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The prediction antidepressant effects of Chai-Hu-Jia-long-gu-Mu-Li decoction by Arrowsmith tool

Drug Combination Therapy 2020年第3期2卷 114-125页

作者： Xi-Wei Yang Ya-long Yu De-Su Yang Chao-Gang Gan Yi-Jian Yang Yunnan University of Traditional Chinese Medicine Kunming 650500China First Affilated Hospital of Yunnan University of TraditioricChinese Medicine/Yunnan Provincial Hospital of Traditional Chinese Medicine Kunming 650021China

Background:To explore the modern pharmacological mechanism of classic ancient prescription of Chinese medicine Chai-Hu-Jia-long-gu-Mu-Li decoction and single drug in classic ancient prescription of Chinese medicine Chai-Hu-Jia-long-gu-Mu-Li decoction on antidepressant from the theoretical ***:The literature related search tool Arrowsmith was used with the help of Cytoscape drawing software,the relationship between classic ancient prescription of Chinese medicine Chai-Hu-Jia-long-gu-Mu-Li decoction and the antidepressant mechanism was ***:Different single drugs in classic ancient prescription of Chinese medicine Chai-Hu-Jia-long-gu-Mu-Li decoction may play an antidepressant effect by regulatingβ-catenin,toll-like receptor 4,brain-derived neurotrophic factor,caspase-3,γ-aminobutyric acid A receptor,MAPK,Akt,ERK,AMPK,Wnt,STAT3,CREB,NMDA,iNOS,PKA,matrix metalloproteinase-9,IL-10,ApoE,P38 MAPK,MMP-2,AMPA,PPARγ,TNFα,NF-κB,TGF,CaMKII and *** key antidepressant site is in the ***:The antidepressant effect of classic ancient prescription of Chinese medicine Chai-Hu-Jia-long-gu-Mu-Li decoction reflects the action characteristics of multi-components,multi-targets,and multi-pathways of traditional Chinese *** the search and analysis by Arrowsmith tools,it provides a scientific basis for in-depth interpretation of the antidepressant mechanism and provides research direction and ideas for the research of traditional Chinese medicine compound prescription.

关键词： Traditional Chinese medicine Chai-Hu-Jia-long-gu-Mu-Li decoction Depression Arrowsmith Mechanism

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面向LBE流动换热的SST k-ω-k_(θ)-ε_(θ)四参数模型构建与验证

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核动力工程 2025年第1期46卷 100-106页

作者：吴杰苏兴康蔡杰进巩子琦顾龙华南理工大学电力学院广州510640 兰州大学核科学与技术学院兰州730000

为解决极低普朗特数流体的数值传热计算问题,提高液态铅铋合金(LBE)流动换热数值计算精度,在OpenFOAM框架下,构建了雷诺应力和湍流热通量的SST k-ω-k_(θ)-ε_(θ)四参数模型。使用四参数模型在垂直管内和带绕丝格架19棒束LBE流动换热... 详细信息

为解决极低普朗特数流体的数值传热计算问题,提高液态铅铋合金(LBE)流动换热数值计算精度,在OpenFOAM框架下,构建了雷诺应力和湍流热通量的SST k-ω-k_(θ)-ε_(θ)四参数模型。使用四参数模型在垂直管内和带绕丝格架19棒束LBE流动换热基准实验的基础上,结合相应的努塞尔数与摩擦因子经验关联式,进行了与湍流普朗特数(Pr_t)模型的对比验证和传热分析。结果表明,SST k-ω-k_(θ)-ε_(θ)四参数模型所预测的温度与实验数据吻合较好,对传热的预测性能优于Pr_t模型,适用于LBE流动换热数值计算。

关键词：四参数模型 OpenFOAM 铅铋合金(LBE) 流动换热

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Latest research progress for LBE coolant reactor of China initiative accelerator driven system project

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Frontiers in Energy 2021年第4期15卷 810-831页

作者： long gu Xingkang SU Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China

China’s accelerator driven subcritical system(ADS)development has made significant progress during the past *** the successful construction and operation of the international prototype of ADS superconducting proton linac,the lead-based critical/subcritical zero-power facility VENUS-II and the comprehensive thermal-hydraulic and material test facilities for LBE(lead bismuth eutectic)coolant,China is playing a pivotal role in advanced steady-state operations toward the next step,the ADS *** China initiative Accelerator Driven System(CiADS)is the next facility for China’s ADS program,aimed to bridge the gaps between the ADS experiment and the LBE cooled subcritical *** total power of the CiADS will reach 10 *** CiADS engineering design was approved by Chinese government in *** then,the CiADS project has been fully transferred to the construction application *** subcritical reactor is an important part of the whole CiADS ***,a pool-type LBE cooled fast reactor is chosen as the subcritical reactor of the *** and thermal experiments and software development for LBE coolant were conducted simultaneously to support the design and construction of the CiADS LBEcooled subcritical ***,it is necessary to introduce the efforts made in China in the LBE-cooled fast reactor to provide certain supporting data and reference solutions for further design and development for ***,the roadmap of China’s ADS,the development process of the CiADS,the important design of the current CiADS subcritical reactor,and the efforts to build the LBE-cooled fast reactor are presented.

