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Molecular dynamics study of hydrogen-induced cracking behavior of ferrite–pearlite gas transmission pipeline steel

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Journal of Iron and Steel Research International 2024年第2期31卷 488-500页

作者： tao-long Xu Si-han Guo Gong-zhen He Hao-yu Han Petroleum Engineering School Southwest Petroleum UniversityChengdu610500SichuanChina Sichuan East Gas Transmission Sales Center of Sinopec Natural Gas Branch Wuhan430074HubeiChina

Hydrogen embrittlement of pipelines depends on the hydrogen-induced cracking behavior of the pipeline steel *** on molecular dynamics analysis,the ferrite–cementite(α-Fe/Fe3C)lamellar atomic structure with the Bagaryatskii orientation relationship was established,and stepwise relaxation of the conjugate gradient energy minimization and constant-temperature and constant-pressure relaxation were performed under NPT(the isothermal–isobaric)*** mechanical property curves of theα-Fe/Fe3C models were obtained under different cementite terminal plane structures,and the evolution of the atomic structure was analyzed in *** addition,the influence of different hydrogen concentrations,different temperatures,different strain rates,changes in voids,and different micro-degrees of freedom on the deformation and failure mechanism of the model was investigated,aiming to provide a reliable way to explore the micro-mechanism of macro-cracking behavior of pipeline steel.

关键词： Ferrite-cementite lamellar structure Pipeline steel Failure mechanism Crack propagation Molecular dynamics

Electrochemical Analysis of Single Glucose Oxidase with a Nanopipette

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Chemical Research in Chinese Universities 2024年第2期40卷 272-278页

作者： WANG Yongyong MA Hui long Yi-tao YING Yi-Lun School of Chemistry and Chemical Engineering Molecular Sensing and Imaging Center(MSIC)Nanjing UniversityNanjing210023P.R.China

Nanopore-based electrochemical technique is a promising tool for detecting single ***,detecting single proteins using a nanopipette in their native state without labeling is challenging due to the rapid translocation,which results in an inefficient signal *** our study,we finely tuned the driving force equilibrium between electrophoretic force(EPF)and electroosmotic flow(EOF)inside the nanopipette for efficient sensing of single glucose oxidase(GOD)*** duration time of GOD within the nanopipette is extended to about 4 *** strategy provided clear ionic current signals with a signal-to-noise ratio of *** EPF increased in the direction opposite to the motion of GOD,we observed a nonlinear growth in GOD’s duration *** extended the duration to about 4.4 times longer at−1000 mV compared to at−800 ***,nanopore-based electrochemical sensing could be used for single GOD molecule analysis as an ultrasensitive method.

关键词： Nanopore Single-molecule analysis Glucose oxidase Electrophoretic force Electroosmotic flow

Elimination of methicillin‑resistant Staphylococcus aureus biofilms on titanium implants via photothermally‑triggered nitric oxide and immunotherapy for enhanced osseointegration

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Military Medical Research 2024年第2期11卷 157-179页

作者： Yong‑Lin Yu Jun‑Jie Wu Chuan‑Chuan Lin Xian Qin Franklin R.Tay Li Miao Bai‑long tao Yang Jiao Department of Pathology Affiliated Hospital of Zunyi Medical UniversityZunyi 563003GuizhouChina Laboratory Research Center the First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Blood Transfusion Laboratory of Radiation Biologythe Second Affiliated HospitalArmy Military Medical UniversityChongqing 400037China Department of Reproductive Endocrinology Chongqing Health Center for Women and ChildrenChongqing 401147China The Graduate School Augusta UniversityAugustaGA 30912USA Department of Stomatology the Seventh Medical Center of PLA General HospitalBeijing 100700China

