扰作用下的非线性网络控制系统,给出了带一个自由控制作用的输出反馈预测控制方法.首先,利用区间二型t-S模糊模型描述具有参数不确定性的非线性对象,采用马尔科夫链描述系统中的随机丢包过程,由此建立了丢包网络环境下的非线性网... 详细信息

针对干扰作用下的非线性网络控制系统,给出了带一个自由控制作用的输出反馈预测控制方法.首先,利用区间二型t-S模糊模型描述具有参数不确定性的非线性对象,采用马尔科夫链描述系统中的随机丢包过程,由此建立了丢包网络环境下的非线性网络控制系统的数学模型.然后,通过引入二次有界技术得到了干扰作用下网络控制系统的稳定性描述方法,并在此基础上给出了状态观测器的线性矩阵不等式条件.最后,基于估计状态,通过将无穷时域控制作用参数化为一个自由控制作用加一个线性反馈律得到了输出反馈预测控制方法.论文的特色在于构建了在线更新误差椭圆集合的基本方法,满足了约束条件下输出反馈预测控制保证稳定性的要求.仿真例子验证了所提方法的有效性.

关键词：网络控制系统预测控制区间二型二次有界

Comparison of acute pneumonia caused by SARS-CoV-2 and other respiratory viruses in children:a ret.ospective multi-center cohort study during CoVID-19 outbreak

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Military Medical Research 2021年第4期8卷 468-480页

作者： Guang-Li Ren Xian-Feng Wang Jun Xu Jun Li Qiong Meng Guo-Qiang Xie Bo Huang Wei-chun Zhu Jing Lin Cheng-He tang Sheng Ye Zhuo Li Jie Zhu Zhen tang Ming-Xin Ma Cong Xie Ying-Wen Wu Chen-Xi Liu Fang Yang Yu-Zong Zhou Ying Zheng Shu-Ling Lan Jian-Feng Chen Feng Ye Yu He BenQing Wu long Chen Si-Mao Fu Cheng-Zhong Zheng Yuan Shi Department.of Pediatrics General Hospital of Southern Theater Command of PLA111 Liuhua RoadYuexiu DistrictGuangzhou 510010GuangdongChina. Department.of Pediatrics the Third People’s Hospital of ShenzhenShenzhen 518100GuangdongChina. Pediatric Intensive Care Unit Wuhan Children’s HospitalTongji Medical CollegeHuazhong University of Science&TechnologyWuhan 430010China. Pediatric Intensive Care Unit Maternal and Child Health Hospital of HuangshiHuangshi 435000HubeiChina. Department.of Pediatrics the Second People’s Hospital of Guangdong ProvinceGuangzhou 510317China. Department.of Pediatrics the Third Affiliated Hospital of Zunyi Medical University(the First People’s Hospital of Zunyi)Guizhou 563000China. Department.of Pediatrics the Eighth People’s Hospital of GuangzhouGuangzhou 510440China. Department.of Pediatrics the First Affiliated Hospital of Xinxiang Medical UniversityXinxiang 453100HenanChina. Pediatric Intensive Care Unit the Children’s Hospital Zhejiang University School of MedicineHangzhou 310000China. Department.of Emergency/Critical Medicine Children’s Hospital of Nanjing Medical UniversityNanjing 210008China. Department.of Pediatrics the Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510260China. Department.of Medical informat.on date room General Hospital of Southern Theater Command of PLAGuangzhou 510010China. Department.of Pediatrics the First Affiliated Hospital of Jinan UniversityGuangzhou 510632China. Department.of Pediatrics Maternal and Child Health Hospital of YangjiangYangjiang 529500GuangdongChina. Department.of Pediatrics Shenzhen Hospital Affiliated to the University of Chinese Academy of SciencesShenzhen 518107GuangdongChina. Department.of Pediatrics Nanfang Hospital of Southern Medical UniversityGuangzhou 510515China. Department.of Pediatrics Zhujiang Hospital of Southern Medical UniversityGuangzhou 510280China. Department.of Pediatrics Military Hospital of 74 Group of PLAGuangzhou 510318China. Department.of Neonatology