关键词： LBE(lead bismuth eutectic)coolant reactor China initiative Accelerator Driven System(CiADS)project research progress

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Itinerant Topological Magnons in SU (2) Symmetric Topological Hubbard Models with Nearly Flat Electronic Bands

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Chinese Physics Letters 2021年第5期38卷 132-136页

作者： Zhao-long gu Jian-Xin Li National Laboratory of Solid State Microstructures and Department of Physics Nanjing UniversityNanjing 210093China Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210093China

We show that a suitable combination of flat-band ferromagnetism,geometry and nontrivial electronic band topology can give rise to itinerant topological *** SU(2) symmetric topological Hubbard model with nearly flat electronic bands,on a Kagome lattice,is considered as the *** model exhibits ferromagnetic order when the lowest electronic band is *** the numerical exact diagonalization method with a projection onto this nearly flat band,we can obtain the magnonic *** the flat-band limit,the spectra exhibit distinct dispersions with Dirac points,similar to those of free electrons with isotropic hoppings,or a local spin magnet with pure ferromagnetic Heisenberg exchanges on the same ***,the non-flatness of the electronic band may induce a topological gap at the Dirac points,leading to a magnonic band with a nonzero Chern *** intriguingly,this magnonic Chern number changes its sign when the topological index of the electronic band is reversed,suggesting that the nontrivial topology of the magnonic band is related to its underlying electronic *** work suggests interesting directions for the further exploration of,and searches for,itinerant topological magnons.

关键词： Itinerant Topological Magnons in SU Symmetric Topological Hubbard Models with Nearly Flat Electronic Bands

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Cluster dynamics modeling of niobium and titanium carbide precipitates inα-Fe andγ-Fe

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Chinese Physics B 2022年第2期31卷 509-515页

作者： Nadezda Korepanova long gu Mihai Dima Hushan Xu Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 101408China Institute for Physics and Nuclear Engineering Bucharest 077125Romania School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China Paul Scherrer Institute Villigen 5232Switzerland

Kinetic behaviors of niobium and titanium carbide precipitates in iron are simulated with cluster *** simulations,carried out in austenite and ferrite for niobium carbides,and in austenite for titanium carbide,are analyzed for dependences on temperature,solute concentration,and initial cluster *** results are presented for different temperatures and solute concentrations,compared to experimental data *** show little impact of initial cluster distribution beyond a certain relaxation time and that highly dilute alloys with monomers only present a significantly different behavior from denser alloys or ones with different initial cluster distributions.

关键词： cluster dynamics precipitates precipitation kinetics carbides

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Synthesis and characterization of biodegradable thermoplastic elastomers derived from N.N-bis （2-carboxyethyl）-pyromellitimide, poly（butylene succinate） and polyethylene glycol

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Frontiers of Chemical Science and Engineering 2018年第3期12卷 457-466页

作者： Jiaojiao Shang guo Yao Ronghui guo Wei Zheng long gu Jianwu Lan College of Light Industry and Textile and Food Engineering Sichuan University Chengdu 610065 China

Abstract Biodegradable poly（ether-imide-ester） elasto- mers were synthesized from succinic acid, 1,4-butanediol, polyethylene glycol 1000 and N＇,N-bis（2-carboxyethyl）- pyromellitimide which was derived from pyromellitic dianhydride and glycine. The chemical structures, crystal- linities, thermal stabilities, mechanical properties, hydro- philicities and biodegradabilities of these elastomers were investigated. The hard segments of the linear aliphatic poly （ether-ester） exhibited monoclinic chain packing. Increas- ing the amount of aromatic bisimide moieties in the poly （ether-ester） reduced the crystallinity of the material and improved the thermal stability and tensile strength of the elastomers. In addition, introducing a suitable amount of aromatic bisimide moieties into the poly（ether-ester） backbones endowed the elastomers with improved biode- gradability but too many aromatic bisimide groups reduced the biodegradability of the elastomers.

关键词： thermoplastic elastomers biodegradability thermo-stability mechanical property aromatic bisimide moiety

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Echinacoside Alleviates Cognitive Impairment in Cerebral Ischemia Rats through α7nAChR-Induced Autophagy

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Chinese Journal of Integrative Medicine 2022年第9期28卷 809-816页

作者： DING Ling YE Hong gu long-dian DU An-qing YUAN Xin-lu Department of Endocrinology and Metabolic Diseases Shanghai Pudong HospitalFudan University Pudong Medical CenterShanghai201399China