Background:Treatment of methicillin-resistant Staphylococcus aureus(MRSA)biofilm infections in implant placement surgery is limited by the lack of antimicrobial activity of titanium(Ti)*** is a need to explore more effective approaches for the treatment of MRSA biofilm ***:Herein,an interfacial functionalization strategy is proposed by the integration of mesoporous polydopamine nanoparticles(PDA),nitric oxide(NO)release donor sodium nitroprusside(SNP)and osteogenic growth peptide(OGP)onto Ti implants,denoted as Ti-PDA@*** physical and chemical properties of Ti-PDA@SNP-OGP were assessed by scanning electron microscopy,X-ray photoelectron spectroscope,water contact angle,photothermal property and NO release *** synergistic antibacterial effect and elimination of the MRSA biofilms were evaluated by 2′,7′-dichlorofluorescein diacetate probe,1-N-phenylnaphthylamine assay,adenosine triphosphate intensity,O-nitrophenyl-β-D-galactopyranoside hydrolysis activity,bicinchoninic acid *** staining,assays for alkaline phosphatase activity,collagen secretion and extracellular matrix mineralization,quantitative real‑time reverse transcription‑polymerase chain reaction,and enzyme-linked immunosorbent assay(ELISA)were used to evaluate the inflammatory response and osteogenic ability in bone marrow stromal cells(MSCs),RAW264.7 cells and their co-culture *** staining,ELISA,micro-CT,hematoxylin and eosin,Masson's trichrome and immunohistochemistry staining were used to evaluate the eradication of MRSA biofilms,inhibition of inflammatory response,and promotion of osseointegration of Ti-PDA@SNP-OGP in ***:Ti-PDA@SNP-OGP displayed a synergistic photothermal and NO-dependent antibacterial effect against MRSA following near-infrared light(NIR)irradiation,and effectively eliminated the formed MRSA biofilms by inducing reactive oxygen species(ROS)-mediated oxidative stress,destroying bacterial membrane integrity and

关键词： Polydopamine nanoparticles Methicillin-resistant Staphylococcus aureus Nitric oxide Osseointegration Osteo-immunomodulation Photothermal effect Titanium implants

Reinforced concrete-like Na_(3.5)V_(1.5)Mn_(0.5)(PO_(4))_(3)@graphene hybrids with hierarchical porosity as durable and high-rate sodium-ion battery cathode

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Chinese Chemical Letters 2024年第4期35卷 214-219页

作者： tao long Peng Chen Bin Feng Caili Yang Kairong Wang Yulei Wang Can Chen Yaping Wang Ruotong Li Meng Wu Minhuan Lan Wei Kong Pang Jian-Fang Wu Yuan-Li Ding College of Materials Science and Engineering Hunan UniversityChangsha 410082China Department of Physics Xiamen UniversityXiamen 361005China College of Chemistry and Chemical Engineering Central South UniversityChangsha 410083China Institute for Superconducting&Electronic Materials Faculty of EngineeringUniversity of WollongongWollongongNSW 2522Australia

Realizing high-rate capability and high-efficiency utilization of polyanionic cathode materials is of great importance for practical sodium-ion batteries(SIBs) since they usually suffer from extremely low electronic conductivity and limited ionic diffusion kinetics. Herein, taking Na_(3.5)V_(1.5)Mn_(0.5)(PO_(4))_(3)(NVMP) as an example, a reinforced concrete-like hierarchical and porous hybrid(NVMP@C@3DPG) built from 3D graphene(“rebar”) frameworks and in situ generated carbon coated NVMP(“concrete”) has been developed by a facile polymer assisted self-assembly and subsequent solid-state method. Such hybrids deliver superior rate capability(73.9 m Ah/g up to 20 C) and excellent cycling stability in a wide temperature range with a high specific capacity of 88.4 m Ah/g after 5000 cycles at 15 C at room temperature, and a high capacity retention of 97.1% after 500 cycles at 1 C(-20 ℃), and maintaining a high reversible capacity of 110.3 m Ah/g in full cell. This work offers a facile and efficient strategy to develop advanced polyanionic cathodes with high-efficiency utilization and 3D electron/ion transport systems.