Background:Until January 18,2021,coronavirus disease-2019(CoVID-19)has infected more than 93 million individuals and has caused a certain degree of *** pneumonia caused by common viruses such as respiratory syncytial virus,rhinovirus,human metapneumovirus,human bocavirus,and parainfluenza viruses have been more common in ***,the incidence of CoVID-19 in children was significantly lower than that in *** purpose of this study was to describe the clinical manifestat.ons,treatment and out.omes of CoVID-19 in children compared with t.ose of other sources of viral pneumonia diagnosed during the CoVID-19 ***:Children with CoVID-19 and viral pneumonia admitted to 20 hospitals were enrolled in this ret.ospective multi-center cohort study.A total of 64 children with CoVID-19 were defined as the CoVID-19 cohort.of which 40 children who developed pneumonia were defined as the CoVID-19 pneumonia *** 284 children with pneumonia caused by other viruses were defined as the viral pneumonia *** epidemiologic,clinical,and laboratory findings were compared by Kolmogorov-Smirnov test,t-test,Mann-Whitney U test and Contingency table *** usage,immunotherapy,blood transfusion,and need for oxygen support were collected as the treatment ***,intensive care needs and symptomatic durat.on were collected as the out.ome ***:Compared with the viral pneumonia cohort,children in the CoVID-19 cohort were mostly exposed to family members confirmed to have CoVID-19(53/64 vs.23/284),were of older median age(6.3 years vs.3.2 years),and had a higher proport.on of ground-glass opacity(GGo)on computed tomography(18/40 vs.0/38,Pthe CoVID-19 pneumonia cohort had a lower proport.on of severe cases(1/40 vs.38/284,P=0.048),and lower cases with high fever(3/40 vs.167/284,Ptensive care(1/40 vs.32/284,Pth shorter symptomatic durat.on(median 5d vs.8d,Pthe propor

关键词： Children Severe acute respiratory syndrome Coronavirus disease-2019 Viral pneumonia

Quantal studies of sodium 3p ← 3s photoabsorpt.on spectra perturbed by ground lithium atoms

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Chinese Physics B 2019年第6期28卷 146-154页

作者： N Lamoudi F talbi M t Bouazza M Bouledroua K Alioua Badji Mokhtar University B.P.12 AnnabaAlgeria Laboratoire LESIMS Laboratoire de Physique des Rayonnements Laboratoire LAMA Souk-Ahras University Souk-Ahras 41000Algeria

the pressure broadening in the far wings, where the sodium Na(3 p ← 3 s) resonance line is perturbed by ground lithium Li(2 s) atoms, has been theoretically analyzed. the NaLi potential–energy curves and the transit.on dipole moments are constructed by using a reliable ab init.o data points to carry out the reduced-absorpt.on coefficients k_r(ν, t). this quantum-mechanical investigat.on have demonstrated that the NaLi profile spectra show a satellite future in the red wing at wavelength λ = 685 nm in the temperature range 4000 K–1.8 × 10~4 K. the computat.on could also exhibit a second satellite, in the blue wing, near the wavelength λ = 574 nm beyond 6000 K and a third peak located at λ = 490 nm which begins to appear at 1.8 × 10~4 K.

关键词： pressure broadening absorpt.on coefficient satellite structure radiative lifetime

Performance evaluat.on of nickel as anode catalyst for DMFC in acidic and alkaline medium

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燃料化学学报 2018年第5期46卷 592-599页

作者： Sunitha.M Durgadevi.N Asha Sathish Ramachandran.t Department.of Sciences Amrita School of Engineering Amrita Vishwa Vidyapeetham Coimbatore 641112 India

Direct methanol fuel cell(DMFC)research is highly focused due to its high energy density,portability and *** the present study convent.onal platinum catalyst used for methanol oxidat.on is being replaced with nickel catalyst supported over nickel *** elect.ode is synthesized by single step elect.o deposit.on *** elect.ode was characterized by SEM,EDAX and AFM techniques to know the surface morphology,composit.on and thickness of the catalyst *** elect.o catalytic behavior of the nickel for methanol oxidat.on was evaluated using cyclic voltammetry *** the DMFC is compatible with both the acidic and alkaline elect.olytes the working of the nickel mesh elect.ode is analyzed in both *** results showed maximum current density of 0.025 and 0.030 A/cm2 in alkaline and acidic medium respectively with less potential around 0.4 and 0.2 *** other parameters such as varying the concentrat.on of methanol,elect.olyte medium,scan rate and thickness of the catalytic layer were analyzed and optimized.