Objectives:To evaluate the effect of echinacoside(ECH)on cognitive dysfunction in post cerebral stroke model ***:The post stroke cognitive impairment rat model was created by occlusion of the transient middle cerebral artery(MCAO).The rats were randomly divided into 3 groups by a random number table:the sham group(sham operation),the MCAO group(received operation for focal cerebral ischemia),and the ECH group(received operation for focal cerebral ischemia and ECH50 mg/kg per day),with 6 rats in each group,The infarct volume and spatial learning were evaluated by triphenyl tetrazolium chloride staining and Morris water *** expression of α7 nAChR in the hippocampus was detected by *** contents of acetylcholine(ACh),malondialdehyde(MDA),glutathione(GSH),superoxide dismutase(SOD),activities of choline acetyltransferase(ChAT),acetylcholinesterase(AChE),and catalase(CAT)were evaluated by enzyme linked immunosorbent *** neural apoptosis and autophagy were determined by TUNEL staining and LC3 staining,***:ECH significantly lessened the brain infarct volume and ameliorated neurological deficit in infarct volume and water content(both Plong retention time at 7,14 and 28 days(all P<0.01),increased the α7 nAChR protein expression,ACh content,and ChAT activity,and decreased AChE activity in MCAO rats(all P<0.01).ECH significantly decreased MDA content and increased the GSH content,SOD,and CAT activities compared with MCAO rats(all P<0.05).ECH suppressed neuronal apoptosis by reducing TUNEL-positive cells and also enhanced autophagy in MCAO rats(all P<0.01).Conclusion:ECH treatment helped improve cognitive impairment by attenuating neurological damage and enhancing autophagy in MCAO rats.

关键词： cerebral ischemia cognitive impairment autophagy echinacoside cholinergic activity

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A morphology screen coding anti-counterfeiting method based on visual characteristics

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Optoelectronics Letters 2008年第5期4卷 371-374页

作者： ZHAO Li-long gu Ze-cang FANG Zhi-liang Institute of Modern Optics Nankai University the Key Laboratory for Optoelectronic Information Science and Technology of MOE Tianjin 300071 China

A paper information anti-fake and tamper-proofing method based on human visual characteristics and morphol-ogy screen coding technology is proposed. Through controlling the distribution of mathematical morphology of screen dot-matrix,warning mark and information are hidden in the background texture. Because of the differ-ences between human vision and the duplicate characteristics of copy machine,warning mark which can not be discriminated by human eyes will emerge after copy. Tampered or fake certificates can be verified by compar-ing embedded information which is extracted from scanned image of certificate with plain text printed on the certificate. This method is applied in many bills and certificates. Experimental results show that the identifica-tion accuracy is above 98%

关键词：形态学视觉安全性复制

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Fabric-Based Triboelectric Nanogenerators

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Research 2019年第1期2019卷 123-135页

作者： Jinmei Liu long gu Nuanyang Cui Qi Xu Yong Qin Rusen Yang School of Advanced Materials and Nanotechnology Xidian UniversityXi’an 710071China Institute of Nanoscience and Nanotechnology Lanzhou UniversityLanzhou 730000China

In the past decades,the progress of wearable and portable electronics is quite rapid,but the power supply has been a great challenge for their practical *** power sources,especially wearable energy-harvesting devices,provide some possible solutions for this *** various wearable energy harvesters,the high-performance fabric-based triboelectric nanogenerators(TENGs)are particularly *** this review paper,we first introduce the fundamentals of TENGs and their four basic working ***,we will discuss the material synthesis,device design,and fabrication of fabric-based ***,we try to give some problems that need to be solved for the further development of TENGs.

关键词： synthesis wear harvesting

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Significant impact of deprotonated status on the photoisomerization dynamics of bacteriophytochrome chromophore

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Chinese Chemical Letters 2023年第7期34卷 428-433页

作者： Haiyi Huang Chao Xu Kunni Lin Jiawei Peng Feng long gu Zhenggang Lan School of Chemistry South China Normal UniversityGuangzhou 510006China MOE Key Laboratory of Environmental Theoretical Chemistry South China Normal UniversityGuangzhou 510006China SCNU Environmental Research Institute Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental SafetySchool of EnvironmentSouthChinaNormal UniversityGuangzhou510006China

We report that the photoinduced dynamics of the phytochrome chromophore is strongly dependent on the protonation/deprotonation states of the pyrrole ring. The on-the-fly surface hopping dynamics simulations were performed to study the photoisomerization of different protonation/deprotonation phytochrome chromophore models. The simulation results indicate that the deprotonations at the pyrrole rings significantly modify the photoinduced nonadiabatic dynamics, leading to distinctive population decay dynamics and different reaction channels. Such feature can be well explained by the formation of the different hydrogen bond network patterns. Therefore, the proper understanding of the photoisomerization mechanism of phytochrome chromophore must take the hydrogen bond network into account. This work provides the new insights into the photobiological functions of phytochrome chromophore and suggests the possible ideas to control of its photoconversion processes for further rational engineering in optical applications.

关键词： Photochemistry Photoreceptors Excited states Non-adiabatic dynamics Conical intersection

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