关键词： Sodium-ion battery Polyanionic cathode Hybrid structure Interconnected structure Energy storage

Clinical effect of operative vs nonoperative treatment on humeral shaft fractures:Systematic review and meta-analysis of clinical trials

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World Journal of Orthopedics 2024年第8期15卷 783-795页

作者： Yang Li Yi Luo Jing Peng Jun Fan Xiao-tao long Department of Traumatic Orthopedics Chongqing General HospitalChongqing UniversityChongqing 401147China Department of Orthopedics Bishan Hospital of ChongqingChongqing 402760China

BACKGROUND Whether operation is superior to non-operation for humeral shaft fracture remains *** hypothesized that operation could decrease the nonunion and reintervention rates and increase the functional *** To compare the clinical efficacy between operative and nonoperative approaches for humeral shaft *** We searched the PubMed,Web of Science,ScienceDirect,and Cochrane databases from 1990 to December 2023 for clinical trials and cohort studies comparing the effects of operative and conservative methods on humeral shaft *** investigators independently extracted data from the eligible studies,and the other two assessed the methodological quality of each *** quality of the included studies was assessed using the Cochrane risk bias or Newcastle-Ottawa *** nonunion,reintervention and the overall complications and functional scores were pooled and analyzed using Review Manager software(version 5.3).RESULTS A total of four randomized control trials and 13 cohort studies were included,with 1285 and 1346 patients in the operative and nonoperative groups,*** in the operative group were treated with a plate or nail,whereas those in the conservative group were managed with splint or functional *** studies were assessed as having a high risk of bias,and the other 13 were of a low risk of bias according to the Newcastle-Ottawa Scale or Cochrane risk bias *** operative group had a significantly decreased rate of nonunion[odds ratio(OR)0.30;95%CI:0.23 to 0.40,reintervention(OR:0.33;95%CI:0.24 to 0.47),and overall complications(OR:0.62;95%CI:0.49 to 0.78)].The pooled effect of the Disabilities of Arm,Shoulder,and Hand score showed a significant difference at 3[mean difference(MD)-8.26;95%CI:-13.60 to-2.92],6(MD:-6.72;95%CI:-11.34 to-2.10),and 12 months(MD:-2.55;95%CI:-4.36 to-0.74).The pooled effect of Visual Analog Scale scores and the Constant-Murley score did not significantly differ between

关键词： Humeral shaft fracture Operation Nonoperation Brace Systematic review

经颏下口腔前庭联合腋窝入路内镜甲状腺手术6例报告

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中国普通外科杂志 2024年第5期33卷 788-795页

作者：陶龙阮剑湖北省武汉市第一医院甲乳外科湖北武汉430030

背景与目的:近年来,各种颈部无痕的甲状腺手术逐渐成熟,经口腔前庭入路全内镜甲状腺手术(TOETVA)由于其路径短、清扫淋巴结方便彻底、体表无痕,逐渐受到医生及患者的青睐。然而,在笔者团队前期开展的TOETVA患者中发现,部分术后有不同程... 详细信息