关键词： direct methanol fuel cell elect.o oxidat.on catalytic activity elect.olyte medium

人工智能和放射科医生对乳腺X线筛查的全民评估

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国际医学放射学杂志 2024年第4期 503-503页

作者： J.Kühl M.t.Elhakim S.W.Stougaard B.S.B.Rasmussen M.Nielsen o.Gerke 高佳音

摘要目的基于对筛查区域内全部适宜人群的乳腺X线摄影，比较初诊乳腺放射科医生和人工智能（AI）在乳腺癌检测方面的价值。方法纳入2014年8月4日—2018年8

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Construct.on and Characterizat.on of Lentiviral shRNA Expression Vector targeting Rat CD40 Gene in Dendritic Cells

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Chemical Research in Chinese Universities 2009年第5期25卷 666-672页

作者： SUN Mei LI Jin-dong JIANG Rui JIN Cheng-yan GAo Nan LUo Shu-li WANG chun-guang WANG Bin WANG Rong-you ZHANG Xing-yi Department.of Pat.ology Second Hospital of Jilin University Changehun 130041 P. R. China Department.of t.oracic Surgery Second Hospital of Jilin University Changehun 130041 P. R. China Department.of ort.opedic Surgery China-Japan Union Hospital of Jilin University Changchun 130033 P. R. China Department.of t.oracic Surgery China-Japan Union Hospital of Jilin University Changchun 130033 P. R. China

to construct a lentiviral shRNA vector targeting rat CD40 gene and detect its effectiveness of gene silencing in dendritic cells（DCs）, specific siRNA targets with short hairpin frame were designed and synthesized according to the mRNA sequence of rat CD40 gene. DNA oligo was cloned into lentiviral expression vector, and then PCR and sequencing analyses were conducted to verify the constructs. the verified plasmids were transfected into 293t cells that.over-express recombinant CD40 in order to select the most effective siRNA targets, shRNA lentiviruses from the selected constructs were propagated and harvested with a virus packaging system, and the virus titers were determined. Western blot and Real-time PCR were performed to determine CD40 expression level in the virusinfected dendritic cells. PCR and sequencing analyses reveal that shRNA plasmids of four targets were successfully constructed. the optimal interfering target was selected, and the virus with a titer of 5 × 10^7 tU/mL was successfully packaged. CD40 expression in rat DCs was knockdown at both mRNA and protein levels by virus infect.on. In comparison to that.of cont.ol groups, CD40 mRNA expression and protein expression were decreased by 60.9% and 61.2%, respectively. We have successfully constructed recombinant lentiviral shRNA expression vector targeting rat CD40 gene that can effectively down-regulate CD40 gene expression at mRNA and protein levels in rat DC.

关键词： CD40 RNA interference Lentivirus Dendritic cell

Delet.ons in the genomes of fifteen inbred mouse lines and their possible implicat.ons for fat accumulat.on

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2007年第11期8卷 777-781页

作者： SCHMItt Armin o. DEMPFLE Astrid BRoCKMANN Gudrun A. Institute for Animal Sciences Humboldt-Universitt zu Berlin Invalidenstraβe 42 10115 Berlin Germany Institute for Medical Biometry and Epidemiology Phillips-Universitt Marburg Bunsenstraβe 3 35037 Marburg Germany

Copy number variants (CNVs) are pieces of genomic DNA of 1000 base pairs or longer which occur in a given genome at a different frequency than in a reference genome. their importance as a source for phenotypic variability has been recognized only in the last couple of years. Chromosomal delet.ons can be seen as a special case of CNVs where stretches of DNA are missing in certain lines when compared to the reference genome of the mouse line C57BL/6, for example. Based upon more than 8 million single nucleotide polymorphisms (SNPs) in the fifteen inbred mouse lines which were determined in a whole genome chip based resequencing project by Perlegen Sciences, we detected 20166 such long chromosomal delet.ons. they cover altogether between 4.4 million and 8.8 million base pairs, depending on the mouse line. thus, their extent is comparable to that.of SNPs. the chromosomal delet.ons were found by searching for clusters of missing values in the genotyping data by applying bioinformatics and biostatistical met.ods. In contrast to isolated missing values, clusters are likely the consequence of missing DNA probe rather than of a failed hybridizat.on or deficient.oligos. We analyzed these delet.on sites in various ways. twenty-t.o percent.of these delet.on sites overlap with exons; they could therefore affect a gene's funct.oning. the corresponding genes seem to exist in alternative forms, a phenomenon that reminds of the alternative forms of mRNA generated during gene splicing. We furthermore detected statistically significant associat.on between hundreds of delet.on sites and fat weight at the age of eight weeks.