背景与目的:近年来,各种颈部无痕的甲状腺手术逐渐成熟,经口腔前庭入路全内镜甲状腺手术(TOETVA)由于其路径短、清扫淋巴结方便彻底、体表无痕,逐渐受到医生及患者的青睐。然而,在笔者团队前期开展的TOETVA患者中发现,部分术后有不同程度的颏部麻木感、下唇运动功能减退、水肿变形、颏部瘢痕增生变硬等不适,于是团队后期采用5 mm内镜进行经口腔甲状腺手术,并加入腋窝通道辅助手术和取出标本,即经口腔联合腋窝入路全内镜甲状腺手术(AcaTOETVA),当面对颏骨过于突出的患者,口腔观察孔隧道比较难建立时,采用颏下5 mm切口建立观察孔隧道,行经颏下口腔前庭联合腋窝入路内镜甲状腺手术(SaAcaTOETVA)。本文通过总结行该术式的有限病例,初步探讨该术式的可行性及优缺点。方法:回顾性分析6例武汉市第一医院甲乳外科2020年9月—11月完成SaAcaTOETVA患者的临床资料。结果:6例患者均顺利完成手术,其中3例行甲状腺左侧腺叶切除术+左侧中央区淋巴结清扫,1例行甲状腺右侧腺叶切除术+右侧中央区淋巴结清扫,1例行甲状腺右侧腺叶近全切除术,1例行甲状腺双侧叶近全切除术,手术时间100~155 min,术中出血量10~20 mL,术后住院时间3 d,患者无喉返神经损伤,无皮下血肿、颏神经损伤、颏部及嘴唇麻木、颏部肿胀、低钙血症、吞咽困难、CO_(2)气体栓塞、切口感染延迟愈合等并发症发生,1例患者出现颏部小范围瘀青,为操作孔穿刺所致,于1周内恢复。术后1个月随访,患者颏下切口愈合良好,正常站立位时,切口隐藏于颏下及腋窝,相对隐蔽不易被发现,患者对颏下及腋窝切口满意,术后复查未发现肿瘤种植、复发或转移。结论:采用SaAcaTOETVA安全可行,是AcaTOETVA的特殊情况的重要补充,具有切口较隐蔽、美观的特点,但5 mm内镜的清晰度问题以及初始建腔空间较小的问题,可能会影响该术式的推广应用。

关键词：甲状腺肿瘤甲状腺切除术内窥镜经口腔入路

Activation of autophagy by Citri Reticulatae Semen extract ameliorates amyloid-beta-induced cell death and cognition deficits in Alzheimer’s disease

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Neural Regeneration Research 2024年第11期19卷 2467-2479页

作者： Yong Tang Jing Wei Xiao-Fang Wang tao long Xiaohong Xiang Liqun Qu Xingxia Wang Chonglin Yu Xingli Xiao Xueyuan Hu Jing Zeng Qin Xu Anguo Wu Jianming Wu Dalian Qin Xiaogang Zhou Betty Yuen-Kwan Law Dr.Neher’s Biophysics Laboratory for Innovative Drug Discovery State Key Laboratory of Quality Research in Chinese MedicineMacao University of Science and TechnologyMacao Special Administrative RegionChina Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica Southwest Medical UniversityLuzhouSichuan ProvinceChina Eye School and Key Laboratory of Sichuan Province Ophthalmopathy Prevention&Cure and Visual Function Protection of Chengdu University of TCM ChengduSichuan ProvinceChina School of Basic Medical Sciences Southwest Medical UniversityLuzhouSichuan ProvinceChina Department of Ophthalmology The Affiliated Hospital of Southwest Medical UniversityLuzhouSichuan ProvinceChina Department of Neurology The First People’s Hospital of NeijiangNeijiangSichuan ProvinceChina

Amyloid-beta-induced neuronal cell death contributes to cognitive decline in Alzheimer’s *** Reticulatae Semen has diverse beneficial effects on neurodegenerative diseases,including Parkinson’s and Huntington’s diseases,however,the effect of Citri Reticulatae Semen on Alzheimer’s disease remains *** the current study,the anti-apoptotic and autophagic roles of Citri Reticulatae Semen extract on amyloid-beta-induced apoptosis in PC12 cells were first *** Reticulatae Semen extract protected PC12 cells from amyloid-beta-induced apoptosis by attenuating the Bax/Bcl-2 ratio via activation of *** addition,Citri Reticulatae Semen extract was confirmed to bind amyloid-beta as revealed by biolayer interferometry in vitro,and suppress amyloid-beta-induced pathology such as paralysis,in a transgenic Caenorhabditis elegans in vivo ***,genetically defective Caenorhabditis elegans further confirmed that the neuroprotective effect of Citri Reticulatae Semen extract was *** importantly,Citri Reticulatae Semen extract was confirmed to improve cognitive impairment,neuronal injury and amyloid-beta burden in 3×Tg Alzheimer’s disease *** revealed by both in vitro and in vivo models,these results suggest that Citri Reticulatae Semen extract is a potential natural therapeutic agent for Alzheimer’s disease via its neuroprotective autophagic effects.

关键词： Alzheimer’s disease amyloid-beta apoptosis autophagy Caenorhabditis elegans Citri Reticulatae Semen

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改流体技术用于中厚急倾斜矿体开采实验研究

煤炭学报 2024年第S1期49卷 12-21页

作者：陶干强龙涛王丽圆梁波孟晓静南华大学资源环境与安全工程学院

采用无底柱分段崩落法开采中厚急倾斜矿体现已在矿山中得到广泛应用，但仍普遍存在矿石损失贫化的问题，至今未得到根本解决。为实现资源与环境协调的绿色开采，以中厚急倾斜矿体开采为研究对象，基于料仓内改流体结构原理，提出了改流... 详细信息

采用无底柱分段崩落法开采中厚急倾斜矿体现已在矿山中得到广泛应用，但仍普遍存在矿石损失贫化的问题，至今未得到根本解决。为实现资源与环境协调的绿色开采，以中厚急倾斜矿体开采为研究对象，基于料仓内改流体结构原理，提出了改流体放矿技术。考虑矿体倾角和厚度、分段高度因素的影响，设计了18组改流体放矿和常规截止品位放矿对比实验，研究了三因素对矿石损失贫化的影响。实验结果表明，不同厚度、不同倾角矿体开采中，改流体放矿技术矿石回收率均高于常规截止品位放矿回收率。在相同废石混入率条件下，改流体放矿矿石回收率为69.09%～82.9%，高于常规截止品位放矿12.66%～30.88%。当矿体倾角为60°～85°时，矿石回收率随矿体倾角的增大而提高；当矿体厚度为6～10 m时，改流体放矿技术矿石回收率高于常规截止品位放矿回收率；当分段高度为10～14 m时，矿石回收率随分段高度的增加而提高。同时，研究了改流体放矿技术机理，通过在采场中设置改流体结构和改变改流板的打开与关闭顺序，从而改变矿岩流动路径，可增大矿石流动范围和流动速率，控制矿岩接触，从而减少矿石损失和贫化。研究表明，改流体放矿技术优于常规截止品位放矿技术，有效改善了矿石损失贫化问题，为中厚急倾斜矿体开采时降低损失贫化提供了新的方法。

关键词：无底柱分段崩落法中厚急倾斜矿体改流体放矿分段高度损失贫化

基于NSGA-Ⅱ算法的制动盘通道内回流区散热优化

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机械设计 2024年第2期41卷 56-65页

作者：李杰陈颖陶龙北京建筑大学机电与车辆工程学院北京102627

为提高通风式制动盘通道内回流区的对流散热性能,以通风式制动盘内部直叶片为研究对象,并基于遗传算法来进行结构优化。首先,采用最优拉丁超立方法进行数据采样,拟合响应面代理模型并验证代理模型的准确性;其次,在直叶片模型的基础上,选... 详细信息

为提高通风式制动盘通道内回流区的对流散热性能,以通风式制动盘内部直叶片为研究对象,并基于遗传算法来进行结构优化。首先,采用最优拉丁超立方法进行数据采样,拟合响应面代理模型并验证代理模型的准确性;其次,在直叶片模型的基础上,选取3个结构参数:槽的宽度、槽的倾斜角度和叶片数量为优化变量,以质量流量和对流换热系数最大为目标,对制动盘内部进行优化设计,得到Pareto最优解;最后,比较优化前后两种制动盘通道内流体流动和散热效果。结果表明:优化后的槽叶片有效削弱了通道内的回流区域,使气流分布更加均匀;相较于直叶片制动盘,槽叶片制动盘的泵送质量流量能力提高了12%,通道内散热率提高了5.6%,总体散热高了9%。

关键词：通风制动盘槽叶片回流区 NSGA-Ⅱ 散热优化