关键词： Copy number variants (CNVs) Chromosomal delet.ons Single nucleotide polymorphisms (SNPs) Resequencing Cluster analysis Associat.on between genotype and phenotype

CD8^+CD45RC^low调节性t细胞在大鼠肝移植自然免疫耐受中的作用机制

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中华实验外科杂志 2019年第5期36卷 849-851页

作者：白纯李先亮杨龙刘焕业寇建涛朱继巧马军吕少诚贺强首都医科大学北京100069 首都医科大学附属北京朝阳医院肝胆胰脾外科 100020

目的探讨CD8^+CD45RC^low的调节性t细胞及相关细胞因子在大鼠同种异体原位肝移植耐受过程中的分布规律。方法近交系BN大鼠为供体,雄性Lewis大鼠为受体,双套袖法同种异体原位肝脏移植。实验分为:肝移植短期组10只,肝移植耐受组10只和对照... 详细信息

目的探讨CD8^+CD45RC^low的调节性t细胞及相关细胞因子在大鼠同种异体原位肝移植耐受过程中的分布规律。方法近交系BN大鼠为供体,雄性Lewis大鼠为受体,双套袖法同种异体原位肝脏移植。实验分为:肝移植短期组10只,肝移植耐受组10只和对照组6只,各组术后常规检测肝功能。苏木精-伊红(HE)染色用于判定移植物达到自然免疫耐受。流式细胞术分析外周血、移植物、淋巴结中淋巴细胞亚群的变化,Luminex技术进行细胞因子定量检测。结果有70%的移植术后大鼠自然免疫耐受。长期耐受组与对照组的谷草转氨酶(ASt)、谷丙转氨酶(ALt)比较,差异无统计学意义[(456±54)U/ml比(460±151)U/ml,(122±35)U/ml比(121±46)U/ml,P>0.05]。与早期移植实验组比较,在免疫耐受大鼠外周血中CD8+CD45RClowt细胞显著增加,移肝脏局部随着耐受时间的延长其相对含量不断增加;移植物周围淋巴结中该类细胞的表达差异无统计学意义(P>0.05);外周血中pDC在与对照组比较短期组明显增加。移植物局部细胞因子检测发现干扰素(IFN)-γ在早期升高,随后恢复到正常水平;白细胞介素(IL)-10出现持续升高的表现。结论在大鼠同种异体原位肝移植免疫耐受过程中,CD8^+CD45RC^low调节性t细胞显著升高,并在外周血和肝脏中高表达,通过提高抑制性的细胞因子IL-10对长期免疫耐受起重要调节作用。

关键词：调节性t细胞大鼠肝移植免疫耐受白细胞介素-10 树突状细胞

Format.on of St Plasmas by ECH on LAtE

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Plasma Science and technology 2004年第4期6卷 2364-2366页

作者： M.Uchida t.Maekawa H.tanaka H.Igami t.Yoshinaga K.Katsuura M.Konno Kyoto University Kita shirakawa Oiwake-choKyoto 606-8502JapanKyoto UniversityKita shirakawa Oiwake-choKyoto 606-8502JapanKyoto UniversityKita shirakawa Oiwake-choKyoto 606-8502JapanKyoto UniversityKita shirakawa Oiwake-choKyoto 606-8502JapanKyoto UniversityKita shirakawa Oiwake-choKyoto 606-8502JapanKyoto UniversityKita shirakawa Oiwake-choKyoto 606-8502JapanKyoto UniversityKita shirakawa Oiwake-choKyoto 606-8502Japan

Experiments on format.on of spherical tokamak (St) plasmas by elect.oncyclot.on heating (ECH) alone wit.out a central oH solenoid have been carried out.on LAtE (LowAspect rat.o torus Experiments). By injecting a 2.45 GHz microwave pulse of 6.3 kW for 4 seconds, aplasma current is initiated and ramped up to I_p approx= 3 kA, and finally maintained for 1 secondby adjusting the external vertical field. Magnetic measurements show that closed flux surfaces areformed and the last closed flux surface has an aspect rat.o of A ～ 1.3 and an elongat.on of κ～1.3. the elect.on density measured by an interferometer is more than 1.5 x 10^(11) cm^(-3) whichexceeds twice of the plasma cut.off density, suggesting that elect.on cyclot.on heating bymode-converted elect.on Bernstein waves may take place.

关键词： spherical tokamak non-inductive start-up elect.on cyclot.on heating